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Myocardial creatine kinase expression after left ventricular assist device support.

Abstract：

OBJECTIVES:We examined whether unloading of the left ventricle with a ventricular assist device (LVAD) can result in normalization of the creatine kinase (CK) abnormalities in the failing human heart. BACKGROUND:Left ventricular failure is associated with a decrease of myocardial total CK activity and a fetal shift in CK isoform expression that results in an increase in the cytosolic brain type homodimeric-creatine kinase (CK-B) subunit and decreases of the cytosolic muscle-creatine kinase (CK-M) and CK-mitochondrial (CK-Mt) isoforms. The mechanisms of this abnormality are not known. METHODS:Total CK activity and CK protein isoform expression (Western blotting) were examined in 11 patients with end-stage cardiomyopathy. In 7 patients, myocardial tissue was also obtained after 4.1 +/- 1.1 months of left ventricular assist device (LVAD) support. RESULTS:Left ventricular unloading produced by LVAD implantation resulted in a 270% +/- 114% increase in total CK activity (p < 0.01) that was associated with a 69% +/- 18% increase in CK-M protein expression (p < 0.01) and a 121% +/- 69% increase in CK-Mt protein expression (p < 0.01), but no significant change in CK-B expression. CONCLUSIONS:Systolic and diastolic unloading provided by the LVAD resulted in increases of total CK activity as well as CK-Mt and CK-M protein expression. The failure of CK-B expression to decrease suggests that abnormalities other than increased loading are responsible for the increase in CK-B expression in the failing heart.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Park SJ,Zhang J,Ye Y,Ormaza S,Liang P,Bank AJ,Miller LW,Bache RJ

doi

10.1016/s0735-1097(02)01860-0

subject

Has Abstract

pub_date

2002-06-05 00:00:00

pages

1773-9

issue

11

eissn

0735-1097

issn

1558-3597

pii

S0735109702018600

journal_volume

39

pub_type

杂志文章

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