Abstract:
:A high degree of polymorphism has been reported at the major histocompatibility class I chain-related gene A (MICA) locus, which is located 46 kb away from HLA-Bin the human major histocompatibility complex (MHC) class I region. Although it is known that the polymorphisms at the conventional MHC class I loci have been maintained by balancing selection, it is unclear whether positive natural selection is also operative in maintaining the polymorphism at the MICA locus. In order to explain the degree of polymorphism at the MICA locus, a computer simulation study was carried out. The high degree of polymorphism at the MICA locus (heterozygosity and number of polymorphic residues) could not be explained solely by balancing selection at the HLA-B locus even if no recombination was assumed between MICA and HLA-B. Although there is no definite evidence indicating that balancing selection is operative at the MICA locus, our results suggest that the MICA gene is subject to weak balancing selection.
journal_name
Hereditasjournal_title
Hereditasauthors
Ohashi J,Tokunaga Kdoi
10.1111/j.1601-5223.2000.00025.xsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
25-8issue
1eissn
0018-0661issn
1601-5223journal_volume
133pub_type
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