Computer simulation analysis suggests weak balancing selection operative at the MICA locus.

Abstract:

:A high degree of polymorphism has been reported at the major histocompatibility class I chain-related gene A (MICA) locus, which is located 46 kb away from HLA-Bin the human major histocompatibility complex (MHC) class I region. Although it is known that the polymorphisms at the conventional MHC class I loci have been maintained by balancing selection, it is unclear whether positive natural selection is also operative in maintaining the polymorphism at the MICA locus. In order to explain the degree of polymorphism at the MICA locus, a computer simulation study was carried out. The high degree of polymorphism at the MICA locus (heterozygosity and number of polymorphic residues) could not be explained solely by balancing selection at the HLA-B locus even if no recombination was assumed between MICA and HLA-B. Although there is no definite evidence indicating that balancing selection is operative at the MICA locus, our results suggest that the MICA gene is subject to weak balancing selection.

journal_name

Hereditas

journal_title

Hereditas

authors

Ohashi J,Tokunaga K

doi

10.1111/j.1601-5223.2000.00025.x

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

25-8

issue

1

eissn

0018-0661

issn

1601-5223

journal_volume

133

pub_type

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