Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.

Abstract:

:In contrast to T cell receptors, signal transducing cell surface membrane molecules involved in the regulation of responses by cells of the innate immune system employ structures that are encoded in the genome rather than generated by somatic recombination and that recognize either classical MHC-I molecules or their structural relatives (such as MICA, RAE-1, or H-60). Considerable progress has recently been made in our understanding of molecular recognition by such molecules based on the determination of their three-dimensional structure, either in isolation or in complex with their MHC-I ligands. Those best studied are the receptors that are expressed on natural killer (NK) cells, but others are found on populations of T cells and other hematopoietic cells. These molecules fall into two major structural classes, those of the immunoglobulin superfamily (KIRs and LIRs) and of the C-type lectin-like family (Ly49, NKG2D, and CD94/NKG2). Here we summarize, in a functional context, the structures of the murine and human molecules that have recently been determined, with emphasis on how they bind different regions of their MHC-I ligands, and how this allows the discrimination of tumor or virus-infected cells from normal cells of the host.

journal_name

Annu Rev Immunol

authors

Natarajan K,Dimasi N,Wang J,Mariuzza RA,Margulies DH

doi

10.1146/annurev.immunol.20.100301.064812

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

853-85

eissn

0732-0582

issn

1545-3278

pii

100301.064812

journal_volume

20

pub_type

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