Topotecan (hycamptin) and topotecan-containing regimens in the treatment of hematologic malignancies.

abstract：:Corn flour and maize meal fortification can benefit the consumer when the added nutrient contents are in amounts appropriate to address nutrient gaps. Legislative instruments (standards and regulations) are needed to provide guidance to the producers and food control authorities. We reviewed a number of national stand...

journal_title：Annals of the New York Academy of Sciences

authors： Makhumula P,Dary O,Guamuch M,Tom C,Afidra R,Rambeloson Z

更新日期：2014-04-01 00:00:00

abstract：:Tight junctions (TJs) regulate paracellular barriers and claudins (Cld) form the backbone of TJ strands. To elucidate the molecular mechanism of claudin polymer formation, TJs were reconstituted by claudin transfection of TJ-free HEK293 cells. Therewith, typical TJ stands can be found at cell-cell contacts. In additio...

journal_title：Annals of the New York Academy of Sciences

authors： Rossa J,Lorenz D,Ringling M,Veshnyakova A,Piontek J

更新日期：2012-06-01 00:00:00

abstract：:Familial British dementia (FBD) is a disorder characterized by the presence of amyloid deposits in cerebral blood vessels and brain parenchyma coexisting with neurofibrillary tangles in limbic areas. The amyloid subunit (ABri) is a 4 kDa fragment of a 266 amino acid type II single-spanning transmembrane precursor prot...

journal_title：Annals of the New York Academy of Sciences

authors： Ghiso J,Vidal R,Rostagno A,Miravalle L,Holton JL,Mead S,Révész T,Plant G,Frangione B

更新日期：2000-01-01 00:00:00

abstract：:The alpha-ketoglutarate dehydrogenase complex (KGDHC) is an important mitochondrial constituent, and deficiency of KGDHC is associated with a number of neurological disorders. KGDHC is composed of three proteins, each encoded on a different and well-characterized gene. The sequences of the human proteins are known. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Sheu KF,Blass JP

更新日期：1999-01-01 00:00:00

abstract：:Osteoclasts are cells of monocyte-macrophage origin that degrade bone matrix. Receptor activator of NF-kappaB ligand (RANKL) induces osteoclast formation in the presence of macrophage-colony-stimulating factor (M-CSF) and costimulatory signals. RANKL induces activation of the TNF receptor-associated factor 6 (TRAF6) a...

journal_title：Annals of the New York Academy of Sciences

authors： Takayanagi H

更新日期：2007-11-01 00:00:00

abstract：:Venous or arterial thrombosis, abortion, and the presence of antiphospholipid antibodies (aPL) define the criteria for the antiphospholipid syndrome (APS). A heterogeneous group of antibodies against phospholipids and plasma proteins may influence several coagulation pathways and lead to thrombophilia. We investigated...

journal_title：Annals of the New York Academy of Sciences

authors： Miesbach W,Matthias T,Scharrer I

更新日期：2005-06-01 00:00:00

abstract：:A rabbit antimouse brain theta reagent was made specific for cells of the T lineage by absorption in vivo in nude mice. When used in double fluorescence together with an antimouse immunoglobulin reagent, four types of cells were found in spleen and lymph nodes of both normal and nude mice: Ig+thetaBr-, Ig-thetaBr+, Ig...

journal_title：Annals of the New York Academy of Sciences

authors： Loor F,Roelants GE

更新日期：1975-06-30 00:00:00

abstract：:The available evidence suggests that plasma leakage in dengue hemorrhagic fever is caused by the action of circulating mediators on the vascular endothelium, and that the host immune response is a critical determinant of this response. We have been exploring the role of dengue virus-specific T lymphocytes in the immun...

journal_title：Annals of the New York Academy of Sciences

authors： Rothman AL

更新日期：2009-09-01 00:00:00

abstract：:The SET domain, first identified within and named after proteins encoded by three Drosophila genes [Su(var)3-9, E(z), and Trithorax], is recognized as a signature motif for histone methyltransferases that are involved in epigenetic processes. The SUV39H family of SET domain proteins methylate specifically the residue ...

journal_title：Annals of the New York Academy of Sciences

authors： Zhao Z,Shen WH

更新日期：2004-12-01 00:00:00

abstract：:Human female reproductive aging consists of multiple processes and interacts with other physiological systems in unique ways. Here we discuss eight recent longitudinal, epidemiologic studies of female reproductive aging that include endocrine data to highlight their contributions to our understanding of these various ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrell RJ,Sowers M

更新日期：2010-08-01 00:00:00

abstract：:Synthetic oligodeoxynucleotides (ODN) capable of "neutralizing" or "inhibiting" immune responses have been described. This review will focus on the properties of phosphorothioate ODN that mimic the immunosuppressive activity of the repetitive TTAGGG motifs present in mammalian telomeres. These TTAGGG multimers block t...

journal_title：Annals of the New York Academy of Sciences

authors： Klinman DM,Tross D,Klaschik S,Shirota H,Sato T

更新日期：2009-09-01 00:00:00

abstract：:Disorientation may draw attention from other activities and its impact on cognition may cause pilot error and problems of concentration in dizzy patients. Tasks used to study the impact of disorientation include number processing, intelligence scales and Brookes matrices (reproduction of 2xD patterns of numbers vs. no...

journal_title：Annals of the New York Academy of Sciences

authors： Gresty MA,Golding JF

更新日期：2009-05-01 00:00:00

abstract：:Antisense oligonucleotides (AON) are being developed for a wide array of therapeutic applications. Significant improvements in their serum stability, target affinity, and safety profile have been achieved with the development of chemically modified oligonucleotides. Here, we compared 2'-deoxy-2'-fluoro-beta-D-arabinon...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari N,Bergeron D,Tedeschi AL,Mangos MM,Paquet L,Renzi PM,Damha MJ

更新日期：2006-10-01 00:00:00

abstract：:Physicians have used various forms of antipyretic therapy since antiquity to lower the temperature of febrile patients. Nevertheless, it has yet to be determined whether the benefits of antipyretic therapy outweigh its risks. It is not known, for example, if core temperatures encountered during the febrile state ever ...

journal_title：Annals of the New York Academy of Sciences

authors： Mackowiak PA,Plaisance KI

更新日期：1998-09-29 00:00:00

abstract：:Exosomes are nanovesicles secreted from cells that play key roles in intercellular communication. They carry unique content derived from parental cells and are capable of transferring this cargo between cells. The role and function of exosomes largely depends on the origin and functional status of the parental cells. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cobelli NJ,Leong DJ,Sun HB

更新日期：2017-12-01 00:00:00

abstract：:Because of certain restrictions in medical praxis, reusable materials are only allowed in some countries. This also applies to electrodes for electromyography; the special single-fiber electromyography electrode must be replaced. This article gives some details of the possibilities of using an alternative-a small conc...

journal_title：Annals of the New York Academy of Sciences

authors： Stålberg E

更新日期：2012-12-01 00:00:00

abstract：:1. The flow divider of the brachiocephalic branching of the rabbit aorta had both high and low shear stress regions, each of which was covered by endothelial cells with low and high permeability respectively, even in normolipidemic intact rabbits. When rabbits were placed on an atherogenic diet, low shear regions were...

journal_title：Annals of the New York Academy of Sciences

authors： Yoshida Y,Okano M,Wang S,Kobayashi M,Kawasumi M,Hagiwara H,Mitsumata M

更新日期：1995-01-17 00:00:00

abstract：:Although stress is tightly connected with elevated levels of catecholamines, stress effects on target structures of catecholamine action--adrenoceptors (ARs)--has not been deeply studied yet. Similarly, very little is known about changes of muscarinic receptors (MRs) during stress. We determined changes in these recep...

journal_title：Annals of the New York Academy of Sciences

authors： Myslivecek J,Tillinger A,Novakova M,Kvetnanský R

更新日期：2008-12-01 00:00:00

abstract：:Tolerance has been defined as a lack of response to self but a more appropriate definition of tolerance is "any mechanism by which a potentially injurious immune response is prevented, suppressed, or shifted to a non-injurious class of immune response." Thus, tolerance is related to productive self-recognition, rather...

journal_title：Annals of the New York Academy of Sciences

authors： Weiner HL

更新日期：2004-12-01 00:00:00

abstract：:The aim of this study was to examine changes in muscle cell injury and antioxidant capacity of weightlifters following a 1-week intensive resistance-training regimen. Thirty-six female subjects participated in this study, and their ages ranged from 18 to 25 years. The sample group included 19 elite weightlifters with ...

journal_title：Annals of the New York Academy of Sciences

authors： Liu JF,Chang WY,Chan KH,Tsai WY,Lin CL,Hsu MC

更新日期：2005-05-01 00:00:00

abstract：:Amperometry is a powerful tool for studying the exocytotic process. Catecholamines released from a single secretory vesicle are oxidized by a carbon fiber microelectrode placed on a chromaffin cell membrane. This phenomenon can be recorded online as an amperometric signal. Each event of exocytosis is called a secretor...

journal_title：Annals of the New York Academy of Sciences

authors： Gomez JF,Brioso MA,Machado JD,Sanchez JL,Borges R

更新日期：2002-10-01 00:00:00

abstract：:Esophageal cancer (EC) is one of the most lethal cancers and a public health concern worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are main histopathological subtypes of EC that show striking differences in geographical...

journal_title：Annals of the New York Academy of Sciences

authors： Talukdar FR,di Pietro M,Secrier M,Moehler M,Goepfert K,Lima SSC,Pinto LFR,Hendricks D,Parker MI,Herceg Z

更新日期：2018-12-01 00:00:00

abstract：:Persorption of large, hard, insoluble, solid particles in micrometer size range is observed with regularity. It is a normal biological effect on the food passage through the intestine. Persorbability of particles is determined by the size of the particles and by their consistency and hardness. PVC particles in microme...

journal_title：Annals of the New York Academy of Sciences

authors： Volkheimer G

更新日期：1975-01-31 00:00:00

abstract：:Tocopherols and tocotrienols (vitamin E) and ascorbic acid (vitamin C) as well as the carotenoids react with free radicals, notably peroxyl radicals, and with singlet molecular oxygen (1O2), this being the basis of their function as antioxidants. RRR-alpha-tocopherol is the major peroxyl radical scavenger in biologica...

journal_title：Annals of the New York Academy of Sciences

authors： Sies H,Stahl W,Sundquist AR

更新日期：1992-09-30 00:00:00

abstract：:Phospholemman (PLM) is the first sequenced member of the FXYD family of regulators of ion transport. The mature protein has 72 amino acids and consists of an extracellular N terminus containing the signature FXYD motif, a single transmembrane (TM) domain, and a cytoplasmic C-terminal domain containing four potential s...

journal_title：Annals of the New York Academy of Sciences

authors： Cheung JY,Rothblum LI,Moorman JR,Tucker AL,Song J,Ahlers BA,Carl LL,Wang J,Zhang XQ

更新日期：2007-03-01 00:00:00

abstract：:The clinical, epidemiological, and therapeutic aspects of 15 patients with Mediterranean spotted fever (MSF), admitted to the Internal Medicine Department of the General Hospital of Sitia (southeastern Crete, Greece) between December 2000 and July 2003, were studied. Diagnosis was made on the basis of clinical signs a...

journal_title：Annals of the New York Academy of Sciences

authors： Germanakis A,Psaroulaki A,Gikas A,Tselentis Y

更新日期：2006-10-01 00:00:00

abstract：:The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated "Neglected Tropical Diseases," and each is also both the result of and a contributor to the poverty of many rural populations. To various degrees, they all have adverse effect...

journal_title：Annals of the New York Academy of Sciences

authors： Hopkins DR,Richards FO Jr,Ruiz-Tiben E,Emerson P,Withers PC Jr

更新日期：2008-01-01 00:00:00

abstract：:Neuromodulation denotes controlled electrical stimulation of the central or peripheral nervous system. The three forms of neuromodulation described in this paper-deep brain stimulation, vagus nerve stimulation, and transcranial magnetic stimulation-were chosen primarily for their demonstrated or potential clinical use...

journal_title：Annals of the New York Academy of Sciences

authors： Andrews RJ

更新日期：2003-05-01 00:00:00

abstract：:In hereditary HTG rats, basal systolic blood pressure using tail-cuff sphygmomanometry was significantly higher (122.1 +/- 2.1 mm Hg; n = 16) than that in NTG animals (107.1 +/- 1.52; n = 16). A low salt diet did not influence blood pressure in NTG rats during the consecutive 4 weekly periods. However, in the second w...

journal_title：Annals of the New York Academy of Sciences

authors： Lichardus B,Seböková E,Jezová D,Mitková A,Zemánková A,Földes O,Vrána A,Klimes I

更新日期：1993-06-14 00:00:00

abstract：:The multiple actions of somatostatin are mediated by specific membrane-bound receptors present in all somatostatin target tissues, such as brain, pituitary, pancreas, gastrointestinal tract, and kidney. For instance, in the human gastrointestinal tract, three different types of tissue compartments express somatostatin...

journal_title：Annals of the New York Academy of Sciences

authors： Reubi JC,Laissue J,Waser B,Horisberger U,Schaer JC

更新日期：1994-09-15 00:00:00