Abstract：
:The biomechanical strength of the skeleton, and hence the risk of future fractures, depends on both the bone quantity (assessed in terms of bone mineral density) and bone quality (assessed in terms of the integrity of its internal architecture). Precise methods of measuring the calcium-equivalent density of both the trabecular and cortical components of vertebral bone using quantitative computed tomography are presented. For a group of post-menopausal Kuwaiti females, we have shown that the trabecular and cortical components are highly correlated with each other at both the L3 and L4 lumbar vertebral levels, with correlation coefficients of 0.78 and 0.74 (P < 0.0001) respectively. We have explored the anisotropic distribution of trabecular bone and considered the use of the standard deviation and the coefficient of variation of trabecular CT numbers as texture indicators and surrogate measures of bone quality. The coefficient of variation was the better texture indicator: used with bone mineral density values it successfully discriminated between two classes of patients (those with fractures and those without) with high sensitivity (> or = 89%) and specificity (> or = 82%).
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Dougherty Gdoi
10.1016/1350-4533(96)00011-2subject
Has Abstractpub_date
1996-10-01 00:00:00pages
557-68issue
7eissn
1350-4533issn
1873-4030pii
1350453396000112journal_volume
18pub_type
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pub_type： 临床试验,杂志文章
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更新日期：2000-06-01 00:00:00
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