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Stress echo results predict mortality: a large-scale multicenter prospective international study.

Abstract：

OBJECTIVES:The purpose of this study was to assess the long-term value of pharmacologic stress echocardiography with either dipyridamole or dobutamine (DET) for prediction of cardiac death in patients with proven or suspected coronary artery disease (CAD). BACKGROUND:Stress echocardiography is an established, cost-effective technique for the detection of CAD. METHODS:From the Echo Persantine International Cooperative-Echo Dobutamine International Cooperative data bank, 7,333 patients (5,452 males; 59 +/- 10 years) underwent pharmacologic stress echocardiography with either high-dose dipyridamole (0.84 mg/kg over 10 min) (n = 4,984) or high-dose dobutamine (up to 40 microg/kg/3 min) (n = 2,349) for diagnostic purposes. Patients were followed up for a mean of 2.6 years (range 1 to 206 months). RESULTS:The DET was positive for myocardial ischemia in 2,854 (35%) patients and negative in 4,479 (61%) patients. During the follow-up there were 161 cardiac deaths (sudden death and fatal myocardial infarction) (2.1% of the total population). Kaplan-Meier survival estimates showed a significantly better outcome for those patients with a negative pharmacologic stress echocardiography test compared with those with a positive test (92 vs. 71.2%, p = 0.0000). CONCLUSIONS:Pharmacologic stress echocardiography with either dipyridamole or dobutamine is effective in predicting cardiac death during a long-term follow-up. A negative stress echocardiography test result is related to a favorable outcome.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Sicari R,Pasanisi E,Venneri L,Landi P,Cortigiani L,Picano E,Echo Persantine International Cooperative (EPIC) Study Group.,Echo Dobutamine International Cooperative (EDIC) Study Group.

doi

10.1016/s0735-1097(02)02863-2

subject

Has Abstract

pub_date

2003-02-19 00:00:00

pages

589-95

issue

4

eissn

0735-1097

issn

1558-3597

pii

S0735109702028632

journal_volume

41

pub_type

杂志文章,多中心研究

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