Abstract:
:Regulation of tyrosine phosphorylation is a critical control point for integration of environmental signals into cellular responses. This regulation is mediated by the reciprocal actions of protein tyrosine kinases and phosphatases. CD45, the first and prototypic receptor-like protein tyrosine phosphatase, is expressed on all nucleated hematopoietic cells and plays a central role in this process. Studies of CD45 mutant cell lines, CD45-deficient mice, and CD45-deficient humans initially demonstrated the essential role of CD45 in antigen receptor signal transduction and lymphocyte development. It is now known that CD45 also modulates signals emanating from integrin and cytokine receptors. Recent work has focused on regulation of CD45 expression and alternative splicing, isoform-specific differences in signal transduction, and regulation of phosphatase activity. From these studies, a model is emerging in which CD45 affects cellular responses by controlling the relative threshold of sensitivity to external stimuli. Perturbation of this function may contribute to autoimmunity, immunodeficiency, and malignancy. Moreover, recent advances suggest that modulation of CD45 function can have therapeutic benefit in many disease states.
journal_name
Annu Rev Immunoljournal_title
Annual review of immunologyauthors
Hermiston ML,Xu Z,Weiss Adoi
10.1146/annurev.immunol.21.120601.140946subject
Has Abstractpub_date
2003-01-01 00:00:00pages
107-37eissn
0732-0582issn
1545-3278pii
120601.140946journal_volume
21pub_type
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journal_title:Annual review of immunology
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更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2020-04-26 00:00:00
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更新日期:2012-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1995-01-01 00:00:00
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journal_title:Annual review of immunology
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