The cardiovascular response to ketamine: the effects of clonidine and lignocaine.

Abstract:

:The effectiveness of clonidine or lignocaine in reducing the cardiostimulatory effects of ketamine was studied. A double-blind, randomized design was used in three groups of 20 patients each, of ASA grade 1 or 2 presenting for minor elective surgery. The clonidine group received 0.3 mg clonidine orally with the premedication while the lignocaine group received 1.5 mg.kg-1 lignocaine prior to induction. The third group formed the controls. All patients were induced with 2 mg.kg-1 ketamine intravenously. The systolic blood pressure in the clonidine group was significantly lower than that of both the control and lignocaine groups throughout the study (P < 0.05). It was concluded that clonidine was effective in reducing the hypertensive response to ketamine, whereas lignocaine had no effect.

authors

Munro HM,Sleigh JW,Paxton LD

doi

10.1111/j.1399-6576.1993.tb03602.x

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

75-8

issue

1

eissn

0001-5172

issn

1399-6576

journal_volume

37

pub_type

临床试验,杂志文章,随机对照试验
  • Segmental epidural analgesia and urinary excretion of catecholamines during labour.

    abstract::Urinary excretion of catecholamines was determined separately during the first stage of labour and during the period from the beginning of the second stage until 1/2 h after delivery in 16 healthy mothers, whose labours were induced at term. Seven mothers were given segmental epidural analgesia, at the height of TH10-...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1977.tb01193.x

    authors: Jouppila R,Hollmén A,Jouppila P,Kärki N

    更新日期:1977-01-01 00:00:00

  • Oxygenation and release of inflammatory mediators after off-pump compared with after on-pump coronary artery bypass surgery.

    abstract:BACKGROUND:In a previous study, we showed that oxygenation was impaired for up to 5 day after conventional coronary artery bypass grafting (CABG). As cardiopulmonary bypass (CPB) may have a detrimental effect on pulmonary function, we hypothesized that coronary revascularization grafting without the use of CPB (OPCAB) ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2007.01426.x

    authors: Rasmussen BS,Laugesen H,Sollid J,Grønlund J,Rees SE,Toft E,Gjedsted J,Dethlefsen C,Tønnesen E

    更新日期:2007-10-01 00:00:00

  • Effect of aminophylline on bispectral index.

    abstract:BACKGROUND:The aim of the present study was to investigate the effects of aminophylline on BIS as well as clinical recovery in patients anesthetized with sevoflurane. METHODS:Sixty patients with status of ASA I-II scheduled for elective surgery were enrolled in this study. Anesthesia was induced by 2 mg kg(-1) of prop...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.0001-5172.2004.00350.x

    authors: Turan A,Memiş D,Karamanlýodthlu B,Pamukçu Z,Süt N

    更新日期:2004-04-01 00:00:00

  • Transcutaneous oxygen measurement in adult intensive care.

    abstract::Transcutaneous oxygen measurement (PtcO2-measurement) gives by a non-invasive technique continuous information about central PO2. The method has as yet been tested mainly on newborns, and systematic studies of the applicability of the method on adults are still few. The current systematic study reports on consecutive ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1979.tb01484.x

    authors: Löfgren O

    更新日期:1979-12-01 00:00:00

  • Cardiovascular effects of pregnanolone emulsion: an experimental study in artificially ventilated dogs.

    abstract::The acute cardiovascular effects of pregnanolone emulsion, a new steroid preparation for intravenous anaesthesia, were investigated in artificially ventilated dogs. The anaesthetic was administered as repeated intravenous bolus injections, doubling the dosage with each injection. The plasma concentration of pregnanolo...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1991.tb03370.x

    authors: Høgskilde S,Wagner J,Strøm J,Sjøntoft E,Olesen HP,Bredgaard Sørensen M

    更新日期:1991-10-01 00:00:00

  • Pre-operative transthoracic echocardiography in ambulatory surgery-A cross-sectional study.

    abstract:BACKGROUND:Cardiac disease and aberrations in central volume status are risk factors for perioperative complications, and should be identified prior to surgery. This study investigated the benefit of transthoracic echocardiography (TTE) for pre-operative identification of cardiac disease and hypovolemia in ambulatory s...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13620

    authors: Stenberg Y,Lindelöf L,Hultin M,Myrberg T

    更新日期:2020-09-01 00:00:00

  • Low dose intrathecal morphine effects on post-hysterectomy pain: a randomized placebo-controlled study.

    abstract:BACKGROUND:Spinal anesthesia with different doses of intrathecal morphine has been shown to relieve post-operative pain. We studied in a prospective randomized, double-blind fashion the effects of morphine 0, 100, 200, or 300 μg added to intrathecal bupivacaine on first post-operative 24 h patient-controlled analgesia ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2011.02574.x

    authors: Hein A,Rösblad P,Gillis-Haegerstrand C,Schedvins K,Jakobsson J,Dahlgren G

    更新日期:2012-01-01 00:00:00

  • The effect of intranasally administered nitroglycerin on the blood pressure response to laryngoscopy and intubation in patients undergoing coronary artery by-pass surgery.

    abstract::The effect of intranasally administered nitroglycerin (NTG) on the cardiovascular response to laryngoscopy and intubation was studied. Thirty patients scheduled to undergo coronary artery by-pass surgery under thiopentone, enflurane and pancuronium anaesthesia were randomly divided into three groups. Group I received ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1986.tb02360.x

    authors: Dich-Nielsen J,Hole P,Lang-Jensen T,Owen-Falkenberg A,Skovsted P

    更新日期:1986-01-01 00:00:00

  • Preload changes by positive pressure ventilation can be used for assessment of left ventricular systolic function.

    abstract:BACKGROUND:Assessment of preload independent left ventricular function with conductance volumetry is traditionally accomplished by inflating a balloon in the inferior caval vein. Our aim was to investigate if a similar change in preload could be achieved by positive pressure ventilation with large tidal volume. METHOD...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2003.00084.x

    authors: Sellgren J,Söderström S,Johansson G,Biber B,Häggmark S,Pontén J

    更新日期:2003-05-01 00:00:00

  • Atelectasis and pulmonary shunting during induction of general anaesthesia--can they be avoided?

    abstract:BACKGROUND:Gas exchange is regularly impaired during general anaesthesia with mechanical ventilation. A major cause of this disorder appears to be atelectasis and consequently pulmonary shunt. After re-expansion, atelectasis reappears very slowly if 30% oxygen in nitrogen is used, but much faster if 100% oxygen is used...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1996.tb04483.x

    authors: Rothen HU,Sporre B,Engberg G,Wegenius G,Reber A,Hedenstierna G

    更新日期:1996-05-01 00:00:00

  • Dermal expression of laminin-332 and type IV collagen in humans with severe sepsis.

    abstract:BACKGROUND:An intact basement membrane at the dermal-epidermal junction is essential to the viability of the skin. The effect of sepsis on the basement membrane is unknown. METHODS:Skin biopsies were used to study basement membrane structure in severe sepsis (Day 1). Subsequent biopsies were taken on Day 8 and at 3 mo...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12539

    authors: Koskela M,Gäddnäs F,Koivukangas V,Oikarinen A,Laurila J,Kallioinen M,Ala-Kokko TI

    更新日期:2015-09-01 00:00:00

  • Efficacy and safety of intravenous fentanyl administered by ambulance personnel.

    abstract:BACKGROUND:Management of pain in the pre-hospital setting is often inadequate. In 2011, ambulance personnel were authorized to administer intravenous fentanyl in the Central Denmark Region. The aim of this study was to evaluate the efficacy and safety of intravenous fentanyl administered by ambulance personnel. METHOD...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12662

    authors: Friesgaard KD,Nikolajsen L,Giebner M,Rasmussen CH,Riddervold IS,Kirkegaard H,Christensen EF

    更新日期:2016-04-01 00:00:00

  • Self-administered prophylactic postoperative positive expiratory pressure in thoracic surgery.

    abstract::Application of self-administered postoperative prophylactic positive expiratory pressure (S-PEP) treatment in addition to conventional physiotherapy was investigated in 75 patients undergoing thoracotomy. Twenty-nine patients used a face-mask set supplied with an expiratory resistance (S-PEP group) and 27 patients use...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1986.tb02435.x

    authors: Frølund L,Madsen F

    更新日期:1986-07-01 00:00:00

  • Evaluation of 119 anaesthetics received after investigation for susceptibility to malignant hyperthermia.

    abstract::A questionnaire was sent to the first 371 patients investigated for MH susceptibility at the Danish MH Register, in order to assess sequelae from the muscle biopsy and possible subsequent anaesthetic complications. The purpose was to evaluate both the safety of anaesthetizing MH-susceptible (MHS) patients without the ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1991.tb03377.x

    authors: Ording H,Hedengran AM,Skovgaard LT

    更新日期:1991-11-01 00:00:00

  • Intrathecal ropivacaine 5 mg/ml for outpatient knee arthroscopy: a comparison with lidocaine 10 mg/ml.

    abstract:PURPOSE:The aim of this prospective, randomised, blind study was to compare the evolution of spinal block produced with 50 mg lidocaine 10 mg/ml and 10 mg ropivacaine 5 mg/ml for outpatient knee arthroscopy. METHODS:Thirty outpatients undergoing knee arthroscopy received 50 mg of lidocaine 10 mg/ml (n=15) or 10 mg of ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2008.01815.x

    authors: Fanelli G,Danelli G,Zasa M,Baciarello M,Di Cianni S,Leone S

    更新日期:2009-01-01 00:00:00

  • The combined effects of antihypertensive drugs and anaesthetics (halothane and ketamine) on the isolated heart.

    abstract::The effects of three concentrations of halothane or ketamine were investigated on isolated rabbit hearts, which were perfused with hydralazine, clonidine, propranolol or methyldopa. In hearts not subjected to the influence of an anaesthetic, clonidine was the only drug stimulating myocardial function. In those perfuse...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1978.tb01349.x

    authors: Kaukinen S

    更新日期:1978-01-01 00:00:00

  • Effects of hypertonic 75 mg/ml (7.5%) saline on extracellular water volume when used for preloading before spinal anaesthesia.

    abstract:BACKGROUND:Prevention of hypotension during spinal anaesthesia is commonly achieved using fluid preloading. This may result in a substantial amount of excess free water retained in the body after spinal anaesthesia. We aimed to evaluate the effects of 7.5% hypertonic saline on extracellular water volume and haemodynami...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2001.045006776.x

    authors: Järvelä K,Kööbi T,Kauppinen P,Kaukinen S

    更新日期:2001-07-01 00:00:00

  • Differential effects of epidural morphine in the treatment of cancer-related pain.

    abstract::Fifty-five patients with pain associated with cancer were selected for long-term treatment with epidural morphine. Patients who had more than one type of pain within the same region were specially analysed concerning differential analgesic effects of the treatment, i.e. the patients served as their own control. Twenty...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1985.tb02155.x

    authors: Arnér S,Arnér B

    更新日期:1985-01-01 00:00:00

  • Calculation of end-tidal carbon dioxide fractions in the Bain system.

    abstract::The validity of the Stenqvist-Sonander formula for calculating the end-expiratory fraction of carbon dioxide (FACO2) in the coaxial Mapleson D (Bain) systems was evaluated using a lung model for simulated spontaneous breathing with an optional respiratory wave form. Two different respiratory flow patterns were used, o...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1989.tb02863.x

    authors: Jonsson LO,Zetterström H

    更新日期:1989-01-01 00:00:00

  • Design and implementation of a closed-loop control system for infusion of propofol guided by bispectral index (BIS).

    abstract:BACKGROUND:This study describes the design of a hypnosis closed-loop control system with propofol. The controller used a proportional-integral (PI) algorithm with the bispectral index (BIS) as the feedback signal. Our hypothesis was that a PI closed-loop control could be applied in clinical practice safely keeping the ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2012.02738.x

    authors: Reboso JA,Méndez JA,Reboso HJ,León AM

    更新日期:2012-09-01 00:00:00

  • The addition of fentanyl to 1.5 mg/ml ropivacaine has no advantage for paediatric epidural analgesia.

    abstract:BACKGROUND:Epidural opioids are frequently combined with local anaesthetics for an additive antinociceptive effect. We investigated the efficacy of epidural fentanyl to 1.25 or 1.5 mg/ml ropivacaine for post-operative epidural analgesia in children. METHODS:One hundred and eight children undergoing hypospadias repair ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2009.02046.x

    authors: Cho JE,Kim JY,Hong JY,Kil HK

    更新日期:2009-09-01 00:00:00

  • A new nomogram facilitating adequate haemodilution.

    abstract::When using deliberate haemodilution to a certain haematocrit value (Hct), the appropriate preoperative blood volume of the patient must be determined and matched with the transfusion volume at a certain blood loss. In order to facilitate such calculations a nomogram was constructed, aiming for a final Hct of 33%. Preo...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1986.tb02418.x

    authors: Zetterström H,Wiklund L

    更新日期:1986-05-01 00:00:00

  • DEX-2-TKA-DEXamethasone twice for pain treatment after Total Knee Arthroplasty: A protocol for a randomized, blinded, three-group multicentre clinical trial.

    abstract:BACKGROUND:Multimodal analgesia is considered the leading principle for post-operative pain treatment, but no gold standard after total knee arthroplasty (TKA) exists. AIM:To investigate the beneficial and harmful effects of one or two doses of 24 mg intravenous dexamethasone (DXM) as part of a multimodal analgesic re...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13481

    authors: Gasbjerg KS,Hägi-Pedersen D,Lunn TH,Jakobsen JC,Overgaard S,Pedersen NA,Bagger J,Lindholm P,Brorson S,Schrøder HM,Thybo KH,Mathiesen O

    更新日期:2020-02-01 00:00:00

  • Anaesthesia for microvascular surgery in children. A combination of general anaesthesia and axillary plexus block.

    abstract::Nowadays, microvascular reconstructions are performed with high success rate even in small children. The combination of general anaesthesia and axillary plexus block was used in this prospective study in order to achieve optimal surgical conditions in these challenging operations. Fifteen children under eight years of...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1995.tb04111.x

    authors: Inberg P,Kassila M,Vilkki S,Tarkkila P,Neuvonen P

    更新日期:1995-05-01 00:00:00

  • Post-operative cognitive dysfunction at 3 months in adults after non-cardiac surgery: a qualitative systematic review.

    abstract:BACKGROUND:Post-operative cognitive dysfunction is defined as a decline in cognitive functions that occurs after surgery, but different diagnostic criteria and incidences have been reported in medical literature. Our aim was to determine incidence of post-operative cognitive dysfunction 3 months after non-cardiac surge...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/aas.12724

    authors: Paredes S,Cortínez L,Contreras V,Silbert B

    更新日期:2016-09-01 00:00:00

  • Clinical effects of carticaine, a new local anesthetic. A survey and a double-blind investigation comparing carticaine with lidocaine in epidural analgesia.

    abstract::Carticaine, a new local anesthetic of the amide type, differs from those previously known in that it contains a thiophene ring. The physico-chemical properties of the compound, its pharmacology and its toxicology are reviewed from the litererture. A controlled, double-blind investigation in which carticaine was compar...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-6576.1977.tb01186.x

    authors: Brinklov MM

    更新日期:1977-01-01 00:00:00

  • Postischaemic regional microvascular variations in the porcine renal cortex.

    abstract::Regional microcirculatory differences in the superficial renal cortex were studied before and during 4 h following 60 min of renal ischaemia in seven pigs under continuous intravenous chlormethiazole-pancuronium anaesthesia. Superficial renal cortical blood flow (Qsrc) was measured by laser Doppler flowmetry (LDF) in ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1991.tb03332.x

    authors: Sandin R,Feuk U,Modig J

    更新日期:1991-08-01 00:00:00

  • Renal function and fluoride formation and excretion during enflurane anaesthesia.

    abstract::Central circulation, renal function, and fluoride formation and excretion were studied in nine patients during enflurane anaesthesia and surgery. Cardiac output and mean systemic arterial pressure remained unchanged compared with preoperative control values. During anaesthesia and surgery, urine flow rate, inulin clea...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1979.tb01473.x

    authors: Järnberg PO,Ekstrand J,Irestedt L,Santesson J

    更新日期:1979-10-01 00:00:00

  • Bystander first aid in trauma - prevalence and quality: a prospective observational study.

    abstract:BACKGROUND:Bystander first aid and basic life support can likely improve victim survival in trauma. In contrast to bystander first aid and out-of-hospital cardiac arrest, little is known about the role of bystanders in trauma response. Our aim was to determine how frequently first aid is given to trauma victims by byst...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12561

    authors: Bakke HK,Steinvik T,Eidissen SI,Gilbert M,Wisborg T

    更新日期:2015-10-01 00:00:00

  • Four years' treatment with ketamine and a trial of dextromethorphan in a patient with severe post-herpetic neuralgia.

    abstract::N-methyl-D-aspartate (NMDA) receptors are involved in the development of neuropathic pain. Ketamine, a non-competitive NMDA receptor antagonist, has in several case reports given pain relief but efficacy in dosages tolerated in long-term ketamine treatment is unknown. Another substance with an antagonist action at NMD...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04709.x

    authors: Klepstad P,Borchgrevink PC

    更新日期:1997-03-01 00:00:00