Abstract:
:The current study assesses the effect of extending column length during gradient packed column sub/supercritical fluid chromatography (PCSFC) experiments on the detection of known and unknown impurities in a drug substance sample. Quantitative drug substance impurity profiles were generated and compared using multiple column PCSFC and HPLC conditions. Also, chromatographic figures of merit were estimated and compared for components of a standard mixture during PCSFC experiments, which used one column, four columns, and six columns in series.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Roston DA,Ahmed S,Williams D,Catalano Tdoi
10.1016/s0731-7085(01)00405-8subject
Has Abstractpub_date
2001-10-01 00:00:00pages
339-55issue
3eissn
0731-7085issn
1873-264Xpii
S0731-7085(01)00405-8journal_volume
26pub_type
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