Abstract:
OBJECTIVE:Relatively little is known about the influence of chronic oral protein intake on the kidney function. In most studies only the effect of a short-term change in protein intake [6-28 days] or the effect of an acute protein load on the glomerular filtration rate was studied. The purpose of this study was to investigate the effect of chronic oral protein intake on endogenous creatinine clearance and on the albumin excretion rate. DESIGN AND SUBJECTS:In a prospective study 88 healthy volunteers with normal renal function (32 vegetarians, 12 body-builders with no supplementary protein concentrates, 28 body-builders with supplementary protein concentrates and 16 subjects with no special diet) were examined. In order to investigate the effect of chronic oral protein intake, the participants were on their diet for at least 4 months. RESULTS:Endogenous creatinine clearance as a measure for glomerular filtration rate varied between 32 ml/min and 197 ml/min or 34 and 186 ml/min x 1.73 m2, respectively. Nitrogen excretion rate was used as a measure for the daily protein intake, since it is known to correlate linearly with the daily protein intake. Nitrogen excretion rates ranged between 2.66 g/d and 33.93 g/d reflecting a daily protein consumption between 17 and 212 g/d or 0.29 g/kg bw/d and 2.6 g/kg bw/day, respectively. Between nitrogen excretion rate and endogenous creatinine clearance a non linear, highly significant correlation was found showing a saturation with a maximum endogenous creatinine clearance of 181.7 ml/min (dose response curve). A similar correlation was observed between urea excretion rate and endogenous creatinine clearance. Using a model for multiple regression analysis the dependence of the albumin excretion rate on nitrogen excretion rate and endogenous creatinine clearance was examined. Only a significant correlation was found between albumin excretion rate and endogenous creatinine clearance, while the correlation between albumin excretion rate and nitrogen excretion rate was not significant. CONCLUSION:This investigation shows that chronic oral protein intake of widely varying amounts of protein is a crucial control variable for the glomerular filtration rate in subjects with healthy kidneys. It is suggested that these changes reflect in part structural changes of the glomerulus and tubules due to chronic protein intake.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Brändle E,Sieberth HG,Hautmann REsubject
Has Abstractpub_date
1996-11-01 00:00:00pages
734-40issue
11eissn
0954-3007issn
1476-5640journal_volume
50pub_type
杂志文章abstract:BACKGROUND/OBJECTIVES:There is limited published research examining lipid-soluble vitamins in human immunodeficiency virus (HIV)-infected pregnant women, particularly in resource-limited settings. SUBJECTS/METHODS:This is an observational analysis of 1078 HIV-infected pregnant women enrolled in a trial of vitamin supp...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/ejcn.2010.76
更新日期:2010-08-01 00:00:00
abstract::Dehydration is a reliable predictor of impaired cognitive status. Objective data, using tests of cortical function, support the deterioration of mental performance in mildly dehydrated younger adults. Dehydration frequently results in delirium as a manifestation of cognitive dysfunction. Although, the occurrence of de...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/sj.ejcn.1601898
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Mild cognitive impairment (MCI), often considered as an early stage of dementia, is heterogeneous, and not all subjects with MCI progress into clinically diagnosed dementia. Low body weight (and body mass index, BMI) as well as losing weight while in MCI stadium have been proposed as possible risk...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/ejcn.2014.167
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:It is unknown if a specific fatty-acid composition influences the development of Alzheimer's disease (AD). Nutrition is a possible target for prevention of dementia and especially omega-3-based fatty acids (n-3 FAs) have previously been suggested to be beneficial for cognition. The objective was t...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.63
更新日期:2012-08-01 00:00:00
abstract::Bone marrow transplantation is often associated with multiple organ failure which is usually reversible. Oral mucositis and dysphagia, vomiting, diarrhoea, protein losing enteropathy, transient exocrine pancreatic impairment, hypoalbuminaemia, biochemical trace element and mineral deficiencies are all common following...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/sj.ejcn.1600669
更新日期:1998-12-01 00:00:00
abstract::The importance of processing conditions, product thickness and effect of egg addition for the glycaemic and hormonal responses to pasta was studied. Healthy subjects were given test meals with an equivalent amount of available carbohydrate from extruded high-temperature dried spaghetti and three varieties of fresh rol...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVE:The object of this study was to investigate the in vivo antioxidant effect of green tea and dosage effect of green tea on antioxidant effect. DESIGN:We tested 10 healthy subjects (aged 23-25 y, five women and five men) with overnight fasting. The total antioxidant capacity of plasma was measured at baseline ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600994
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Several diets, e.g., those low in fruits/vegetables, high in sodium, and red/processed meat, have been related to a higher stroke risk. We investigated stroke mortality associated with a priori diet-quality indices in the Multiethnic Cohort study. SUBJECTS/METHODS:Based on 172,043 observations in...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0103-4
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To determine the origin of the poor digestibility of banana starch granules in the human small intestine. DESIGN:The subjects received the same experimental meal. SETTING:Nutrition Research Unit, Laënnec Hospital, CHU, Nantes. SUBJECTS:Six healthy young subjects. INTERVENTIONS:The digestion of raw green b...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::Adverse reaction to cow's milk and infant formulas are common during infancy. Cow's milk has more than 20 constituents proteins and in principle many are capable of giving rise to an IgE mediated response. The prevalence of cow's milk allergy is between 0.5-10% of the paediatric population (Frier & Kletter, 1970, Gerr...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Early insulin secretion following a meal is representative for normal physiology and may depend on meal composition. To compare the effects of a fat-rich and a carbohydrate-rich mixed meal on insulinogenic index as a measure of early insulin secretion in normoglycemic women (NGM) and in women with ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602953
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of biochemical iron deficiency and identify factors associated with ferritin levels among 6-24-month-old urban South Island New Zealand children. DESIGN:Cross-sectional survey conducted from May 1998 to March 1999. SETTING:The cities of Christchurch, Dunedin and Invercargill. S...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601751
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To study the variation in selenoprotein P levels in serum among healthy subjects from 17 European regions representing nine countries. SUBJECTS:Survey of 414 37-70-year-old subjects (197/217 males/females) from 17 regions. RESULTS:The level of selenoprotein P varied significantly among regions and countries...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:A case-control study was conducted to evaluate the effects of diabetes mellitus on serum levels of vitamin A, alpha-carotene, beta-carotene, alpha-tocopherol, serum and urine RBP. SUBJECTS:One hundred and seven patients with Type 2 diabetes mellitus (28-74 y) were recruited from those attending a primary hea...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600825
更新日期:1999-08-01 00:00:00
abstract::The effect of guar on the absorption of the calcium isotope 45Ca was measured in six normal subjects. Values for the delay before the initial rise of radioactivity in plasma (delta t) and the initial fractional absorption rate (alpha) were derived using a non-linear curve-fitting computer programme. Guar significantly...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
abstract:OBJECTIVE:There are still controversies as to the potential beneficial effects of milk and fermented milk products on the level of lipoproteins. The objective of the present investigation was to test the effect of a moderate daily intake of a new fermented milk product, which was based on a bacterial culture obtained f...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The European Food Safety Authority approved a health claim (ID558) relating to lowered postprandial glycaemia when fructose replaces 30% of sucrose in foods and beverages. We assessed the effects of partial replacement of sucrose with fructose on serum glucose, uric acid and blood pressure. SUBJE...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41430-018-0134-x
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:To explore the different characteristics of high and low fat consumers, in particular their macronutrient intake and body mass index. DESIGN:Reanalysis of data from the Dietary and Nutritional Survey of British Adults. Comparisons were made between groups defined as high and low fat consumers on the basis o...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To collect (i) baseline data and (ii) execute a large multicentre study examining the effect of trans alpha-linolenic acid on its incorporation into plasma lipids and on risk factors for coronary heart disease. DESIGN:Male volunteers were recruited and the habitual diet assessed by a 4-d weighed record. Fatt...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1600903
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Healthy eating advice is informed, in part, by dietary surveys that rely on self-reported data. Misreporting of food intake may distort relationships between diet and health outcomes. This study directly quantified the food groups that were under-reported or over-reported in common dietary assessm...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0199-6
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Body composition parameters are linked to cardio-metabolic risk. However, high-quality reference values of body composition are scarce, particularly in Asian population. The aim of study was to construct sex- and age-specific normative reference values of body composition for the Vietnamese population. METH...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-00840-y
更新日期:2021-01-18 00:00:00
abstract:OBJECTIVE:To estimate the current burden of mortality attributable to excess weight in the European Union (EU). METHODS:Prevalence of overweight (body mass index, BMI 25-29.9 kg/m(2)) and obesity (BMI >or=30 kg/m(2)) were based on self-reported data from a survey with samples representative of the 15 EU Member States ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601538
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Sarcopenia and sarcopenic obesity (SO) are geriatric syndromes leading to physical disability, poor quality of life and death. The aim of this study was to investigate the prevalence of sarcopenia and SO in nursing homes in Turkey and to define local disparities for diagnosing sarcopenia and SO. ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究
doi:10.1038/ejcn.2014.15
更新日期:2014-06-01 00:00:00
abstract::This paper was based on collaborative research efforts from Wageningen University and the University Medical Centre St Radboud in The Netherlands and describes the rationale for web-based nutrition counselling applications in general practice as well as some of the frequently used models and theories (predominantly th...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602185
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:To examine the effects of alpha (s1)-casein hydrolysate on females with stress-related symptoms. DESIGN:Double-blind, randomized, crossover, placebo-controlled trial. SETTING:The alpha (s1)-casein hydrolysate was manufactured by INGREDIA (Arras, France) and the placebo was manufactured by DIETAROMA (Bourg, ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602553
更新日期:2007-04-01 00:00:00
abstract::As type 2 diabetes mellitus (DM2), obesity and sedentary lifestyles are increasing in developing countries, this observational study investigated the role of physical activity on DM2 in Jamaica. Anthropometry, body composition (by bioelectrical impedance analysis) and glucose tolerance status was assessed in 722 adult...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602011
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Anorexia or lack of appetite is common in chronic obstructive pulmonary disease (COPD) and may be caused or augmented by several symptoms affecting appetite and eating. We aimed to investigate and quantify the extent of nutrition impact symptoms (NIS) in patients with COPD and to explore relations...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2014.76
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The roles of vitamin B12 and homocysteine concentration in depression are not clear. We investigated cross-sectional and prospective associations of serum vitamin B12 and plasma homocysteine with depressive symptoms in Dutch older adults. SUBJECTS/METHODS:In the Longitudinal Aging Study Amsterdam...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2016.224
更新日期:2017-04-01 00:00:00
abstract::The application of molecular biology and genetics in the field of cholesterol and lipoprotein metabolism has resulted in a tremendous expansion of knowledge during the past decade. In this short review, the normal metabolism of lipoproteins is first discussed briefly, and several clinically important examples of genet...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
abstract::A cross-sectional study of children in West Kalimantan, Indonesia, was conducted to examine the relationship between malnutrition history, child IQ, school attendance, socioeconomic status, parental education and parental IQ. In unadjusted analyses, severely stunted children had significantly lower IQ scores than mild...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602103
更新日期:2005-04-01 00:00:00