Amoxycillin, clarithromycin and either sucralfate or pantoprazole for eradication of Helicobacter pylori in duodenal ulcer (a randomized controlled trial).

Abstract:

BACKGROUND:Sucralfate enhances the anti-Helicobacter pylori activity of antimicrobials and has an inhibitory effect on H. pylori. AIM:To evaluate the efficacy and safety of one-week sucralfate-based eradication therapy for H. pylori infection in patients with duodenal ulcers, compared with treatment based on pantoprazole, in a randomized controlled multicenter study. METHODS:One hundred and twenty patients with active duodenal ulcers and H. pylori infection were treated with amoxycillin 1 g b.d. plus clarithromycin 500 mg b.d. for the first 7 days. Patients were randomly assigned to receive either sucralfate 1 g t.d.s. for 4 weeks (SAC group; n = 60) or pantoprazole (PAC group; n = 60) 40 mg b.d. for the first 7 days and 40 mg o.d. for the next 3 weeks. The patient's H. pylori status was determined by a urease test and histological investigation before the treatment, and again 4 weeks after cessation of all medication. RESULTS:One hundred and eleven patients completed the study. H. pylori infection was eradicated in 76.4% (42/55) of patients in the SAC group (ITT analysis: 70%, 95% CI: 58-80%) vs. 85.7% (48/56) of patients in the PAC group (ITT analysis: 80%, 95% CI: 70-89) (N.S.). All ulcers had healed. There were no significant differences between the two regimens regarding the occurrence of adverse effects. CONCLUSION:Our study shows that one-week triple therapy with amoxycillin, clarithromycin and either pantoprazole or sucralfate are effective regimens to cure H. pylori infection in patients with duodenal ulcer.

journal_name

Wien Klin Wochenschr

authors

Vcev A,Vceva A,Kurbel S,Takac B,Stimac D,Ivandić A,Ostojić R,Barbir A,Hovat D,Mihaljević S

subject

Has Abstract

pub_date

2001-12-17 00:00:00

pages

939-41

issue

23-24

eissn

0043-5325

issn

1613-7671

journal_volume

113

pub_type

临床试验,杂志文章,随机对照试验
  • [Type 2 Diabetes mellitus-screening and prevention: Update 2016].

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  • [The influence of somatostatin on serum gastrin concentrations in patients after total duodenopancreatectomy (author's transl)].

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    pub_type: 杂志文章

    doi:

    authors: Pointner H,Flegel U,Tragl KH,Hengl G

    更新日期:1977-02-04 00:00:00

  • [Ulcerative colitis in childhood and its differential diagnosis].

    abstract::Ulcerative colitis occurs before the age of 15 years in 20% and before 20 years in 40% of all patients involved. The frequency of this disease in patients at the University Children's Hospital of Munich has clearly risen over the past years. In many patients we found characteristic differences in history, clinical pic...

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    pub_type: 杂志文章

    doi:

    authors: Harms HK,Bertele-Harms RM

    更新日期:1986-08-29 00:00:00

  • Effect of preoperative feeding on gastric emptying following spinal anesthesia: a randomized controlled trial.

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    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00508-009-1301-9

    authors: Protic A,Turina D,Matanić D,Spanjol J,Zuvic-Butorac M,Sustic A

    更新日期:2010-01-01 00:00:00

  • Lab-score is a valuable predictor of serious bacterial infection in infants admitted to hospital.

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    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/s00508-015-0831-6

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    更新日期:2015-12-01 00:00:00

  • [Use of monomeric trains in diagnosis of twins (author's transl)].

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    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Graninger W,Grossmann W

    更新日期:1980-01-18 00:00:00

  • Outcome in patients with intracerebral hemorrhage: predictors of survival.

    abstract:BACKGROUND AND PURPOSE:The aim of this retrospective study was to determine in-hospital mortality and morbidity secondary to intracerebral hemorrhage and to analyse variables considered to be significantly associated with survival in these patients. PATIENTS AND METHODS:The study cohort consisted of 135 consecutive pa...

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    pub_type: 杂志文章

    doi:

    authors: Karnik R,Valentin A,Ammerer HP,Hochfelner A,Donath P,Slany J

    更新日期:2000-02-25 00:00:00

  • An outbreak of norovirus gastroenteritis in an Austrian hospital, winter 2006-2007.

    abstract:BACKGROUND:Norovirus is easily spread from person to person by the fecal-oral route and through aerosols or by vehicles such as contaminated food or water. The virus is able to survive in the environment for many days, which enables outbreaks to be prolonged. We describe a norovirus outbreak and its control measures in...

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    pub_type: 杂志文章

    doi:10.1007/s00508-008-1135-x

    authors: Fretz R,Schmid D,Jelovcan S,Tschertou R,Krassnitzer E,Schirmer M,Hell M,Allerberger F

    更新日期:2009-01-01 00:00:00

  • Cardiac rehabilitation and risk factor management after myocardial infarction. Clinical and economic evaluation.

    abstract::The increasing scarcity of available, and finite, health care resources, and the increased demands for health care, have made consideration of effectiveness and cost-effectiveness of health care services, such as the secondary prevention of heart disease, an imperative. There is considerable evidence that modification...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章,评审

    doi:

    authors: Oldridge NB

    更新日期:1997-01-01 00:00:00

  • [Gastroplasty in the treatment of morbid obesity].

    abstract::A series of 90 gastroplasty operations based on Eckhout's vertical banded procedure are described. The average weight loss at follow up 2 years postoperatively was 66%. There were no operative or late deaths nor any serious complications. The constricting Gore-Tex band had to be lengthened in 3 cases of outlet stenosi...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Hell E

    更新日期:1990-11-23 00:00:00

  • [The urological spiral. A real alternative to the indwelling catheter? Experience in 23 patients].

    abstract::Our experiences are reported with the "intraprostatic spiral" in 23 high-risk patients with prostatic adenoma. The intraprostatic spiral was used only in selected patients for medical indications. Patients confined to bed as well as those with detrusor instability or secondary dilatation of the upper urinary tract wer...

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    pub_type: 杂志文章

    doi:

    authors: Tomschi W,Lüftenegger W

    更新日期:1990-11-09 00:00:00

  • [Changes in serum lipoproteins in cerebrovascular disease (author's transl)].

    abstract::The determination of serum cholesterol, triglycerides and lipoprotein cholesterol (VLDL, LDL and HDL) in 96 patients suffering from cerebral vascular disease showed that some parameters were significantly different from those recorded in a control population of corresponding age HDL values below 40 mg/dl were found in...

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    pub_type: 杂志文章

    doi:

    authors: Bruck J,Fischer M,Tschabitscher H

    更新日期:1981-10-16 00:00:00

  • Dabigatran in patients with atrial fibrillation: perioperative and periinterventional management.

    abstract::In any type of invasive surgery, the patient's individual risk of thromboembolism has to be weighed against the risk of bleeding. Based on various everyday situations in clinical routine, the purpose of the present expert recommendations is to provide appropriate perioperative and periinterventional management for pat...

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:

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  • [Incidence of alcoholism and problem drinking in Austria].

    abstract::The prevalence of problem-drinking and alcohol dependence in Austria was assessed on the basis of two random samples of the general population drawn in 1995 (n=216) and in 1996 (n=531). Measurements were performed using the CAGE questionnaire (Mayfield et al. 1974). Both cut-off points (> or = 1, > or = 2) of the CAGE...

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    doi:

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  • Influence of the birth attendant on maternal and neonatal outcomes during normal vaginal delivery: a comparison between midwife and physician management.

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    journal_title:Wiener klinische Wochenschrift

    pub_type: 临床试验,杂志文章

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    更新日期:2004-06-30 00:00:00

  • Thromboembolic complications in a patient with heparin-induced thrombocytopenia (HIT) showing cross-reactivity to a low molecular weight heparin-treatment with Org 10172 (Lomoparan).

    abstract::Heparin-induced thrombocytopenia is an immuno-mediated life-threatening side effect of heparin therapy which poses difficulties in diagnosis and major therapeutic problems. Heparin must be instantly discontinued. We describe the case of a 60-year-old male patient with type II heparin-induced thrombocytopenia, complica...

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    pub_type: 杂志文章

    doi:

    authors: Muhm M,Claeys L,Huk I,Koppensteiner R,Kyrle PA,Minar E,Stümpflen A,Ehringer H,Polterauer P

    更新日期:1997-02-28 00:00:00

  • [Clinical results with dopamine in acute renal failure (author's transl)].

    abstract::Dopamine possesses specific pharmacological actions which distinguish it from the other catecholamines. Apart from its positive inotropic effect, dopamine exerts a favourable influence on renal function with an increase in renal blood flow and alterations in intrarenal haemodynamics. The use of dopamine in the early s...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Pichler M,Kleinberger G,Kotzaurek R,Pall H,Szeless S

    更新日期:1976-01-23 00:00:00

  • [Arteriovenous fistula of the lung: a rare cause of erythrocytosis].

    abstract::Various chronic pulmonary diseases can cause hypoxia mediated erythrocytosis. We report on a 46 year old male patient presenting with erythrocytosis, in whom a pulmonary arteriovenous fistula on the basis of a vascular malformation was identified as a rare cause of hypoxic erythrocytosis. Thus, congenital pulmonary va...

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    pub_type: 杂志文章

    doi:

    authors: Yavuz AS,Nisanci Y,Umman S,Sargin D,Dinçol G

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  • Regression of atherosclerosis: which components regress and what influences their reversal.

    abstract::Two major features of atherosclerosis may be distinguished: (a) atherosis caused by lipid infiltration in cells and extracellularly and (b) sclerosis caused by connective tissue deposition and by functional disturbance of the endothelium, leading to impairment of endothelium-derived relaxing factor (EDRF)-release and ...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章,评审

    doi:

    authors: Kramsch DM,Blankenhorn DH

    更新日期:1992-01-01 00:00:00

  • [Pancreaticopleural fistula formation: a rare complication in chronic pancreatitis].

    abstract::Pleural effusions are found in 3 to 17% of patients with chronic pancreatitis. The most likely underlying pathogenetic mechanism is transdiaphragmatic lymphatic transfer of pancreatic secretions to the subpleural space, whilst a rare cause is the formation of pancreatico-pleural fistulae. The measurement of amylase ac...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Feist H

    更新日期:1985-12-20 00:00:00

  • The clinical morphology of human atherosclerotic lesions. Lessons from the PDAY Study. Pathobiological Determinants of Atherosclerosis in Youth.

    abstract::The PDAY study addresses the role traditional risk factors play in the development and progression of arterial lesions in youth (15 to 34 years of age). This autopsy based study indicates that in the aorta and in the right coronary artery, atherosclerosis is positively associated with cholesterol (LDL+VLDL), glucose i...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Cornhill JF,Herderick EE,Vince DG

    更新日期:1995-01-01 00:00:00

  • Lyme borreliosis in Portugal caused by Borrelia lusitaniae? Clinical report on the first patient with a positive skin isolate.

    abstract:BACKGROUND:Borrelia lusitaniae was isolated from an Ixodes ricinus tick in Portugal in 1993 for the first time. Further, this borrelia genospecies has been found in ixodid ticks collected around the coasts of southern Portugal and North Africa. Its reservoir has not been defined yet. B. lusitaniae was isolated once unt...

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    pub_type: 杂志文章

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    更新日期:2005-06-01 00:00:00

  • [Anti-T in newborn infants].

    abstract::IgM (Immunoglobin M) antibodies to the antigen T (Thomsen-Friedenreich antigen, transformation antigen) were detected by normal agglutination technique in the serum of 7 out of 73 newborn children. Neither the mother's anti-T titre, nor the quantity of IgM and IgG (Immunoglobulin G) in the sera of mother and child was...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Hajek-Rosenmayr A,Petzl DH,Heger ME

    更新日期:1982-08-06 00:00:00

  • [Forms of manifestations of breast cancer in sonography].

    abstract::40 women with breast cancer were checked by the ultrasound Octoson technique and the results compared with the histological tumour types. We grouped the carcinomas into 3 types: scirrhous, solid or medullary, and the invasive lobular tumour. Our diagnostic ultrasound criteria: internal echoes, as well as contour and b...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Bartl W,Bernaschek G

    更新日期:1984-10-26 00:00:00

  • A family outbreak of cryptosporidiosis: Probable nosocomial infection and person-to-person transmission.

    abstract::Cryptosporidium is an important cause of community gastroenteritis, usually associated with drinking contaminated water, visits to swimming pools or animal exposure. In immunocompetent patients, cryptosporidiosis is usually a self-limiting disease but it can be devastating illness in immunocompromised persons. This re...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/s00508-006-0637-7

    authors: Pandak N,Zeljka K,Cvitkovic A

    更新日期:2006-08-01 00:00:00

  • [Duration of spiral after-effects in psychosomatic patients (a psychophysiologic study and analysis of data using multivariate procedures)].

    abstract::In a psychophysiological study the spiral after-effect, as measured by means of the Archimedes spiral, was investigated in 182 patients with psychosomatic disorders including duodenal ulcers, ulcerative colitis, anorexia nervosa, asthma and heart neurosis and compared with the results obtained in a control group of he...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Grünberger J,Linzmayer L,Gathmann P,Saletu B

    更新日期:1984-08-03 00:00:00

  • Acute kidney injury with medazepam-hyoscine buthylbromide.

    abstract::An 84-year-old female patient was admitted to our internal medicine outpatient clinic complaining of stomach ache, nausea, and vomiting. She had hepatitis C infection for 10 years that was managed with antiviral treatment. On the second day of admission, she developed anxiety and complained about dysuria. Medazepam an...

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    pub_type: 杂志文章

    doi:10.1007/s00508-014-0523-7

    authors: Sayiner ZA,Ozturk ZA

    更新日期:2014-05-01 00:00:00

  • [Exocrine pancreatic function in chronic alcoholics in Austria (author's transl)].

    abstract::97 chronic alcoholic patients were investigated with regard to exocrine pancreatic function. Chronic calcifying pancreatitis was radiologically established in 7.2% of the cases. Secretin-pancreozymin tests were performed in 30 patients. Pancreatic insufficiency was found in 8 patients, while 8 patients showed marked h...

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    pub_type: 杂志文章

    doi:

    authors: Pointner H,Flegel U,Bayer PM,Czembirek H,Kryspin-Exner K

    更新日期:1977-06-24 00:00:00

  • Intentionally hastening death by withholding or withdrawing treatment.

    abstract:PURPOSE:This study aims to provide empirical data on physicians' intentions in withholding and withdrawing treatment, and to discuss possible implications for the ethical debate. BASIC PROCEDURES:The data presented come from EURELD, a large research project designed to investigate medical end-of-life decisions in six ...

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