Clinical Features of CADASIL.

abstract：:In a placebo-controlled double-blinded study, the effect of 8 weeks of grape juice was compared to the effect of isocaloric placebo juice. Volunteers with a systolic blood pressure > 130 mmHg and diastolic blood pressure > 90 mmHg were recruited. A total of 40 healthy subjects were randomized to receive isocaloric jui...

journal_title：Annals of the New York Academy of Sciences

authors： Park YK,Lee SH,Park E,Kim JS,Kang MH

更新日期：2009-08-01 00:00:00

abstract：:An inactive form of erythrocyte CA I was found in patients with primary aldosteronism. The levels of CA I in the patients were within the normal range: however, the specific esterase activity of CA I from three patients was in the range of 0.12-0.26 u/mg CA I (normal control: 0.66 +/- 0.1 u/mg CA I). In one subject, w...

journal_title：Annals of the New York Academy of Sciences

authors： Kondo T,Taniguchi N,Hirano T,Kawakami Y

更新日期：1984-01-01 00:00:00

abstract：:Autophagy is a phylogenetically conserved process that plays a critical role in the degradation of oxidatively damaged proteins and organelle turnover. The role of oxidative stress and apoptosis in methamphetamine (METH)-induced neurotoxicity is well known; however, the potential contribution of autophagy to METH-indu...

journal_title：Annals of the New York Academy of Sciences

authors： Kanthasamy A,Anantharam V,Ali SF,Kanthasamy AG

更新日期：2006-08-01 00:00:00

abstract：:The presence of R. prowazekii in lice using R. prowazekii-specific qPCR cassettes showed the changes of the rickettsial burden in the lice post-infection. ...

journal_title：Annals of the New York Academy of Sciences

authors： Rozmajzl PJ,Houhamdi L,Jiang J,Raoult D,Richards AL

更新日期：2006-10-01 00:00:00

abstract：:Little is known about how mitogenic factors generate growth regulatory signals and how these are mediated within the cell. We have developed three different types of mitogenic stimuli in order to identify the possible existence of common denominators in a complex and perhaps pleiotypic signal-response system. 3T3 cell...

journal_title：Annals of the New York Academy of Sciences

authors： Zetterberg A,Engström W,Larsson O

更新日期：1982-12-10 00:00:00

abstract：:As the second synapse in the central gustatory pathway of the rodent, the parabrachial nucleus of the pons (PbN) receives information about taste stimuli directly from the nucleus of the solitary tract (NTS). Data show that NTS cells amplify taste responses before transmitting taste-related signals to the PbN. NTS cel...

journal_title：Annals of the New York Academy of Sciences

authors： Di Lorenzo PM,Platt D,Victor JD

更新日期：2009-07-01 00:00:00

abstract：:We have previously shown that bone marrow will seed and proliferate in normal recipients. Transfusion of 50 million cells on each of 4 or 5 consecutive days, a total of 200-250 million cells, resulted in the recipient's marrow being 20-40% of donor origin. The present paper reported on the marked enhancement of prolif...

journal_title：Annals of the New York Academy of Sciences

authors： Brecher G,Mulcahy K,Tjio JH,Raveché E

更新日期：1985-01-01 00:00:00

abstract：:Mitochondria display considerable structural diversity particularly in terms of the folding of the energy-transducing inner membrane. The hypothesis is forwarded that the topology of the mitochondrial inner membrane is not random but rather is a regulated cell parameter. Its effects on internal diffusion of metabolite...

journal_title：Annals of the New York Academy of Sciences

authors： Mannella CA

更新日期：2008-12-01 00:00:00

abstract：:Reports on patients with hemiparalysis indicate the importance of the nervous system for the pathophysiology of rheumatoid arthritis (RA) or osteoarthritis (OA). Norepinephrine (NE) and opioids seem to be more antiinflammatory neurotransmitters whereas substance P is proinflammatory. The study aimed to investigate the...

journal_title：Annals of the New York Academy of Sciences

authors： Miller LE,Wessinghage D,Müller-Ladner U,Schölmerich J,Falk W,Kerner T,Straub RH

更新日期：1999-06-22 00:00:00

abstract：:Sleep deprivation severely compromises the ability of human beings to respond to stimuli in a timely fashion. These deficits have been attributed in large part to failures of vigilant attention, which many theorists believe forms the bedrock of the other more complex components of cognition. One of the leading paradig...

journal_title：Annals of the New York Academy of Sciences

authors： Lim J,Dinges DF

更新日期：2008-01-01 00:00:00

abstract：:Nanomedicine is the application of nanotechnology to the discipline of medicine: the use of nanoscale materials for the diagnosis, monitoring, control, prevention, and treatment of disease. Nanomedicine holds tremendous promise to revolutionize medicine across disciplines and specialties, but this promise has yet to b...

journal_title：Annals of the New York Academy of Sciences

authors： Tinkle S,McNeil SE,Mühlebach S,Bawa R,Borchard G,Barenholz YC,Tamarkin L,Desai N

更新日期：2014-04-01 00:00:00

abstract：:The intracellular bacterium, Ehrlichia ruminantium, is the causative agent of heartwater, a tick-borne disease of livestock. Because vaccines need to incorporate components from several virulent isolates, it is essential to have information on the extent of genetic variation among isolates. We therefore amplified and ...

journal_title：Annals of the New York Academy of Sciences

authors： Allsopp M,Steyn H,Zweygarth E,Allsopp B

更新日期：2005-12-01 00:00:00

abstract：:MRI is a robust technology that allows for superior contrast of muscles, tissues, and bones within the body, which enables visualization of soft tissue pathology that cannot be seen with CT or plain film radiography. In order to appreciate the subtle (and sometimes not so subtle) intricacies of MRI, one must have a ba...

journal_title：Annals of the New York Academy of Sciences

authors： Khanna S,Crues JV 3rd

更新日期：2009-02-01 00:00:00

abstract：:Phagocytes play a major role in several diseases. In particular mononuclear phagocyte-derived foam cells have a prominent role in the development of the atherosclerotic lesions. Macrophages are present in all stages of atherogenesis; they internalize lipoproteins and accumulate cholesterol. Moreover, lipid-filled macr...

journal_title：Annals of the New York Academy of Sciences

authors： Paoletti R,Bellosta S,Bernini F

更新日期：1997-12-15 00:00:00

abstract：:In this paper, we consider minimizing the action functional as a method for numerically discovering periodic solutions to the n-body problem. With this method, we can find a large number of choreographies and other more general solutions. We show that most of the solutions found, including all but one of the choreogra...

journal_title：Annals of the New York Academy of Sciences

authors： Vanderbei RJ

更新日期：2004-05-01 00:00:00

abstract：:Nervous systems of helminths are highly peptidergic. Species in the phylum Nematoda (roundworms) possess at least 50 FMRFamide-related peptides (FaRPs), with more yet to be identified. To date, few non-FaRP neuropeptides have been identified in these organisms, though evidence suggests that other families are present....

journal_title：Annals of the New York Academy of Sciences

authors： Geary TG,Marks NJ,Maule AG,Bowman JW,Alexander-Bowman SJ,Day TA,Larsen MJ,Kubiak TM,Davis JP,Thompson DP

更新日期：1999-01-01 00:00:00

abstract：:The signal peptidases from both chicken oviduct and dog pancreas microsomes have been detected by a post-translational assay and, in the case of dog microsomes, by a cotranslational assay. This proteolytic activity is not sensitive to a variety of conventional protease inhibitors under the conditions used in these ass...

journal_title：Annals of the New York Academy of Sciences

authors： Thibodeau SN,Walsh KA

更新日期：1980-01-01 00:00:00

abstract：:As studied by single cell RT-PCR of pituitary hormones, we demonstrated that the pituitaries of rats and mice contain a subpopulation of cells that express two or more hormone phenotypes typically belonging to lineages that are branched separately early during embryonic development, such as glycoprotein hormone alpha-...

journal_title：Annals of the New York Academy of Sciences

authors： Denef C,Pals K,Hauspie A,Vankelecom H,Seuntjens E

更新日期：2005-04-01 00:00:00

abstract：:The strategy of antigenic variation is to present a constantly changing population phenotype that enhances parasite transmission, through evasion of immunity arising within, or existing between, host animals. Trypanosome antigenic variation occurs through spontaneous switching among members of a silent archive of many...

journal_title：Annals of the New York Academy of Sciences

authors： Barry JD,Hall JP,Plenderleith L

更新日期：2012-09-01 00:00:00

abstract：:Auditory stimulation via rhythmic cues can be used successfully in the rehabilitation of motor function in patients with motor disorders. A prototypical example is provided by dysfunctional gait in patients with idiopathic Parkinson's disease (PD). Coupling steps to external rhythmic cues (the beat of music or the sou...

journal_title：Annals of the New York Academy of Sciences

authors： Bella SD,Benoit CE,Farrugia N,Schwartze M,Kotz SA

更新日期：2015-03-01 00:00:00

abstract：:Mitochondrial dysfunction is a common characteristic of all neurodegenerative diseases. However, the cause of this dysfunction remains a mystery. Here, we discuss the potential role of mitochondrial fission and fusion in the onset and progression of neurodegenerative diseases. Specifically, we propose that an imbalanc...

journal_title：Annals of the New York Academy of Sciences

authors： Knott AB,Bossy-Wetzel E

更新日期：2008-12-01 00:00:00

abstract：:A rabbit antimouse brain theta reagent was made specific for cells of the T lineage by absorption in vivo in nude mice. When used in double fluorescence together with an antimouse immunoglobulin reagent, four types of cells were found in spleen and lymph nodes of both normal and nude mice: Ig+thetaBr-, Ig-thetaBr+, Ig...

journal_title：Annals of the New York Academy of Sciences

authors： Loor F,Roelants GE

更新日期：1975-06-30 00:00:00

abstract：:Liquid diffusion experiments conducted on the MIR space station using the Canadian Space Agency QUELD II processing facility and the microgravity isolation mount (MIM) showed that g-jitter significantly increased the measured solute diffusion coefficients. In some experiments, milli-g forced vibration was superimposed...

journal_title：Annals of the New York Academy of Sciences

authors： Smith RW,Yang BJ,Huang WD

更新日期：2004-11-01 00:00:00

abstract：:Cardiomyocytes in the adult mammal retain little or none of their developmental capacity for hyperplastic growth. As a consequence of this differentiated, nonproliferative phenotype, cardiomyocyte loss due to injury or disease is irreversible. Therapeutic intervention in end-stage diseased hearts is currently limited ...

journal_title：Annals of the New York Academy of Sciences

authors： Soonpaa MH,Daud AI,Koh GY,Klug MG,Kim KK,Wang H,Field LJ

更新日期：1995-03-27 00:00:00

abstract：:A cardinal feature of neurons is the morphological polarity of neurons with serious functional implications. Typically, a neuron has a single axon and several dendrites. Neuronal polarity is essential for the unidirectional signal flow from somata or dendrites to axons in neurons. The initial event in establishing a p...

journal_title：Annals of the New York Academy of Sciences

authors： Yoshimura T,Arimura N,Kaibuchi K

更新日期：2006-11-01 00:00:00

abstract：:This study explores the mechanisms dominating the regulation of the biochemical energy consumption and the mechanical output of the actin-myosin motor units, the crossbridges (Xbs), in the cardiac sarcomere. Our analytical model, which couples Xbs cycling dynamics with the kinetics of the free Ca(2+) binding to tropon...

journal_title：Annals of the New York Academy of Sciences

authors： Landesberg A,Levy C,Yaniv Y,Sideman S

更新日期：2004-05-01 00:00:00

abstract：:The expression of beta2-adrenergic receptors (beta2-R) on B lymphocytes and agonist-induced cAMP production is reduced in patients with rheumatoid arthritis (RA). To further study functional consequences of the diminished beta2-R density on B lymphocytes in RA patients, agonist-induced cell death was evaluated and com...

journal_title：Annals of the New York Academy of Sciences

authors： Wahle M,Pierer M,Krause A,Kolker S,Baerwald CG

更新日期：2002-06-01 00:00:00

abstract：:The aim of this study was to investigate the influence of long-lasting, extensive rowing training on body fluids in 12 experienced rowers (23.3 +/- 6.3 years, 188.7 +/- 5.9 cm, 82.0 +/- 10.8 kg, body mass index [BMI] 23.7 +/- 2.1). All rowers had a light traditional breakfast about 3 h before the training. The subject...

journal_title：Annals of the New York Academy of Sciences

authors： Jürimäe J,Jürimäe T,Pihl E

更新日期：2000-05-01 00:00:00

abstract：:Anatomic and electrophysiologic studies have provided evidence that CRF meets some of the criteria as a neurotransmitter in the noradrenergic nucleus, the locus coeruleus (LC), although some of the criteria have yet to be satisfied. Thus, immunohistochemical findings suggest that CRF innervates the LC, but this must b...

journal_title：Annals of the New York Academy of Sciences

authors： Valentino RJ,Foote SL,Page ME

更新日期：1993-10-29 00:00:00

abstract：:Genes play a major role in behavioral adaptation to challenging environmental stimuli, but the complexity of their contribution remains unclear. There is growing evidence linking disease phenotypes with genes on the one hand, and the genesis of stress-related disorders like major depression, as a result of exposure to...

journal_title：Annals of the New York Academy of Sciences

authors： Jabbi M,Korf J,Ormel J,Kema IP,den Boer JA

更新日期：2008-12-01 00:00:00