Increased in vitro cytotoxicity of TNF-alpha analog LK-805 is based on the interaction with cell surface heparan sulfate proteoglycan.

abstract：:The investigations with the NZB X SWR model show that the development of systemic autoimmune disease is a multistep, multigene process. Severe lupus nephritis in the NZB X SWR hybrids results from the interaction of genes inherited from both the autoimmune NZB and the normal SWR parents. A similar genetic interaction ...

journal_title：Annals of the New York Academy of Sciences

authors： Datta SK,Gavalchin J

更新日期：1986-01-01 00:00:00

abstract：:Insulin therapy is often necessary for glycemic control, and its effect on plasma lipids is an important issue with respect to arteriosclerosis. Previous reports suggested that increased cholesteryl ester transfer protein (CETP) appeared in diabetic patients with hyperinsulinemia or given a lot of insulin is atherogen...

journal_title：Annals of the New York Academy of Sciences

authors： Ai M,Tanaka A,Baba T,Yui K,Numano F

更新日期：2001-12-01 00:00:00

abstract：:Gastrointestinal peptides play important roles regulating feeding and energy homeostasis. Most gastrointestinal peptides including glucagon like peptide-1, peptide YY, amylin, and oxytomodulin are anorectic, and only ghrelin is an orexigenic peptide. Ghrelin increases appetite, modulates energy balance, suppresses inf...

journal_title：Annals of the New York Academy of Sciences

authors： Ueno H,Shiiya T,Nakazato M

更新日期：2010-07-01 00:00:00

abstract：:The endometrium acquires the ability to implant the developing embryo within a specific time window, termed the "receptive phase." During this period, the endometrium undergoes pronounced structural and functional changes induced by the ovarian steroids, estrogen and progesterone, which prepare it to be receptive to i...

journal_title：Annals of the New York Academy of Sciences

authors： Bagchi IC,Li Q,Cheon YP

更新日期：2001-09-01 00:00:00

abstract：:Myasthenia gravis (MG) is usually caused by autoantibodies against muscle nicotinic acetylcholine receptor (AChR), which is composed of five subunits (alpha(2)betagammadelta or alpha(2)betaepsilondelta). Current treatments, including plasmapheresis, are nonspecific, causing several side effects. We aim to develop an a...

journal_title：Annals of the New York Academy of Sciences

authors： Tzartos SJ,Bitzopoulou K,Gavra I,Kordas G,Jacobson L,Kostelidou K,Lagoumintzis G,Lazos O,Poulas K,Sideris S,Sotiriadis A,Trakas N,Zisimopoulou P

更新日期：2008-01-01 00:00:00

abstract：:The aim of this retrospective study is to assess the frequency of HLA-B27 and HLA-B51 in healthy subjects from the center of Tunisia and to investigate their usefulness in the diagnosis of ankylosing spondylitis (AS) and Behçet's disease (BD), respectively. Microlymphocytotoxicity test was used to perform serologic HL...

journal_title：Annals of the New York Academy of Sciences

authors： Sakly N,Boumiza R,Zrour-Hassen S,Hamzaoui A,Ben Yahia S,Amara H,Khairallah M,Mahjoub S,Bergaoui N,Ghedira I

更新日期：2009-09-01 00:00:00

abstract：:The Cape Town Case Study (CTCS) was a multi-institutional collaborative project initiated by CUBES, a knowledge networking initiative of UNESCO's Ecological Sciences Division and the Earth Institute at Columbia University. Cape Town was selected as a CUBES site on the basis of its high biological and cultural signific...

journal_title：Annals of the New York Academy of Sciences

authors： Stanvliet R,Jackson J,Davis G,De Swardt C,Mokhoele J,Thom Q,Lane BD

更新日期：2004-06-01 00:00:00

abstract：:We have studied the developmental patterns of vasoactive intestinal polypeptide (VIP) binding sites in the human hypothalamus. VIP recognition sites were widely distributed throughout the rostrocaudal extent of the hypothalamus. VIP binding was generally low in the fetal and neonatal periods and a tendency in increasi...

journal_title：Annals of the New York Academy of Sciences

authors： Najimi M,Rachidi F,Afif A,Chigr F

更新日期：2006-07-01 00:00:00

abstract：:Dr. Josep Font (Barcelona, 1953-2006) devoted his professional career to the care of patients with systemic autoimmune diseases (SAD). In 1995, he created the Department of Autoimmune Diseases at the Hospital Clinic in Barcelona, a pioneering unit in Europe specifically dedicated to the clinical management of these pa...

journal_title：Annals of the New York Academy of Sciences

authors： Ramos-Casals M,Khamashta MA

更新日期：2007-06-01 00:00:00

abstract：:The effects of rhythmic auditory stimulation (RAS) on gait in adolescents with acquired brain injury (ABI) were investigated. A total of 14 adolescents with ABI were initially recruited, and 12 were included in the final analysis (n = 6 each). They were randomly assigned to the experimental (RAS) or the control (conve...

journal_title：Annals of the New York Academy of Sciences

authors： Kim SJ,Shin YK,Yoo GE,Chong HJ,Cho SR

更新日期：2016-12-01 00:00:00

abstract：:Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder of the neuromuscular synapse. About half of LEMS patients have an associated small cell lung carcinoma (SCLC), which is usually detected after diagnosis of LEMS. This short review summarizes clinical and serological markers shown to predict the presenc...

journal_title：Annals of the New York Academy of Sciences

authors： Lipka AF,Verschuuren JJ,Titulaer MJ

更新日期：2012-12-01 00:00:00

abstract：:The presence in the serum of specific autoantibodies, such as antinuclear antibodies (ANA), anti-double-stranded DNA (anti-dsDNA), and antiextractable nuclear antigens (anti-ENA), is one of the diagnostic criteria for autoimmune rheumatic disease, and the requests for these tests in the last few years have grown remar...

journal_title：Annals of the New York Academy of Sciences

authors： Bonaguri C,Melegari A,Dall'Aglio P,Ballabio A,Terenziani P,Russo A,Battistelli L,Aloe R,Camisa R,Campaniello G,Sartori E,Monica C

更新日期：2009-09-01 00:00:00

abstract：:The effects of TCDD exposure on the developing immune system were investigated in Wistar/Fischer hybrid or Fischer rats. Fetal and neonatal rats were exposed to TCDD through maternal dosing (5 muk/kg) on day 18 of gestation and on days 0, 7, and 14 of postnatal life (group 1). Another group of neonatal rats was expose...

journal_title：Annals of the New York Academy of Sciences

authors： Luster MI,Faith RE,Clark G

更新日期：1979-05-31 00:00:00

abstract：:Two major methodological problems that impact clinical research in endometriosis are the absence of a low-cost, highly reliable method for diagnosing endometriosis and the possibility that endometriosis is actually multiple different diseases that we have not yet been able to differentiate. Animal models of endometrio...

journal_title：Annals of the New York Academy of Sciences

authors： Barbieri RL,Missmer S

更新日期：2002-03-01 00:00:00

abstract：:Chlorine (Cl2 ) and bromine (Br2 ) are produced in large quantities throughout the world and used in the industry and the sanitation of water. These halogens can pose a significant threat to public health when released into the atmosphere during transportation and industrial accidents, or as acts of terrorism. In this...

journal_title：Annals of the New York Academy of Sciences

authors： Lazrak A,Song W,Zhou T,Aggarwal S,Jilling T,Garantziotis S,Matalon S

更新日期：2020-11-01 00:00:00

abstract：:Blood-borne beta-amyloids (A beta s) could affect brain function by (1) crossing the BBB to directly interact with brain tissues or (2) altering BBB function by interacting with the brain capillaries that make up the BBB. Several radioactively labeled A beta s have been examined for such interactions. Blood-borne A be...

journal_title：Annals of the New York Academy of Sciences

authors： Banks WA,Kastin AJ,Maness LM,Banks MF,Shayo M,McLay RN

更新日期：1997-09-26 00:00:00

abstract：:(a) The PR elicited by excitotoxic destruction of intrinsic neurons in the CN has a rapid onset, peaks within 2 weeks, and persists indefinitely; (b) the majority of the proliferating cells are not intrinsic to the CNS but are of hematic origin; (c) a small mirror-image response is seen in the contralateral CN; (d) th...

journal_title：Annals of the New York Academy of Sciences

authors： Katz IR,Iacovitti L,Reis DJ

更新日期：1988-01-01 00:00:00

abstract：:Pain is a subjective symptom whose prevalence can be grossly underestimated. The high proportion of adults with thalassemia who experience chronic pain is evident from recent surveys. However, pain has not received enough attention in the overall management of thalassemia. The association of pain with the type and tre...

journal_title：Annals of the New York Academy of Sciences

authors： Lal A

更新日期：2016-03-01 00:00:00

abstract：:This paper reports CFD-simulations of the turbulent flow, pressure loss and heat transfer occurring in ribbed passages. The channel section is rectangular, with an aspect ratio of 2.04. Ribs are square cross-section, their height is 10% of the channel height, and their inclination is varied from 90 degrees to 33 degre...

journal_title：Annals of the New York Academy of Sciences

authors： Hermanson K,Parneix S,von Wolfersdorf J,Semmler K

更新日期：2001-05-01 00:00:00

abstract：:Age-associated alterations in the mitochondrial electron transport system (ETS) may lead to free radical generation and contribute to aging. The complexes of the ETS were screened spectrophotometrically in gastrocnemius of young (10 month) as well as older (20 and 26 month) B6C3F1 female mice fed an ad libitum (AL) di...

journal_title：Annals of the New York Academy of Sciences

authors： Feuers RJ

更新日期：1998-11-20 00:00:00

abstract：:Internuclear ophthalmoparesis (INO) is the most common saccadic eye movement disorder observed in patients with multiple sclerosis (MS). It is characterized by slowing of the adducting eye during horizontal saccades, and most commonly results from a demyelinating lesion in the medial longitudinal fasciculus (MLF) with...

journal_title：Annals of the New York Academy of Sciences

authors： Frohman TC,Davis SL,Frohman EM

更新日期：2011-09-01 00:00:00

abstract：:Disorders of sexual differentiation (DSDs) presenting during adolescence are discussed, and molecular explanations are given for some. DSD conditions are often discovered during early adolescence, an age well known to predispose to high risk for adjustment problems. Presentation may be with lack of or minimal pubertal...

journal_title：Annals of the New York Academy of Sciences

authors： Lee PA,Houk CP

更新日期：2008-01-01 00:00:00

abstract：:There has been renewed interest in the role of strategies in sensorimotor learning. The combination of new behavioral methods and computational methods has begun to unravel the interaction between processes related to strategic control and processes related to motor adaptation. These processes may operate on very diff...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor JA,Ivry RB

更新日期：2012-03-01 00:00:00

abstract：:Four weeks immobilization of the right leg of aged rats (26 months old) caused a marked 31% and 27% reduction of muscle mass of the plantaris and soleus muscles, respectively. In animals treated with 0.6 mg/kg body weight of growth hormone (GH), the reduction of weight of the above muscles was only 14.7 and 16.1%, res...

journal_title：Annals of the New York Academy of Sciences

authors： Fares FA,Gruener N,Carmeli E,Reznick AZ

更新日期：1996-06-15 00:00:00

abstract：:Platelets play important roles for hemostasis with activated platelets adhering to the injured vessel wall to initiate platelet aggregation. At the same time, our study revealed the cytotoxic effect on endothelial cells characterized by an increase of intracellular Ca++ and a decrease of EDRF production, which may cau...

journal_title：Annals of the New York Academy of Sciences

authors： Numano F,Kishi Y,Ashikaga T,Hata A,Makita T,Watanabe R

更新日期：1995-01-17 00:00:00

abstract：:Information from the vestibular nuclei ascending through the brainstem to the oculomotor and trochlear nuclei (NIII, NIV), the interstitial nucleus of Cajal (INC), the pretectum, or thalamus, is thought to be distributed in at least five different pathways. They include the medial longitudinal fasciculus (MLF), the as...

journal_title：Annals of the New York Academy of Sciences

authors： Zwergal A,Strupp M,Brandt T,Büttner-Ennever JA

更新日期：2009-05-01 00:00:00

abstract：:Pharmacological actions of methamphetamine (METH) and phencyclidine (PCP) are different, but both of them can induce similar psychiatric disorders including abuse, intoxication, withdrawal, and psychotic symptoms like those of schizophrenia. These mental disorders are caused not only by their direct pharmacological ef...

journal_title：Annals of the New York Academy of Sciences

authors： Ouchi Y,Kubota Y,Ito C

更新日期：2004-10-01 00:00:00

abstract：:To evaluate the effect of Lactobacillus casei on the effectiveness of the Mexican bovine babesiosis mixed vaccine, 20 bovines were randomly allocated into four groups of five animals (I, II, III, and IV). At day -2 animals in groups I and II were inoculated with saline solution by intramuscular route (i.m.) and animal...

journal_title：Annals of the New York Academy of Sciences

authors： Bautista CR,Alvarez JA,Mosqueda JJ,Falcon A,Ramos JA,Rojas C,Figueroa JV,Ku M

更新日期：2008-12-01 00:00:00

abstract：:Long-term repopulating hematopoietic stem cells can be separated from cells which provided radioprotection (short-term repopulating cells) on the basis of size. This might be a result of the quiescent nature of long-term repopulating cells. To define the activity of these populations we utilized a dye, PKH26, which in...

journal_title：Annals of the New York Academy of Sciences

authors： Lanzkron SM,Collector MI,Sharkis SJ

更新日期：1999-04-30 00:00:00

abstract：:Efficient conservation management is particularly important because current spending is estimated to be insufficient to conserve the world's biodiversity. However, efficient management is confounded by uncertainty that pervades conservation management decisions. Uncertainties exist in objectives, dynamics of systems, ...

journal_title：Annals of the New York Academy of Sciences

authors： McCarthy MA

更新日期：2014-08-01 00:00:00