[Ocular Manifestation of Mucopolysaccharidosis I-S (Scheie's Syndrome)].

Abstract:

BACKGROUND:Bilateral stromal corneal opacifications are a differential diagnostical challenge to identify associated systemic diseases. CASE-REPORT:A 47-year old civil engineer (height 167 cm) with bilateral stromal corneal clouding presented with visual loss for the last 27 years: VA 20/100 OD and 20/50 OS (following penetrating keratoplasty OS). The cornea showed milky-whitish, cloudy, diffuse stromal deposits without a separate lipoid arc. The posterior segment showed tapetoretinal degeneration. Scotopic ERG was decreased. A suspicious stiffness of interphalangeal joints on both hands was observed. There was an aortic and mitral insufficiency grade I. Serum levels of LDL, HDL and triglycerides were normal. The biomicroscopical diagnosis of Scheie's syndrome (mucopolysaccharidosis I-S) was confirmed by a deficiency of alpha-L-iduronidase in leukocytes (0.02 nmol/min/mg protein, normal range: 0.3 - 1.5). CONCLUSION:The differential diagnosis of bilateral corneal stromal opacification includes in addition to the mucopolysaccharidoses HDL-deficiency diseases (LCAT deficiency, Tangier disease, Fish eye disease), Schnyder's crystalline stromal dystrophy, cystinosis, gout and mucolipidoses. MPS I-S may easily be detected by alpha-L-iduronidase deficiency in leukocytes and increased mucopolysaccharides in the urine. Furthermore, patients with MPS I-S need general medical care because of cardiovascular abnormalities, joint stiffness and myopathies.

journal_name

Klin Monbl Augenheilkd

authors

Viestenz A,Shin YS,Viestenz A,Naumann GO

doi

10.1055/s-2002-35688

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

745-8

issue

10

eissn

0023-2165

issn

1439-3999

journal_volume

219

pub_type

杂志文章
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    doi:

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    更新日期:1987-09-01 00:00:00

  • [The judgement of the degree of disability in cases of aphakia and pseudoaphakia (author's transl)].

    abstract::Since more than 40 years the judgement of the degree of disability in cases of unilateral aphakia is discussed. This means the effort toward an advisory objectivity on the one hand and human understanding for the patient's damage on the other hand. It is supposed to repeal the 4th emergency ordinance of 1932 and to pa...

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    doi:

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    更新日期:1979-07-01 00:00:00

  • [Perimetric and visumetric methods for measuring individually tolerated intraocular pressure in glaucoma].

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    更新日期:1982-06-01 00:00:00

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  • [Modified moisture chamber].

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    doi:

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    更新日期:1978-02-01 00:00:00

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    doi:

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  • [Influence of floor disinfection on microbial and particulate burden measured under low turbulance air flow in ophthalmological operation theatres].

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