Enhanced reinnervation of the paralyzed orbicularis oculi muscle after insulin-like growth factor-I (IGF-I) delivery to a nerve graft.

Abstract:

:Facial paralysis (FP) remains today one of the most disturbing cranial nerve disorders. The present study utilized the rat model of FP and examined a dual approach of combining the current microsurgical treatment of cross-facial nerve graft (CFNG) with local administration of insulin-like growth factor-I (IGF-I). The efficacy of this combined treatment approach was assessed by motor end-plate analysis of the reinnervated orbicularis oculi muscle (OOM). Local administration of IGF-I (50 microg/ml) to the CFNG demonstrated a 61 percent increase in the number of end-plates in the reinnervated OOMs, compared to the OOMs reinnervated with CFNG plus vehicle. These results indicate that the local therapeutic augmentation of IGF-I levels at the coaptation site(s) of the CFNG may, in fact, enhance reinnervation of muscle and recovery of function in general.

journal_name

J Reconstr Microsurg

authors

Thanos PK,Tiangco DA,Terzis JK

doi

10.1055/s-2001-16028

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

357-62

issue

5

eissn

0743-684X

issn

1098-8947

journal_volume

17

pub_type

杂志文章
  • Improved location technology of perforators of anterolateral thigh flap for Chinese patients.

    abstract:BACKGROUND:The anterolateral thigh (ALT) flap has been widely used in reconstruction of soft tissue defects. The anatomic variations of perforators increase the difficulties of flap elevation. The ABC system has been described for locating the most common three perforators in Western populations. Less evidence has been...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0033-1343496

    authors: Zhou H,Tan Q,Liu S,Zhou H,Wang S,Yan X,Zheng D,Wang D

    更新日期:2013-06-01 00:00:00

  • Regeneration along intact nerves using nerve growth factor and ciliary neurotrophic factor.

    abstract::The purpose of this investigation was to evaluate the ability of a specific growth factor combination, nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF), to enhance peripheral nerve regeneration. Eight groups of eight Sprague-Dawley rats underwent repair of a nerve gap defect: Group A (immediate repair)...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2004-833499

    authors: McCallister WV,McCallister EL,Dubois B,Trumble TE

    更新日期:2004-08-01 00:00:00

  • Successful correction of severe contracture of the palm using arterialized venous flaps.

    abstract::Severe contracture of the palm causes great difficulty in the performance of the tasks required in daily life. Resurfacing with skin grafts may be sufficient for treating mild and small contractures; but severe and extensive contractures involving the joints, tendons, and neurovascular bundles should be covered with t...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2004-836124

    authors: Nakazawa H,Nozaki M,Kikuchi Y,Honda T,Isago T

    更新日期:2004-10-01 00:00:00

  • Free vascularized toe-joint transfer in hand reconstruction: a series of 25 patients.

    abstract::Twenty-eight vascularized toe-joint transfers performed on 25 patients were reviewed. A number of different techniques were used: proximal interphalangeal joint or metacarpophalangeal joint reconstruction, one-stage double joint transfer, and interphalangeal thumb or trapezometacarpal joint replacement. Using these ty...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006819

    authors: Foucher G,Sammut D,Citron N

    更新日期:1990-07-01 00:00:00

  • Epidural anesthesia during lower extremity free tissue transfer.

    abstract::A continuous epidural bupivacaine infusion was used for anesthesia in 20 patients who underwent lower extremity free tissue transfer. In 60 percent of the patients, general anesthesia supplementation with nitrous oxide was used for comfort during prolonged lying on the operating table. In all cases, this technique pro...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006939

    authors: Strecker WB,Wood MB,Wedel DJ

    更新日期:1988-07-01 00:00:00

  • Blood-flow contributions by the superior and inferior epigastric arterial systems in TRAM flaps, based on laser Doppler flowmetry.

    abstract::This study was designed to quantify the relative contribution of the inferior and superior epigastric systems to infraumbilical TRAM flap skin blood flow, using laser Doppler flowmetry. In twelve flaps (11 patients), blood-flow measurements were obtained during routine elevation of the TRAM flap for breast reconstruct...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006593

    authors: Hendricks DL,Wilkens TH,Witt PD

    更新日期:1994-07-01 00:00:00

  • FK506 and nerve regeneration: past, present, and future.

    abstract::Promoting neurological recovery requires strategies that simultaneously provide protection to injured neurons and increase the numbers of neurons that extend axons while inducing more rapid and extensive axon regeneration across long nerve gaps. An agent that facilitates the speed and success of reinnervation will hav...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1333314

    authors: Konofaos P,Terzis JK

    更新日期:2013-03-01 00:00:00

  • Intramuscular perforator dissection with the hydrodissection technique.

    abstract:BACKGROUND:Perforator flap breast reconstruction requires increased time for safe perforator dissection, especially the intramuscular course. We describe an adjunctive technique using hydrodissection to assist with the intramuscular perforator dissection. METHODS:Hydrodissection techniques were used for perforator dis...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0032-1326738

    authors: Singhal D,Momoh AO,Colakoglu S,Qureshi A,Tobias AM,Lee BT

    更新日期:2013-01-01 00:00:00

  • Multiple vascular anastomoses with vein grafts for salvage of congestive flaps.

    abstract::The authors present two cases in which the venous drainage of transferred flaps was compromised and the flaps were salvaged by vein grafts. Traditionally, once transferred free flaps had become congestive, surgeons would re-anastomose the thrombosed veins, and administer anticoagulants or carry out peripheral vessel d...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2004-815639

    authors: Namba Y,Takahashi Y,Ito S,Koshima I

    更新日期:2003-11-01 00:00:00

  • Successful replantation of the lower leg after 42-hour ischemia: case report.

    abstract::A case of right lower-leg replantation after 42-hr ischemia is presented. Revascularization of the other foot with circulatory decompensation after 36-hr ischemia was carried out simultaneously. The replanted lower leg survived. Following its shortening in replantation by 12 cm, right lower-leg lengthening by 8 cm was...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006729

    authors: Datiashvili RO,Chichkin VG

    更新日期:1992-11-01 00:00:00

  • Nerve repair at different angles of attachment: experiment in rats.

    abstract::Sixteen rats underwent two procedures to test the efficacy of oblique vs. transverse nerve repair. On the left, the peroneal nerve was transected at an oblique angle (30-degree) with subsequent oblique end-to-end repair performed. On the right, the peroneal nerve was transected at a transverse angle (90-degree) with s...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2002-36503

    authors: Yan YH,Yan JG,Sanger JR,Zhang LL,Riley DA,Matloub HS

    更新日期:2002-11-01 00:00:00

  • Microarterial anastomosis with a distal tapering technique.

    abstract::In microsurgical arterial anastomoses, there are some occasions in which the diameter of the distal artery is much larger than that of the proximal one. A fish-mouth incision technique is useful when there is considerable size discrepancy. However, this method cannot be used when the distal artery is much larger than ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006576

    authors: Ueda K,Harashina T,Inoue T,Kurihara T,Harada T,Oba S

    更新日期:1994-03-01 00:00:00

  • A case of degloving injury of the whole hand reconstructed by a combination of distant flaps comprising an anterolateral thigh flap and a groin flap.

    abstract::A case of degloving injury of the whole hand reconstructed by a combination of an anterolateral thigh (ALT) flap and a groin flap applied as a pedicled distant flap was reported. Despite complications of congestion of the ALT flap and superficial infection, both flaps were severed at 4 weeks after transplantation, and...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0031-1278708

    authors: Senda H,Muro H,Terada S,Okamoto H

    更新日期:2011-06-01 00:00:00

  • Role of plastic surgeons in hepatic artery anastomosis in living donor liver transplantation: our experience of 10 cases.

    abstract:AIM:To understand the practical difficulties encountered while performing hepatic artery anastomosis by microsurgical technique in living donor liver transplantation. MATERIALS AND METHODS:We undertook a retrospective study of 10 cases of hepatic artery anastomosis done at the level of bifurcation of the right hepatic...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0032-1313763

    authors: Mangal M,Gambhir S,Gupta A,Shah A

    更新日期:2012-07-01 00:00:00

  • Microsurgical reconstruction: a more conservative method of managing large scalp defects?

    abstract::Scalp reconstruction is a challenging problem requiring attention to the etiology, size, and condition of the defect to formulate an optimal reconstructive plan. Although many "conservative" options have been described even for large wounds, the use of local flaps or split-thickness skin grafts (STSG) may actually res...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0029-1224860

    authors: Labow BI,Rosen H,Pap SA,Upton J

    更新日期:2009-11-01 00:00:00

  • Short-term response of a skeletal growth plate to heterotopic microvascular transfer.

    abstract::The capacity of the epiphyseal growth cartilage from the dog fibula to retain its growth potential after heterotopic transfer to a distal radial defect was investigated and compared to orthotopically transferred controls. Autoradiographs of the physes cultured in 3H-thymidine indicated continued proliferation of the g...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1007072

    authors: Nettelblad H,Randolph MA,Weiland AJ

    更新日期:1985-01-01 00:00:00

  • A case of replantation of a completely amputated digit after 26 hours of warm ischemia.

    abstract::A seven-year-old-boy received a digit replantation after 26 hours of warm ischemia and showed good recovery of motor and sensory functions. In the case reported, replantation was performed after a much longer ischemic time than had been considered an indication for the procedure in previous reports. Successful replant...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006977

    authors: Seo T,Matsuda M

    更新日期:1987-01-01 00:00:00

  • Effect of systemic piracetam treatment on flap survival and vascular endothelial growth factor expression after ischemia-reperfusion injury.

    abstract::The effects of piracetam on flap survival, ischemia-reperfusion (I/R) injury, and vascular endothelial growth factor (VEGF) expression were evaluated in this study. Unipedicled epigastric flap model was used in 36 rats and was evaluated within 4 groups. The flap was elevated and untreated in Group 1. Postoperative pir...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0031-1281523

    authors: Tuncer S,Ayhan S,Findikcioglu K,Ergun H,Tuncer I

    更新日期:2011-09-01 00:00:00

  • Recurrent phyllodes tumor of the breast: defining the role for skin-sparing mastectomy and autologous reconstruction.

    abstract::Phyllodes tumors (PTs) are uncommon fibroepithelial tumors of the breast, noteworthy for their difficult excisions and high recurrence rates. In the setting of recurrence, there is no consensus in the literature as to the extent of excision or the impact on reconstructive options. Breast-conserving surgery and simple ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1275493

    authors: Atalla MA,Rozen WM,Grinsell D,Hyett A,Prakash S,Cham A

    更新日期:2011-05-01 00:00:00

  • Cortical brain mapping of peripheral nerves using functional magnetic resonance imaging in a rodent model.

    abstract::The regions of the body have cortical and subcortical representation in proportion to their degree of innervation. The rat forepaw has been studied extensively in recent years using functional magnetic resonance imaging (fMRI), typically by stimulation using electrodes directly inserted into the skin of the forepaw. H...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0028-1088231

    authors: Cho YR,Jones SR,Pawela CP,Li R,Kao DS,Schulte ML,Runquist ML,Yan JG,Hudetz AG,Jaradeh SS,Hyde JS,Matloub HS

    更新日期:2008-11-01 00:00:00

  • Outcomes of Subfascial, Suprafascial, and Super-Thin Anterolateral Thigh Flaps: Tailoring Thickness without Added Morbidity.

    abstract:BACKGROUND: Subfascial anterolateral thigh (ALT) flap thickness can be problematic with regards to bulk, oral competence, shoe-fit, or as a potential source of recurrent wound breakdown. We have utilized distinct upper thigh fascial planes to fashion thin (suprafascial) or super-thin (periscarpal) ALT flaps to improve ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0037-1607426

    authors: Diamond S,Seth AK,Chattha AS,Iorio ML

    更新日期:2018-03-01 00:00:00

  • Measuring the pressure in the superficial inferior epigastric vein to monitor for venous congestion in deep inferior epigastric artery perforator breast reconstructions: a pilot study.

    abstract::During deep inferior epigastric artery perforator (DIEP) flap dissection, we noted that in many cases the superficial vein on the ipsilateral side of the flap was engorged and tense, and in others, it was empty. This led us to believe that the pressure is increased as the result of preferential outflow through the sup...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0029-1243294

    authors: Smit JM,Audolfsson T,Whitaker IS,Werker PM,Acosta R,Liss AG

    更新日期:2010-02-01 00:00:00

  • The Role of Duplex Ultrasound in Microsurgical Reconstruction: Review and Technical Considerations.

    abstract:BACKGROUND: With the technological advances, microsurgery has evolved to the era of supermicrosurgery since its inception. With the popularization of these flaps, proficiency in using tools such as color Doppler ultrasound (CDU) has become crucial. Despite the increased interest, studies regarding the role of ultrasoun...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0040-1709479

    authors: Cho MJ,Kwon JG,Pak CJ,Suh HP,Hong JP

    更新日期:2020-09-01 00:00:00

  • Protective effects of monoclonal antibody to intercellular adhesion molecule-1 in venous ischemia-reperfusion injury: experimental study in rats.

    abstract::Flaps with venous occlusion have a decreased survival rate compared with arterial occlusion. It seems that several factors are involved in the etiology of total venous occlusion, including free radicals, edema, thrombosis, and reperfusion injury. In the present study, the authors evaluated the blockage of polymorphonu...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2006-958701

    authors: Demirseren ME,Sarici M,Gokrem S,Yenidunya S

    更新日期:2007-01-01 00:00:00

  • The treatment of peripheral nerve injuries using irradiated allografts and temporary host immunosuppression (in a rat model).

    abstract::Irradiation of allografts prior to transplantation and host immunosuppression with cyclosporin-A were studied separately and in combination as means of lessening the rejection of transplanted peripheral nerve tissue. Lewis and Brown Norway rats were used in the animal model, as they differ at both major and minor hist...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006834

    authors: Easterling KJ,Trumble TE

    更新日期:1990-10-01 00:00:00

  • Revascularization of nerve grafts: an experimental study.

    abstract::The time course of revascularization of grafted nerves, and the possible dependence of this revascularization on the length of the graft are two related questions that are addressed. Survival of Schwann cells in the nerve graft and a timely revascularization must be seen as a precondition for an optimal regeneration p...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006938

    authors: Penkert G,Bini W,Samii M

    更新日期:1988-07-01 00:00:00

  • Superficial Circumflex Iliac Artery-Based Iliac Bone Flap Transfer for Reconstruction of Bony Defects.

    abstract:BACKGROUND: The superficial circumflex iliac artery (SCIA)-based iliac bone flap has yet to be widely used. The purpose of this article is to validate the feasibility of SCIA-based iliac bone flap transfers for reconstruction of small to moderate-sized bony defects. Retrospective outcome comparisons between SCIA-based ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0038-1651489

    authors: Yoshimatsu H,Iida T,Yamamoto T,Hayashi A

    更新日期:2018-11-01 00:00:00

  • Bridging critical nerve defects through an acellular homograft seeded with autologous schwann cells obtained from a regeneration neuroma of the proximal stump.

    abstract::Over the last decade, several models have investigated the usefulness of different biologic and/or synthetic matrices as alternatives to conventional nerve grafts. Still, axonal regeneration did not occur over longer (> 3 cm) distances. One problem may be that a growth-promoting environment not only includes physical ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2008-1076091

    authors: Aszmann OC,Korak KJ,Luegmair M,Frey M

    更新日期:2008-04-01 00:00:00

  • Different types of sleeve anastomosis.

    abstract::Microvascular techniques are important in making routine anastomoses quicker and difficult anastomoses easier. The authors have developed three types of sleeve anastomoses for different size vessels: a three-stitch sleeve anastomosis, four-stitch sleeve anastomosis, and sidecut sleeve anastomosis. Arteriography, in vi...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006561

    authors: Zhang L,Moskovitz M,Baron DA,Siebert JW

    更新日期:1995-11-01 00:00:00

  • Iatrogenic arteriovenous fistula after revascularization of the hand.

    abstract::This is the first report of an iatrogenic arteriovenous fistula complicating revascularization of an incomplete amputation of the hand, due to inadvertent anastomosis of the proximal radial artery to the distal cephalic vein. This resulted in a severely painful, massively swollen hand, which was initially diagnosed as...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2005-871767

    authors: Jones NF,Brown EE,Khiabani KT

    更新日期:2005-07-01 00:00:00