Low prevalence of alterations in the pancreatic duct system in patients with primary sclerosing cholangitis.

Abstract:

BACKGROUND AND STUDY AIMS:Primary sclerosing cholangitis (PSC) is a rare disease of unknown origin that involves the intrahepatic or extrahepatic biliary system, or both. To obtain more precise information on concomitant involvement of the pancreatic duct system, a comparatively large group of 44 patients was studied. PATIENTS AND METHODS:Between 1989 and 1995, 44 patients took part in a study of the therapeutic effect of ursodeoxycholic acid, and their data were analyzed. In 42 of the 44 patients, both the pancreatic and biliary system were visualized by endoscopic retrograde cholangiopancreatography (ERCP). RESULTS:Pancreas divisum was detected in four patients (9.5%) with an otherwise normal major pancreatic duct. Three (7.1%) patients had pancreatic duct changes of the type seen in chronic pancreatitis. When risk factors such as alcohol abuse were excluded, there was only one patient with PSC and pancreatic duct alterations. CONCLUSION:In PSC patients, the prevalence of chronic pancreatitis is low.

journal_name

Endoscopy

journal_title

Endoscopy

authors

Schimanski U,Stiehl A,Stremmel W,Theilmann L

doi

10.1055/s-2007-1005478

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

346-9

issue

4

eissn

0013-726X

issn

1438-8812

journal_volume

28

pub_type

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