Abstract：
:The short-term (7 days) effect of tamoxifen on apoptosis and mitosis index, p53, Bcl2 and Her-2/neu/c-erb2 expression in invasive ductal mammary carcinoma was studied histologically in the diagnostic biopsy and surgically removed tumor tissue of 10 patients. Following tamoxifen treatment expression of HER-2 and p53 decreased but Bcl2 remained unchanged. Mitotic activity decreased slightly, but not significantly. Apoptotic activity increased in six cases in the second sample compared to the values measured of the first biopsy. These changes may be attributed to the effect of antiestrogen therapy.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Farczádi E,Kaszás I,Baki M,Szende Bsubject
Has Abstractpub_date
2002-01-01 00:00:00pages
101-3issue
2eissn
0028-2685issn
1338-4317journal_volume
49pub_type
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