Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase.

abstract：:Hepatocyte nuclear factor 4 (HNF-4), a highly conserved member of the steroid hormone receptor superfamily critical for development and liver-specific gene expression, is very similar to another superfamily member, retinoid X receptor alpha (RXR alpha), in overall amino acid sequence and DNA binding specificity. Since...

journal_title：Molecular and cellular biology

authors： Jiang G,Nepomuceno L,Hopkins K,Sladek FM

更新日期：1995-09-01 00:00:00

abstract：:Glutamine is the preferred source of nitrogen of Neurospora crassa. In its presence and that of the gene product of MS5 (nmr-1), the fungus represses the assimilation of less preferred forms of nitrogen, such as nitrate. In the absence of glutamine and the presence of the product of gene nit-2, less preferred forms of...

journal_title：Molecular and cellular biology

authors： Sorger GJ,Brown D,Farzannejad M,Guerra A,Jonathan M,Knight S,Sharda R

更新日期：1989-09-01 00:00:00

abstract：:The 3' noncoding region element (AUUUA)n specifically targets many short-lived mRNAs for degradation. Although the mechanism by which this sequence functions is not yet understood, a potential link between facilitated mRNA turnover and translation has been implied by the stabilization of cellular mRNAs in the presence...

journal_title：Molecular and cellular biology

authors： Aharon T,Schneider RJ

更新日期：1993-03-01 00:00:00

abstract：:During the functional analysis of open reading frames (ORFs) identified during the sequencing of chromosome III of Saccharomyces cerevisiae, the previously uncharacterized ORF YCL031C (now designated RRP7) was deleted. RRP7 is essential for cell viability, and a conditional null allele was therefore constructed, by pl...

journal_title：Molecular and cellular biology

authors： Baudin-Baillieu A,Tollervey D,Cullin C,Lacroute F

更新日期：1997-09-01 00:00:00

abstract：:Myoblast city (mbc), a member of the CDM superfamily, is essential in the Drosophila melanogaster embryo for fusion of myoblasts into multinucleate fibers. Using germ line clones in which both maternal and zygotic contributions were eliminated and rescue of the zygotic loss-of-function phenotype, we established that m...

journal_title：Molecular and cellular biology

authors： Balagopalan L,Chen MH,Geisbrecht ER,Abmayr SM

更新日期：2006-12-01 00:00:00

abstract：:In eukaryotes, crossovers in mitotic cells can have deleterious consequences and therefore must be suppressed. Mutations in BLM give rise to Bloom syndrome, a disease that is characterized by an elevated rate of crossovers and increased cancer susceptibility. However, simple eukaryotes such as Saccharomyces cerevisiae...

journal_title：Molecular and cellular biology

authors： Hu Y,Lu X,Barnes E,Yan M,Lou H,Luo G

更新日期：2005-05-01 00:00:00

abstract：:The RBP-J/Su(H) DNA-binding protein plays a key role in transcriptional regulation by targeting Epstein-Barr virus nuclear antigen 2 (EBNA2) and the intracellular portions of Notch receptors to specific promoters. Using the yeast two-hybrid system, we isolated a LIM-only protein, KyoT, which physically interacts with ...

journal_title：Molecular and cellular biology

authors： Taniguchi Y,Furukawa T,Tun T,Han H,Honjo T

更新日期：1998-01-01 00:00:00

abstract：:The coordinated expression of CD4 and CD8 during T-cell development is tightly coupled with the maturation state of the T cell. Additionally, the mutually exclusive expression of these receptors in mature T cells is representative of the functional T-cell subclasses (CD4+ helper T cells versus CD8+ cytotoxic T cells)....

journal_title：Molecular and cellular biology

authors： Wurster AL,Siu G,Leiden JM,Hedrick SM

更新日期：1994-10-01 00:00:00

abstract：:Three classes of E3 ubiquitin ligases, members of the Cbl, Hakai, and SOCS-Cul5-RING ligase families, stimulate the ubiquitination of phosphotyrosine-containing proteins, including receptor and nonreceptor tyrosine kinases and their phosphorylated substrates. Because ubiquitination frequently routes proteins for degra...

journal_title：Molecular and cellular biology

authors： Cooper JA,Kaneko T,Li SS

更新日期：2015-06-01 00:00:00

abstract：:Mammalian eukaryotic translation initiation factor 4F (eIF4F) is a cap-binding protein complex consisting of three subunits: eIF4E, eIF4A, and eIF4G. In yeast and plants, two related eIF4G species are encoded by two different genes. To date, however, only one functional eIF4G polypeptide, referred to here as eIF4GI, h...

journal_title：Molecular and cellular biology

authors： Gradi A,Imataka H,Svitkin YV,Rom E,Raught B,Morino S,Sonenberg N

更新日期：1998-01-01 00:00:00

abstract：:Transcriptional insulators are cis regulatory elements that organize chromatin into independently regulated domains. At the imprinted murine Igf2/H19 locus, the H19-ICR insulator prevents the activation of the Igf2 promoter on the maternal allele by enhancers that activate H19 on the same chromosome. Given the well-de...

journal_title：Molecular and cellular biology

authors： Singh V,Srivastava M

更新日期：2008-06-01 00:00:00

abstract：:Essential for embryonic development, the polycomb group protein enhancer of zeste homolog 2 (EZH2) is overexpressed in breast and prostate cancers and is implicated in the growth and aggression of the tumors. The tumorigenic mechanism underlying EZH2 overexpression is largely unknown. It is believed that EZH2 exerts i...

journal_title：Molecular and cellular biology

authors： Shi B,Liang J,Yang X,Wang Y,Zhao Y,Wu H,Sun L,Zhang Y,Chen Y,Li R,Zhang Y,Hong M,Shang Y

更新日期：2007-07-01 00:00:00

abstract：:Mxi2 is a p38alpha splice isoform that is distinctively activated by mitogenic stimuli. Here we show that Mxi2 immunoprecipitates carry a kinase activity that is persistently activated by epidermal growth factor in a fashion regulated by Ras, Raf, and MEK. We demonstrate that this kinase activity can be attributed not...

journal_title：Molecular and cellular biology

authors： Sanz-Moreno V,Casar B,Crespo P

更新日期：2003-05-01 00:00:00

abstract：:NIH3T3 cells transformed by mouse Int-2/Fgf-3 cDNA express a series of Int-2-related products representing discrete stages of processing and glycosylation. We confirm that in at least two highly transformed clonal lines, Int-2 products acquire further modifications and are efficiently secreted into the culture medium....

journal_title：Molecular and cellular biology

authors： Kiefer P,Peters G,Dickson C

更新日期：1991-12-01 00:00:00

abstract：:We show that the extent of transcriptional regulation of many, apparently unrelated, genes in Saccharomyces cerevisiae is dependent on RPD1 (and RPD3 [M. Vidal and R. F. Gaber, Mol. Cell. Biol. 11:6317-6327, 1991]). Genes regulated by stimuli as diverse as external signals (PHO5), cell differentiation processes (SPO11...

journal_title：Molecular and cellular biology

authors： Vidal M,Strich R,Esposito RE,Gaber RF

更新日期：1991-12-01 00:00:00

abstract：:The loss of p53 induces spontaneous tumors in mice, and p53 mutations are found in approximately 50% of human tumors. These tumors are generally caused by a number of events, including genomic instability, checkpoint defects, mitotic defects, deregulation of transcriptional targets, impaired apoptosis, and G(1) deregu...

journal_title：Molecular and cellular biology

authors： Padmakumar VC,Aleem E,Berthet C,Hilton MB,Kaldis P

更新日期：2009-05-01 00:00:00

abstract：:Osteoclast differentiation factor (ODF)/receptor activator of NF-kappaB ligand is essential for inducing the differentiation of mature osteoclasts. We find that nuclear factor Y (NF-Y) binds to the CCAAT box on the ODF promoter and regulates its basal transcriptional activity. The CCAAT box on the ODF gene is required...

journal_title：Molecular and cellular biology

authors： Kabe Y,Yamada J,Uga H,Yamaguchi Y,Wada T,Handa H

更新日期：2005-01-01 00:00:00

abstract：:We demonstrate that a member of the fos family, the fosB gene, gives rise to two transcripts by alternative splicing of exon 4, generating two proteins, FosB of 338 amino acids and a short form, FosB/SF, which contains the DNA binding and dimerization domains but not the 101 amino acids of the C terminus. FosB/SF acti...

journal_title：Molecular and cellular biology

authors： Dobrazanski P,Noguchi T,Kovary K,Rizzo CA,Lazo PS,Bravo R

更新日期：1991-11-01 00:00:00

abstract：:The v-myb oncogene of avian myeloblastosis virus causes acute myelomonocytic leukemia in chickens and transforms avian myeloid cells in vitro. Its protein product p48v-myb is a nuclear, sequence-specific, DNA-binding protein which activates gene expression in transient DNA transfection studies. To investigate the rela...

journal_title：Molecular and cellular biology

authors： Lane T,Ibanez C,Garcia A,Graf T,Lipsick J

更新日期：1990-06-01 00:00:00

abstract：:The pluripotent factor Oct4 is a key transcription factor that maintains embryonic stem (ES) cell self-renewal and is down-regulated upon the differentiation of ES cells and silenced in somatic cells. A combination of cis elements, transcription factors, and epigenetic modifications, such as DNA methylation, are invol...

journal_title：Molecular and cellular biology

authors： Gu P,Le Menuet D,Chung AC,Cooney AJ

更新日期：2006-12-01 00:00:00

abstract：:We recently identified Vav, the product of the vav proto-oncogene, as a guanine nucleotide exchange factor (GEF) for Ras. Vav is enzymatically activated by lymphocyte antigen receptor-coupled protein tyrosine kinases or independently by diglycerides. To further evaluate the physiological role of Vav, we assessed its G...

journal_title：Molecular and cellular biology

authors： Gulbins E,Coggeshall KM,Langlet C,Baier G,Bonnefoy-Berard N,Burn P,Wittinghofer A,Katzav S,Altman A

更新日期：1994-02-01 00:00:00

abstract：:The transcription factor LFB1 (HNF1) was initially identified as a regulator of liver-specific gene expression in mammals. It interacts with the promoter element HP1, which is functionally conserved between mammals and amphibians, suggesting that a homologous factor, XLFB1, also exists in Xenopus laevis. To study the ...

journal_title：Molecular and cellular biology

authors： Bartkowski S,Zapp D,Weber H,Eberle G,Zoidl C,Senkel S,Klein-Hitpass L,Ryffel GU

更新日期：1993-01-01 00:00:00

abstract：:The cytoplasm of Saccharomyces cerevisiae contains two major classes of protein-encapsulated double-stranded ribonucleic acids (dsRNA's), L and M. Replication of L and M dsRNA's was examined in cells arrested in the G1 phase by either alpha-factor, a yeast mating pheromone, or the restrictive temperature for a cell cy...

journal_title：Molecular and cellular biology

authors： Zakian VA,Wagner DW,Fangman WL

更新日期：1981-08-01 00:00:00

abstract：:The simian virus 40 large T antigen (T antigen) inactivates tumor suppressor proteins and therefore has been used in numerous studies to probe the mechanisms that control cellular growth and to generate immortalized cell lines. Binding of T antigen to the Rb family of growth-regulatory proteins is necessary but not su...

journal_title：Molecular and cellular biology

authors： Sullivan CS,Cantalupo P,Pipas JM

更新日期：2000-09-01 00:00:00

abstract：:Regulation of chromatin through histone acetylation is an important step in gene expression. The Gcn5 histone acetyltransferase is part of protein complexes, e.g., the SAGA complex, that interact with transcriptional activators, targeting the enzyme to specific promoters and assisting in recruitment of the basal RNA p...

journal_title：Molecular and cellular biology

authors： Qi D,Larsson J,Mannervik M

更新日期：2004-09-01 00:00:00

abstract：:HIRA-like (Hir) proteins are evolutionarily conserved and are implicated in the assembly of repressive chromatin. In Saccharomyces cerevisiae, Hir proteins contribute to the function of centromeres. However, S. cerevisiae has point centromeres that are structurally different from the complex centromeres of metazoans. ...

journal_title：Molecular and cellular biology

authors： Blackwell C,Martin KA,Greenall A,Pidoux A,Allshire RC,Whitehall SK

更新日期：2004-05-01 00:00:00

abstract：:The active beta-globin genes in chicken erythrocytes, like all active genes, reside in large chromatin domains which are preferentially sensitive to digestion by DNase I. We have recently proposed that the special structure of chromatin in active domains is maintained by torsional stress in the DNA (Villeponteau et al...

journal_title：Molecular and cellular biology

authors： Villeponteau B,Martinson HG

更新日期：1987-05-01 00:00:00

abstract：:Wnt signaling is critical to many aspects of development, and aberrant activation of the Wnt signaling pathway can cause cancer. Dishevelled (Dvl) protein plays a central role in this pathway by transducing the signal from the Wnt receptor complex to the beta-catenin destruction complex. Dvl also plays a pivotal role ...

journal_title：Molecular and cellular biology

authors： Cong F,Schweizer L,Varmus H

更新日期：2004-03-01 00:00:00

abstract：:Two Drosophila tumor necrosis factor receptor-associated factors (TRAF), DTRAF1 and DTRAF2, are proposed to have similar functions with their mammalian counterparts as a signal mediator of cell surface receptors. However, their in vivo functions and related signaling pathways are not fully understood yet. Here, we sho...

journal_title：Molecular and cellular biology

authors： Cha GH,Cho KS,Lee JH,Kim M,Kim E,Park J,Lee SB,Chung J

更新日期：2003-11-01 00:00:00

abstract：:Entry into mitosis depends upon activation of the dual-specificity phosphatase Cdc25C, which dephosphorylates and activates the cyclin B-Cdc2 complex. Previous work has shown that the Xenopus polo-like kinase Plx1 can phosphorylate and activate Cdc25C in vitro. In the work presented here, we demonstrate that Plx1 is a...

journal_title：Molecular and cellular biology

authors： Qian YW,Erikson E,Li C,Maller JL

更新日期：1998-07-01 00:00:00