Comparison of drug substance impurity profiles generated with extended length columns during packed-column SFC.

Abstract:

:The current study assesses the effect of extending column length during gradient packed column sub/supercritical fluid chromatography (PCSFC) experiments on the detection of known and unknown impurities in a drug substance sample. Quantitative drug substance impurity profiles were generated and compared using multiple column PCSFC and HPLC conditions. Also, chromatographic figures of merit were estimated and compared for components of a standard mixture during PCSFC experiments, which used one column, four columns, and six columns in series.

journal_name

J Pharm Biomed Anal

authors

Roston DA,Ahmed S,Williams D,Catalano T

doi

10.1016/s0731-7085(01)00405-8

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

339-55

issue

3

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(01)00405-8

journal_volume

26

pub_type

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