Local delivery of mitoxantrone for the treatment of malignant brain tumors in rats.

abstract：:Delayed nonhemorrhagic encephalopathy following mild head trauma is a rare condition with an unknown etiology. The few cases reported in the literature are in young adults, all of them in the era before computerized tomography (CT) became available, and all had a devastating clinical course with multifocal ischemia or...

journal_title：Journal of neurosurgery

authors： Ram Z,Hadani M,Spiegelman R,Tadmor R,Shacked I

更新日期：1989-10-01 00:00:00

abstract：OBJECT:The aim of this study was to evaluate different types of sensory stimulation used to distinguish between microvasculature and venous drainage on functional magnetic resonance (fMR) images with blood oxygen level-dependent (BOLD) contrast. METHODS:Seven volunteers received three sensory stimulations. One consist...

journal_title：Journal of neurosurgery

authors： Le Rumeur E,Allard M,Poiseau E,Jannin P

更新日期：2000-09-01 00:00:00

abstract：:The common carotid, femoral, and middle cerebral arteries in the rat have been occluded thrombotically by means of a rose bengal dye-sensitized photochemical reaction initiated in vascular endothelium by the 514.5-nm beam of an argon laser, focused for maximum excitation efficiency of the photosensitizer according to ...

journal_title：Journal of neurosurgery

authors： Watson BD,Dietrich WD,Prado R,Ginsberg MD

更新日期：1987-05-01 00:00:00

abstract：OBJECT:Previous small studies disagree about which clinical risk factors influence ependymoma incidence. The authors analyzed a large, population-based cancer registry to examine the relationship of incidence to patient age, sex, race, and tumor location, and to determine incidence trends over the past 3 decades. METH...

journal_title：Journal of neurosurgery

authors： McGuire CS,Sainani KL,Fisher PG

更新日期：2009-04-01 00:00:00

abstract：:A patient with findings of bilateral cortical blindness and a unilateral carotid bruit is reported. A persistent trigeminal artery allowed emboli from a unilateral ulcerated internal carotid plaque to affect the visual cortex bilaterally. The angiographic findings and a brief discussion of this anomalous artery are pr...

journal_title：Journal of neurosurgery

authors： Heeney DJ,Koo AH

更新日期：1980-05-01 00:00:00

abstract：:A follow-up study was performed on 41 hydrocephalic children with primary (10 patients) or secondary (31 patients) placement of an anti-siphon device (ASD) connected to their shunt. The clinical course before and after ASD implantation was compared in these two groups, including studies of the head circumference, the ...

journal_title：Journal of neurosurgery

authors： Gruber R,Jenny P,Herzog B

更新日期：1984-07-01 00:00:00

abstract：:OBJECTIVE The molecular mechanisms behind cerebral aneurysm formation and rupture remain poorly understood. In the past decade, microRNAs (miRNAs) have been shown to be key regulators in a host of biological processes. They are noncoding RNA molecules, approximately 21 nucleotides long, that posttranscriptionally inhi...

journal_title：Journal of neurosurgery

authors： Bekelis K,Kerley-Hamilton JS,Teegarden A,Tomlinson CR,Kuintzle R,Simmons N,Singer RJ,Roberts DW,Kellis M,Hendrix DA

更新日期：2016-12-01 00:00:00

abstract：OBJECT:The purpose of this study was to evaluate both replication-competent and replication-restricted recombinant vesicular stomatitis virus (VSV) vectors as therapeutic agents for high-grade gliomas by using an organotypic brain tissue slice-glioma coculture system. METHODS:The coculture system involved growing diff...

journal_title：Journal of neurosurgery

authors： Duntsch CD,Zhou Q,Jayakar HR,Weimar JD,Robertson JH,Pfeffer LM,Wang L,Xiang Z,Whitt MA

更新日期：2004-06-01 00:00:00

abstract：:Two patients with chronic spinal subdural hematomas are described. Both had a fluctuating clinical course, not previously documented in the literature. Surgical evacuation resulted in almost complete recovery. The pathogenesis of spinal subdural hematoma is discussed and the pertinent literature is reviewed. ...

journal_title：Journal of neurosurgery

authors： Khosla VK,Kak VK,Mathuriya SN

更新日期：1985-10-01 00:00:00

abstract：:The authors report on the case of a 15-year-old boy with Crouzon syndrome (CS) who presented with headache and facial diplegia. He had undergone several craniofacial interventions and a posterior fossa decompression for tonsillar herniation caused by the CS. A ventriculoperitoneal (VP) shunt had been inserted for hydr...

journal_title：Journal of neurosurgery

authors： Thines L,Vinchon M,Lahlou A,Pellerin P,Dhellemmes P

更新日期：2007-07-01 00:00:00

abstract：:Two phenomena associated with malignant gliomas are: 1) the ability to metastasize systemically, and 2) the capacity to induce sarcomatous transformation within the supportive mesenchyma. An unusual case is presented of selective metastases of the sarcomatous elements of a mixed gliosarcoma. Immunohistochemical cell s...

journal_title：Journal of neurosurgery

authors： Weaver D,Vandenberg S,Park TS,Jane JA

更新日期：1984-09-01 00:00:00

abstract：:OBJECTIVE Neurosurgical intervention may increase the risk of developing cerebral vein and dural sinus thrombosis (CVT). The clinical management of CVT in postoperative patients remains unclear. This retrospective study explores the disease occurrence, associated risk factors, and outcomes in patients with tumors who ...

journal_title：Journal of neurosurgery

authors： Gessler F,Bruder M,Duetzmann S,Tritt S,Bernstock JD,Seifert V,Senft C

更新日期：2018-02-01 00:00:00

abstract：OBJECT:Intracerebral hemorrhage (ICH) is an uncommon complication of carotid endarterectomy (CEA), and carries a high rate of mortality and morbidity. Traditionally, attention has been focused on the cerebral hyperperfusion syndrome (HPS) as the leading cause of ICH after CEA. Other mechanisms, such as a perioperative ...

journal_title：Journal of neurosurgery

authors： Henderson RD,Phan TG,Piepgras DG,Wijdicks EF

更新日期：2001-12-01 00:00:00

abstract：:Although the development of tonsillar herniation (acquired Chiari malformation) in association with lumboperitoneal (LP) shunting is well recognized, it has previously been considered rare. In order to ascertain the incidence of this complication after LP shunting, the authors undertook a retrospective study of all pa...

journal_title：Journal of neurosurgery

authors： Chumas PD,Armstrong DC,Drake JM,Kulkarni AV,Hoffman HJ,Humphreys RP,Rutka JT,Hendrick EB

更新日期：1993-04-01 00:00:00

abstract：:This case report of 74-year-old man with trigeminal neuralgia is presented to underscore the importance of evaluating the entire treatment plan, especially when delivering large doses where even a low percentage of the prescription dose can contribute a substantial dose to an unintended target. The patient was treated...

journal_title：Journal of neurosurgery

authors： Peddada AV,Sceats DJ,White GA,Bulz G,Gibbs GL,Switzer B,Anderson S,Monroe AT

更新日期：2011-11-01 00:00:00

abstract：:Cavernous hemangiomas of the orbit are benign vascular growths that commonly occur in adults and account for 6% of all intraorbital tumors. Multifocal intraorbital cavernous hemangiomas are quite rare. The reported incidence of arachnoid cysts accounts for only 1% of lesions that occupy intracranial space, and they ar...

journal_title：Journal of neurosurgery

authors： Tatli M,Guzel A,Keklikci U,Guzel E

更新日期：2005-11-01 00:00:00

abstract：OBJECT:The difference in the hemodynamics of wall shear stress (WSS) and oscillatory shear index (OSI) between ruptured and unruptured aneurysms is not well understood. The authors investigated the hemodynamic similarities and dissimilarities in ruptured and thin-walled unruptured aneurysm blebs. METHODS:Magnetic reso...

journal_title：Journal of neurosurgery

authors： Kawaguchi T,Nishimura S,Kanamori M,Takazawa H,Omodaka S,Sato K,Maeda N,Yokoyama Y,Midorikawa H,Sasaki T,Nishijima M

更新日期：2012-10-01 00:00:00

abstract：OBJECT:The aim of this study was to investigate the incidence of elevated (> or = 75%) jugular venous oxygen saturation (SjvO2) and its relationship to cerebral hemodynamic and metabolic parameters and to outcome after severe head injury. METHODS:Data from 450 severely head injured patients admitted to the Neurosurgic...

journal_title：Journal of neurosurgery

authors： Cormio M,Valadka AB,Robertson CS

更新日期：1999-01-01 00:00:00

abstract：OBJECT:Skull bone regeneration induced by transforming growth factor-beta1 (TGFbeta1)-containing gelatin hydrogels (TGFbeta1-hydrogels) was investigated using a rabbit skull defect model. Different strengths of TGFbeta1 were examined and compared: different TGFbeta1 doses in gelatin hydrogels with a fixed water content...

journal_title：Journal of neurosurgery

authors： Hong L,Tabata Y,Miyamoto S,Yamamoto M,Yamada K,Hashimoto N,Ikada Y

更新日期：2000-02-01 00:00:00

abstract：:This Phase III trial tested the efficacy and safety of intra-arterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) for the treatment of newly resected malignant glioma, comparing intra-arterial BCNU and intravenous BCNU (200 mg/sq m every 8 weeks), each regimen without or with intravenous 5-fluorouracil (1 gm/sq m thre...

journal_title：Journal of neurosurgery

authors： Shapiro WR,Green SB,Burger PC,Selker RG,VanGilder JC,Robertson JT,Mealey J Jr,Ransohff J,Mahaley MS Jr

更新日期：1992-05-01 00:00:00

abstract：OBJECT:Diffusely infiltrating astrocytomas are the most common primary brain tumors. As a group, they demonstrate an inherent tendency toward malignant progression. Histological grading using the guidelines of the World Health Organization (WHO) remains the gold standard for predicting the biological behavior of these ...

journal_title：Journal of neurosurgery

authors： Mott RT,Turner KC,Bigner DD,McLendon RE

更新日期：2008-02-01 00:00:00

abstract：:OBJECTIVE Dysexecutive syndrome is common in patients with moyamoya disease (MMD), a chronic cerebrovascular disease that is characterized by stenosis of the bilateral internal carotid arteries and progressive collateral revascularization, and MMD can be classified as ischemic or hemorrhagic according to the disease p...

journal_title：Journal of neurosurgery

authors： Fang L,Huang J,Zhang Q,Chan RC,Wang R,Wan W

更新日期：2016-08-01 00:00:00

abstract：:A case is reported of severe unilateral hemispheric edema and localized hemorrhage associated with seizures following endarterectomy of an ipsilateral high-grade carotid stenosis. Imaging studies including angiography, computerized tomography (CT), magnetic resonance imaging/angiography, and xenon-CT, suggested postop...

journal_title：Journal of neurosurgery

authors： Penn AA,Schomer DF,Steinberg GK

更新日期：1995-07-01 00:00:00

abstract：OBJECT:The goals of this study were to report the clinical presentation, radiographic findings, operative strategy, and outcomes among patients with temporal bone encephaloceles and cerebrospinal fluid fistulas (CSFFs) and to identify clinical variables associated with surgical outcome. METHODS:A retrospective case se...

journal_title：Journal of neurosurgery

authors： Carlson ML,Copeland WR 3rd,Driscoll CL,Link MJ,Haynes DS,Thompson RC,Weaver KD,Wanna GB

更新日期：2013-11-01 00:00:00

abstract：:Excellent results from multiple burr-hole operations for adult moyamoya disease are reported in this study. Ten patients had between one and four burr holes (mean 2.1) drilled in each hemisphere. In four patients new burr holes were added on the opposite side after depression of cerebral blood flow (CBF) was detected ...

journal_title：Journal of neurosurgery

authors： Kawaguchi T,Fujita S,Hosoda K,Shose Y,Hamano S,Iwakura M,Tamaki N

更新日期：1996-03-01 00:00:00

abstract：:Macroprolactinomas rarely present with apoplexy. The authors describe a patient with a macroprolactinoma who presented with apoplexy and rapid progression of a third nerve palsy. The patient was managed expectantly with bromocriptine, and within 48 hours, the patient's third nerve palsy had completely resolved. The au...

journal_title：Journal of neurosurgery

authors： Brisman MH,Katz G,Post KD

更新日期：1996-12-01 00:00:00

abstract：:The clinical and pathological data of 66 patients with orbital cavernous hemangioma are presented. This tumor occurs in females more frequently than in males, and has its peak incidence in early middle age. Visual disability results from a high degree of relative hyperopia or from optic-nerve compression. Postural or ...

journal_title：Journal of neurosurgery

authors： Harris GJ,Jakobiec FA

更新日期：1979-08-01 00:00:00

abstract：:Pial artery constriction following fluid-percussion injury to the brain is associated with elevated cerebrospinal fluid (CSF) vasopressin concentration in newborn pigs. It has also been observed that fluid-percussion injury reverses the function of vasopressin from that of a dilator to a constrictor. Endothelin-1 (ET-...

journal_title：Journal of neurosurgery

authors： Armstead WM

更新日期：1996-11-01 00:00:00

abstract：:A study was designed to investigate hyperperfusion syndrome after the restoration of normal cerebral blood flow in a chronically cerebral ischemic state resulting from high-flow arteriovenous malformations or severe carotid stenosis. A fistula between the left distal common carotid artery and the jugular vein was crea...

journal_title：Journal of neurosurgery

authors： Sakaki T,Tsujimoto S,Nishitani M,Ishida Y,Morimoto T

更新日期：1992-03-01 00:00:00

abstract：:A 30-year-old man presented with a subacute course of myelopathic signs and symptoms. Magnetic resonance imaging demonstrated an epidural mass lesion of the spinal canal at the cervicothoracic junction causing compression of the spinal cord. Laminectomy with resection of this lesion revealed a large varix with acute a...

journal_title：Journal of neurosurgery

authors： Dickman CA,Zabramski JM,Sonntag VK,Coons S

更新日期：1988-12-01 00:00:00