The gene for human glutaredoxin (GLRX) is localized to human chromosome 5q14.

Abstract:

:Glutaredoxin is a small protein (12 kDa) catalyzing glutathione-dependent disulfide oxidoreduction reactions in a coupled system with NADPH, GSH, and glutathione reductase. A cDNA encoding the human glutaredoxin gene (HGMW-approved symbol GLRX) has recently been isolated and cloned from a human fetal spleen cDNA library. The screening of a human genomic library in Charon 4A led to the identification of three genomic clones. Using fluorescence in situ hybridization to metaphase chromosomes with one genomic clone as a probe, the human glutaredoxin gene was localized to chromosomal region 5q14. This localization at chromosome 5 was in agreement with the somatic cell hybrid analysis, using DNA from a human-hamster and a human-mouse hybrid panel and using a human glutaredoxin cDNA as a probe.

journal_name

Genomics

journal_title

Genomics

authors

Padilla CA,Bajalica S,Lagercrantz J,Holmgren A

doi

10.1006/geno.1996.0141

subject

Has Abstract

pub_date

1996-03-15 00:00:00

pages

455-7

issue

3

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(96)90141-X

journal_volume

32

pub_type

杂志文章

相关文献

GENOMICS文献大全
  • A 1.5-Mb-resolution radiation hybrid map of the cat genome and comparative analysis with the canine and human genomes.

    abstract::We report the construction of a 1.5-Mb-resolution radiation hybrid map of the domestic cat genome. This new map includes novel microsatellite loci and markers derived from the 2X genome sequence that target previous gaps in the feline-human comparative map. Ninety-six percent of the 1793 cat markers we mapped have ide...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2006.08.007

    authors: Murphy WJ,Davis B,David VA,Agarwala R,Schäffer AA,Pearks Wilkerson AJ,Neelam B,O'Brien SJ,Menotti-Raymond M

    更新日期:2007-02-01 00:00:00

  • Zinc finger protein gene complexes on mouse chromosomes 8 and 11.

    abstract::Two murine homologs of the Drosophila Krüppel gene, a member of the gap class of developmental control genes that encode a protein with zinc fingers, were mapped to mouse chromosomes 8 and 11 by using somatic cell hybrids and an interspecific backcross. Surprisingly, both genes were closely linked to two previously ma...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(90)90033-q

    authors: Nadeau JH,Birkenmeier CS,Chowdhury K,Crosby JL,Lalley PA

    更新日期:1990-11-01 00:00:00

  • Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.

    abstract::The single functional mouse gene for MIF (macrophage migration inhibitory factor) has been cloned from a P1 library, and its exon/intron structure determined and shown to resemble that of the human gene. The gene was mapped to chromosome 10 using two multilocus crosses between laboratory strains and either Mus musculu...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1995.1070

    authors: Kozak CA,Adamson MC,Buckler CE,Segovia L,Paralkar V,Wistow G

    更新日期:1995-06-10 00:00:00

  • Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.

    abstract::Four highly conserved members of the skeletal protein 4.1 gene family encode a diverse array of protein isoforms via tissue-specific transcription and developmentally regulated alternative pre-mRNA splicing. In addition to the prototypical red blood cell 4.1R (human gene symbol EPB41,) these include two homologues tha...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1998.5537

    authors: Peters LL,Weier HU,Walensky LD,Snyder SH,Parra M,Mohandas N,Conboy JG

    更新日期:1998-12-01 00:00:00

  • Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.

    abstract::The beclin 1 (BECN1) gene encodes a 60-kDa coiled-coil protein that interacts with the prototypic apoptosis inhibitor Bcl-2. Previous studies indicate that beclin 1 maps to a region approximately 150 kb centromeric to BRCA1 on chromosome 17q21 that is commonly deleted in breast, ovarian, and prostate cancer. The compl...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1999.5851

    authors: Aita VM,Liang XH,Murty VV,Pincus DL,Yu W,Cayanis E,Kalachikov S,Gilliam TC,Levine B

    更新日期:1999-07-01 00:00:00

  • De novo transcriptome assembly and preliminary analyses of two avian malaria parasites, Plasmodium delichoni and Plasmodium homocircumflexum.

    abstract::Parasites of the genus Plasmodium infect a wide array of hosts, causing malaria in all major groups of terrestrial vertebrates including primates, reptiles, and birds. Molecular mechanisms explaining why some Plasmodium species are virulent, while other closely related malaria pathogens are relatively benign in the sa...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2018.12.004

    authors: Weinberg J,Field JT,Ilgūnas M,Bukauskaitė D,Iezhova T,Valkiūnas G,Sehgal RNM

    更新日期:2019-12-01 00:00:00

  • Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12.

    abstract::Because of the conservation of the ubiquitin coding sequence and the number of transcriptionally active genes and reverse-transcribed pseudogenes, it has not been possible to use ubiquitin cDNA clones to map the functional ubiquitin genes. The UBB and UBC polyubiquitin genes have previously been mapped by the use of s...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1994.1108

    authors: Webb GC,Baker RT,Coggan M,Board PG

    更新日期:1994-02-01 00:00:00

  • Gene expression profiling in livers of mice after acute inhibition of beta-oxidation.

    abstract::Inborn errors of mitochondrial beta-oxidation cause ectopic fat accumulation, particularly in the liver. Fatty liver is associated with insulin resistance and predisposes to hepatic fibrosis. The factors underlying the pathophysiological consequences of hepatic fat accumulation have remained poorly defined. Gene expre...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2007.08.004

    authors: van der Leij FR,Bloks VW,Grefhorst A,Hoekstra J,Gerding A,Kooi K,Gerbens F,te Meerman G,Kuipers F

    更新日期:2007-12-01 00:00:00

  • Correlation of serpin-protease expression by comparative analysis of real-time PCR profiling data.

    abstract::Imbalanced protease activity has long been recognized in the progression of disease states such as cancer and inflammation. Serpins, the largest family of endogenous protease inhibitors, target a wide variety of serine and cysteine proteases and play a role in a number of physiological and pathological states. The exp...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2006.03.017

    authors: Badola S,Spurling H,Robison K,Fedyk ER,Silverman GA,Strayle J,Kapeller R,Tsu CA

    更新日期:2006-08-01 00:00:00

  • Molecular characterization of cystic fibrosis: 16 novel mutations identified by analysis of the whole cystic fibrosis conductance transmembrane regulator (CFTR) coding regions and splice site junctions.

    abstract::The spectrum of cystic fibrosis (CF) mutations was determined in 105 patients by using denaturing gradient gel electrophoresis to screen the entire coding regions and adjacent cystic fibrosis transmembrane conductance regulator (CFTR) gene sequences. The nucleotide substitutions detected included 16 novel mutations, 1...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(92)90152-i

    authors: Fanen P,Ghanem N,Vidaud M,Besmond C,Martin J,Costes B,Plassa F,Goossens M

    更新日期:1992-07-01 00:00:00

  • Molecular cloning of a human co-beta-glucosidase cDNA: evidence that four sphingolipid hydrolase activator proteins are encoded by single genes in humans and rats.

    abstract::Authentic cDNAs encoding the activator protein for acid beta-glucosidase (EC3.2.1.45), co-beta-glucosidase, were cloned from the pCD and lambda gt11 human cDNA libraries. Initial screening with oligonucleotide mixtures encoding amino acid sequences of co-beta-glucosidase identified partial cDNAs which were used to obt...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(89)90014-1

    authors: Rorman EG,Grabowski GA

    更新日期:1989-10-01 00:00:00

  • Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro.

    abstract::Mefloquine is associated with adverse neurological effects that are mediated via unknown mechanisms. Recent in vitro studies have shown that mefloquine disrupts neuronal calcium homeostasis via liberation of the endoplasmic reticulum (ER) store and induction of calcium influx across the plasma membrane. In the present...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2005.07.004

    authors: Dow GS,Caridha D,Goldberg M,Wolf L,Koenig ML,Yourick DL,Wang Z

    更新日期:2005-11-01 00:00:00

  • A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor.

    abstract::Recently, we reported genetic linkage in Pima Indians between the acute insulin response to an intravenous glucose challenge and the short tandem repeat marker D1S198, indicative of a genetic element in this region that controls the phenotypic variation in the first phase of insulin secretion. As a first step to isola...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1996.4504

    authors: Thompson DB,Sutherland J,Apel W,Ossowski V

    更新日期:1997-01-15 00:00:00

  • The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26.

    abstract::We have mapped the mouse protein tyrosine phosphatase epsilon (PTP epsilon, gene symbol Ptpre) gene to the distal region of chromosome 7 by linkage analysis using two sets of multilocus genetic crosses. The human PTP epsilon gene (gene symbol PTPRE) was mapped to chromosome 10q26 by fluorescence in situ hybridization....

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1996.0061

    authors: Elson A,Kozak CA,Morton CC,Weremowicz S,Leder P

    更新日期:1996-02-01 00:00:00

  • Human collagen gene COL5A1 maps to the q34.2----q34.3 region of chromosome 9, near the locus for nail-patella syndrome.

    abstract::Type V collagen is a fibrillar collagen that is widely distributed in tissues as a minor component of extracellular matrix and is usually composed of one pro alpha 2 (V) and two pro alpha 1 (V) chains. In this report, recently isolated cDNA and genomic clones, which encode the pro alpha 1 (V) chain, are used as probes...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(92)90320-r

    authors: Greenspan DS,Byers MG,Eddy RL,Cheng W,Jani-Sait S,Shows TB

    更新日期:1992-04-01 00:00:00

  • A draft gene regulatory network for cellular totipotency reprogramming during plant somatic embryogenesis.

    abstract::The complexity of the somatic embryogenesis (SE) transcriptome suggests that numerous molecules are involved. To understand better the functional genomics of complex molecular systems during this important reprogramming process, we used bioinformatics and a pathway database to construct a draft network based on transc...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2007.07.007

    authors: Zeng F,Zhang X,Cheng L,Hu L,Zhu L,Cao J,Guo X

    更新日期:2007-11-01 00:00:00

  • Genome-wide identification and characterization of WRKY gene family in Hevea brasiliensis.

    abstract::WRKY proteins constitute a large family of transcription factors. In this study, we identified 81 WRKY genes (named HbWRKY1 to HbWRKY81) in the latest rubber tree genome. Tissue-specific expression profiles showed that 74 HbWRKYs were expressed in at least one of the tissues and the other 7 genes showed very low expre...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2014.04.004

    authors: Li HL,Guo D,Yang ZP,Tang X,Peng SQ

    更新日期:2014-07-01 00:00:00

  • SNP identification, linkage disequilibrium, and haplotype analysis for a 200-kb genomic region in a Korean population.

    abstract::Understanding patterns of linkage disequilibrium (LD) across genomes may facilitate association mapping studies to localize genetic variants influencing complex diseases, a recognition that led to the International Haplotype Mapping Project (HapMap). Divergent patterns of haplotype frequency and LD across global popul...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2006.03.003

    authors: Kim KJ,Lee HJ,Park MH,Cha SH,Kim KS,Kim HT,Kimm K,Oh B,Lee JY

    更新日期:2006-11-01 00:00:00

  • A microdeletion of D6S305 in a family of autosomal recessive juvenile parkinsonism (PARK2).

    abstract::A gene for autosomal recessive juvenile parkinsonism (ARJP; HGMW-approved symbol PARK2; MIM 600116) has recently been mapped to a 17-cM interval on chromosome 6q25.2-q27. We here report an inbred family with ARJP showing a perfect cosegregation with null allele for D6S305, which is a marker within the ARJP locus. We a...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1997.5196

    authors: Matsumine H,Yamamura Y,Hattori N,Kobayashi T,Kitada T,Yoritaka A,Mizuno Y

    更新日期:1998-04-01 00:00:00

  • Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene.

    abstract::The general strategies of phototransduction in vertebrates and invertebrates share many similarities, but differ significantly in their underlying molecular machinery. The CDS gene encodes the CDP-diacylglycerol synthase (CDS) enzyme and is required for phototransduction in Drosophila. Using a bioinformatic approach, ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1998.5610

    authors: Volta M,Bulfone A,Gattuso C,Rossi E,Mariani M,Consalez GG,Zuffardi O,Ballabio A,Banfi S,Franco B

    更新日期:1999-01-01 00:00:00

  • Construction of a gene map of the nephronophthisis type 1 (NPHP1) region on human chromosome 2q12-q13.

    abstract::A gene for the autosomal recessive kidney disorder juvenile nephronophthisis (NPH) is located on chromosome 2q between markers D2S1893 and D2S1888. Recently, the presence of large homozygous deletions was described in the majority of NPH patients. We constructed an integrated YAC/PAC contig of 54 markers and 30 PAC cl...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1997.5102

    authors: Nothwang HG,Stubanus M,Adolphs J,Hanusch H,Vossmerbäumer U,Denich D,Kübler M,Mincheva A,Lichter P,Hildebrandt F

    更新日期:1998-01-15 00:00:00

  • The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region.

    abstract::The intron-containing genes encoding rat and human ribosomal protein L19 (RPL19) have been cloned. The DNA sequences of the entire rat RPL19 gene and the 5' end of the human RPL19 gene have been determined. Sequence comparison of corresponding regions of the two genes reveals a striking interspecies homology in the 5'...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(95)80036-l

    authors: Davies B,Fried M

    更新日期:1995-01-20 00:00:00

  • Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

    abstract::Olfactory receptors constitute the largest family among G protein-coupled receptors, with up to 1000 members expected. We have previously shown that genes belonging to this family were expressed in the male germ line from both dog and human. We have subsequently demonstrated the presence of one of the corresponding ol...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1996.4490

    authors: Vanderhaeghen P,Schurmans S,Vassart G,Parmentier M

    更新日期:1997-02-01 00:00:00

  • Structure of the human 4-hydroxyphenylpyruvic acid dioxygenase gene (HPD).

    abstract::4-Hydroxyphenylpyruvic acid dioxygenase (HPD) is an important enzyme in tyrosine catabolism in most organisms. The activity of this enzyme is expressed mainly in the liver and developmentally regulated in mammals, and a genetic deficiency in this enzyme in humans and mice leads to hereditary tyrosinemia type 3. Using ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1994.1540

    authors: Awata H,Endo F,Matsuda I

    更新日期:1994-10-01 00:00:00

  • A high-resolution cat radiation hybrid and integrated FISH mapping resource for phylogenomic studies across Felidae.

    abstract::We describe the construction of a high-resolution radiation hybrid (RH) map of the domestic cat genome, which includes 2662 markers, translating to an estimated average intermarker distance of 939 kilobases (kb). Targeted marker selection utilized the recent feline 1.9x genome assembly, concentrating on regions of low...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2008.09.010

    authors: Davis BW,Raudsepp T,Pearks Wilkerson AJ,Agarwala R,Schäffer AA,Houck M,Chowdhary BP,Murphy WJ

    更新日期:2009-04-01 00:00:00

  • Mapping of the taurine transporter gene to mouse chromosome 6 and to the short arm of human chromosome 3.

    abstract::Transport proteins have essential functions in the uptake of neurotransmitters and neuromodulators. We have mapped the gene encoding the taurine transporter, Taut, to the central region of mouse chromosome 6. Analysis of a cross segregating the neurological mutant mnd2 excluded Taut as a candidate gene for this closel...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(95)80146-d

    authors: Patel A,Rochelle JM,Jones JM,Sumegi J,Uhl GR,Seldin MF,Meisler MH,Gregor P

    更新日期:1995-01-01 00:00:00

  • Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system.

    abstract::The yeast RAD52-dependent pathway is involved in DNA recombination and double-strand break repair. Yeast ubiquitin-conjugating enzyme UBC9 participates in S- and M-phase cyclin degradation and mitotic control. Using the human RAD52 protein as the "bait" in a yeast two-hybrid system, we have identified a human homolog ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1996.0540

    authors: Shen Z,Pardington-Purtymun PE,Comeaux JC,Moyzis RK,Chen DJ

    更新日期:1996-10-15 00:00:00

  • SCOPE++: sequence classification of homoPolymer emissions.

    abstract:BACKGROUND:mRNA polyadenylation, the addition of a poly(A) tail to the 3'-end of pre-mRNA, is a process critical to gene expression and regulation in eukaryotes. To understand the molecular mechanisms governing polyadenylation and other relevant biological processes, it is important to identify these poly(A) tails accu...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2014.07.005

    authors: Morton JT,Abrudan P,Figueroa N,Liang C,Karro JE

    更新日期:2014-09-01 00:00:00

  • YY1-dependent transcriptional regulation of the human GDAP1 gene.

    abstract::Charcot-Marie-Tooth disease (CMT) is a heritable neurodegenerative condition, some types of which (notably CMT4A) are caused by mutations in the GDAP1 gene that encodes a protein of unknown molecular function implicated in regulation of mitochondrial fission. Here we present for the first time a functional analysis of...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2009.08.014

    authors: Ratajewski M,Pulaski L

    更新日期:2009-12-01 00:00:00

  • Genomic mapping by end-characterized random clones: a mathematical analysis.

    abstract::Physical maps can be constructed by "fingerprinting" a large number of random clones and inferring overlap between clones when the fingerprints are sufficiently similar. E. Lander and M. Waterman (Genomics 2: 231-239, 1988) gave a mathematical analysis of such mapping strategies. The analysis is useful for comparing v...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(95)80086-2

    authors: Port E,Sun F,Martin D,Waterman MS

    更新日期:1995-03-01 00:00:00