Abstract:
:The electrochemical reduction of meloxicam has been studied at a mercury electrode using various electrochemical methods in aqueous solutions over a wide pH range. The reduction of the drug produced a single reduction step in acidic media, whereas in slightly acidic and neutral media two reduction steps were observed. In alkaline media meloxicam shows a single pH-independent reduction step. The irreversibility of the electrode process was verified by different criteria. At all pH values, reactant adsorption at mercury electrode was observed. The mechanism of reduction was discussed. Using differential-pulse voltammetry, the drug yielded a well-defined voltammetric response in Britton-Robinson buffer solution, pH 4.0 at -1.286 V (vs. Ag/AgCl). This process could be used to determine meloxicam concentration in the range 1.0 x 10(-8)-5.0 x 10(-6) M. The method was successfully applied for the analysis of meloxicam in the tablet dosage form.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Beltagi AM,Ghoneim MM,Radi Adoi
10.1016/s0731-7085(01)00528-3subject
Has Abstractpub_date
2002-02-01 00:00:00pages
795-801issue
5eissn
0731-7085issn
1873-264Xpii
S0731708501005283journal_volume
27pub_type
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