Delayed maturation of interstitial cells of Cajal in meconium obstruction.

Abstract:

BACKGROUND/PURPOSE:The etiology of meconium obstruction without cystic fibrosis is unclear. Interstitial cells of Cajal (ICC) function as pacemakers in gut motility and may play a role in the pathophysiology of the disease. METHODS:The ICC were examined by immunohistochemical staining with anti-c-kit antibody in the bowel walls of 6 neonates who had meconium obstruction without cystic fibrosis, and the results were compared with specimens from normal neonates (n = 2). RESULTS:Six patients underwent ileostomy between 2 and 15 days after birth, and 5 of them presented with microcolon. Ganglion cells were present in the ileum and colon. Whereas ICC were evenly distributed in the control specimens, they were not seen at the time of ileostomy in the colons of 2 patients, and the other 4 showed scanty distribution in muscle layers. However, ileum showed normal distribution of ICC in all patients. The ileostomies were closed between 39 and 104 days of age, and the ICC distribution was changed to a normal pattern in the colons of all 6 patients. Their bowel movements were restored to normal after closure. CONCLUSION:The findings of this study suggest that delayed maturity of ICC may be a cause of meconium obstruction without cystic fibrosis.

journal_name

J Pediatr Surg

authors

Yoo SY,Jung SH,Eom M,Kim IH,Han A

doi

10.1053/jpsu.2002.36715

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

1758-61

issue

12

eissn

0022-3468

issn

1531-5037

pii

S0022346802003160

journal_volume

37

pub_type

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