Redox-triggered infection by disulfide-shackled human immunodeficiency virus type 1 pseudovirions.

abstract：:Two species of basic internal proteins were found in osmotic shock supernatant solutions of bacteriophages T4B, T4D, T2H, T2L, and T6. The major species of protein isolated had a molecular weight of approximately 21,000 daltons, whereas the minor protein molecular weight was near 9,500 daltons. The two protein species...

journal_title：Journal of virology

authors： Stone KR,Cummings DJ

更新日期：1970-10-01 00:00:00

abstract：:Regulatory elements interacting with DNA-binding proteins have been investigated in the promoter sequence of the early PE38 gene in the Autographa californica nuclear polyhedrosis virus (AcNPV). A GATA motif located 50 nucleotides upstream of the PE38 transcriptional start site is recognized differentially in the cour...

journal_title：Journal of virology

authors： Krappa R,Behn-Krappa A,Jahnel F,Doerfler W,Knebel-Mörsdorf D

更新日期：1992-06-01 00:00:00

abstract：:Murine cytomegalovirus encodes three regulators of antigen presentation to antiviral CD8 T cells. According to current paradigms, all three regulators are committed to the inhibition of the presentation of antigenic peptides. Whereas m152/gp40 catalyzes the retention of peptide-loaded major histocompatibility complex ...

journal_title：Journal of virology

authors： Holtappels R,Gillert-Marien D,Thomas D,Podlech J,Deegen P,Herter S,Oehrlein-Karpi SA,Strand D,Wagner M,Reddehase MJ

更新日期：2006-08-01 00:00:00

abstract：:Recently, novel arenaviruses were found in snakes with boid inclusion body disease (BIBD); these form the new genus Reptarenavirus within the family Arenaviridae. We used next-generation sequencing and de novo sequence assembly to investigate reptarenavirus isolates from our previous study. Four of the six isolates an...

journal_title：Journal of virology

authors： Hepojoki J,Salmenperä P,Sironen T,Hetzel U,Korzyukov Y,Kipar A,Vapalahti O

更新日期：2015-08-01 00:00:00

abstract：:We describe here the neurovirulence properties of a herpes simplex virus type 1 gamma34.5 second-site suppressor mutant. gamma34.5 mutants are nonneurovirulent in animals and fail to grow in a variety of cultured cells due to a block at the level of protein synthesis. Extragenic suppressors with restored capacity to r...

journal_title：Journal of virology

authors： Mohr I,Sternberg D,Ward S,Leib D,Mulvey M,Gluzman Y

更新日期：2001-06-01 00:00:00

abstract：:Cells that express glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) resist infection by HSV-1 and HSV-2 because of interference with viral penetration. The results presented here show that both HSV-1 and HSV-2 gD can mediate interference and that various HSV-1 and HSV-2 strains differ in sensitivity to this ...

journal_title：Journal of virology

authors： Dean HJ,Warner MS,Terhune SS,Johnson RM,Spear PG

更新日期：1995-08-01 00:00:00

abstract：:Antibodies directed to Sindbis virus (SV) envelope protein E2 are able to control virus replication in vivo and in persistently infected cultures of neurons in vitro. We investigated the mechanisms by which anti-E2 monoclonal antibody (MAb) alters virus replication by using AT3 rat prostatic carcinoma cells expressing...

journal_title：Journal of virology

authors： Després P,Griffin JW,Griffin DE

更新日期：1995-11-01 00:00:00

abstract：:Live-attenuated vesicular stomatitis virus (VSV) vectors expressing foreign antigens induce potent immune responses and protect against viral diseases in animal models. Highly attenuated (VSV-CT1) or single-cycle VSV (VSVDeltaG) vectors induce immune responses lower than those generated by attenuated wild-type VSV vec...

journal_title：Journal of virology

authors： Simon ID,Publicover J,Rose JK

更新日期：2007-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are key regulators of gene expression in higher eukaryotes. Recently, miRNAs have been identified from viruses with double-stranded DNA genomes. To attempt to identify miRNAs encoded by herpes simplex virus 1 (HSV-1), we applied a computational method to screen the complete genome of HSV-1 for seque...

journal_title：Journal of virology

authors： Cui C,Griffiths A,Li G,Silva LM,Kramer MF,Gaasterland T,Wang XJ,Coen DM

更新日期：2006-06-01 00:00:00

abstract：:The occurrence of genome segment reassortment between two antigenically related orbiviruses was demonstrated in cattle. Individual virus clones were isolated by cell culture plaque assays directly from the blood of a calf infected with two serotypes of bluetongue virus. The majority (89%) of progeny viruses isolated f...

journal_title：Journal of virology

authors： Stott JL,Oberst RD,Channell MB,Osburn BI

更新日期：1987-09-01 00:00:00

abstract：:Nonstructural protein 1 (NS1) of yellow fever virus (YF) is a glycoprotein localized to extracytoplasmic compartments within infected cells. We have previously shown that NS1 can be supplied in trans and is required for viral RNA replication, a process thought to occur in membrane-bound cytoplasmic complexes. Here we ...

journal_title：Journal of virology

authors： Lindenbach BD,Rice CM

更新日期：1999-06-01 00:00:00

abstract：:Some of the properties of a new human papovavirus, BK, have been examined. Host range studies of BK virus (BKV) showed human cells to be more sensitive to infection than monkey cells; human fetal brain cells appear to be highly sensitive to BKV, with the production of extensive cytopathology characterized by cytoplasm...

journal_title：Journal of virology

authors： Takemoto KK,Mullarkey MF

更新日期：1973-09-01 00:00:00

abstract：:Today, global attention is focused on two influenza virus strains: the current pandemic strain, swine origin influenza virus (H1N1-2009), and the highly pathogenic avian influenza virus, H5N1. At present, the infection caused by the H1N1-2009 is moderate, with mortality rates of less <1%. In contrast, infection with t...

journal_title：Journal of virology

authors： Achdout H,Meningher T,Hirsh S,Glasner A,Bar-On Y,Gur C,Porgador A,Mendelson M,Mandelboim M,Mandelboim O

更新日期：2010-04-01 00:00:00

abstract：:Grasshoppers, Melanoplus sanguinipes (F.), infected with the grasshopper inclusion body virus (GIBV) showed a general torpor, took longer to develop, and had abnormally high rates of mortality. Infection was found only in the fat body, and developing viruses and inclusion bodies were observed in the nuclei and cytopla...

journal_title：Journal of virology

authors： Henry JE,Nelson BP,Jutila JW

更新日期：1969-06-01 00:00:00

abstract：:We used a transfected L cell and a vaccinia vector carrying the herpes simplex virus type 1 (HSV-1) gene coding for glycoprotein D (gD) to characterize HSV-specific T-cell responses. Various studies with mice revealed that the vectors could stimulate some HSV-specific T-cell responses. Although the majority of the T c...

journal_title：Journal of virology

authors： Martin S,Moss B,Berman PW,Laskey LA,Rouse BT

更新日期：1987-03-01 00:00:00

abstract：:CD8+ T cells are the key cellular effectors mediating the clearance of hepatitis B virus (HBV) infections. However, early immunological events surrounding the priming of HBV-specific CD8+ T cell responses remain poorly understood. This study examined the importance of priming location and the relative contribution of ...

journal_title：Journal of virology

authors： Murata Y,Kawashima K,Sheikh K,Tanaka Y,Isogawa M

更新日期：2018-10-12 00:00:00

abstract：:Little is known about the transmission or tropism of the newly discovered human retrovirus, human T-cell lymphotropic virus type 3 (HTLV-3). Here, we examine the entry requirements of HTLV-3 using independently expressed Env proteins. We observed that HTLV-3 surface glycoprotein (SU) binds efficiently to both activate...

journal_title：Journal of virology

authors： Jones KS,Huang YK,Chevalier SA,Afonso PV,Petrow-Sadowski C,Bertolette DC,Gessain A,Ruscetti FW,Mahieux R

更新日期：2009-05-01 00:00:00

abstract：:BALB/c mice treated with pristane and Abelson virus have been used as an animal model system for the rapid induction of plasmacytomas. Myelomonocytic tumors with helper Moloney murine leukemia virus clonally inserted into the c-myb locus were observed in about 10% of pristane-primed BALB/c mice infected with Abelson v...

journal_title：Journal of virology

authors： Shen-Ong GL,Wolff L

更新日期：1987-12-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus of the Birnaviridae family. Its two genome segments are encapsidated together with multiple copies of the viral RNA-dependent RNA polymerase, VP1, in a single-shell capsid that is composed of VP2 and VP3. In this study we identified the doma...

journal_title：Journal of virology

authors： Tacken MG,Peeters BP,Thomas AA,Rottier PJ,Boot HJ

更新日期：2002-11-01 00:00:00

abstract：:Human cytomegalovirus (CMV) is the leading cause of prenatal viral infection. Affected infants may suffer intrauterine growth retardation and serious neurologic impairment. Analysis of spontaneously aborted conceptuses shows that CMV infects the placenta before the embryo or fetus. In the human hemochorial placenta, m...

journal_title：Journal of virology

authors： Fisher S,Genbacev O,Maidji E,Pereira L

更新日期：2000-08-01 00:00:00

abstract：:The nonpathogenic human adeno-associated virus (AAV) has developed a mechanism to integrate its genome into human chromosome 19 at 19q13.4 (termed AAVS1), thereby establishing latency. Here, we provide evidence that the chromosomal signals required for site-specific integration are conserved in the mouse genome proxim...

journal_title：Journal of virology

authors： Dutheil N,Yoon-Robarts M,Ward P,Henckaerts E,Skrabanek L,Berns KI,Campagne F,Linden RM

更新日期：2004-08-01 00:00:00

abstract：:Poliovirus-specific T lymphocytes were isolated from virus-immunized mice of different H-2 haplotypes. Immunological characterization of this population indicates that the effector population involved in the observed poliovirus-specific proliferative response was that of CD4-positive T-helper cells. Proliferative resp...

journal_title：Journal of virology

authors： Kutubuddin M,Simons J,Chow M

更新日期：1992-05-01 00:00:00

abstract：:Virus-specific RNA synthesized in monkey cells after infection by both wild-type simian virus 40 (SV40) and the early SV40 temperature-sensitive mutant tsA58 has been analyzed. The fraction of SV40-specific RNA increased throughout infection with either wild-type SV40 or with tsA58 in direct proportion to the accumula...

journal_title：Journal of virology

authors： Khoury G,May E

更新日期：1977-07-01 00:00:00

abstract：:We have examined the pathway of rhinovirus interaction with soluble intercellular adhesion molecule 1 (sICAM-1). Binding of sICAM-1 to rhinovirus serotypes 3 and 14 gives particles with sedimentation coefficients from 145 to 120S, depending on the amount of sICAM-1 bound. The formation of 120S particles is faster and ...

journal_title：Journal of virology

authors： Casasnovas JM,Springer TA

更新日期：1994-09-01 00:00:00

abstract：:Infectious poxvirus particles are unusual in that they are brick shaped and lack symmetry. Nevertheless, an external honeycomb lattice comprised of a capsid-like protein dictates the spherical shape and size of immature poxvirus particles. In the case of vaccinia virus, trimers of 63-kDa D13 polypeptides form the buil...

journal_title：Journal of virology

authors： Bisht H,Weisberg AS,Szajner P,Moss B

更新日期：2009-09-01 00:00:00

abstract：:A consensus binding site for the human papillomavirus (HPV) E2 protein was determined from an unbiased set of degenerate oligonucleotides using cyclic amplification and selection of targets (CASTing). Detectable DNA-protein complexes were formed after six to nine cycles of CASTing. A population of selected binding sit...

journal_title：Journal of virology

authors： Newhouse CD,Silverstein SJ

更新日期：2001-02-01 00:00:00

abstract：:T-cell responses of pigs to hog cholera virus (HCV) have reportedly been absent or difficult to detect. Therefore, little is known about cellular immunity to HCV. In this study, we used an attenuated strain of pseudorabies virus expressing the envelope glycoprotein E1 of HCV and purified recombinant E1 to examine whet...

journal_title：Journal of virology

authors： Kimman TG,Bianchi AT,Wensvoort G,de Bruin TG,Meliefste C

更新日期：1993-05-01 00:00:00

abstract：:Misfolded alpha-synuclein (αS) may exhibit a number of characteristics similar to those of the prion protein, including the apparent ability to spread along neuroanatomical connections. The demonstration for this mechanism of spread is largely based on the intracerebral injections of preaggregated αS seeds in mice, in...

journal_title：Journal of virology

authors： Ayers JI,Riffe CJ,Sorrentino ZA,Diamond J,Fagerli E,Brooks M,Galaleldeen A,Hart PJ,Giasson BI

更新日期：2018-08-29 00:00:00

abstract：:The replication of porcine circovirus type 1 (PCV1) is thought to occur by rolling-circle replication (RCR), whereby the introduction of a single-strand break generates a free 3'-hydroxyl group serving as a primer for subsequent DNA synthesis. The covalently closed, single-stranded genome of PCV1 replicates via a doub...

journal_title：Journal of virology

authors： Steinfeldt T,Finsterbusch T,Mankertz A

更新日期：2006-07-01 00:00:00

abstract：:Open reading frame 24 (ORF24) of murine gammaherpesvirus 68 (MHV-68) is conserved among beta- and gammaherpesviruses; however, its function in viral replication has not been defined. Using MHV-68 as a model, we have identified ORF24 as being essential for viral replication. An ORF24-null virus was generated and shown ...

journal_title：Journal of virology

authors： Wong E,Wu TT,Reyes N,Deng H,Sun R

更新日期：2007-06-01 00:00:00