Phase II-study for treatment of refractory acute leukemia with intermediate-dose cytosine arabinoside and amsacrine.

Abstract:

:25 consecutive leukemia patients (21 AML, 4 ALL) with either primary resistance (n = 22) or resistant relapse (n = 3) of all FAB-subtypes were treated with 1 or 2 cycles of ID-ara C (1 g/m2 i.v. q 12h days 1-6) and AMSA (120 mg/m2 i.v. days 5-7). Patients reaching CR received 1 cycle of intensive consolidation using ara C 3 g/m2 i.v. q 12 h days 1-4 and AMSA 120 mgm2 day 5. Two patients received an allograft thereafter and are still alive and in CCR. CR was achieved in 12/25 patients (48%), in 10 after 1 cycle of induction and in 2 after 2 cycles. 10/22 patients with primary resistant disease reached CR, and 2/3 with resistant relapse. 9 patients remained refractory (36%) and 4 died during hypoplasia (16%) Median DFS of the 12 responders was 2.9 months and median survival from time of CR 8.9 mo. Median overall survival of responders and non-responders was 6 mo from time of resistance. The survival advantage of responding patients (n = 12) as compared to non-responders (n = 13) was 10.7 vs. 3.2 mo (p = 0.002). Toxicity of chemotherapy was acceptable. 1 patient experienced pulmonary edema due to ara C, 2 patients developed life threatening systemic fungal infections, one of whom died while in CR.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Jehn U,Heinemann V

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

379-81

issue

2

eissn

0250-7005

issn

1791-7530

journal_volume

13

pub_type

临床试验,杂志文章
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    authors: Lindahl B,Ranstam J,Willén R

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    authors: Ho TH,Chew EC,Tam JS,Hou HJ,Yam HF,Chew-Cheng SB,Wong FW

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  • CHML suppresses cell growth and induces apoptosis in multiple human tumor lines.

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    authors: Zhan Q,Xu Z

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    journal_title:Anticancer research

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    doi:

    authors: Schut HA

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  • Vitamin D receptor genetic polymorphisms are associated with PSA level, Gleason score and prostate cancer risk in African-American men.

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    doi:

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  • Vinorelbine as palliative therapy in advanced breast cancer.

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    authors: Gasco M,Gardin G,Repetto L,Campora E,Rosso R

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  • Geographical Differences in Likelihood of Home Death Among Palliative Cancer Patients: A National Population-based Register Study.

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    pub_type: 杂志文章

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    更新日期:1997-09-01 00:00:00

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

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