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Characterization of the human jumonji gene.

Abstract：

:While constructing a cDNA library of human embryos, we have isolated a clone homologous to jumonji, a mouse gene required for neural tube formation. We have determined the complete coding sequence of the human homologue (JMJ) and deduced the amino acid sequence of the putative protein. We show here that human and mouse jumonji putative proteins are homologous and present 90% identity. During human embryogenesis, JMJ mRNAs are predominantly expressed in neurons and particularly in dorsal root ganglion cells. They are also expressed in neurons of human adult cerebral cortex. In view of these observations, we propose JMJ as a candidate gene for developmental defects of the central nervous system in the human. The human JMJ gene maps at position 6p24-6p23.

journal_name

Hum Mol Genet

journal_title

Human molecular genetics

authors

Bergé-Lefranc JL,Jay P,Massacrier A,Cau P,Mattei MG,Bauer S,Marsollier C,Berta P,Fontes M

doi

10.1093/hmg/5.10.1637

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

1637-41

issue

10

eissn

0964-6906

issn

1460-2083

journal_volume

5

pub_type

杂志文章

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