An intranuclear frame for chromatin compartmentalization and higher-order folding.

abstract：:Exposure of cells to ionizing radiation (IR) determines cellular lesions, such as DNA and membrane damage, which involve a coordinate network of signal transduction pathways responsible for resistance to or delay of apoptosis, depending on cell type and administered dose. Since, after IR exposure, the apoptotic profil...

journal_title：Journal of cellular biochemistry

authors： Cataldi A,Rapino M,Centurione L,Sabatini N,Grifone G,Garaci F,Rana R

更新日期：2003-08-01 00:00:00

abstract：:Evidence for multiprotein complexes playing a role in DNA replication has been growing over the years. We have previously reported on a replication-competent multiprotein form of DNA polymerase isolated from human (HeLa) cell extracts. The proteins that were found at that time to co-purify with the human cell multipro...

journal_title：Journal of cellular biochemistry

authors： Applegren N,Hickey RJ,Kleinschmidt AM,Zhou Q,Coll J,Wills P,Swaby R,Wei Y,Quan JY,Lee MY

更新日期：1995-09-01 00:00:00

abstract：:The basement membrane (BM) protein laminin-332 (Lm332) (laminin-5) has unique activity and structure as compared with other laminins: it strongly promotes cellular adhesion and migration, and its alpha3, beta3, and gamma2 chains are all truncated in their N-terminal regions (short arms). In the present study, we inves...

journal_title：Journal of cellular biochemistry

authors： Nakashima Y,Kariya Y,Miyazaki K

更新日期：2007-02-15 00:00:00

abstract：:Small molecule inhibitors of cyclin-dependent kinase 5 (CDK5) protect neurons from cell death following various insults. To elucidate the cellular mechanism of action we investigated changes in protein phosphorylation in cultured rat cerebellar granule neurons after administration of the CDK5 inhibitor Indolinone A. B...

journal_title：Journal of cellular biochemistry

authors： Gillardon F,Schrattenholz A,Sommer B

更新日期：2005-07-01 00:00:00

abstract：:Breast cancer frequently metastasizes to the bone, often leading to the formation of osteolytic lesions. This work compares the paracrine-induced osteoclastogenesis mediated by four human breast cancer cell lines, the estrogen-receptor positive T47D and MCF-7 and the estrogen-negative SK-BR-3 and Hs-578T cell lines. H...

journal_title：Journal of cellular biochemistry

authors： Costa-Rodrigues J,Moniz KA,Teixeira MR,Fernandes MH

更新日期：2012-03-01 00:00:00

abstract：:Although, the precise host defence mechanism(s) is not completely understood, T cell-mediated immune responses is believed to play a pivotal role in controlling parasite infection. Here we target the stage dependent over expressed gene. Here, the consensus based computational approach was adopted for the screening of ...

journal_title：Journal of cellular biochemistry

authors： Dikhit MR,Vijayamahantesh.,Kumar A,Amit A,Dehury B,Nathsharma YP,Ansari MY,Ali V,Topno RK,Das V,Pandey K,Sahoo GC,Bimal S,Das P

更新日期：2018-01-01 00:00:00

abstract：:One of the most frequent chromosomal translocation found in patients with acute myeloid leukemia (AML) is the t(8;21). This translocation involves the RUNX1 and ETO genes. The breakpoints regions for t(8;21) are located at intron 5 and intron 1 of the RUNX1 and ETO gene respectively. To date, no homologous sequences h...

journal_title：Journal of cellular biochemistry

authors： Stuardo M,Nicovani S,Javed A,Gutierrez S

更新日期：2013-11-01 00:00:00

abstract：:Two pathways operate during Xenopus oogenesis to localize a small number of RNAs to the vegetal cortex. Correct localization of these RNAs is essential to normal development as the proteins they encode are involved in specifying cell type and in patterning the early embryo. Binding these RNAs to the vegetal cortex and...

journal_title：Journal of cellular biochemistry

authors： Bubunenko M,King ML

更新日期：2001-01-01 00:00:00

abstract：:Homocysteine-thiolactone (HcyT) is a toxic product whose synthesis is directly proportional to plasma homocysteine (Hcy) levels. Previous studies demonstrated that the interaction between HcyT and low density lipoproteins (LDL) induces the formation of homocystamide-LDL adducts (Hcy-LDL). Structural and functional alt...

journal_title：Journal of cellular biochemistry

authors： Ferretti G,Bacchetti T,Moroni C,Vignini A,Nanetti L,Curatola G

更新日期：2004-05-15 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor has recently been identified in bone, but the molecular composition of this receptor expressed by bone cells is unknown. NMDA receptor (NMDAR) is a hetero-oligomeric protein composed of two classes of subunits, the essential subunit NR1 and NR2A to D su...

journal_title：Journal of cellular biochemistry

authors： Itzstein C,Cheynel H,Burt-Pichat B,Merle B,Espinosa L,Delmas PD,Chenu C

更新日期：2001-04-02 00:00:00

abstract：:Neuropathic pain is a kind of pain caused by primary or secondary impairment or dysfunction of peripheral or central nervous system. Patients with neuropathic pain were often with poor clinical outcome. We screened the differentially expressed genes between sciatic nerve injury and dorsal root ganglion gene in the sha...

journal_title：Journal of cellular biochemistry

authors： Yang JA,He JM,Lu JM,Jie LJ

更新日期：2018-06-01 00:00:00

abstract：:We examined the effects of photobiomodulation (PBM) independently and combined with curcumin on stereological parameters and basic fibroblast growth factor (bFGF), hypoxia-inducible factor-1α (HIF-1α), and stromal cell-derived factor-1α (SDF-1α) gene expressions in an excisional wound model of rats with type one diabe...

journal_title：Journal of cellular biochemistry

authors： Amini A,Soleimani H,Abdollhifar MA,Moradi A,Ghoreishi SK,Chien S,Bayat M

更新日期：2019-10-01 00:00:00

abstract：:Accumulating studies indicates that circular RNAs (circRNAs) play an imperative role in modulating cancer progression and metastasis. In the previous study, elevated circ_0029426 was first observed in glioblastoma (GBM) tissues compared with normal tissues by circRNA microarray. Our aim is to study the function and me...

journal_title：Journal of cellular biochemistry

authors： Zhang G,Sun W,Zhu L,Feng Y,Wu L,Li T

更新日期：2019-06-01 00:00:00

abstract：:The characterization of the superfamily of nuclear receptors, in particular the steroid/retinoid/thyroid hormone receptors, has resulted in a more complete understanding of how a repertoire of hormonally and nutritionally derived lipophilic ligands controls cell functions to effect development and homeostasis. As tran...

journal_title：Journal of cellular biochemistry

authors： Whitfield GK,Jurutka PW,Haussler CA,Haussler MR

更新日期：1999-01-01 00:00:00

abstract：:c-fos gene has a close relationship with the osteoblasts. Mechanical signal effect on osteoblasts would change the expression level of c-fos. Authors introduce the signal pathways of four cis-response elements on the promoter of c-fos, that is, CRE (cAMP responsive element), FAP-1 (Fbs-AP-1 site), SRE (serum response ...

journal_title：Journal of cellular biochemistry

authors： He H,Ping F

更新日期：2009-04-01 00:00:00

abstract：:We recently reported (Larsson and Nemere [2003]: Endocrinology 144:1726) the effects of growth and maturation on 1,25(OH)2D3-membrane initiated effects in the intestine of male chickens. Here we extend our observations to studies on females with two stages of high calcium demand: growth (7-14 weeks) and egg laying (28...

journal_title：Journal of cellular biochemistry

authors： Larsson B,Nemere I

更新日期：2003-12-01 00:00:00

abstract：:We have compared the cytotoxic/cytostatic responses of the SKW6.4 lymphoblastoid B-cells to the alkylating agent chlorambucil, the purine analog fludarabine, the non-genotoxic activator of the p53 pathway, Nutlin-3, used alone or in association with the death-inducing ligand recombinant TRAIL. Exposure to chlorambucil...

journal_title：Journal of cellular biochemistry

authors： Barbarotto E,Corallini F,Rimondi E,Fadda R,Mischiati C,Grill V,Vaccarezza M,Celeghini C

更新日期：2008-05-15 00:00:00

abstract：:It has been reported that the antitumor drug doxorubicin (Dox) exerts its toxic effects via GATA-4 depletion and that over-expression of GATA-4 reverses Dox-induced toxicity and apoptosis; however, the precise mechanisms remain unclear. In this study, we observed, for the first time, that EGF protects cells against Do...

journal_title：Journal of cellular biochemistry

authors： Yao CX,Shi JC,Ma CX,Xiong CJ,Song YL,Zhang SF,Zhang SF,Zang MX,Xue LX

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Dysfunction of the peritoneum as a dialysis organ may result from progressive membrane injury on peritoneal dialysis (PD). It has been increasingly recognized that the human peritoneal mesothelial cells (HPMCs) play a key role in peritoneal membrane early injury. Recently, it has been reported that bioincomp...

journal_title：Journal of cellular biochemistry

authors： Zhu N,Gu L,Jia J,Wang X,Wang L,Yang M,Yuan W

更新日期：2019-03-01 00:00:00

abstract：:Previously, we have reported that inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels by glibenclamide induced intracellular Ca2+ release from IP(3)-sensitive stores and apoptosis in HepG2 human hepatoblastoma cells (Kim JA, Kang YS, Lee SH, Lee EH, Yoo BH, Lee YS. 1999. Biochem Bioph...

journal_title：Journal of cellular biochemistry

authors： Kim JA,Kang YS,Lee SH,Lee EH,Lee YS

更新日期：2001-01-01 00:00:00

abstract：:Chondrocyte differentiation is a fundamental process during endochondral ossification. Several factors regulate maturation via the activity of downstream signaling pathways that target specific transcription factors and regulate chondrocyte-specific genes. In this study, we investigated the mechanisms involved in the ...

journal_title：Journal of cellular biochemistry

authors： Drissi MH,Li X,Sheu TJ,Zuscik MJ,Schwarz EM,Puzas JE,Rosier RN,O'Keefe RJ

更新日期：2003-12-15 00:00:00

abstract：:Lysophosphatidic acid (LPA) elicits diverse cellular responses through cell surface LPA receptors in nervous system-derived cells and cell lines. The developing nervous system is one of the major loci for LPA receptor expression. Recent studies have also revealed that metabolic pathways of LPA are present in the nervo...

journal_title：Journal of cellular biochemistry

authors： Fukushima N

更新日期：2004-08-01 00:00:00

abstract：:Cancer stem cells (CSCs) are tumoral cells which have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. In the last 10 years the pathological meaning and the existence of CSCs have been matter of discussion and a large number of articles have been published abo...

journal_title：Journal of cellular biochemistry

authors： Graziano A,d'Aquino R,Tirino V,Desiderio V,Rossi A,Pirozzi G

更新日期：2008-02-01 00:00:00

abstract：:Mouse strains which develop tumors at a high incidence with characteristics very similar to human cancers have been derived over the last 8 years. The tumors are caused by defined genetic alterations in the mouse genome. Three areas of research have contributed to the derivation of these mouse strains: (1) Molecular a...

journal_title：Journal of cellular biochemistry

authors： Groner B

更新日期：1992-06-01 00:00:00

abstract：:The examination of scaffold attachment factor B1 (SAFB1) and its multiple functions and tasks in cellular processes provides insight into its role in diseases, such as cancer. SAFB1 is a large multi-domain protein with well-described functions in transcriptional repression, and RNA splicing. It is ubiquitously express...

journal_title：Journal of cellular biochemistry

authors： Garee JP,Oesterreich S

更新日期：2010-02-01 00:00:00

abstract：:Monoclonal antibodies that bind a large molecular weight plasma membrane protein of Acanthamoeba castellanii cause the cells to differentiate. A different monoclonal antibody that binds specifically to the major plasma membrane protein has no effect upon cell division or differentiation. The induction of differentiati...

journal_title：Journal of cellular biochemistry

authors： Villemez CL,Carlo PL,Russell MA

更新日期：1985-01-01 00:00:00

abstract：:The cellular basis of metastasis is poorly understood. An important step to understanding this process is to be able to visualize the routes by which cancer cells migrate from the primary tumor to various distant sites to eventually form metastasis. Our laboratory previously developed single-cell in vivo imaging using...

journal_title：Journal of cellular biochemistry

authors： Zhang Y,Wang X,Hoffman RM,Seki N

更新日期：2016-04-01 00:00:00

abstract：:As a microaerobe, Helicobacter pylori employs the global regulator SpoT for defending against oxidative stress in vitro. However, the mechanisms how SpoT affects bacterial gene expression is still unknown. Moreover, the function of SpoT in H. pylori colonization in the host is remaining undetermined. To explore the fu...

journal_title：Journal of cellular biochemistry

authors： Sun Y,Li X,Li W,Zhao M,Wang L,Liu S,Zeng J,Liu Z,Jia J

更新日期：2012-11-01 00:00:00

abstract：:The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Judged by the inhibiting effect of wortmannin, phosphatidyl-inositol-3 (PI-3) kinases such as DNA-dependent protein kina...

journal_title：Journal of cellular biochemistry

authors： Solhaug A,Refsnes M,Holme JA

更新日期：2004-12-15 00:00:00

abstract：:Although several studies have shown that an induction of insulin-like growth factor (IGF) components occurs during hyperoxia-mediated lung injury, the role of these components in tissue repair is not well known. The present study aimed to elucidate the role of IGF system components in normal tissue remodeling. We used...

journal_title：Journal of cellular biochemistry

authors： Narasaraju TA,Chen H,Weng T,Bhaskaran M,Jin N,Chen J,Chen Z,Chinoy MR,Liu L

更新日期：2006-04-01 00:00:00