Overview of clinical trials with epidermal growth factor receptor inhibitors in advanced non-small cell lung cancer.

Abstract:

OBJECTIVES:To provide an overview of the clinical development of ZD1839 and other epidermal growth factor receptor (EGFR) inhibitors in the treatment of advanced non-small cell lung cancer (NSCLC). DATA SOURCES:Research articles and abstracts. CONCLUSIONS:Increased understanding of cancer biology has led to the development of multiple targeted agents to evaluate clinically in the treatment of various cancers. The EGFR inhibitors appear promising in the treatment of NSCLC. ZD1839 has shown activity and symptom and quality-of-life improvements in two large phase II trials. Ongoing and future trials will continue to explore the optimal use of ZD1839 and other EGFR inhibitors in the treatment of NSCLC. IMPLICATIONS FOR NURSING PRACTICE:Several investigational EGFR inhibitors are likely to become commercially available over the next few years. Nurses should be knowledgeable regarding these agents to provide appropriate patient and family education and to assure safe drug delivery.

journal_name

Semin Oncol Nurs

authors

Thomas M

doi

10.1053/sonu.2002.37408

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

20-7

issue

4 Suppl 4

eissn

0749-2081

issn

1878-3449

pii

S0749-2081(02)80083-3

journal_volume

18

pub_type

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