Electrochemical reduction of meloxicam at mercury electrode and its determination in tablets.

Abstract:

:The electrochemical reduction of meloxicam has been studied at a mercury electrode using various electrochemical methods in aqueous solutions over a wide pH range. The reduction of the drug produced a single reduction step in acidic media, whereas in slightly acidic and neutral media two reduction steps were observed. In alkaline media meloxicam shows a single pH-independent reduction step. The irreversibility of the electrode process was verified by different criteria. At all pH values, reactant adsorption at mercury electrode was observed. The mechanism of reduction was discussed. Using differential-pulse voltammetry, the drug yielded a well-defined voltammetric response in Britton-Robinson buffer solution, pH 4.0 at -1.286 V (vs. Ag/AgCl). This process could be used to determine meloxicam concentration in the range 1.0 x 10(-8)-5.0 x 10(-6) M. The method was successfully applied for the analysis of meloxicam in the tablet dosage form.

journal_name

J Pharm Biomed Anal

authors

Beltagi AM,Ghoneim MM,Radi A

doi

10.1016/s0731-7085(01)00528-3

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

795-801

issue

5

eissn

0731-7085

issn

1873-264X

pii

S0731708501005283

journal_volume

27

pub_type

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