Proteomics and systems biology approaches to signal transduction in sepsis.

abstract：:A meta-analysis was performed of 15 randomized studies on the prophylaxis with cimetidine and/or ant-acids of upper GI bleeding acquired in the ICU. There were eight comparisons of a group receiving cimetidine with a control group, nine comparisons of a group receiving antacids with a control group, and ten comparison...

journal_title：Critical care medicine

authors： Lacroix J,Infante-Rivard C,Jenicek M,Gauthier M

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVES:To describe the timing of onset of organ system failure, multiple organ system failure diagnosis, and the subsequent death in children admitted to a pediatric intensive care unit (ICU). Second, to identify independent risk markers of death in pediatric patients with multiple organ system failure. DESIGN:Rev...

journal_title：Critical care medicine

authors： Proulx F,Gauthier M,Nadeau D,Lacroix J,Farrell CA

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine the accuracy of clinical diagnoses compared to autopsy findings in critically ill patients in the current medical era. DESIGN:We conducted a retrospective, blinded review of matched medical records and postmortem findings in patients who died between June 2006 and ...

journal_title：Critical care medicine

authors： Fröhlich S,Ryan O,Murphy N,McCauley N,Crotty T,Ryan D

更新日期：2014-02-01 00:00:00

abstract：:The effect of halothane on electrodes covered with polypropylene and FEP teflon membranes, used for monitoring transcutaneous oxygen tension, was compared in vitro and in patients anesthetized with halothane. In vitro experiments with halothane showed a false increase in PO2 measured by the electrode covered with poly...

journal_title：Critical care medicine

authors： Samra SK

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Increased intracranial pressure (ICP) worsens the outcome of acute liver failure (ALF). This study investigates the underlying pathophysiological mechanisms and evaluates the therapeutic effect of albumin dialysis in ALF with use of the Molecular Adsorbents Recirculating System without hemofiltration/dialysi...

journal_title：Critical care medicine

authors： Sen S,Rose C,Ytrebø LM,Davies NA,Nedredal GI,Drevland SS,Kjønnø M,Prinzen FW,Hodges SJ,Deutz NE,Williams R,Butterworth RF,Revhaug A,Jalan R

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To determine whether continuous gas flow in the breathing circuit or an airleak around the tracheal tube cuff will introduce errors into the measurement of oxygen consumption (VO2) with indirect calorimetry. DESIGN:Nonrandomized, controlled trial. SETTING:Experimental laboratory. SUBJECTS:Ten healthy, anes...

journal_title：Critical care medicine

authors： Räsänen J

更新日期：1992-09-01 00:00:00

abstract：:To further define cardiovascular abnormalities in patients with septic shock, serial conventional hemodynamic measurements combined with two-dimensional echocardiographic studies were performed at the bedside in 21 patients admitted for an acute episode of sepsis-related circulatory failure. Measurements obtained duri...

journal_title：Critical care medicine

authors： Jardin F,Brun-Ney D,Auvert B,Beauchet A,Bourdarias JP

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVES:Recently, recombinant angiotensin-converting enzyme 2 was shown to protect mice from acute lung injury, an effect attributed to reduced bioavailability of angiotensin II. Since angiotensin-converting enzyme 2 metabolizes angiotensin II to angiotensin-(1-7), we hypothesized that this effect is alternatively m...

journal_title：Critical care medicine

authors： Klein N,Gembardt F,Supé S,Kaestle SM,Nickles H,Erfinanda L,Lei X,Yin J,Wang L,Mertens M,Szaszi K,Walther T,Kuebler WM

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:To elucidate sources of variability in the estimate of treatment effects in a successful phase 3 trial in severe sepsis and to assess their implications on the design of future clinical trials. DESIGN:Retrospective evaluation of prospectively defined subgroups from a large phase 3, placebo-controlled clinica...

journal_title：Critical care medicine

authors： Macias WL,Vallet B,Bernard GR,Vincent JL,Laterre PF,Nelson DR,Derchak PA,Dhainaut JF

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND METHODS:This study was designed to test whether dopexamine, a dopaminergic and beta 2-adrenergic agonist, would a) increase systemic oxygen delivery (DO2) in endotoxic dogs, and b) interfere with the ability of resting skeletal muscle to extract oxygen. There were three treatment groups (n = 6 in each gr...

journal_title：Critical care medicine

authors： Bredle DL,Cain SM

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVE:The efficacy of noninvasive mechanical ventilation (NIMV) in improving breathing pattern and arterial blood gases (ABG) in hypercapnic patients has been well documented; however, little attention has been given to the choice of the interface and the ventilatory mode. We evaluated the effects of three types of...

journal_title：Critical care medicine

authors： Navalesi P,Fanfulla F,Frigerio P,Gregoretti C,Nava S

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:We hypothesized that the extent of injury and release of xanthine oxidase, an oxidant generator, into the circulation would be less in normal-flow hypoxia-reoxygenation than in equal duration no-flow ischemia-reperfusion. DESIGN:Randomized study. SETTING:University-based animal research facility. SUBJECTS:...

journal_title：Critical care medicine

authors： Tan S,Yokoyama Y,Wang Z,Zhou F,Nielsen V,Murdoch AD,Adams C,Parks DA

更新日期：1998-06-01 00:00:00

abstract：:A small, double-blind crossover study compared the efficacy of aminophylline and doxapram in ventilator weaning of eight premature infants recovering from respiratory distress syndrome (RDS). Although neither drug was significantly better than the other, four infants were weaned from mechanical ventilation after drug ...

journal_title：Critical care medicine

authors： Eyal FG,Sagi EF,Alpan G,Glick B,Arad I

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:To establish the effect of an audible airleak (around an endotracheal tube) on oxygen consumption (VO2) measurements in pediatric ICU patients. DESIGN:Prospective trial comparing VO2 measurements before and after deflation of the endotracheal tube cuff. SETTING:Pediatric ICU in a large pediatric tertiary ca...

journal_title：Critical care medicine

authors： Chwals WJ,Lally KP,Woolley MM

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:Procalcitonin has been advocated as a specific biomarker for bacterial infection. We performed this study to determine whether accuracy of procalcitonin for diagnosis of postoperative bacterial infection is affected by renal function after aortic surgery. DESIGN:Single-center prospective study. SETTING:Univ...

journal_title：Critical care medicine

authors： Amour J,Birenbaum A,Langeron O,Le Manach Y,Bertrand M,Coriat P,Riou B,Bernard M,Hausfater P

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE AND DESIGN:To review and discuss selected literature, expert opinion, and conventional care of the hyperglycemic perioperative or critically ill patient. MAIN POINTS:Diabetes mellitus, the most commonly encountered perioperative endocrinopathy, continues to increase dramatically in prevalence. Diabetes is th...

journal_title：Critical care medicine

authors： Coursin DB,Connery LE,Ketzler JT

更新日期：2004-04-01 00:00:00

abstract：:A patient with neurogenic pulmonary edema was successfully treated with the alpha-blocking agent, chlorpromazine. A pathophysiologic basis for this drug's efficacy is discussed. ...

journal_title：Critical care medicine

authors： Wohns RN,Tamas L,Pierce KR,Howe JF

更新日期：1985-03-01 00:00:00

abstract：OBJECTIVES:Regional tidal lung strain may trigger local inflammation during mechanical ventilation, particularly when additional inflammatory stimuli are present. However, it is unclear whether inflammation develops proportionally to tidal strain or only above a threshold. We aimed to 1) assess the relationship between...

journal_title：Critical care medicine

authors： Wellman TJ,Winkler T,Costa EL,Musch G,Harris RS,Zheng H,Venegas JG,Vidal Melo MF

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:To synthesize the literature describing interventions to improve hand hygiene in ICUs, to evaluate the quality of the extant research, and to outline the type, and efficacy, of interventions described. DATA SOURCES:Systematic searches were conducted in November 2016 using five electronic databases: Medline,...

journal_title：Critical care medicine

authors： Lydon S,Power M,McSharry J,Byrne M,Madden C,Squires JE,O'Connor P

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To prospectively evaluate the oxygenation effect of inhaled nitric oxide (INO) delivered during high-frequency oscillatory ventilation in adult patients with the acute respiratory distress syndrome and oxygenation failure. DESIGN Prospective, clinical study. SETTING:Intensive care unit of a university teachi...

journal_title：Critical care medicine

authors： Mehta S,MacDonald R,Hallett DC,Lapinsky SE,Aubin M,Stewart TE

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To define the relative needs of the staffs of rural, community hospitals for training in advanced cardiac life support (ACLS), identify weaknesses, and modify a standard ACLS course to meet these needs. DESIGN:Prospective assessment of knowledge and skills relating to the practice of ACLS. SETTING:Rural, co...

journal_title：Critical care medicine

authors： Birnbaum ML,Kuska BM,Stone HL,Robinson NE

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:To assess the value of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of infection in patients with neutropenic fever comparing with procalcitonin and C-reactive protein. DESIGN:Prospective, comparative, single-center study. SETTING:Hematology ward at a university hospital. SUBJECT...

journal_title：Critical care medicine

authors： Lin CH,Yao M,Hsu SC,Ho CC,Lin MT,Lin CA,Hu FC,Yu CJ,Tien HF

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVES:Endovascular treatment for acute ischemic stroke with a large vessel occlusion was recently shown to be effective. We aimed to develop a score capable of predicting large vessel occlusion eligible for endovascular treatment in the early hospital management. DESIGN:Retrospective, cohort study. SETTING:Two t...

journal_title：Critical care medicine

authors： Vanacker P,Heldner MR,Amiguet M,Faouzi M,Cras P,Ntaios G,Arnold M,Mattle HP,Gralla J,Fischer U,Michel P

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:To discuss a possible role of the endothelium in sepsis. DATA SOURCES:Studies published in biomedical journals and our own experimental results. STUDY SELECTION:Studies on endothelial mechanisms in the context of sepsis. DATA EXTRACTION AND SYNTHESIS:Changes in endothelial cells on activation by inflammato...

journal_title：Critical care medicine

authors： Hack CE,Zeerleder S

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:Hypoxemic reperfusion attenuates brain injury secondary to severe cerebral ischemia, myocardial, and intestinal injury occurring in intestinal postischemic shock, and offers hemodynamic stabilization and attenuation of inflammatory response when applied in the resuscitation from hemorrhagic shock. In this stu...

journal_title：Critical care medicine

authors： Douzinas EE,Orfanos SE,Livaditi O,Augustatou K,Villiotou V,Kavantzas N,Flevari A,Korkolopoulou P,Roussos C,Patsouris E

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:In patients with acute hypoxemic respiratory failure, noninvasive ventilation and high-flow nasal cannula oxygen are alternative strategies to conventional oxygen therapy. Endotracheal intubation is frequently needed in these patients with a risk of delay, and early predictors of failure may help clinicians ...

journal_title：Critical care medicine

authors： Frat JP,Ragot S,Coudroy R,Constantin JM,Girault C,Prat G,Boulain T,Demoule A,Ricard JD,Razazi K,Lascarrou JB,Devaquet J,Mira JP,Argaud L,Chakarian JC,Fartoukh M,Nseir S,Mercat A,Brochard L,Robert R,Thille AW,REV

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Clinical predictors for acute respiratory distress syndrome (ARDS) have been studied in few prospective studies. Although transfusions are common in the intensive care unit, the role of submassive transfusion in non-trauma-related ARDS has not been studied. We describe here the clinical predictors of ARDS ris...

journal_title：Critical care medicine

authors： Gong MN,Thompson BT,Williams P,Pothier L,Boyce PD,Christiani DC

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To examine the isolated and combined effects of positive end-expiratory pressure (PEEP) and partial liquid ventilation (PLV) on the development of ventilator-induced lung injury in an ovine model. DESIGN:Prospective controlled animal study. SETTING:University-based cardiovascular animal physiology laborator...

journal_title：Critical care medicine

authors： Reickert CA,Rich PB,Crotti S,Mahler SA,Awad SS,Lynch WR,Johnson KJ,Hirschl RB

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Glycemic control is increasingly being recognized as a priority in the treatment of critically ill patients. Titration and monitoring of insulin infusions involve frequent blood glucose measurement to achieve target glucose ranges and prevent adverse events related to hypoglycemia. Therefore, it is imperativ...

journal_title：Critical care medicine

authors： Kanji S,Buffie J,Hutton B,Bunting PS,Singh A,McDonald K,Fergusson D,McIntyre LA,Hebert PC

更新日期：2005-12-01 00:00:00

abstract：:To understand better the incidence and meaning of hyperamylasemia in the intensive care setting, cellulose acetate membrane electrophoresis was used to measure the isoenzymes of serum amylase in 192 patients with a variety of critical illnesses. Seventy of these patients had elevated serum amylase levels, but none had...

journal_title：Critical care medicine

authors： Weaver DW,Busuito MJ,Bouwman DL,Wilson RF

更新日期：1985-07-01 00:00:00