Marine lipids normalize cholesteryl ester transfer in IDDM.

abstract：AIMS/HYPOTHESIS:Aggregation of islet amyloid polypeptide (IAPP) to form amyloid contributes to beta cell dysfunction in type 2 diabetes. Human but not non-amyloidogenic rodent IAPP induces islet macrophage proIL-1β synthesis. We evaluated the effect of IL-1 receptor antagonist (IL-1Ra) on islet inflammation and dysfunc...

journal_title：Diabetologia

authors： Westwell-Roper CY,Chehroudi CA,Denroche HC,Courtade JA,Ehses JA,Verchere CB

更新日期：2015-03-01 00:00:00

abstract：UNLABELLED:125I-insulin binding and receptor-mediated insulin degradation were studied in isolated human fat cells from subcutaneous tissue. A high albumin concentration during cell isolation and incubation protected the fragile human adipocyte from lysis. Binding of tracer was pH dependent with an optimum between 7.4 ...

journal_title：Diabetologia

authors： Pedersen O,Hjøllund E,Beck-Nielsen H,Lindskov HO,Sonne O,Gliemann J

更新日期：1981-06-01 00:00:00

abstract：:Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 d...

journal_title：Diabetologia

authors： Comi G,Galardi G,Amadio S,Bianchi E,Secchi A,Martinenghi S,Caldara R,Pozza G,Canal N

更新日期：1991-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the prognostic significance of autoantibodies to IA-2beta (IA2betaA) in a large, well-characterised population of islet cell antibody (ICA)-positive relatives followed for 5 years in the European Nicotinamide Diabetes Intervention Trial. METHODS:Autoantibodies to i...

journal_title：Diabetologia

authors： Achenbach P,Bonifacio E,Williams AJ,Ziegler AG,Gale EA,Bingley PJ,ENDIT Group.

更新日期：2008-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:As glycaemia and the incidence of microvascular diabetes complications follow a log-linear relationship, it becomes increasingly difficult to demonstrate a microvascular benefit of glucose-lowering when the HbA1c level is close to normal. METHODS:The Outcome Reduction with an Initial Glargine Intervent...

journal_title：Diabetologia

authors： ORIGIN trial investigators.,Gilbert RE,Mann JF,Hanefeld M,Spinas G,Bosch J,Yusuf S,Gerstein HC

更新日期：2014-07-01 00:00:00

abstract：:Non-obese diabetic mice aged 30 to 60 days were treated orally with Cyclosporin at doses of 25, 15 and 2.5 mg/kg every 2 days until 160 days of age. Diabetes developed in 12 out of 18 oil-treated mice (67%), with partial to complete Langerhans' islet destruction associated with lymphocytic infiltration. The non-obese ...

journal_title：Diabetologia

authors： Mori Y,Suko M,Okudaira H,Matsuba I,Tsuruoka A,Sasaki A,Yokoyama H,Tanase T,Shida T,Nishimura M

更新日期：1986-04-01 00:00:00

abstract：:Severe microvascular disease exists at the stage of clinical diabetic neuropathy. A non-invasive test that will identify those diabetic subjects who will eventually develop neuropathy is essential for early intervention. Sural sensory conduction velocity was recorded (x3) in 12 non-neuropathic diabetic subjects, 15 di...

journal_title：Diabetologia

authors： Tesfaye S,Harris ND,Wilson RM,Ward JD

更新日期：1992-02-01 00:00:00

abstract：:Factor VIII-related antigen and von Willebrand factor are synthesised by and released from vascular endothelium. Acute increases in the plasma concentration of these proteins may reflect endothelial cell damage. We have thus measured the plasma concentration of factor VIII-related antigen and von Willebrand factor, to...

journal_title：Diabetologia

authors： Greaves M,Pickering C,Knight G,Boulton AJ,Ball J,Ward JD,Preston FE

更新日期：1987-03-01 00:00:00

abstract：:In postnatal organisms, insulin is well known as an essential anabolic hormone responsible for maintaining glucose homeostasis. Its biosynthesis by the pancreatic beta cell has been considered a model of tissue-specific gene expression. However, proinsulin mRNA and protein have been found in embryonic stages before th...

journal_title：Diabetologia

authors： Hernández-Sánchez C,Mansilla A,de la Rosa EJ,de Pablo F

更新日期：2006-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The molecular factors that cause an acute wound in diabetic patients to become chronic have not yet been established. Wound healing is known to require a balance between the accumulation of collagenous and non-collagenous extracellular matrix components and their remodelling by matrix metalloproteinases...

journal_title：Diabetologia

authors： Lobmann R,Ambrosch A,Schultz G,Waldmann K,Schiweck S,Lehnert H

更新日期：2002-07-01 00:00:00

abstract：:Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after...

journal_title：Diabetologia

authors： Krentz AJ,Clark PM,Cox L,Williams AC,Nattrass M

更新日期：1992-12-01 00:00:00

abstract：:The cardiovascular effects of glibenclamide, gliclazide and carbutamide were studied on myocardial contractile force, cardiac output, mean arterial pressure and heart rate in 43 intact, 14 pancreatectomized and 18 adrenalectomized dogs. It is shown that a positive inotropic and hypertensive effect of hypoglycaemic sul...

journal_title：Diabetologia

authors： Pogátsa G,Dubecz E

更新日期：1977-09-01 00:00:00

abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

journal_title：Diabetologia

authors： Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

更新日期：1984-08-01 00:00:00

abstract：:In healthy subjects hypoglycaemia causes a fall in body temperature through increased sweating and limb blood flow, and despite increased metabolic heat production. We studied thermoregulatory responses to hyperinsulinaemic (100 mU.m-2.min-1) (a) hypoglycaemia (2.5 mmol/l) and (b) euglycaemia (4.5 mmol/l) in insulin-d...

journal_title：Diabetologia

authors： Maggs DG,Macdonald IA,Tattersall RB

更新日期：1994-07-01 00:00:00

abstract：:Efforts to phenotype pancreatic islets have contributed tremendously to our present understanding of endocrine function and diabetes. A continued evolution in approaches to study islet physiology is important given the need to establish reference points for mature islet functionality, understanding biological variatio...

journal_title：Diabetologia

authors： Arrojo E Drigo R,Roy B,MacDonald PE

更新日期：2020-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The receptor for AGEs (RAGE) contributes to the development and progression of diabetic nephropathy. In this study, we examined whether the protective effects of RAGE blockade are exerted via modulation of the renal angiotensin II type 2 (AT2) receptor. METHODS:Control and streptozotocin diabetic mice,...

journal_title：Diabetologia

authors： Sourris KC,Morley AL,Koitka A,Samuel P,Coughlan MT,Penfold SA,Thomas MC,Bierhaus A,Nawroth PP,Yamamoto H,Allen TJ,Walther T,Hussain T,Cooper ME,Forbes JM

更新日期：2010-11-01 00:00:00

abstract：:The binding of 125I-labelled insulin to human adipocytes was studied at 37 degrees C. The precipitability of the 125I-labelled insulin preparation (0.03 nmol/l) in trichloroacetic acid and the concentration of biologically active insulin (7.5 nmol/l) remained constant in buffer incubated with human adipocytes (100 mic...

journal_title：Diabetologia

authors： Andersen O,Gliemann J,Gammeltoft S

更新日期：1977-12-01 00:00:00

abstract：:The effect of endogenous hyperinsulinaemia, produced by syngeneic transplantation of rat insulinoma at an extrapancreatic site, on pancreatic insulin and pancreatic polypeptide has been examined by radioimmunoassay and immunohistochemistry. Twenty days after subcutaneous transplantation, tumour-bearing rats exhibited ...

journal_title：Diabetologia

authors： O'Hare MM,Shaw C,Swanston-Flatt SK,Marcelli M,Buchanan KD,Flatt PR

更新日期：1985-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on th...

journal_title：Diabetologia

authors： Deleskog A,Hilding A,Brismar K,Hamsten A,Efendic S,Östenson CG

更新日期：2012-06-01 00:00:00

abstract：:Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...

journal_title：Diabetologia

authors： Qiang X,Satoh J,Sagara M,Fukuzawa M,Masuda T,Sakata Y,Muto G,Muto Y,Takahashi K,Toyota T

更新日期：1998-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:We tested the hypothesis that silent coeliac disease is more frequent than expected in both patients with Type I (insulin-dependent) diabetes mellitus and their first-degree relatives. We evaluated how the presence of other autoimmune disorders in diabetic patients and their first-degree relatives is re...

journal_title：Diabetologia

authors： Not T,Tommasini A,Tonini G,Buratti E,Pocecco M,Tortul C,Valussi M,Crichiutti G,Berti I,Trevisiol C,Azzoni E,Neri E,Torre G,Martelossi S,Soban M,Lenhardt A,Cattin L,Ventura A

更新日期：2001-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. METHODS:Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 ...

journal_title：Diabetologia

authors： Lim EL,Hollingsworth KG,Aribisala BS,Chen MJ,Mathers JC,Taylor R

更新日期：2011-10-01 00:00:00

abstract：:To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibodies and high titre...

journal_title：Diabetologia

authors： Betterle C,Presotto F,Pedini B,Moro L,Slack RS,Zanette F,Zanchetta R

更新日期：1987-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased oxidative-nitrosative stress, poly(ADP-ribose) polymerase (PARP) activation and subsequent cellular damage play important roles in the complications of both diabetes mellitus and pregnancy. Our aim was to investigate nitrative stress and PARP activity levels during normal and gestational diabe...

journal_title：Diabetologia

authors： Horváth EM,Magenheim R,Kugler E,Vácz G,Szigethy A,Lévárdi F,Kollai M,Szabo C,Lacza Z

更新日期：2009-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The prevalence of diabetes and heart failure is increasing, and diabetes has been associated with an increased risk of heart failure. However, whether diabetes confers the same excess risk of heart failure in women and men is unknown. The aim of this study was to conduct a comprehensive systematic revie...

journal_title：Diabetologia

authors： Ohkuma T,Komorita Y,Peters SAE,Woodward M

更新日期：2019-09-01 00:00:00

abstract：:To determine whether increased oxidative stress in diabetes mellitus is due to an impaired free-radical scavenger function in endothelial cells, GSH-dependent H2O2 degradation in human umbilical vein endothelial cells was studied. The GSH-dependent, NaN3-uninhibitable H2O2-degradation in endothelial cells was reduced ...

journal_title：Diabetologia

authors： Kashiwagi A,Asahina T,Ikebuchi M,Tanaka Y,Takagi Y,Nishio Y,Kikkawa R,Shigeta Y

更新日期：1994-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes promotes cerebral neovascularisation via increased vascular endothelial growth factor (VEGF) angiogenic signalling. Roundabout-4 (ROBO4) protein is an endogenous inhibitor of VEGF signalling that stabilises the vasculature. Yet, how diabetes affects ROBO4 function remains unknown. We hypothesis...

journal_title：Diabetologia

authors： Abdelsaid M,Coucha M,Hafez S,Yasir A,Johnson MH,Ergul A

更新日期：2017-04-01 00:00:00

abstract：:[Nepsilon-palmitoyl Lys (B29)] human insulin is a fatty acid-acylated derivative of insulin with extended action compared to unmodified insulin when infused intravenously (i.v.) secondary to its binding to circulating albumin. The duration and activity profile of the acylated (A) and NPH (B) insulins were assessed fol...

journal_title：Diabetologia

authors： Radziuk J,Pye S,Bradley B,Braaten J,Vignati L,Roach P,Bowsher R,DiMarchi R,Chance R

更新日期：1998-01-01 00:00:00

abstract：:The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell funct...

journal_title：Diabetologia

authors： Hussain MA,Akalestou E,Song WJ

更新日期：2016-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis. MATERIALS AND METHODS:Oesophageal manometry and ...

journal_title：Diabetologia

authors： Ohlsson B,Melander O,Thorsson O,Olsson R,Ekberg O,Sundkvist G

更新日期：2006-09-01 00:00:00