A comparison of protoporphyrin IX and protoporphyrin IX dimethyl ester as a photosensitizer in poorly differentiated human nasopharyngeal carcinoma cells.

Abstract:

:Protoporphyrin IX dimethyl ester (PME), a dimethyl esterification of protoporphyrin IX (PpIX), exhibits higher intracellular uptake into NPC/CNE2 cells, a poorly differentiated human nasopharyngeal carcinoma, than does PpIX. Phototoxicity studies reveal PME to be a more potent photosensitizer than is PpIX, at the early and late incubation time points. Correlating phototoxicity with subcellular localization indicates that PME is a more potent photosensitizer when its primary target of photodamage is mitochondria. Also, additional targeting of lysosome enhances phototoxicity.

journal_name

Photochem Photobiol

authors

Yee KK,Soo KC,Bay BH,Olivo M

doi

10.1562/0031-8655(2002)076<0678:acopia>2.0.co;2

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

678-82

issue

6

eissn

0031-8655

issn

1751-1097

journal_volume

76

pub_type

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