Evaluation of factors to convert absorbed dose calibrations from graphite to water for the NPL high-energy photon calibration service.

Abstract:

:The National Physical Laboratory (NPL) provides a high-energy photon calibration service using 4-19 MV x-rays and 60Co gamma-radiation for secondary standard dosemeters in terms of absorbed dose to water. The primary standard used for this service is a graphite calorimeter and so absorbed dose calibrations must be converted from graphite to water. The conversion factors currently in use were determined prior to the launch of this service in 1988. Since then, it has been found that the differences in inherent filtration between the NPL LINAC and typical clinical machines are large enough to affect absorbed dose calibrations and, since 1992, calibrations have been performed in heavily filtered qualities. The conversion factors for heavily filtered qualities were determined by interpolation and extrapolation of lightly filtered results as a function of tissue phantom ratio 20,10 (TPR20,10). This paper aims to evaluate these factors for all mega-voltage photon energies provided by the NPL LINAC for both lightly and heavily filtered qualities and for 60Co y-radiation in two ways. The first method involves the use of the photon fluence-scaling theorem. This states that if two blocks of different material are irradiated by the same photon beam, and if all dimensions are scaled in the inverse ratio of the electron densities of the two media, then, assuming that all photon interactions occur by Compton scatter the photon attenuation and scatter factors at corresponding scaled points of measurement in the phantom will be identical. The second method involves making in-phantom measurements of chamber response at a constant target-chamber distance. Monte Carlo techniques are then used to determine the corresponding dose to the medium in order to determine the chamber calibration factor directly. Values of the ratio of absorbed dose calibration factors in water and in graphite determined in these two ways agree with each other to within 0.2% (1sigma uncertainty). The best fit to both sets of results agrees with values determined in previous work to within 0.3% (1sigma uncertainty). It is found that the conversion factor is not sensitive to beam filtration.

journal_name

Phys Med Biol

authors

Nutbrown RF,Duane S,Shipley DR,Thomas RA

doi

10.1088/0031-9155/47/3/306

subject

Has Abstract

pub_date

2002-02-07 00:00:00

pages

441-54

issue

3

eissn

0031-9155

issn

1361-6560

journal_volume

47

pub_type

杂志文章
  • Treatment time reduction for large thermal lesions by using a multiple 1D ultrasound phased array system.

    abstract::To generate large thermal lesions in ultrasound thermal therapy, cooling intermissions are usually introduced during the treatment to prevent near-field heating, which leads to a long treatment time. A possible strategy to shorten the total treatment time is to eliminate the cooling intermissions. In this study, the t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/48/9/307

    authors: Liu HL,Chen YY,Yen JY,Lin WL

    更新日期:2003-05-07 00:00:00

  • In vivo electric conductivity of cervical cancer patients based on B₁⁺ maps at 3T MRI.

    abstract::The in vivo electric conductivity (σ) values of tissue are essential for accurate electromagnetic simulations and specific absorption rate (SAR) assessment for applications such as thermal dose computations in hyperthermia. Currently used σ-values are mostly based on ex vivo measurements. In this study the conductivit...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/4/1596

    authors: Balidemaj E,de Boer P,van Lier AL,Remis RF,Stalpers LJ,Westerveld GH,Nederveen AJ,van den Berg CA,Crezee J

    更新日期:2016-02-21 00:00:00

  • The sliding slit test for dynamic IMRT: a useful tool for adjustment of MLC related parameters.

    abstract::For treatments with dynamic intensity modulated radiotherapy (IMRT), the adjustment of multileaf collimator (MLC) parameters affecting both the optimization algorithm and dose distributions is crucial. The main parameters characterizing the MLC are the transmission (T) and the dosimetric leaf separation (DLS). The aim...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/4/001

    authors: Chauvet I,Petitfils A,Lehobey C,Kristner JY,Brunet Y,Lembrez R,Gaboriaud G,Mazal A,Zefkili S,Rosenwald JC

    更新日期:2005-02-21 00:00:00

  • A phantom for the testing and calibration of near infra-red spectrometers.

    abstract::This note describes a simple phantom which can be used to check the long term stability and accuracy of relative attenuation measurements made by near infra-red (NIR) spectrometers. The phantom has been calibrated, and the results of the calibration are shown to agree with theoretical predictions of the relative atten...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/39/9/015

    authors: Firbank M,Delpy DT

    更新日期:1994-09-01 00:00:00

  • High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals.

    abstract::We have developed an x-ray imaging system for in vivo four-dimensional computed tomography (4DCT) of small animals for pre-clinical lung investigations. Our customized laboratory facility is capable of high resolution in vivo imaging at high frame rates. Characterization using phantoms demonstrate a spatial resolution...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aab8d2

    authors: Preissner M,Murrie RP,Pinar I,Werdiger F,Carnibella RP,Zosky GR,Fouras A,Dubsky S

    更新日期:2018-04-20 00:00:00

  • Development and evaluation of a deep learning based artificial intelligence for automatic identification of gold fiducial markers in an MRI-only prostate radiotherapy workflow.

    abstract::Identification of prostate gold fiducial markers in magnetic resonance imaging (MRI) images is challenging when CT images are not available, due to misclassifications from intra-prostatic calcifications. It is also a time consuming task and automated identification methods have been suggested as an improvement for bot...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abb0f9

    authors: Gustafsson CJ,Swärd J,Adalbjörnsson SI,Jakobsson A,Olsson LE

    更新日期:2020-11-12 00:00:00

  • The impact of tracking system properties on the most likely path estimation in proton CT.

    abstract::Proton CT nowadays aims at improving hadron therapy treatment planning by mapping the stopping power of materials. In order to optimize a spatial resolution of the reconstructed images, the most likely path (MLP) of each proton can be computed. We investigated the errors in the computation of this path due to the conf...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/23/N197

    authors: Bopp C,Rescigno R,Rousseau M,Brasse D

    更新日期:2014-12-07 00:00:00

  • Direct aperture optimization for a variable aperture collimator for intensity-modulated radiation therapy.

    abstract::In this note a technique is described for direct aperture optimization of components deliverable by a variable aperture collimator (VAC) for intensity-modulated radiation therapy. The first key result found was that, provided a large number of VAC components were selected for optimization, the resulting fluence profil...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/5/n02

    authors: Webb S

    更新日期:2004-03-07 00:00:00

  • Sensitivity study of the microdosimetric kinetic model parameters for carbon ion radiotherapy.

    abstract::In carbon ion therapy treatment planning, the relative biological effectiveness (RBE) is accounted for by optimization of the RBE-weighted dose (biological dose). The RBE calculation methods currently applied clinically in carbon ion therapy are derived from the microdosimetric kinetic model (MKM) in Japan and the loc...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aae8b4

    authors: Dahle TJ,Magro G,Ytre-Hauge KS,Stokkevåg CH,Choi K,Mairani A

    更新日期:2018-11-12 00:00:00

  • The Monte Carlo calculation of integral radiation dose in xeromammography.

    abstract::A Monte Carlo computer program has been developed for the computation of integral radiation dose to the breast in xeromammography. The results are given in terms of the integral dose per unit area of the breast per unit incident exposure. The calculations have been made for monoenergetic incident photons and the resul...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/25/1/003

    authors: Dance DR

    更新日期:1980-01-01 00:00:00

  • Mucosal deformation from an impinging transonic gas jet and the ballistic impact of microparticles.

    abstract::By means of a transonic gas jet, gene guns ballistically deliver microparticle formulations of drugs and vaccines to the outer layers of the skin or mucosal tissue to induce unique physiological responses for the treatment of a range of conditions. Reported high-speed imaging experiments show that the mucosa deforms s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/19/010

    authors: Hardy MP,Kendall MA

    更新日期:2005-10-07 00:00:00

  • Symmetries of the 2D magnetic particle imaging system matrix.

    abstract::In magnetic particle imaging (MPI), the relation between the particle distribution and the measurement signal can be described by a linear system of equations. For 1D imaging, it can be shown that the system matrix can be expressed as a product of a convolution matrix and a Chebyshev transformation matrix. For multidi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/10/4033

    authors: Weber A,Knopp T

    更新日期:2015-05-21 00:00:00

  • Volumetric CT with sparse detector arrays (and application to Si-strip photon counters).

    abstract::Novel x-ray medical imaging sensors, such as photon counting detectors (PCDs) and large area CCD and CMOS cameras can involve irregular and/or sparse sampling of the detector plane. Application of such detectors to CT involves undersampling that is markedly different from the commonly considered case of sparse angular...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/1/90

    authors: Sisniega A,Zbijewski W,Stayman JW,Xu J,Taguchi K,Fredenberg E,Lundqvist M,Siewerdsen JH

    更新日期:2016-01-07 00:00:00

  • Monte Carlo study of x-ray detection configurations for benchtop x-ray fluorescence computed tomography of gold nanoparticle-loaded objects.

    abstract::Over the last decade, the performance of benchtop x-ray fluorescence computed tomography (XFCT) systems has been significantly enhanced through hardware and software optimizations. Recent studies have indicated the need of energy-resolving pixelated/array detectors in the x-ray detection component to further improve t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab9774

    authors: Moktan H,Ahmed MF,Jayarathna S,Deng L,Cho SH

    更新日期:2020-08-31 00:00:00

  • Wall effects in plane-parallel ionization chambers.

    abstract::All dosimetry protocols recommend the use of plane-parallel chambers for dose determination in electron beams with energies below 10-15 MeV. The protocols have assumed chamber perturbation effects to be negligible. The new AAPM Protocol (TG39) includes a cavity replacement factor prepl that differs from unity for some...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/4/003

    authors: Nilsson B,Montelius A,Andreo P

    更新日期:1996-04-01 00:00:00

  • Comparison of 3D-OP-OSEM and 3D-FBP reconstruction algorithms for High-Resolution Research Tomograph studies: effects of randoms estimation methods.

    abstract::The High-Resolution Research Tomograph (HRRT) is a dedicated human brain positron emission tomography (PET) scanner. Recently, a 3D filtered backprojection (3D-FBP) reconstruction method has been implemented to reduce bias in short duration frames, currently observed in 3D ordinary Poisson OSEM (3D-OP-OSEM) reconstruc...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/12/010

    authors: van Velden FH,Kloet RW,van Berckel BN,Wolfensberger SP,Lammertsma AA,Boellaard R

    更新日期:2008-06-21 00:00:00

  • Respiration gated radiotherapy treatment: a technical study.

    abstract::In order to optimize external-beam conformal radiotherapy, patient movement during treatment must be minimized. For treatment on the upper torso, the target organs are known to move substantially due to patient respiration. This paper deals with the technical aspects of gating the radiotherapy beam synchronously with ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/1/007

    authors: Kubo HD,Hill BC

    更新日期:1996-01-01 00:00:00

  • An alternative to gamma histograms for ROI-based quantitative dose comparisons.

    abstract::An alternative to gamma (gamma) histograms for ROI-based quantitative comparisons of dose distributions using the gamma concept is proposed. The method provides minimum values of dose difference and distance-to-agreement such that a pre-set fraction of the region of interest passes the gamma test. Compared to standard...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/12/N03

    authors: Dvorak P

    更新日期:2009-06-21 00:00:00

  • Optimization of image quality and dose for Varian aS500 electronic portal imaging devices (EPIDs).

    abstract::This study was carried out to investigate whether the electronic portal imaging (EPI) acquisition process could be optimized, and as a result tolerance and action levels be set for the PIPSPro QC-3V phantom image quality assessment. The aim of the optimization process was to reduce the dose delivered to the patient wh...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/23/006

    authors: McGarry CK,Grattan MW,Cosgrove VP

    更新日期:2007-12-07 00:00:00

  • Determination of elemental tissue composition following proton treatment using positron emission tomography.

    abstract::Positron emission tomography (PET) has been suggested as an imaging technique for in vivo proton dose and range verification after proton induced-tissue activation. During proton treatment, irradiated tissue is activated and decays while emitting positrons. In this paper, we assessed the feasibility of using PET imagi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/11/3815

    authors: Cho J,Ibbott G,Gillin M,Gonzalez-Lepera C,Min CH,Zhu X,El Fakhri G,Paganetti H,Mawlawi O

    更新日期:2013-06-07 00:00:00

  • Novel adaptive beam-dependent margins for additional OAR sparing.

    abstract::Margins are employed in radiotherapy treatment planning to mitigate the dosimetric effects of geometric uncertainties for the clinical target volume (CTV). Unfortunately, whilst the use of margins can increase the probability that sufficient dose is delivered to the CTV, it can also result in delivering high dose of r...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aae658

    authors: Tsang HS,Kamerling CP,Ziegenhein P,Nill S,Oelfke U

    更新日期:2018-10-29 00:00:00

  • Simulation of voltage-sensitive optical signals in three-dimensional slabs of cardiac tissue: application to transillumination and coaxial imaging methods.

    abstract::Voltage-sensitive dyes are an important tool in visualizing electrical activity in cardiac tissue. Until today, they have mainly been applied in cardiac electrophysiology to subsurface imaging. In the present study, we assess different imaging methods used in optical tomography with respect to their effectiveness in v...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/2/003

    authors: Bernus O,Wellner M,Mironov SF,Pertsov AM

    更新日期:2005-01-21 00:00:00

  • Meshless reconstruction technique for digital tomosynthesis.

    abstract::A novel meshless reconstruction algorithm for digital tomosynthesis (DT) is presented and assessed against experimental data. The algorithm does not require a three-dimensional grid or mesh allocation and performs a slice-by-slice reconstruction where each slice position can be chosen at runtime. The methodology is ba...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab7685

    authors: Soloviev VY,Renforth KL,Dirckx CJ,Wells SG

    更新日期:2020-04-20 00:00:00

  • Assessment of thermal effects in a model of the human head implanted with a wireless active microvalve for the treatment of glaucoma creating a filtering bleb.

    abstract::A 3D anatomical computational model is developed to assess thermal effects due to exposure to the electromagnetic field required to power a new investigational active implantable microvalve for the treatment of glaucoma. Such a device, located in the temporal superior eye quadrant, produces a filtering bleb, which is ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa5dae

    authors: Schaumburg F,Guarnieri FA

    更新日期:2017-05-07 00:00:00

  • Real-time prediction and gating of respiratory motion using an extended Kalman filter and Gaussian process regression.

    abstract::Motion-adaptive radiotherapy aims to deliver a conformal dose to the target tumour with minimal normal tissue exposure by compensating for tumour motion in real time. The prediction as well as the gating of respiratory motion have received much attention over the last two decades for reducing the targeting error of th...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/1/233

    authors: Bukhari W,Hong SM

    更新日期:2015-01-07 00:00:00

  • Estimation of the absorption coefficients of two-layered media by a simple method using spatially and time-resolved reflectances.

    abstract::Our newly developed method using spatially and time-resolved reflectances can easily estimate the absorption coefficients of each layer in a two-layered medium if the thickness of the upper layer and the reduced scattering coefficients of the two layers are known a priori. We experimentally validated this method using...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/16/014

    authors: Shimada M,Sato C,Hoshi Y,Yamada Y

    更新日期:2009-08-21 00:00:00

  • A point kernel algorithm for microbeam radiation therapy.

    abstract::Microbeam radiation therapy (MRT) is a treatment approach in radiation therapy where the treatment field is spatially fractionated into arrays of a few tens of micrometre wide planar beams of unusually high peak doses separated by low dose regions of several hundred micrometre width. In preclinical studies, this treat...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa8d63

    authors: Debus C,Oelfke U,Bartzsch S

    更新日期:2017-10-19 00:00:00

  • Temperature elevation in the eye of anatomically based human head models for plane-wave exposures.

    abstract::This study investigated the temperature elevation in the eye of anatomically based human head models for plane-wave exposures. The finite-difference time-domain method is used for analyzing electromagnetic absorption and temperature elevation. The eyes in the anatomic models have average dimensions and weight. Computa...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/21/003

    authors: Hirata A,Watanabe S,Fujiwara O,Kojima M,Sasaki K,Shiozawa T

    更新日期:2007-11-07 00:00:00

  • The calibration of CT Hounsfield units for radiotherapy treatment planning.

    abstract::Computer tomographic (CT) scans are used to correct for tissue inhomogeneities in radiotherapy treatment planning. In order to guarantee a precise treatment, it is important to obtain the relationship between CT Hounsfield units and electron densities (or proton stopping powers for proton radiotherapy), which is the b...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/1/009

    authors: Schneider U,Pedroni E,Lomax A

    更新日期:1996-01-01 00:00:00

  • A multi-scale framework with unsupervised joint training of convolutional neural networks for pulmonary deformable image registration.

    abstract::To achieve accurate and fast deformable image registration (DIR) for pulmonary CT, we proposed a Multi-scale DIR framework with unsupervised Joint training of Convolutional Neural Network (MJ-CNN). MJ-CNN contains three models at multi-scale levels for a coarse-to-fine DIR to avoid being trapped in a local minimum. It...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab5da0

    authors: Jiang Z,Yin FF,Ge Y,Ren L

    更新日期:2020-01-13 00:00:00