Abstract:
:Thirty years ago, it was suggested that maternal intake of certain vitamins during pregnancy affected the incidence of serious fetal malformations. Subsequent research has revealed that folate (folic acid), a B vitamin, plays a crucial role in the development of the central nervous system during the early weeks of gestation, which is generally before the pregnancy is confirmed. In a significant number of embryos, an inadequate supply of folate at this time leads to a failure of the primitive neural tube to close and differentiate normally and results in neural tube birth defects (NTD). Numerous studies have confirmed the importance of an adequate intake of folate during the weeks just before and after conception. Overall, the data predict that if women consume multivitamin supplements containing folic acid during the periconceptional period, the number of children born with serious malformations (such as spina bifida and anencephaly) could be reduced by half. Although programs to increase dietary folate intake of potential mothers may be effective in reducing NTD, the only proven and practical preventive measure currently available is to take oral multivitamin supplements containing folic acid. Multivitamin supplementation has also been associated with reduced incidence of other congenital malformations. Current research is focusing on the role of micronutrients in embryogenesis, and on methods to identify prospective mothers at increased risk for bearing a child with NTD or with other major malformations shown to occur at reduced frequency with multivitamin supplementation. Of equal importance is the development of methods to communicate current knowledge as a public health measure.
journal_name
Annu Rev Nutrjournal_title
Annual review of nutritionauthors
Butterworth CE Jr,Bendich Adoi
10.1146/annurev.nu.16.070196.000445subject
Has Abstractpub_date
1996-01-01 00:00:00pages
73-97eissn
0199-9885issn
1545-4312journal_volume
16pub_type
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:1990-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071812-161156
更新日期:2014-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章
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更新日期:2020-09-23 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.27.061406.093734
更新日期:2007-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.20.1.699
更新日期:2000-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.22.110901.145412
更新日期:2002-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.06.070186.001301
更新日期:1986-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.20.1.395
更新日期:2000-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.22.010402.102745E
更新日期:2002-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.09.070189.001221
更新日期:1989-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.05.070185.002251
更新日期:1985-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.28.061807.155333
更新日期:2008-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.012809.104813
更新日期:2010-08-21 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.02.070182.001221
更新日期:1982-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071715-050916
更新日期:2016-07-17 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071714-034449
更新日期:2015-01-01 00:00:00
abstract::The recognition that mitochondria participate in folate-mediated one-carbon metabolism grew out of pioneering work beginning in the 1950s from the laboratories of D.M. Greenberg, C.G. Mackenzie, and G. Kikuchi. These studies revealed mitochondria as the site of oxidation of one-carbon donors such as serine, glycine, s...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.012809.104810
更新日期:2010-08-21 00:00:00
abstract::The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates. The imidazole ring of GTP is hydrolytically opened, yielding a 4, 5-diaminopyrimidine which is converted to 5-amino-6-ribitylamino-2, 4(1H,3H)-pyrimidinedione by a sequence of deamination, ...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.20.1.153
更新日期:2000-01-01 00:00:00
abstract::During the recent resurgence of interest in the clinical uses of vitamin E, one of the major foci of attention has been the neurologic role of vitamin E in humans. Studies in patients with secondary vitamin E deficiency, caused by fat malabsorption disorders and total parenteral nutrition lacking an adequate supply of...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.08.070188.002031
更新日期:1988-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071813-105557
更新日期:2014-01-01 00:00:00
abstract::The objective of this review is to evaluate the evidence for a link between maternal obesity and poor lactation performance. In nonhuman species, excess maternal fatness is deleterious for lactation and also for maternal health and survival. These effects occur during pregnancy and as milk production is beginning. The...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.27.061406.093738
更新日期:2007-01-01 00:00:00
abstract::Oxidative stress is implicated in the pathogenesis of several viral infections, including hepatitis, influenza, and AIDS. Dietary oxidative stress due to either selenium or vitamin E deficiency increases cardiac damage in mice infected with a myocarditic strain of coxsackievirus B3. Such dietary oxidative stress also ...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.18.1.93
更新日期:1998-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.23.011702.073247
更新日期:2003-01-01 00:00:00