Cell activation and death (apoptosis) induced by IL-2: ultrastructural evidence.

abstract：BACKGROUND/AIM:Intrapelvic bleeding after extended pelvic surgery is fatal, but few reports have addressed this serious situation. The objective of the present study was to evaluate the short-term clinical outcome of this complication. PATIENTS AND METHODS:This study was a retrospective medical chart review of 130 pat...

journal_title：Anticancer research

authors： Ogawa H,Mizushima T,Takemasa I,Yamamoto H,Doki Y,Mori M

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND/AIM:Vanek's tumor is an inflammatory fibroid polyp (IFP) of very low incidence, which originates in the submucosa of the stomach, duodenum, jejunum and ileum. The etiology of this tumor is still unknown. Histologically, IFP is characterized by submucosal spindle cell proliferation in fibromyxoid stroma with ...

journal_title：Anticancer research

authors： Jukic Z,Ferencic Z,Radulovic P,Mijic A,Fucic A

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Targeted agents present with a new spectrum of side-effects, including toxicities that negatively impact the risk of atherosclerosis. The aim of the present study was to evaluate the effect of the combination of targeted therapy and chemotherapy on serum homocysteine and other laboratory parameters of cardio...

journal_title：Anticancer research

authors： Melichar B,Kalábová H,Krcmová L,Kasparová M,Malírová E,Melicharová K,Pecka M,Hyspler R,Solichová D

更新日期：2009-11-01 00:00:00

abstract：:Most current anticancer drugs have shown excellent therapeutic effects on human oral squamous cell carcinoma (OSCC), but they also produce potent cytotoxicity in normal oral keratinocytes. This review article summarizes our extensive research of tumor specificity and keratinocyte toxicity of nine groups of compounds s...

journal_title：Anticancer research

authors： Sugita Y,Takao K,Uesawa Y,Sakagami H

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The prognostic significance of angiogenesis, proliferation and apoptosis after interferon (IFN) was investigated in 96 patients with renal cell carcinoma (RCC). MATERIALS AND METHODS:Microvessel density in the tumor(MVD), proliferative index(PI) and apoptotic index(AI) were quantified using immunohistochemi...

journal_title：Anticancer research

authors： Yoshino S,Kato M,Okada K

更新日期：2000-01-01 00:00:00

abstract：:Transcatheter embolization is considered to be less effective for early-stage hepatocellular carcinomas (HCCs) without a hypervascular arterial supply. In the present case report, a 65-year-old male with hepatitis type C and non-hypervascular HCC located in the hepatic hilum was successfully treated by bland transarte...

journal_title：Anticancer research

authors： Tanaka T,Maeda S,Nishiofuku H,Masada T,Sato T,Anai H,Sakaguchi H,Kichikawa K

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast tumors and these breast tumors are usually aggressive and highly metastatic. Unfortunately, treatment options for TNBCs are limited; we have identified a novel molecule, 2'-3'-dehydrosalannol (DHS) and in this study we investigated the an...

journal_title：Anticancer research

authors： Boopalan T,Arumugam A,Damodaran C,Rajkumar L

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The tumor-suppressive effects of rabbit anti-p53 antibodies on chemically induced rat colon cancer were demonstrated previously (Cancer J, 10:116-120, 1997). METHODS:In this communication, the spleen's role in the immune response of rats to cancer and vaccination was evaluated histologically and immunohisto...

journal_title：Anticancer research

authors： Ben-Hur H,Gurevich P,Zion H,Berman V,Tendler Y,Sandler B,Zinder O,Zusman I

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIM:This study aimed to identify the prognostic factors and outcomes of osteosarcoma (OS) located in proximal versus distal extremity long bones. PATIENTS AND METHODS:A nationwide cohort comprising all Norwegian high-grade OSs in extremity long bones between 1982 and 2009 was investigated. RESULTS:The univ...

journal_title：Anticancer research

authors： Berner K,Bruland ØS

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Neutral endopeptidase 24.11 (NEP) is a cell-surface peptidase that inactivates a variety of neuropeptide substrates. In addition to catalytic activity, NEP can exert biological effects through protein-protein interactions. We previously reported that NEP directly associated with tyrosine-phosphorylated Lyn k...

journal_title：Anticancer research

authors： Shen R,Milowsky MI,Ozaki N,Navarro D,Sumitomo M,Xu Y,Nanus DM

更新日期：2002-09-01 00:00:00

abstract：:A large number of different papillomavirus types have been identified. Several viruses often infect the same species and each virus is associated with a defined tissue. Recent evidence has shown that certain benign lesions can undergo malignant transformation in both animals and humans in response to genetic or enviro...

journal_title：Anticancer research

authors： Smith KT,Campo MS

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND/AIM:Cyclin D1 is a mediator of cell-cycle control that is frequently overexpressed in primary ductal breast carcinomas, but its role is controversial. A polymorphism in the CCND1 gene, G870A, results in an aberrantly spliced protein (cyclin D1b) lacking the Thr-286 phosphorylation site necessary for nuclear ...

journal_title：Anticancer research

authors： Abramson VG,Troxel AB,Feldman M,Mies C,Wang Y,Sherman L,McNally S,Diehl A,Demichele A

更新日期：2010-04-01 00:00:00

abstract：:Previous reports suggest that age, household income and travel distance from residence to treatment facility are barriers which influence access to radiotherapy. The purpose of this study was to analyse the utilisation of palliative radiotherapy in a health care system where the main goal is equal access despite place...

journal_title：Anticancer research

authors： Nieder C,Norum J,Spanne O,Bilberg I,Vagstad G,Dalhaug A

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND/AIM:AZD8055 is an inhibitor of mammalian target of rapamycin (mTOR) that can suppress both mTOR complex 1 (mTORC1) and mTORC2. This study investigated the antitumor effects of AZD8055 on colon cancer. MATERIALS AND METHODS:The effects of AZD8055 on proliferation, apoptosis, and cell cycle of colon cancer ce...

journal_title：Anticancer research

authors： Chen Y,Lee CH,Tseng BY,Tsai YH,Tsai HW,Yao CL,Tseng SH

更新日期：2018-03-01 00:00:00

abstract：:Chemopreventative phytochemicals having antitumour and antioxidant properties can overcome problems of chemoresistance and nonspecific toxicity towards normal cells that are associated with platinum-based chemotherapy against cancer. These agents exert their effects by bringing into play numerous cellular proteins tha...

journal_title：Anticancer research

authors： Nessa MU,Beale P,Chan C,Yu JQ,Huq F

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Treatment for advanced pancreatic cancer is still very unsatisfactory. Treosulfan is an alkylating agent used for conventional, as well as high-dose chemotherapy regimens, whereby plasma concentrations over 500 μg/ml can be achieved. We investigated the effects of treosulfan on pancreatic cancer cell lines. ...

journal_title：Anticancer research

authors： Nitsch E,Mina S,Brammer I,Pace A,Schuch G,Bokemeyer C,Zander A,Kröger N,Ayuk F

更新日期：2014-04-01 00:00:00

abstract：:Using a cultured human colon cancer cell line (Col 2), a structurally diverse group of chemopreventive agents was evaluated for their potential to induce apoptosis. As a result, 1,4-phenylenebis(methylene)selenocyanate (p-xylylselenocyanate; p-XSC) was found to be active in this process. p-XSC, a synthetic organoselen...

journal_title：Anticancer research

authors： Lee SK,Heo YH,Steele VE,Pezzuto JM

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Although p21 is an important component that regulates cell-cycle progression, no consensus has been reached about its clinicopathological significance in esophageal squamous cell carcinoma (ESCC). In the present study, we investigated its prognostic significance and correlation with cyclin-D1 (CCND1) express...

journal_title：Anticancer research

authors： Shiozaki A,Nakashima S,Ichikawa D,Fujiwara H,Konishi H,Komatsu S,Kubota T,Okamoto K,Iitaka D,Shimizu H,Nako Y,Takemoto K,Kishimoto M,Otsuji E

更新日期：2013-10-01 00:00:00

abstract：:E-selectin which is expressed on endothelial cells plays an important role in the adhesion of cancer cells to the vascular endothelium, being the ligand for a carbohydrate antigen expressed on cancer cells. In this study, the clinical usefulness of this protein was examined. E-selectin was expressed on the endothelial...

journal_title：Anticancer research

authors： Matsuura N,Narita T,Mitsuoka C,Kimura N,Kannagi R,Imai T,Funahashi H,Takagi H

更新日期：1997-03-01 00:00:00

abstract：:Paclitaxel has been approved as second-line therapy after anthracyclines in AIDS-Kaposi's sarcoma (KS) patients. To date, only one patient with classical KS and treated with standard dose (175 mg/m2) 3-weekly paclitaxel as first line therapy has been reported in the literature. Herein, the first case is presented of a...

journal_title：Anticancer research

authors： Silvestris N,Galetta D,Colucci G

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:A case control association study was carried out to investigate polymorphisms in genes CYP1A1 (3801T > C), GSTM1, and GSTT1 (null genotypes) and oral squamous cell carcinoma (OSCC), including a correlation with some histopathological findings (tumor size, lymph node invasion and degree of tumor differentiati...

journal_title：Anticancer research

authors： Losi-Guembarovski R,Cólus IM,De Menezes RP,Poliseli F,Chaves VN,Kuasne H,Leichsenring A,Guembarovski AL,Oliveira BW,Ramos G,Cavalcanti TC,Mizuno LT,Cavalli IJ,Ribeiro EM

更新日期：2008-03-01 00:00:00

abstract：AIM:After radical prostatectomy, PSA levels that reach near zero values in less than 14 days are associated with a favourable prognosis. The aim of this analysis was to investigate whether PSA also declines to near zero values after combined tele-brachytherapy. MATERIALS AND METHODS:Forty-one patient, treated with com...

journal_title：Anticancer research

authors： Schüller P,Schäfer U,Micke O,Panke JE,Willich N

更新日期：2005-05-01 00:00:00

abstract：:It was the aim of this study to compare drug-resistant sublines of the murine P388 in relation to resistance markers, the resistant phenotype and immunogenicity. Resistance to drugs either belonging to the MDR type (Doxorubicin, Vincristine, Mitoxantrone) or to the non-MDR type (Methotrexate) was generated in vivo in ...

journal_title：Anticancer research

authors： Fichtner I,Stein U,Hoffmann J,Winterfeld G,Pfeil D,Hentschel M

更新日期：1994-09-01 00:00:00

abstract：:Myc is an oncogenic transcription factor that promotes tumorigenesis. Recently, a dominant negative form of Myc (Omomyc) was shown to cause regression of lung tumors in a mouse model of lung cancer caused by KRAS mutation, suggesting that Myc might be a potential therapeutic target to treat the KRAS lung cancer. Howev...

journal_title：Anticancer research

authors： Fukazawa T,Maeda Y,Matsuoka J,Yamatsuji T,Shigemitsu K,Morita I,Faiola F,Durbin ML,Soucek L,Naomoto Y

更新日期：2010-10-01 00:00:00

abstract：:The technical performance and clinical usefulness of the newly developed Elecsys CA 125 II assay (Boehringer Mannheim) was evaluated in a multicenter study. Imprecision studies were carried out using control sera and human pool sera with CA 125 concentrations from 11 to 1026 U/ml. Within-run CVs between 0.7 to 4.8% (m...

journal_title：Anticancer research

authors： Hubl W,Chan DW,Van Ingen HE,Miyachi H,Molina R,Filella X,Pitzel L,Ruibal A,Rymer JC,Bagnard G,Domke I

更新日期：1999-07-01 00:00:00

abstract：AIM:The aim of the present study was to determine if febuxostat could prevent tumor lysis syndrome (TLS) in children who received induction chemotherapy for hematologic malignancies. PATIENTS AND METHODS:A retrospective analysis was performed in 45 pediatric patients with hematological malignancies who received febuxo...

journal_title：Anticancer research

authors： Kishimoto K,Kobayashi R,Hori D,Sano H,Suzuki D,Kobayashi K

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Molecular alterations such as DNA microsatellite instability (MSI/RER), single nucleotide polymorphism (SNP) and loss of heterozygosity (LOH) can occur throughout the genome and be associated with different types of cancer. In the present study, we aimed at detecting molecular alterations within the mismatch...

journal_title：Anticancer research

authors： Arzimanoglou II,Hansen LL,Chong D,Li Z,Psaroudi MC,Dimitrakakis C,Jacovina AT,Shevchuk M,Reid L,Hajjar KA,Vassilaros S,Michalas S,Gilbert F,Chervenak FA,Barber HR

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Experimental data at the molecular, cellular and organismal levels have implicated dietary components in cancer. Exposure to numerous growth factors, hormones and environmental agents, that can regulate signaling events, is involved in carcinogenesis. Research targets on gene-nutrient interactions may give u...

journal_title：Anticancer research

authors： Updike MS,Sawdy JC,Wang LS,Liu S,Huang YW,Ye W,Farrar WB,Lin YC,Wick M

更新日期：2007-01-01 00:00:00

abstract：AIM:To investigate whether the negative quality of life result of a large randomized exercise intervention study (BREX) was due to considerable spontaneous recovery after adjuvant treatments. PATIENTS AND METHODS:The change in QoL was studied in the control patients of the BREX study (Group 1) and a group of similar f...

journal_title：Anticancer research

authors： Penttinen H,Rautalin M,Roine R,Jahkola T,Kellokumpu-Lehtinen PL,Huovinen R,Kautiainen H,Järvenpää S,Hakamies-Blomqvist L,Blomqvist C,Saarto T

更新日期：2014-03-01 00:00:00

abstract：:A brief review summarizing the relationships that exist between the DEK protein and gene regulation, oncogenesis and AIDS. ...

journal_title：Anticancer research

authors： Sitwala KV,Mor-Vaknin N,Markovitz DM

更新日期：2003-05-01 00:00:00