Cytolethal distending toxin of Actinobacillus actinomycetemcomitans. Occurrence and association with periodontal disease.

Abstract:

:The cytolethal distending toxin (Cdt) of Actinobacillus actinomycetemcomitans, a periodontal pathogen, is a newly described cytotoxin with immunosuppressive properties, capable of causing cell cycle arrest of lymphocytes. The objectives of this study were to investigate the occurrence of A. actinomycetemcomitans with the cdt genotype in the subgingival plaque of periodontitis patients and to determine the association of this bacterial genotype with periodontal disease. A total of 146 subgingival plaque samples from periodontitis patients were assayed by the PCR method using oligonucleotide primers targeting the cdt operon of A. actinomycetemcomitans. Primers targeting the leukotoxin gene A (ltxA) of A. actinomycetemcomitans was used to determine the occurrence of the bacteria in the plaque samples at baseline. At baseline, A. actinomycetemcomitans was detected in 106 out of 146 (73%) diseased sites studied. Among the 106 diseased sites found to harbor A. actinomycetemcomitans, 13 sites were positive for the bacteria with the cdt genotype (12%). Out of the 13 positive sites, 10 sites were obtained from patients diagnosed with aggressive periodontitis (77%). Thus, A. actinomycetemcomitans with the cdt genetic subtype has low occurrence in the subgingival plaque of periodontitis patients. However, a strong association was observed between the presence of the bacteria and aggressive forms of periodontitis. Thus, the cytotoxic and immunosuppressive properties of A. actinomycetemcomitans Cdt may function to cripple the host immunity and contribute to the pathogenesis of aggressive periodontitis.

journal_name

J Periodontal Res

authors

Tan KS,Song KP,Ong G

doi

10.1034/j.1600-0765.2002.01618.x

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

268-72

issue

4

eissn

0022-3484

issn

1600-0765

journal_volume

37

pub_type

杂志文章
  • Activation of cannabinoid receptor CB2 regulates osteogenic and osteoclastogenic gene expression in human periodontal ligament cells.

    abstract:BACKGROUND AND OBJECTIVE:Cannabinoid receptor CB2, expressed in osteoblasts and osteoclasts, plays a crucial role in the regulation of bone metabolism. Since periodontal ligament (PDL) cells can differentiate into osteoblasts, this study was undertaken to investigate CB2 expression and the effect of CB2 activation on o...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2009.01265.x

    authors: Qian H,Zhao Y,Peng Y,Han C,Li S,Huo N,Ding Y,Duan Y,Xiong L,Sang H

    更新日期:2010-08-01 00:00:00

  • Evaluation of apoptosis and hypoxia-related factors in gingival tissues of smoker and non-smoker periodontitis patients.

    abstract:OBJECTIVE:Smoking causes pathological changes in all tissues, including gingiva and alveolar bone. The aim of present study was to evaluate apoptotic tissue alterations and tissue destruction in smoker and non-smoker periodontitis patients and healthy individuals. METHODS:Gingival biopsy samples from 15 systemically a...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/jre.12723

    authors: Karatas O,Balci Yuce H,Tulu F,Taskan MM,Gevrek F,Toker H

    更新日期:2020-06-01 00:00:00

  • Experimental periodontitis induced by Porphyromonas gingivalis does not alter the onset or severity of diabetes in mice.

    abstract:BACKGROUND AND OBJECTIVE:Diabetes mellitus is believed to increase the risk and severity of periodontitis. However, less evidence is available on the converse effects of periodontitis on diabetes. The objective of the study was to investigate to what degree experimental periodontitis induced by Porphyromonas gingivalis...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/jre.12041

    authors: Li H,Yang H,Ding Y,Aprecio R,Zhang W,Wang Q,Li Y

    更新日期:2013-10-01 00:00:00

  • Expression of transforming growth factor-beta receptors types II and III within various cells in the rat periodontium.

    abstract::This study reports the immunohistochemical localization of TGF-beta receptor type II (T beta R-II) and type III (T beta R-III) in cells of the forming periodontal ligament (PDL) in rat first molar roots. Mandibular periodontium was obtained from 3, 6 and 12-wk-old rats. This represented tissue from the initial, pre-ma...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.1999.tb02230.x

    authors: Gao J,Symons AL,Bartold PM

    更新日期:1999-02-01 00:00:00

  • Effects of intermittent treatment with parathyroid hormone (PTH) on osteoblastic differentiation and mineralization of mouse induced pluripotent stem cells in a 3D culture model.

    abstract:BACKGROUND/OBJECTIVES:PTH plays an important role in bone remodeling, and different actions have been reported depending on its administration method. iPSCs are promising as a cell source for regeneration of periodontal tissue due to their ability of proliferation and pluripotency. However, the effects of PTH on iPSCs ...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/jre.12762

    authors: Sato M,Aoki H,Nakamura T,Onodera S,Yamaguchi A,Saito A,Azuma T

    更新日期:2020-10-01 00:00:00

  • Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats.

    abstract:BACKGROUND AND OBJECTIVE:Cyclosporine A treatment is important in the therapy of a number of medical conditions; however, alveolar bone loss is an important negative side-effect of this drug. As such, we evaluated whether concomitant administration of simvastatin would minimize cyclosporine A-associated alveolar bone l...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2008.01143.x

    authors: Nassar PO,Nassar CA,Guimarães MR,Aquino SG,Andia DC,Muscara MN,Spolidorio DM,Rossa C Jr,Spolidorio LC

    更新日期:2009-08-01 00:00:00

  • Inhibitory effect of enamel matrix derivative on osteoblastic differentiation of rat calvaria cells in culture.

    abstract:BACKGROUND AND OBJECTIVE:The effect of enamel matrix derivative (EMD) on bone differentiation remains unclear. Transforming growth factor beta1 (TGF-beta1) is reported to be contained in EMD. The aim of this study was to clarify the effect of EMD on osteoblastic cell differentiation and the possible role of TGF-beta1. ...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2007.01010.x

    authors: Hama H,Azuma H,Seto H,Kido J,Nagata T

    更新日期:2008-04-01 00:00:00

  • Merkel-like cells in Malassez epithelium in the periodontal ligament of cats: an immunohistochemical, confocal-laser scanning and immuno electron-microscopic investigation.

    abstract::The cellular heterogeneity of Malassez epithelium (ME) residing in the periodontal ligament has recently been reported, and the presence and coexistence of the neuropeptides calcitonin gene-related peptide (CGRP), substance P (SP) and vasoactive intestinal peptide (VIP) in single cells in ME has been shown (1). Howeve...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1034/j.1600-0765.2002.01374.x

    authors: Tadokoro O,Maeda T,Heyeraas KJ,Vandevska-Radunovic V,Kozawa Y,Hals Kvinnsland I

    更新日期:2002-12-01 00:00:00

  • Periodontal therapy decreases serum levels of adipocyte fatty acid-binding protein in systemically healthy subjects: a pilot clinical trial.

    abstract:BACKGROUND AND OBJECTIVE:Adipocyte fatty acid-binding protein (A-FABP) is expressed in adipocytes, macrophages and microvascular endothelial cells, and it plays a central role in inflammation, atherosclerosis and metabolic responses. This pilot study investigated the effect of nonsurgical periodontal therapy on the ser...

    journal_title:Journal of periodontal research

    pub_type: 临床试验,杂志文章

    doi:10.1111/jre.12009

    authors: Li X,Tse HF,Yiu KH,Zhang C,Jin LJ

    更新日期:2013-06-01 00:00:00

  • Five parameters of gingival crevicular fluid from eight surfaces in periodontal health and disease.

    abstract::Volume and amounts of myeloperoxidase (MPO), lactoferrin (LF), aryl sulfatase (AS) and lactate dehydrogenase (LDH) were measured in gingival crevicular fluid (GCF) collected from the mesial and distal proximal surfaces of the premolars and first and second molars of 3 subject groups. Group assignment was based on subj...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.1992.tb01819.x

    authors: Smith QT,Au GS,Freese PL,Osborn JB,Stoltenberg JL

    更新日期:1992-09-01 00:00:00

  • Reactions of periodontal ligament epithelial cell clusters and OX6-immunopositive cells to experimental tooth movement and periodontitis.

    abstract:BACKGROUND AND OBJECTIVE:The aim of this study was to investigate reactions of periodontal ligament epithelial cell clusters and major histocompatibility complex class II (OX6)-immunopositive cells to simultaneously induced tooth movement and periodontitis employing Waldo's method. MATERIAL AND METHODS:Elastic gums we...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2011.01376.x

    authors: Tadokoro O,Kawahara I,Vandevska-Radunovic V

    更新日期:2011-10-01 00:00:00

  • Retrospectively analysed tooth loss in periodontally compromised patients: Long-term results 10 years after active periodontal therapy-Patient-related outcomes.

    abstract:BACKGROUND AND OBJECTIVE:Long-term tooth retention is the ultimate goal of periodontal therapy. Aim of this study was to evaluate tooth loss (TL) during 10 years of supportive periodontal therapy (SPT) in periodontal compromised patients and to identify factors influencing TL on patient level. MATERIAL AND METHODS:Pat...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/jre.12786

    authors: Petsos H,Schacher B,Ramich T,Nickles K,Dannewitz B,Arendt S,Seidel K,Eickholz P

    更新日期:2020-12-01 00:00:00

  • Effects of cytomegalovirus infection on the mRNA expression of collagens and matrix metalloproteinases in gingival fibroblasts.

    abstract:BACKGROUND AND OBJECTIVE:The purpose of this in vitro investigation was to study the effects of human cytomegalovirus infection on the mRNA expression for collagens I and III and for matrix metalloproteinases 1 and 2 in gingival fibroblasts. MATERIAL AND METHODS:Gingival fibroblasts were experimentally infected with t...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2007.01053.x

    authors: Botero JE,Contreras A,Parra B

    更新日期:2008-12-01 00:00:00

  • Anti-inflammatory properties of enamel matrix derivative in human blood.

    abstract:BACKGROUND AND OBJECTIVE:Enamel matrix derivative (EMD), extracted from porcine tooth buds, has been shown to promote periodontal healing in patients with severe periodontitis. This involves modulation of the inflammatory response followed by the onset of periodontal regeneration. Based on these observations, we examin...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2005.00863.x

    authors: Myhre AE,Lyngstadaas SP,Dahle MK,Stuestøl JF,Foster SJ,Thiemermann C,Lilleaasen P,Wang JE,Aasen AO

    更新日期:2006-06-01 00:00:00

  • Antibiotic administration alleviates the aggravating effect of orthodontic force on ligature-induced experimental periodontitis bone loss in mice.

    abstract:BACKGROUND AND OBJECTIVES:It is recognized that orthodontic force (OF) has an aggravating effect on the progression of destructive periodontitis if periodontitis have not been well controlled. However, the underlying mechanism is not completely clear. This study was to investigate the effect of antibiotic administratio...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/jre.12439

    authors: Shi J,Liu Z,Kawai T,Zhou Y,Han X

    更新日期:2017-08-01 00:00:00

  • Clinical, microbiological and immunological profile of healthy, gingivitis and putative active periodontal subjects.

    abstract::Thirteen periodontally healthy subjects were monitored clinically for 6-12 months. Clinical measurements at 6-weekly intervals included duplicate PD measurements, presence of plaque, redness, and bleeding on probing. Baseline measurements consisted of 2 visits 1 wk apart. Microbial samples were taken from 11 of the su...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.1996.tb00484.x

    authors: Tanner A,Kent R,Maiden MF,Taubman MA

    更新日期:1996-04-01 00:00:00

  • Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population.

    abstract:BACKGROUND AND OBJECTIVE:It has been suggested that aggressive periodontitis has a genetic basis. Monocyte chemoattractant protein 1 (MCP-1) plays a critical role in the recruitment of monocytes and the development of periodontitis. The -2518MCP-1(A/G) polymorphism has been implicated as a risk or susceptibility factor...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2011.01426.x

    authors: Zhu XL,Meng HX,Zhang L,Xu L,Chen ZB,Shi D,Feng XH,Zhang X

    更新日期:2012-06-01 00:00:00

  • Salivary infectious agents and periodontal disease status.

    abstract:BACKGROUND AND OBJECTIVES:The potential of salivary microorganisms to diagnose periodontal disease and to guide periodontal treatment is a research topic of current interest. This study aimed to determine whether the salivary counts of periodontopathic microbes correlated with the periodontal pocket counts of the same ...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2010.01335.x

    authors: Saygun I,Nizam N,Keskiner I,Bal V,Kubar A,Açıkel C,Serdar M,Slots J

    更新日期:2011-04-01 00:00:00

  • Role of the junctional epithelium in periodontal innate defense and homeostasis.

    abstract:BACKGROUND AND OBJECTIVE:  The junctional epithelium provides the front-line defense against periodontal bacterial infection. The migration of neutrophils into the junctional epithelium might represent a protective reaction against bacterial infections. However, neutrophils penetrate into the junctional epithelium even...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2012.01490.x

    authors: Tsukamoto Y,Usui M,Yamamoto G,Takagi Y,Tachikawa T,Yamamoto M,Nakamura M

    更新日期:2012-12-01 00:00:00

  • Quantifying oral inflammatory load: oral neutrophil counts in periodontal health and disease.

    abstract:BACKGROUND AND OBJECTIVE:Neutrophils are the primary white blood cells that are recruited to fight the initial phases of microbial infections. While healthy norms have been determined for circulating blood neutrophil counts in order to identify patients with suspected systemic infections, the levels of oral neutrophils...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/jre.12211

    authors: Landzberg M,Doering H,Aboodi GM,Tenenbaum HC,Glogauer M

    更新日期:2015-06-01 00:00:00

  • Expression and function of laminin and integrins on adhesion/migration of primary culture cells derived from rat oral epithelium.

    abstract:BACKGROUND AND OBJECTIVE:It remains controversial whether or not the junctional epithelium cells that are directly attached to teeth migrate on the enamel surface, as those cells are able to adhere firmly to the enamel. The aim of this study was to investigate the expression patterns of laminin gamma(2), integrin beta(...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2009.01231.x

    authors: Sugisawa M,Masaoka T,Enokiya Y,Muramatsu T,Hashimoto S,Yamada S,Shimono M

    更新日期:2010-04-01 00:00:00

  • Expression of TIMP-1, TIMP-2 and collagenase mRNA in periodontitis-affected human gingival tissue.

    abstract::Collagenolysis in periodontitis is thought to be modulated by the expression of three genes, collagenase, tissue inhibitors of metalloproteinases-1 and -2 (TIMP-1 and -2). We assessed the possible difference in TIMP-1, TIMP-2 and collagenase mRNA levels between gingival samples from patients with periodontitis and tho...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.1993.tb01079.x

    authors: Nomura T,Takahashi T,Hara K

    更新日期:1993-09-01 00:00:00

  • Implant osseointegration in irradiated bone: an experimental study.

    abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the effect of radiotherapy on the osseointegration of dental implants in the tibia and the action of platelet-rich plasma (PRP) as an adjuvant therapy. MATERIAL AND METHODS:A total of 18 rabbits received two implants in each tibial epiphysis, totalizing 7...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/jre.12416

    authors: Ocaña RP,Rabelo GD,Sassi LM,Rodrigues VP,Alves FA

    更新日期:2017-06-01 00:00:00

  • The cagE gene sequence as a diagnostic marker to identify JP2 and non-JP2 highly leukotoxic Aggregatibacter actinomycetemcomitans serotype b strains.

    abstract:BACKGROUND AND OBJECTIVE:Aggregatibacter actinomycetemcomitans is involved in oral and systemic infections, and is associated with, eg aggressive forms of periodontitis and with endocarditis. The cagE gene encodes a ≈39 kDa putative exotoxin expressed by A. actinomycetemcomitans. The level of conservation of cagE, and ...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/jre.12462

    authors: Johansson A,Claesson R,Höglund Åberg C,Haubek D,Oscarsson J

    更新日期:2017-10-01 00:00:00

  • Is self interdental cleaning associated with dental plaque levels, dental calculus, gingivitis and periodontal disease?

    abstract:BACKGROUND AND OBJECTIVE:To ascertain whether interdental cleaning behaviours of Australian adults were associated with lower levels of plaque, gingivitis and periodontal disease. MATERIAL AND METHODS:Data were obtained from the National Survey of Adult Oral Health 2004-06. Outcome variables were three indicators of o...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2011.01420.x

    authors: Crocombe LA,Brennan DS,Slade GD,Loc DO

    更新日期:2012-04-01 00:00:00

  • Decreased expression of E-cadherin by Porphyromonas gingivalis-lipopolysaccharide attenuates epithelial barrier function.

    abstract:BACKGROUND AND OBJECTIVE:The gingival epithelium is a first line of defense against bacterial challenge. E-cadherin (E-cad) plays an important role in cell-cell adhesion as a barrier in the epithelium. Recently, a decrease in the expression of E-cad has been observed in inflamed gingival tissue. The aims of this study ...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/jre.12367

    authors: Abe-Yutori M,Chikazawa T,Shibasaki K,Murakami S

    更新日期:2017-02-01 00:00:00

  • Bradykinin-2 receptor-mediated release of 3H-arachidonic acid and formation of prostaglandin E2 in human gingival fibroblasts.

    abstract::Bradykinin stimulated production of prostaglandin E2 (PGE2) and the release of 3H-arachidonic acid by gingival fibroblasts in a time- and dose-dependent manner. The effect on PGE2 biosynthesis was seen already after 15 seconds and was maximal after 5 minutes. Several structurally unrelated inhibitors of arachidonic ac...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.1990.tb00928.x

    authors: Modéer T,Ljunggren O,Lerner UH

    更新日期:1990-11-01 00:00:00

  • Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease.

    abstract:BACKGROUND AND OBJECTIVE:Biological plausibility of an association between severe periodontitis and cardiovascular disease (CVD) has been proven. Genetic characteristics play an important role in both complex inflammatory diseases. Polymorphisms (single nucleotide polymorphisms [SNPs]) in the long noncoding RNA, antise...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/jre.12555

    authors: Schulz S,Seitter L,Werdan K,Hofmann B,Schaller HG,Schlitt A,Reichert S

    更新日期:2018-10-01 00:00:00

  • Bone remodeling-associated salivary biomarker MIP-1α distinguishes periodontal disease from health.

    abstract:BACKGROUND AND OBJECTIVE:The field of salivary diagnostics lacks an accepted and validated biomarker of alveolar bone remodeling. To address this, we examined levels of salivary biomolecules specifically associated with biological aspects of bone remodeling in subjects with chronic periodontitis in a case-control study...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2011.01445.x

    authors: Al-Sabbagh M,Alladah A,Lin Y,Kryscio RJ,Thomas MV,Ebersole JL,Miller CS

    更新日期:2012-06-01 00:00:00

  • Chemical sympathectomy inhibits periodontal disease in Fischer 344 rats.

    abstract:OBJECTIVE:The responsiveness of the sympathetic nervous system (SNS) and the hypothalamic--pituitary--adrenal (HPA) axis plays a major role in immune regulation and for the outcome of infections and inflammatory disorders. This study was designed to investigate whether chemical SNS denervation with the noradrenaline-se...

    journal_title:Journal of periodontal research

    pub_type: 杂志文章

    doi:10.1111/j.1600-0765.2005.00803.x

    authors: Breivik T,Gundersen Y,Opstad PK,Fonnum F

    更新日期:2005-08-01 00:00:00