Abstract:
:Clinical and experimental studies have been conducted to improve the survival of venous flaps. As a result of these studies, although various survival mechanisms were raised, none obtained satisfactory information. Venous stasis, and the resultant venous thrombosis, is a factor that decreases the survival of venous flaps. In this study, we evaluated the effects of two antiinflammatory agents, etodolac and etofenamate, on the survival of unipedicled venous flaps. In this study, 35 male New Zealand white rabbits (3,500-4,000 g) (70 ears) were used. Perichondrocutaneous flaps, 3 x 4.5 cm in size, were designed and raised, keeping the central veins intact in the middle of venous flap. Central arteries and nerves were ligated and transected both proximally and distally, to prepare unipedicled venous flaps. A silicone sheet was placed between the cartilage tissue and flap, to prevent blood flow and revascularization beneath. The subjects were divided into seven groups, consisting of five rabbits (10 ears). In the negative control group (group I), the single vascular pedicle of venous flaps, central veins were ligated and flaps sutured into their own place as the composite graft. In the positive control group (group II), after venous flaps were prepared, normal saline, 0.2 mL, was given subcutaneously. In the first of five experimental groups (group III), unfractionated heparin (100 U/day) was given subcutaneously. In the second experimental group (group IV), etodolac (5 mg/kg/day) was given subcutaneously. In the third experimental group (group V), etophenamate (5 mg/kg/day) was given orally through a feeding tube. In the fourth experimental group (group VI), parnaparin (5 anti-Xa U/kg/day) was given subcutaneously. In the fifth experimental group (group VII), nadroparin (5 anti-Xa U/kg/day) was given subcutaneously, about 7 days postoperatively. At the eighth postoperative day, surviving areas of venous flaps were measured, and the results were evaluated by Kruskal-Wallis ANOVA and Mann-Whitney U-test (P < 0.05). Biopsies were also taken from the flaps for histological evaluation of border of necrotic tissue. Surviving areas of unipedicled venous flaps were larger in experimental groups than those in negative and positive control group (P < 0.05). However, comparison of the experimental groups demonstrated no statistically significant difference (P > 0.05). We concluded that all pharmacological agents used in the experimental groups succeeded in increasing the survival of unipedicled venous flaps. Survival of the unipedicled venous flap was higher in venous flaps than that of composite graft, clearly showing the importance of the venous pedicle.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Askar I,Saray A,Gurlek A,Sevin K,Sabuncuoglu BTdoi
10.1002/micr.21801subject
Has Abstractpub_date
2001-01-01 00:00:00pages
350-6issue
8eissn
0738-1085issn
1098-2752pii
10.1002/micr.21801journal_volume
21pub_type
杂志文章相关文献
MICROSURGERY文献大全abstract::The effect of hyperbaric oxygen (HBO) on the survival rate of experimental rat pedicle island flaps with arterial, venous, and combined arteriovenous insufficiency was evaluated. Forty male Wistar rats with pedicle island flaps were divided into four groups with different types of vascular status. Another 40 male Wist...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.22004
更新日期:2002-01-01 00:00:00
abstract::Intrinsic haemangioma of the median nerve is an extremely rare tumor that represents a challenge to diagnose and treat. Only a few cases have been reported in the literature. We present a 10-year-old girl who was diagnosed having an intrinsic haemangioma of the median nerve and treated with total surgical resection of...
journal_title:Microsurgery
pub_type: 杂志文章,评审
doi:10.1002/micr.20456
更新日期:2008-01-01 00:00:00
abstract::We employed a forearm flap that had been thinned through primary defatting for nasal covering in three cases to reduce the need for secondary revision. Partial flap loss did occur in one case due to subcutaneous vascular plexus injury, but acceptable results were obtained in the remaining two cases. Donor site concave...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2752(1996)17:4<184::AID-MICR4>3
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:Plate extrusions after free tissue transfer for mandibular reconstruction can be problematic and generally require revision surgery. Our objective was to assess the predictors of plate extrusion and compare outcomes between fibular free flaps (FFF), lateral border scapular flaps (LBSF), and scapular tip free...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.30349
更新日期:2018-09-01 00:00:00
abstract::The creation of a distal arteriovenous fistula for haemodialysis is made easier by using preventive haemostasis with an inflatable tourniquet. Preventive haemostasis reduces the duration of the surgery and reduces the arterial spasm provoked by the dissection. When microsurgical techniques and preventive haemostasis a...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920140709
更新日期:1993-01-01 00:00:00
abstract::The morphological features of regeneration in long-distance (3 cm) muscle-vein-combined grafts were experimentally investigated in the rat sciatic nerve by means of light and electron microscopy. In the early phases of regeneration (14 days after surgery), many regenerating nerve fibers were detected along the muscle-...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/(sici)1098-2752(2000)20:1<37::aid-micr7>3.
更新日期:2000-01-01 00:00:00
abstract::A neuroma is a collection of disorganized nerve sprouts emanating from an interruption of axonal continuity, forming within a collagen scar as the nerve attempts to regenerate. Lingual neuroma formation secondary to iatrogenic trauma to the tongue is likely not uncommon; however, we could not find a report in the lite...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.22171
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:The proximal peroneal artery perforator (PPAP) flap is a reliable, thin fasciocutaneous flap. The purpose of this article was to report our experience with the use of free PPAP flaps for reconstruction of defects of the distal hand and foot. PATIENTS AND METHODS:From November 2012 to September 2013, 9 patie...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.22364
更新日期:2016-03-01 00:00:00
abstract::In order to understand the mechanisms involved in the hypertrophy of vascularized bone grafts, a series of animal experiments were carried out and 32 clinical cases were studied. A defect in the tibial shaft was created in puppies and the ipsilateral fibula was transferred into the medullary cavity of the tibia with t...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920151012
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Wound dehiscence, infection, and necrosis of tendon and overlying skin are severe complications after open repairs of Achilles tendon. A simultaneous reconstruction should be provided in a single stage operation. We evaluated the outcomes of one of the possible options: the radial forearm free flap with Flex...
journal_title:Microsurgery
pub_type: 临床试验,杂志文章
doi:10.1002/micr.22481
更新日期:2015-11-01 00:00:00
abstract::Reconstructive surgery of the head and neck has particularly benefited from the rapid developments in microsurgery. Resection of tumours from the head and neck which are associated with serious physical and psychological problems, or which often require multiple reconstructive procedures, can now be performed as a sin...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920150711
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Mandibular reconstruction with a mandibular reconstruction plate (MRP) and free flap transfer can involve serious plate-related complications. The aim of our study is to present our new "no-touch-technique" which keeps an MRP not contaminated to saliva during the entire operation for the reduction of plate-re...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.22403
更新日期:2016-02-01 00:00:00
abstract::In this report, we present a case of the use of a conjoined fabricated free anterolateral thigh (ALT)/tensor fascia latae (TFL) perforator flap for reconstruction of the lower extremity with intraoperative flap design using intraoperative indocyanine green (ICG) monitoring. The flap was used for reconstruction of a 16...
journal_title:Microsurgery
pub_type:
doi:10.1002/micr.22424
更新日期:2016-11-01 00:00:00
abstract::To evaluate the natural course of postsurgical adhesion formation, a descriptive animal study was performed in a standardized rat adhesion model, involving the uterine horn and peritoneal side wall. Extent and type of postsurgical adhesion formation was evaluated at increasing postoperative time intervals up to 1 year...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920160912
更新日期:1995-01-01 00:00:00
abstract::A study was designed to investigate the role of terminal probes as determinates of two-point discrimination in the normal hand. A Vernier caliper was modified to allow an exchange of probes with different diameters and with different terminal shapes. These terminal devices included flat, sharp, and rounded probe tips ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920100318
更新日期:1989-01-01 00:00:00
abstract::Silicone rubber (polydimethyl siloxane) tubes are used clinically in peripheral nerve reconstruction. A disadvantage of this procedure is that the material often has to be removed owing to its mechanical properties. The aim of our study was to investigate the healing of reconstructed sensory nerves tubulized by silico...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1057
更新日期:2001-01-01 00:00:00
abstract::Replantation of an amputated digit in a child demands special techniques for success. Our experiences with replantation in this age group have shown that although these patients have a lower viability rate after digital replantation, those digits that do survive develop excellent function. In this case report of a 7-m...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920090308
更新日期:1988-01-01 00:00:00
abstract::This is an experimental study comparing the suturing time and patency rate of a spiral interrupted suturing technique to those of conventional interrupted and continuous suturing technique in end-to-end as well as end-to-side anastomosis. The spiral interrupted suturing technique requires less time for either end-to-e...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920070205
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:In the last years, limb salvage has become the gold standard treatment over amputation. Today, 90% of extremity osteogenic sarcomas can be treated with limb salvage surgery. However, these reconstructions are not exempt from complications. Massive allografts have been associated to high risk of nonunion (1...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.30647
更新日期:2020-09-19 00:00:00
abstract::Lipoprostaglandin E1 (lipo-PGE1) has been found accumulating in injured vascular regions. This study examined the localization of lipo-PGE1 in the anastomotic region. The study was divided into three parts. First, we performed anastomosis of the rat femoral artery and vein (n = 17). Lipo-PGE1 labeled with 1,1'-dioctad...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20890
更新日期:2011-07-01 00:00:00
abstract::The authors present two cases of complete median nerve paralysis due to entrapment after posterior dislocation of the elbow. Previous literature on the subject matter is reviewed, and management and therapeutic indication of these lesions are discussed. ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920040403
更新日期:1983-01-01 00:00:00
abstract::While free flaps are reliant on their vascular pedicle for survival intraoperatively and for a variable period of time postoperatively, there have been reports of late pedicle compromise after which complete flap survival has ensued. Successful neovascularization and revascularization at the edges of a flap in such ca...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20781
更新日期:2010-09-01 00:00:00
abstract::Vasospasm is known to be present during most microvascular procedures. Not until recently has microsurgery made it possible to directly observe the dynamic nature of vascular spasm. This report reviews the physiologic events and the causes of vascular spasm during microsurgery. The current research models and the use ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920080413
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Reconstructing soft tissue defect on the trochanteric area is challenging. Due to the significant complications associated with regional flap, free tissue transfer is an appropriate option. However, this area has poor recipient vessels. Therefore, we present perforators as suitable recipient vessels to facil...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.30424
更新日期:2020-01-01 00:00:00
abstract::End-to-side neurorrhaphy, a possible strategy for treating nerve lesions without useable proximal nerve stumps, has been experimentally and clinically investigated. In end-to-side neurorrhaphy, three main elements should be considered: 1) the induction of axonal collateral sprouting in the donor nerve; 2) the ability ...
journal_title:Microsurgery
pub_type: 杂志文章,评审
doi:10.1002/micr.21736
更新日期:2002-01-01 00:00:00
abstract::In order to raise an abundant and accessible reservoir for Schwann cells (SCs), which are used as seed cells for constructing tissue-engineered nerve grafts, we investigated the feasibilty of in vivo differentiation of bone marrow stromal cells (MSCs) into SC-like cells. In this study, MSCs were harvested from adult r...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20184
更新日期:2006-01-01 00:00:00
abstract::The effect of five different irrigating solutions on patency of four different types of microvascular anastomoses was studied. The solutions used were lactated Ringer's without heparin and four lactated Ringer's solutions with varying concentrations of heparin ranging from 10,000 units/liter to 100,000 units/liter. Th...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920100205
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Previous neck dissection and irradiation is believed to affect the success of free tissue transfers in head and neck reconstruction, but evidence is scarce and conflicting. This study seeks to evaluate flap success rates in the presence of these two factors. METHODS:Over a ten-year period, a total of 853 fr...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.22270
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Free tissue transfers performed in patients with hematological diseases represent significant challenges for micro-surgeons. There are rare literatures that address the outcome in these patients. Therefore, we collected our database, analyzed the outcome, reliability, and related-management of microsurgical ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.22243
更新日期:2014-10-01 00:00:00
abstract::In September 1998, a surgical team in Lyon, France, performed the first successful hand transplant. After this historic event, in January 1999, the University of Louisville performed the first hand transplant in the United States. These events sparked interest and debate concerning the justification of performing limb...
journal_title:Microsurgery
pub_type: 历史文章,杂志文章,评审
doi:10.1002/1098-2752(2000)20:8<393::aid-micr9>3.0.co;
更新日期:2000-01-01 00:00:00