Abstract：
:In vitro NWSM has been shown to be a B cell mitogen and a polyclonal activator. Although NWSM has been also shown to be adjuvant active in vivo, motogenicity and polyclonal activation are not observed when this fraction has been administered to mice. In contrast, the experiments reported here demonstrate that after in vivo administration several effects of NWSM on mouse peritoneal macrophages can be observed: NWSM was able to induce an important increase in the ability of peritoneal macrophages to inhibit in vitro growth of tumor cells, to increase their phagocytic activity and to enhance their ability to induce an immune response, following the incubation with an antigen NWSM was able to stimulate phagocytic activity of macrophages of C3H/He Orl. mice (LPS-resistant strain). Those findings suggest that the adjuvant activity of NWSM in vivo can be related to its capacity to activate macrophages.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Löwy I,Juy D,Bono C,Chedid Ldoi
10.1007/978-1-4684-3593-1_31subject
Has Abstractpub_date
1979-01-01 00:00:00pages
351-60issue
Aeissn
0065-2598issn
2214-8019journal_volume
121pub_type
杂志文章abstract：:Advances in the design of cochlear implants (CIs), as well as improved CI surgical techniques, have led to an increase in the number of patients who retain some residual low-frequency acoustic hearing in the implanted ear. Many of these patients also possess some hearing in the unimplanted ear. Although their low-freq...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4614-1590-9_28
更新日期：2013-01-01 00:00:00
abstract：:4-1BB (CD137) is being thought of as an attractive target for immunotherapy of many human immune diseases based on encouraging results with 4-1BB agonistic antibody treatment in mouse models of cancer, autoimmune disease, asthma and additionally as a means to improve vaccination. In this review, we will summarize the ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-0-387-89520-8_8
更新日期：2009-01-01 00:00:00
abstract：:Signal interneurones have a crucial part to play in the control of motoneurones. Newer methods are being added to the ways in which they can be studied, both in animal and human experiments. This chapter provides some background to a re-evaluation of the role of interneurones in motor control. ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Better understanding of central nervous system (CNS) molecules can include the identification of new molecules and their receptor systems. Discovery of novel proteins and elucidation of receptor targets can be accomplished using mass spectrometry (MS). We describe a case study of such a molecule, which our lab has stu...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-06068-2_25
更新日期：2014-01-01 00:00:00
abstract：:Dopamine (DA) and noradrenaline (NA) were measured in the rabbit carotid body (CB) in vitro bv HPLC-ED under the following experimental conditions: 1h superfusion in normoxic, hypoxic (10% O2 in N2) or hypercapnic (8% CO2, 20% O2, 72% N2) medium, 5h superfusion in normoxia or hypoxia. The contents of DA and NA were de...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-2966-8_26
更新日期：1993-01-01 00:00:00
abstract：:MerTK is required for photoreceptor outer segment (POS) phagocytosis by retinal pigment epithelial (RPE) cells, a diurnal function essential for vision maintenance. In vivo, MerTK is stimulated at the time of the phagocytic peak through an intracellular signaling pathway. However, MerTK ligands Gas6 and Protein S are ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-319-75402-4_70
更新日期：2018-01-01 00:00:00
abstract：:The rates of ethanol oxidation in various species are linked to the rates of general metabolism, and more specifically that of O2 utilization by the liver. After chronic ethanol administration, increased oxidation of ethanol is accompanied by increased total hepatic O2 utilization, as studied in the whole animal, the ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4899-5181-6_22
更新日期：1977-01-01 00:00:00
abstract：:Identification of thyroid stem cells in the past few years has made important contributions to our understanding of the cellular and molecular mechanisms that induce tissue regeneration and repair. Embryonic stem (ES) cells and induced-pluripotent stem cells have been used to establish reliable protocols to obtain mat...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-030-24108-7_5
更新日期：2019-01-01 00:00:00
abstract：:The Notch pathway is crucial in the regulation of stem cells biology. Notch-mediated signalling controls several aspects of tissue homeostasis in both embryonic and adult tissues, balancing stem cells maintenance and differentiation. Although the major elements of the pathway are well conserved throughout evolution, i...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-89512-3_12
更新日期：2018-01-01 00:00:00
abstract：:The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis. This protein and the other two members of this small gene family, Gadd45b and Gadd45g, have been implicated in a variety of the r...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-8289-5_1
更新日期：2013-01-01 00:00:00
abstract：:The perception of the timing of milk arrival has been identified as an important predictor of breast-feeding success. Because this indicator has the potential to be used as a proxy for the onset of lactogenesis stage II and is relatively simple to measure, it is possible to include it as part of large-scale surveys. I...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:CD133 antigen (prominin-1) is a useful cell surface marker of very small embryonic-like stem cells (VSELs). Antibodies against it, conjugated to paramagnetic beads or fluorochromes, are thus powerful biological tools for their isolation from human umbilical cord blood, mobilized peripheral blood, and bone marrow. VSEL...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4614-5894-4_9
更新日期：2013-01-01 00:00:00
abstract：:This chapter gives an overview of present knowledge and clinical aspects of antidiabetic drugs according to the recently available research evidence and clinical expertise.Many agents are acting on eight groups of pathophysiological mechanisms, which is commonly called as "Ominous Octet" by DeFronzo. The muscle, liver...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/5584_2020_516
更新日期：2021-01-01 00:00:00
abstract：:The interaction between two neuropeptides, VIP and TRH, was studied. The TRH receptor binding ability was examined using intact GH3 cells and its membrane fraction. The TRH binding ability decreased when intact cells were preincubated with VIP, forskolin or db-cAMP, but not when the membrane fraction was treated with ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4757-5971-6_10
更新日期：1988-01-01 00:00:00
abstract：:Phenobarbital, when administered prenatally in a small dose to animals, produced profound, and permanent effects on reproductive function in the offspring. Preliminary analysis of a unique cohort of adolescents who were exposed to phenobarbital in utero, suggests that long-term effects are also evident in the human. T...
journal_title：Advances in experimental medicine and biology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/978-1-4684-8047-4_9
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVES:The urinary bladder wall can be separated into two major compartments: the urothelium (mucosa) and the detrusor smooth muscle. Specific dysfunctions of both layers have been linked to ischemia, which may induce significant cellular and subcellular membrane damage via the activation of selective calcium depen...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-4737-2_20
更新日期：1999-01-01 00:00:00
abstract：:Anthropogenically generated underwater noise in the marine environment is ubiquitous, comprising both intense impulse and continuous noise. The installation of offshore wind farms across the North Sea has triggered a range of ecological questions regarding the impact of anthropogenically produced underwater noise on m...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4939-2981-8_23
更新日期：2016-01-01 00:00:00
abstract：:Alkaline treatment of proteins leads to chemical changes which alter the proteins' digestibility. Severely alkali-treated casein (0.2N NaOH, 80 degrees C, 1 hour) in the diet reduces food intake and growth of young but not of adult Sprague Dawley rats. Gastrointestinal transit time is not reduced significantly in eith...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4757-0022-0_30
更新日期：1986-01-01 00:00:00
abstract：:In a mouse model of acute light-induced retinal degeneration, positive correlations between the levels of DHA, the levels of n3 PUFA lipid peroxidation, and the vulnerability to photooxidative stress were observed. On the other hand, higher sensitivity of the electroretinogram a-wave response, a measure of the amplifi...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4419-1399-9_65
更新日期：2010-01-01 00:00:00
abstract：:Epigenetic mechanisms, which include DNA methylation, histone modification, and microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA sequence. Disruption of gene expression patterns which are governed by epigenetics can result in autoimmune diseases, cancers, and various other maladies. M...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-15-3449-2_1
更新日期：2020-01-01 00:00:00
abstract：:The de novo generation of hematopoietic stem and progenitor cells (HSPC) occurs solely during embryogenesis from a population of epithelial cells called hemogenic endothelium (HE). During midgestation HE cells in multiple intra- and extraembryonic vascular beds leave the vessel wall as they transition into HSPCs in a ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-10-3233-2_4
更新日期：2017-01-01 00:00:00
abstract：:Properly performed, biomarker discovery can lead to effective candidates that can ultimately serve as predictors of disease, medical condition, define therapeutic parameters, and many other applications in medicine. Preferably, biomarkers comprise a panel of indicators, e.g. proteins and/or peptides that can be predic...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-41448-5_21
更新日期：2016-01-01 00:00:00
abstract：:In summary, the studies reviewed here have indicated which neural functions might be directly influenced by the nucleus basalis. Basalis neurons do not appear to be directly involved in trial-specific memory because, in memory tasks, they have non-differential responses that do not correspond to the information being ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4757-0145-6_12
更新日期：1991-01-01 00:00:00
abstract：:Olive oil is a key ingredient in the Mediterranean diet and offers many health benefits. However, many factors affect the quality and quantity of olive oil such as olive tree diseases and olive-related pests. Unfortunately, the procedure of identifying pests or the outbreak of a disease is time-consuming, and it depen...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-32622-7_22
更新日期：2020-01-01 00:00:00
abstract：:Maturation of the fetal lung is a complex process involving interactions between intrinsic biologic development of several cell types and hormonal triggering of biochemical and functional alterations. Catecholamines, corticosteroids, thyroid hormones and perhaps prolactin, all influence the transition from non-functio...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:Economic and social burden of cardiovascular diseases remains enormous and even still rising. There is not enough mass evidence in scientific journals that could describe the course of the process of neoangiogenesis in relatively "healthy" heart after regular endurance exercise. Even though, in this review, we are sho...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-10-4307-9_7
更新日期：2017-01-01 00:00:00
abstract：:The effects of high hydrostatic pressure (HHP) on gel strength, microbial numbers, proteolytic activity, color and pH of Pacific whiting surimi gels were investigated. Strong gels without the use of protease inhibitors were formed with HHP treatments from 1-4 kBars. Gel strength was not affected by holding time. Total...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4899-1925-0_6
更新日期：1998-01-01 00:00:00
abstract：:Susceptibility to type 1 diabetes (T1D) is determined by interactions of multiple genes with environmental triggers. Thus far, more than 50 T1D susceptibility regions have been suggested from genetic studies by employing either genome-wide or candidate gene approaches. Because the lack of a linear correlation between ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-50044-7_18
更新日期：2017-01-01 00:00:00
abstract：:Plasticity in the nervous system, whether for establishing connections and networks during development, repairing networks after injury, or modifying connections based on experience, relies primarily on highly coordinated patterns of neural activity. Rhythmic, synchronized bursting of neuronal ensembles is a fundament...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-94-017-8914-1_8
更新日期：2014-01-01 00:00:00
abstract：:We demonstrated that ischemic strokes exhibit an increase of deoxyhemoglobin during activation. We evaluated the effect of revascu-larization on the abnormal evoked cerebral blood oxygenation (CBO) re-sponses in these patients, employing near-infrared spectroscopy (NIRS). We selected five patients who exhibited an inc...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4419-1241-1_76
更新日期：2010-01-01 00:00:00
