Proton nuclear magnetic resonance studies of the complexation of zinc(II) with glycyl-L-histidylglycine.

Abstract:

:The complexation of Zn(II) with glycyl-L-histidylglycine and its deuterated derivatives, glycyl-d2-L-histidylglycine and glycyl-L-histidylglycine-d2, was studied by proton nuclear magnetic resonance spectroscopy over the pD range, from 3.4 to 11.0, at 25 degrees C. Addition of Zn(II) to the peptide made the resonances of both imidazole C2-H and C4-H and both methylene-protons of glycyl residues at the amino-terminal and carboxylate end split to three lines in the pD range above 7.0. From the behavior of the C2-H and C4-H chemical shifts, formation of at least two species, in which the imidazole and amino nitrogens coordinated to the metal ion forming a chelate ring, was suggested. Those two species, the ratio of which varied depending on the total concentrations of complexes, seemed to be interconvertible; one referred to as B is a monomer and the other, referred to as C, may be a dimeric or polymeric complex.

authors

Ueda J,Hanaki A,Yoshida N,Nakajima T

doi

10.1248/cpb.43.2042

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

2042-7

issue

12

eissn

0009-2363

issn

1347-5223

journal_volume

43

pub_type

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