Abstract:
:The deleted-in-colorectal-cancer (DCC) gene, located on chromosome 18q 21.3, is considered to be a tumor suppressor gene related to cellular adhesion receptors. A loss of heterozygosity (LOH) on chromosome 18q is frequently observed in adenomatous polyposis coli, as well as in sporadic colon carcinoma and its liver metastatic loci. In this study, we investigated the expression of DCC mRNA in the resected specimens of 38 gastric cancers and 28 colorectal cancers by a reverse transcription-polymerase chain reaction method. In the gastric cancer patients, the mean expression level of DCC mRNA in the tumors was significantly lower than that in normal tissues (p = 0.009), but no difference was observed in the colorectal cancer patients. DCC mRNA expression was decreased in 15 gastric cancers (40%) and 10 colorectal cancers (36%), and there was a significant correlation between the decreased expression of DCC mRNA and nodal metastasis in colorectal cancer (chi 2 = 7.049, DF = 1, P = 0.0079). Two of four gastric cancer patients and none of seven colorectal cancer patients whose cancers were confined to the muscularis propria without metastasis showed decreased expression of DCC mRNA. These findings demonstrate that decreased expression of DCC mRNA may occur at an early stage in gastric cancer and at a late stage in colorectal cancer and that this decreased expression correlates with the potential to develop nodal metastasis.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Kataoka M,Okabayashi T,Orita Kdoi
10.1007/BF00311682subject
Has Abstractpub_date
1995-01-01 00:00:00pages
1001-7issue
12eissn
0941-1291issn
1436-2813journal_volume
25pub_type
杂志文章相关文献
SURGERY TODAY文献大全abstract::This study was conducted to examine the effects of peptidoleukotrienes on the ileal contractility disturbances induced by Serratia marcescens endotoxin in rats. Thirty-two male Wistar rats were divided into four groups (n = 8 each). The first group was given only an anesthetic agent (control group); the second group w...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s005950170108
更新日期:2001-01-01 00:00:00
abstract::In order to establish a therapeutic approach for primary breast cancer of medial and central origin, we reviewed 183 patients who had been treated by one of the following three modalities at the Second Department of Surgery, Osaka University Medical School between January, 1965 and December, 1980. Group A (n = 70): st...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00311336
更新日期:1992-01-01 00:00:00
abstract::The influence of warm ischemia on the metabolism of prostaglandins was investigated using a pig liver transplantation model employing the temporary portal arterialization technique. Eighteen pigs were divided into three groups according to warm ischemia time: 0 min (group I, n = 6), 30 min (group II, n = 6), and 60 mi...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF02484623
更新日期:1998-01-01 00:00:00
abstract::We report the case of a simultaneous occurrence of papillary intrafollicular and microcarcinomas with bilateral medullary microcarcinoma of the thyroid in a patient with multiple endocrine neoplasia type 2A. The concurrent presence of two thyroid carcinomas is rare. The simultaneous occurrence of two different tumors ...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s005950200112
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:Acute diffuse peritonitis (ADP) is an important surgical complication associated with high morbidity and mortality; however, the risk factors associated with a poor outcome have remained controversial. This study aimed in collecting integrated data using a web-based national database system to build a risk mode...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-014-1026-x
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:We evaluated the safety and efficacy of adult-to-adult right-lobe living donor liver transplantation (ARL-LDLT) in HBV-related benign liver disease recipients with high model for end-stage liver disease (MELD) scores. METHODS:The subjects of this study were 70 adult patients who underwent ARL-LDLT and 191 who ...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-013-0539-z
更新日期:2013-09-01 00:00:00
abstract::The influence of operative treatment and chemotherapy on the prognosis in 93 gastric cancer patients with liver metastasis was studied. Chemotherapy included the systemic administration of mitomycin C (MMC) (39 patients), an intra-hepatoarterial infusion of MMC (MMC IAC group) (19 patients) and an intra-hepatoarterial...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00308831
更新日期:1992-01-01 00:00:00
abstract::We report herein the case of 65-year-old man in whom a diagnosis of primary carcinoma of the cystic duct was made on the basis of Farrar's criteria. The patient was admitted with upper abdominal pain, and although there was no evidence of jaundice or a palpable mass, there was tenderness in his right upper quadrant. C...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00311692
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:Patients with Crohn's disease (CD) often need home parenteral nutrition for short bowel syndrome (SBS), as a result of frequent surgery and extended bowel resections. We conducted this study to evaluate the influence of the patient's condition on the occurrence of SBS in CD. METHODS:The subjects of this study ...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-011-0098-0
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:Tumors expressing high levels of CYP3A4 are likely to have a poor treatment response to docetaxel (DOC), which is metabolized by CYP3A4. Tissue samples of recurrent breast cancer are sometimes hard to obtain just before treatment because the tumor is often difficult to access. Using immunohistochemistry, we mea...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-009-4328-7
更新日期:2011-05-01 00:00:00
abstract::Papillary fibroelastoma is a rare, benign cardiac tumor that can cause multiple emboli. We report herein a case of papillary fibroelastoma developing from the chordae of the tricuspid valve which was detected by echocardiography and confirmed by surgical resection. To our knowledge, this is only the fifth documented c...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s005950050154
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:Functional outcomes were prospectively compared between two types of reconstruction [double tract (L-DT; n = 15) and jejunal interposition (L-JIP; n = 15)] following laparoscopic half-proximal gastrectomy (LPG), including laparoscopic total gastrectomy (L-TG; n = 30) as a control group, at 1 year after surgery....
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-018-1699-7
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to clarify the usefulness of staging laparoscopy for planning the treatment strategy in patients with advanced gastric cancer. METHODS:This was a retrospective study of patients with gastric cancer who underwent staging laparoscopy. The patients were divided into three groups accordin...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-009-4017-6
更新日期:2010-01-01 00:00:00
abstract::Patients who have undergone major surgery such as esophagectomy may develop peripheral edema in the immediate postoperative period, the cause of which is not fully understood. The purpose of this study was therefore to determine the mechanism of this phenomenon. Finger edema was measured as a marker for peripheral ede...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF02483601
更新日期:1998-01-01 00:00:00
abstract::The expression of alpha2beta1 and alpha3beta1 integrins was studied immunohistochemically in 110 resected human gastric carcinomas. Formalin-fixed and paraffin-embedded samples were serially sectioned and stained with monoclonal antibodies specifically against the alpha2 and alpha3 subunits of beta1 integrins. Approxi...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF02483952
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:The scheduled administration of intravenous acetaminophen (scheduled-IV-AcA) is one of the more effective multimodal analgesic approaches for postoperative pain in abdominal/orthopedic surgeries. However, there is little evidence concerning scheduled-IV-AcA after general thoracic surgery, especially when limite...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-020-02127-y
更新日期:2020-09-02 00:00:00
abstract::In a previous study, we used a murine monoclonal antibody, A7, against human colon carcinoma as a drug-carrier to treat colorectal cancer. In the present study, we found that MAb A7 also reacted immunohistochemically with 73% of human pancreatic carcinoma cell lines, with the A7 antigen mainly being detected on the ce...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00308745
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:To investigate the effects of antibiotics and the probiotic, Saccharomyces boulardii, on indigenous microflora and bacterial translocation (BT) in burned rats. METHODS:Twenty-three male albino rats were divided into a sham burn group (group 1, n = 7) exposed to 21 degrees C water, a burn + antibiotic group (gr...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-003-2677-1
更新日期:2004-01-01 00:00:00
abstract::Because of the low incidence rate of combined hepatocellular-cholangiocarcinoma (combined HCC-CC), the clinicopathological features of a recurrent tumor of this disease remain to be elucidated. We describe a 47-year-old Japanese woman with a 5-cm diameter mass lesion in the liver. A hepatectomy and dissection of the l...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s005950200140
更新日期:2002-01-01 00:00:00
abstract::While pulmonary tuberculosis is a very frequent infection, chylothorax is an unusual manifestation of tuberculous disease. A 71-year-old woman with chylothorax is herein presented. The ductus thoracicus was ligated and lymphadenomegaly, which was adjacent to diaphragm, was resected. Based on the findings of various te...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-007-3739-6
更新日期:2008-01-01 00:00:00
abstract::For the purpose of predicting postoperative local recurrence and/or distant metastasis in differentiated thyroid cancer, a discriminant analysis was done. To assess the reliability of this method and the induced function, simulation was done by using random samples under various conditions. Simulation revealed that th...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00311619
更新日期:1993-01-01 00:00:00
abstract::Portal annular pancreas (PAP) is a rare anatomical anomaly in which the pancreatic parenchyma surrounds the superior mesenteric vein and portal vein (PV) annularly. This anomaly requires careful consideration in pancreatic resection. A case is presented and the technical issues are discussed. A 61-year-old female was ...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-012-0280-z
更新日期:2013-08-01 00:00:00
abstract::We describe how we developed a new method of tying an intracorporeal suture of monofilament material using a bowline knot, which eliminates the troublesome C-loop formation for winding the thread on the rod. The winding-forceps point to the site of suturing, and the needle end of the thread is placed under the rod of ...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-013-0596-3
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:We evaluated the technical and oncological safety of laparoscopic multivisceral resection (MVR) in selected patients with locally advanced colon cancer (LACC). METHODS:We compared the clinical backgrounds, and short- and long-term outcomes of patients who underwent laparoscopic vs. those who underwent open MVR...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-020-01986-9
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To investigate the safety and efficacy of fondaparinux (FPX) for venous thromboembolism (VTE) prophylaxis in Japanese patients undergoing colorectal cancer surgery. METHODS:The subjects of this multicenter, open-label, prospective observational study were patients undergoing resection of the colon/rectum for c...
journal_title:Surgery today
pub_type: 杂志文章,多中心研究
doi:10.1007/s00595-014-0911-7
更新日期:2014-11-01 00:00:00
abstract::A 53-year-old man who had the habit of consuming fish bones was referred to our clinic because of a suspected malignant abdominal wall tumor. Computed tomography (CT) showed a mass (10 x 5 cm) in continuity with the transverse abdominal muscle, containing a small calcification. A laparotomy was performed with a preope...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-005-3110-8
更新日期:2006-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide, yet there are still no satisfactory protocols available for treating this disease, emphasizing the urgency for more effective therapies. Recent clinical trials have provided encouraging evidence of the benefits of certain forms of immunotherapy. Here, we summ...
journal_title:Surgery today
pub_type: 杂志文章,评审
doi:10.1007/s00595-010-4478-7
更新日期:2011-05-01 00:00:00
abstract::Although over 3000 da Vinci Surgical System (DVSS) devices have been installed worldwide, robotic surgery for gastric cancer has not yet become widely spread and is only available in several advanced institutions. This is because, at least in part, the advantages of robotic surgery for gastric cancer remain unclear. T...
journal_title:Surgery today
pub_type: 杂志文章,评审
doi:10.1007/s00595-015-1190-7
更新日期:2016-05-01 00:00:00
abstract::This report presents the case of a common hepatic artery (CHA) pseudoaneurysm secondary to postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD), which was successfully treated using a coronary covered stent. A 70-year-old female underwent subtotal stomach-preserving PD for middle cholangiocarcinoma...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-012-0314-6
更新日期:2014-01-01 00:00:00
abstract::A 2-year-old female was hospitalized because of generalized peritonitis with pneumoperitoneum. A laparotomy disclosed a perforated ulcer of the cecum. A resection of the perforated portion of the cecum was then performed. Histopathologic examinations confirmed that the ulcer was non-specific in nature. No recurrence w...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00308750
更新日期:1992-01-01 00:00:00