Elements and factors involved in tissue-specific and embryonic expression of the liver transcription factor LFB1 in Xenopus laevis.

abstract：:Resistance to the growth-inhibitory action of retinoic acid (RA), the bioactive derivative of vitamin A, is common in human tumors. One form of RA resistance has been associated with silencing and hypermethylation of the retinoic acid receptor beta2 gene (RARbeta2), an RA-regulated tumor suppressor gene. The presence ...

journal_title：Molecular and cellular biology

authors： Ren M,Pozzi S,Bistulfi G,Somenzi G,Rossetti S,Sacchi N

更新日期：2005-12-01 00:00:00

abstract：:Protein sumoylation plays an important but poorly understood role in controlling genome integrity. In Saccharomyces cerevisiae, the Slx5-Slx8 SUMO-targeted Ub ligase appears to be needed to ubiquitinate sumoylated proteins that arise in the absence of the Sgs1 DNA helicase. WSS1, a high-copy-number suppressor of a mut...

journal_title：Molecular and cellular biology

authors： Mullen JR,Chen CF,Brill SJ

更新日期：2010-08-01 00:00:00

abstract：:Inactivation of the TATA-binding protein-containing complex TFIIIB contributes to the mitotic repression of RNA polymerase III transcription, both in frogs and in humans (J. M. Gottesfeld, V. J. Wolf, T. Dang, D. J. Forbes, and P. Hartl, Science 263:81-84, 1994; R. J. White, T. M. Gottlieb, C. S. Downes, and S. P. Jac...

journal_title：Molecular and cellular biology

authors： White RJ,Gottlieb TM,Downes CS,Jackson SP

更新日期：1995-12-01 00:00:00

abstract：:The Rel family of transcription factors participate in a diverse array of processes, including acute responses to injury and infection, lymphocyte differentiation, and embryonic patterning. These proteins show homology in an extended region spanning about 300 amino acids (the Rel homology domain [RHD]). The RHD mediat...

journal_title：Molecular and cellular biology

authors： Tatei K,Levine M

更新日期：1995-07-01 00:00:00

abstract：:The proto-oncogene c-myb is essential for a controlled balance between cell growth and differentiation. Aberrant c-Myb activity has been reported for numerous human cancers, and enforced c-Myb transcription can transform cells of lymphoid origin by stimulating cellular proliferation and inhibiting apoptotic pathways. ...

journal_title：Molecular and cellular biology

authors： Nicot C,Mahieux R,Pise-Masison C,Brady J,Gessain A,Yamaoka S,Franchini G

更新日期：2001-11-01 00:00:00

abstract：:Transcription by RNA polymerase I (pol I), pol II, and pol III requires the TATA-binding protein (TBP). This protein functions in association with distinct TBP-associated factors (TAFs) which may specify the nature of the polymerase selected for initiation at a promoter site. In the pol III transcription system, the T...

journal_title：Molecular and cellular biology

authors： Meyers RE,Sharp PA

更新日期：1993-12-01 00:00:00

abstract：:Gene activation requires alteration of chromatin structure to facilitate active transcription complex formation at a gene promoter. Nucleosome remodeling complexes and histone modifying complexes each play unique and interdependent roles in bringing about these changes. The role of distant enhancers in these structura...

journal_title：Molecular and cellular biology

authors： Kim A,Dean A

更新日期：2003-11-01 00:00:00

abstract：:Microinjection of p21Ha-ras proteins into Xenopus laevis oocytes induces a rapid increase of 1,2-diacylglycerol (DAG) levels. The observed alterations in DAG levels were consistent with the ability of the protein to induce maturation, measured by germinal vesicle breakdown (GVBD). Both the increase in DAG levels and G...

journal_title：Molecular and cellular biology

authors： Lacal JC

更新日期：1990-01-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved. One potential mechanism for RTK specificity is control of the magnitude and kinetics of activation of downstream pathways. We have found that the...

journal_title：Molecular and cellular biology

authors： Zhang SQ,Tsiaras WG,Araki T,Wen G,Minichiello L,Klein R,Neel BG

更新日期：2002-06-01 00:00:00

abstract：:The inducer of short transcripts, or IST, is an unusual transcriptional element located downstream of the human immunodeficiency virus type 1 (HIV-1) promoter. IST activates HIV-1 transcription, but the resulting RNAs are short and end at approximately position +59. IST, therefore, appears to promote the formation of ...

journal_title：Molecular and cellular biology

authors： Sheldon M,Ratnasabapathy R,Hernandez N

更新日期：1993-02-01 00:00:00

abstract：:In this report, we document an unusual mode of tissue-enriched gene expression that is primarily mediated by alternative and inefficient splicing. We have analyzed posttranscriptional regulation of the Drosophila erect wing gene, which provides a vital neuronal function and is essential for the formation of certain mu...

journal_title：Molecular and cellular biology

authors： Koushika SP,Soller M,DeSimone SM,Daub DM,White K

更新日期：1999-06-01 00:00:00

abstract：:Throughout life, intestinal Lgr5+ stem cells give rise to proliferating transient amplifying cells in crypts, which subsequently differentiate into one of the five main cell types and migrate along the crypt-villus axis. These dynamic processes are coordinated by a relatively small number of evolutionarily conserved s...

journal_title：Molecular and cellular biology

authors： van Es JH,Haegebarth A,Kujala P,Itzkovitz S,Koo BK,Boj SF,Korving J,van den Born M,van Oudenaarden A,Robine S,Clevers H

更新日期：2012-05-01 00:00:00

abstract：:The uptake of various nucleosides by S49 mouse T-lymphoma cells and that by a single-step nucleoside transport-defective mutant thereof (AE1) were compared. Residual nucleoside entry into AE1 cells occurred via two routes, nonmediated permeation and saturable, non-concentrative transport with broad substrate specifici...

journal_title：Molecular and cellular biology

authors： Plagemann PG,Woffendin C

更新日期：1987-01-01 00:00:00

abstract：:One of the proteins identified as being involved in ribosome biogenesis by high-throughput studies, a putative P-loop-type kinase termed Fap7 (YDL166c), was shown to be required for the conversion of 20S pre-rRNA to 18S rRNA. However, the mechanism underlying this function has remained unclear. Here we demonstrate tha...

journal_title：Molecular and cellular biology

authors： Granneman S,Nandineni MR,Baserga SJ

更新日期：2005-12-01 00:00:00

abstract：:Transcription from the Moloney murine leukemia virus (Mo-MuLV) long terminal repeat (LTR) is inhibited in murine stem cells and induced during maturation of these cells. We have investigated whether alterations in the activity of this viral regulatory element also occur during differentiation of human myeloid leukemia...

journal_title：Molecular and cellular biology

authors： Reisman D,Rotter V

更新日期：1989-08-01 00:00:00

abstract：:Activation-induced deaminase (AID) is essential for class switch recombination and somatic hypermutation, and it has the ability to deaminate single-stranded DNA at cytidines. Mammalian class switch regions form R-loops upon transcription in the physiological orientation. The displaced DNA strand of an R-loop is force...

journal_title：Molecular and cellular biology

authors： Yu K,Roy D,Bayramyan M,Haworth IS,Lieber MR

更新日期：2005-03-01 00:00:00

abstract：:MOT1 is an essential Saccharomyces cerevisiae protein and a member of the SNF2/SWI2 family of ATPases. MOT1 functions by removing TATA-binding protein (TBP) from DNA, and as a consequence, MOT1 can regulate transcription both in vitro and in vivo. Here we describe the in vivo and in vitro activities of MOT1 deletion a...

journal_title：Molecular and cellular biology

authors： Auble DT,Wang D,Post KW,Hahn S

更新日期：1997-08-01 00:00:00

abstract：:Following hepatic injury or stress, gluconeogenic and acute-phase response genes are rapidly upregulated to restore metabolic homeostasis and limit tissue damage. Regulation of the liver-restricted insulin-like growth factor binding protein 1 (IGFBP-1) gene is dramatically altered by changes in the metabolic state and...

journal_title：Molecular and cellular biology

authors： Leu JI,Crissey MA,Leu JP,Ciliberto G,Taub R

更新日期：2001-01-01 00:00:00

abstract：:Gene expression results from the coordinated actions of transcription factor proteins and coregulators. Estrogen receptor alpha (ERalpha) is a ligand-activated transcription factor that can both activate and repress the expression of genes. Activation of transcription by estrogen-bound ERalpha has been studied in deta...

journal_title：Molecular and cellular biology

authors： Ellison-Zelski SJ,Solodin NM,Alarid ET

更新日期：2009-09-01 00:00:00

abstract：:Osteoclasts are bone-resorbing cells essential for skeletal development, homeostasis, and regeneration. They derive from hematopoietic progenitors in the monocyte/macrophage lineage and differentiate in response to RANKL. However, the precise nature of osteoclast progenitors is a longstanding and important question. U...

journal_title：Molecular and cellular biology

authors： Wei W,Zeve D,Wang X,Du Y,Tang W,Dechow PC,Graff JM,Wan Y

更新日期：2011-12-01 00:00:00

abstract：:The Cyp cell line consists of mouse cells transformed by a thermosensitive polyomavirus (Py) genome and routinely propagated at 39 degrees C. Cyp cells are readily induced to synthesize free Py DNA by being transferred to 33 degrees C. In one subclone (C12/a1/S48, or S48) of this line, such induction resulted in the i...

journal_title：Molecular and cellular biology

authors： Huberdeau D,Sylla BS,Herring-Gillam E,Bourgaux-Ramoisy D,Bourgaux P

更新日期：1985-10-01 00:00:00

abstract：:In Drosophila melanogaster, X chromosome dosage compensation is achieved by doubling the transcription of most X-linked genes. The male-specific lethal (MSL) complex is required for this process and binds to hundreds of sites on the male X chromosome. The MSL1 protein is essential for X chromosome binding and serves a...

journal_title：Molecular and cellular biology

authors： Li F,Parry DA,Scott MJ

更新日期：2005-10-01 00:00:00

abstract：:TRAF2 is an adaptor protein that regulates the activation of the c-Jun N-terminal kinase (JNK) and IkappaB kinase (IKK) signaling cascades in response to tumor necrosis factor alpha (TNF-alpha) stimulation. Although the downstream events in TNF-alpha signaling are better understood, the membrane-proximal events are st...

journal_title：Molecular and cellular biology

authors： Blackwell K,Zhang L,Thomas GS,Sun S,Nakano H,Habelhah H

更新日期：2009-01-01 00:00:00

abstract：:A series of extraction procedures were applied to avian nuclei which allowed us to define three types of association of v-myc- and c-myc-encoded proteins with nuclei: (i) a major fraction (60 to 90%) which is retained in DNA- and RNA-depleted nuclei after low- and high-salt extraction, (ii) a small fraction (1%) relea...

journal_title：Molecular and cellular biology

authors： Eisenman RN,Tachibana CY,Abrams HD,Hann SR

更新日期：1985-01-01 00:00:00

abstract：:Human platelet-derived endothelial cell growth factor (hPD-ECGF) is a novel angiogenic factor which stimulates endothelial cell growth in vitro and promotes angiogenesis in vivo. We report here the cloning and sequencing of the gene for hPD-ECGF and its flanking regions. This gene is composed of 10 exons dispersed ove...

journal_title：Molecular and cellular biology

authors： Hagiwara K,Stenman G,Honda H,Sahlin P,Andersson A,Miyazono K,Heldin CH,Ishikawa F,Takaku F

更新日期：1991-04-01 00:00:00

abstract：:Protein tyrosine kinase Pyk2 is activated by a variety of G-protein-coupled receptors and by extracellular signals that elevate intracellular Ca2+ concentration. We have identified a new Pyk2 binding protein designated Pap. Pap is a multidomain protein composed of an N-terminal alpha-helical region with a coiled-coil ...

journal_title：Molecular and cellular biology

authors： Andreev J,Simon JP,Sabatini DD,Kam J,Plowman G,Randazzo PA,Schlessinger J

更新日期：1999-03-01 00:00:00

abstract：:P bodies are cytoplasmic RNA granules containing the Dcp1-Dcp2 decapping enzymes where mRNA decay can occur. Here, we describe the characterization of P bodies in the fission yeast Schizosaccharomyces pombe. Most information on the property and function of P bodies stems from studies in the distantly related budding y...

journal_title：Molecular and cellular biology

authors： Wang CY,Chen WL,Wang SW

更新日期：2013-03-01 00:00:00

abstract：:A mutant has been isolated from the J558 (immunoglobulin A, lambda, anti-alpha 1 leads to 3 dextran) cell line which synthesizes a heavy-chain immunoglobulin twice the size of normal heavy chain. Secondary variants that synthesized heavy chains either 1.5 times as large as wild type or the same size as wild type were ...

journal_title：Molecular and cellular biology

authors： Matsuuchi L,Morrison SL

更新日期：1982-09-01 00:00:00

abstract：:In thyroid hormone-depleted rats, the rate of transcription of the growth hormone (GH) gene in the anterior pituitary gland is lower than the rate in euthyroid controls, and there is a corresponding reduction in the abundance of the GH mRNA. Concomitantly, the poly(A) tail of the GH mRNA increases in length. Examinati...

journal_title：Molecular and cellular biology

authors： Murphy D,Pardy K,Seah V,Carter D

更新日期：1992-06-01 00:00:00

abstract：:Eukaryotic elongation factor 1 alpha 2 (eEF1A2) is a transforming gene product that is highly expressed in human tumors of the ovary, lung, and breast. eEF1A2 also stimulates actin remodeling, and the expression of this factor is sufficient to induce the formation of filopodia, long cellular processes composed of bund...

journal_title：Molecular and cellular biology

authors： Jeganathan S,Morrow A,Amiri A,Lee JM

更新日期：2008-07-01 00:00:00