Abstract:
:Protoporphyrin IX dimethyl ester (PME), a dimethyl esterification of protoporphyrin IX (PpIX), exhibits higher intracellular uptake into NPC/CNE2 cells, a poorly differentiated human nasopharyngeal carcinoma, than does PpIX. Phototoxicity studies reveal PME to be a more potent photosensitizer than is PpIX, at the early and late incubation time points. Correlating phototoxicity with subcellular localization indicates that PME is a more potent photosensitizer when its primary target of photodamage is mitochondria. Also, additional targeting of lysosome enhances phototoxicity.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Yee KK,Soo KC,Bay BH,Olivo Mdoi
10.1562/0031-8655(2002)076<0678:acopia>2.0.co;2subject
Has Abstractpub_date
2002-12-01 00:00:00pages
678-82issue
6eissn
0031-8655issn
1751-1097journal_volume
76pub_type
杂志文章abstract::In this study, we investigated whether the spectrum of p53 mutations in skin tumors induced in hairless SKH-hr1 mice by a solar simulator (290-400 nm) are similar to those found in skin tumors induced in C3H mice by UV radiation from unfiltered (250-400 nm) and Kodacel-filtered (290-400 nm) FS40 sunlamps. Analysis of ...
journal_title:Photochemistry and photobiology
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abstract::Exploration of environmental dynamics using intrinsic biological probe tryptophan is very important; however, it suffers from various difficulties. An alternative probe, kynurenine (KN), has been found to be an efficient probe for the ultrafast dynamics in the biological environment (Goswami et al., [2010] J. Phys. Ch...
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journal_title:Photochemistry and photobiology
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journal_title:Photochemistry and photobiology
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更新日期:1998-04-01 00:00:00
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更新日期:2019-11-01 00:00:00
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