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Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.

Abstract：

:A new kaurane type diterpene lactone, neotripterifordin (1), has been isolated from the roots of Tripterygium wilfordii. The structure of 1 was elucidated by spectroscopic methods, which included the concerted application of a number of 2-D NMR techniques including 1H-1H COSY, phase-sensitive NOESY, HETCOR, and long-range HETCOR. Compound 1 showed potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Chen K,Shi Q,Fujioka T,Nakano T,Hu CQ,Jin JQ,Kilkuskie RE,Lee KH

doi

10.1016/0968-0896(95)00114-v

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

1345-8

issue

10

eissn

0968-0896

issn

1464-3391

pii

096808969500114V

journal_volume

3

pub_type

杂志文章

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