Abstract:
:Glutaredoxin is a small protein (12 kDa) catalyzing glutathione-dependent disulfide oxidoreduction reactions in a coupled system with NADPH, GSH, and glutathione reductase. A cDNA encoding the human glutaredoxin gene (HGMW-approved symbol GLRX) has recently been isolated and cloned from a human fetal spleen cDNA library. The screening of a human genomic library in Charon 4A led to the identification of three genomic clones. Using fluorescence in situ hybridization to metaphase chromosomes with one genomic clone as a probe, the human glutaredoxin gene was localized to chromosomal region 5q14. This localization at chromosome 5 was in agreement with the somatic cell hybrid analysis, using DNA from a human-hamster and a human-mouse hybrid panel and using a human glutaredoxin cDNA as a probe.
journal_name
Genomicsjournal_title
Genomicsauthors
Padilla CA,Bajalica S,Lagercrantz J,Holmgren Adoi
10.1006/geno.1996.0141subject
Has Abstractpub_date
1996-03-15 00:00:00pages
455-7issue
3eissn
0888-7543issn
1089-8646pii
S0888-7543(96)90141-Xjournal_volume
32pub_type
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