Advances in the treatment of von Willebrand disease.

Abstract:

:Von Willebrand disease (VWD) is the most commonly inherited bleeding disorder, caused by inheritance of a quantitative or qualitative abnormality of von Willebrand factor (VWF). While the majority of patients with VWD are successfully treated with adjunctive therapies or with the synthetic vasopressin analog desmopressin acetate (DDAVP), a subset of patients requires replacement therapy. In the past, cryoprecipitate was the mainstay of therapy; however, it was associated with seroconversion to hepatitis B (HBV), hepatitis C (HCV), and the human immunodeficiency virus (HIV) in treated individuals. With the advent of virucidal methodology and, more recently, nucleic acid testing (NAT) of plasma fractions, the plasma-derived concentrates containing VWF are now considered the therapeutic standard of care.

journal_name

Semin Hematol

journal_title

Seminars in hematology

authors

Hambleton J

doi

10.1016/s0037-1963(01)90131-3

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

7-10

issue

4 Suppl 9

eissn

0037-1963

issn

1532-8686

pii

ashem0384c0007

journal_volume

38

pub_type

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