Ultrastructure of the putative stem cell niche in rat mammary epithelium.

Abstract:

:There is now strong evidence that the stem cells of many tissues reside in specialized structures termed niches. The stem cell niche functions to house and regulate symmetric and asymmetric mitosis of stem cells in mammalian skin, mouse and human bone marrow, mouse brain, gut, and hair follicle, and Drosophila ovary and testis. This regulation is effected through the action of various signaling pathways such as Notch, Hedgehog, Wnt and others. The hormones of the estrous cycle, pregnancy and lactation that initiate growth in mouse mammary epithelium appear to act at a paracrine level to regulate mitosis through Notch receptors. Previous work has established that the putative stem cells of the mammary epithelium in several animal species reside near the basement membrane and never make contact with the ductal lumen. We show that these putative stem cells are found in anatomically specialized places created by the cytoplasmic extensions and modifications of neighboring differentiated cells. Such specializations may help to regulate stem cell activity by modulating molecular traffic to putative stem cells and contact with signaling molecules in the basement membrane. The histological characteristics of these putative niches vary as to the kinds of relationships the cells can have with the basement membrane and neighboring cells and as to how many stem or progenitor cells they may contain. This suggests a plasticity that may be relevant to the response of niches to tissue demands, such as wound healing, the periodic growth and regression of mammary epithelium, the process of mammary tumorigenesis therapeutic strategies for breast cancer.

journal_name

Tissue Cell

journal_title

Tissue & cell

authors

Chepko G,Dickson RB

doi

10.1016/s0040-8166(02)00107-6

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

83-93

issue

2

eissn

0040-8166

issn

1532-3072

pii

S0040816602001076

journal_volume

35

pub_type

杂志文章
  • Effects of insulin, hydrocortisone and prolactin on cell morphology, growth and survival of mammary organoids from mid-pregnant mice cultured on collagen gels.

    abstract::Mammary epithelial organoids consisting of groups of lobular-alveolar acini were prepared from mid-pregnant mice and cultured for 24, 48, 96 and 192 hr on attached collagen gels in the presence of combinations of insulin, hydrocortisone and prolactin. The organoids rapidly attached to the gels and with all the combina...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(92)90094-n

    authors: Barber MC,Dils RR

    更新日期:1992-01-01 00:00:00

  • Na(+)/K(+)-ATPase activity and immunocytochemical labeling in podobranchial filament and lamina of the freshwater crayfish Astacus leptodactylus Eschscholtz: evidence for the existence of sodium transport in the filaments.

    abstract::In the crayfish Astacus leptodactylus, the podobranch, bearing respiratory and ion-transporting filaments, is attached to the lamina. The Na(+)/K(+)-ATPase activity is higher in filaments than in lamina. Using a mouse monoclonal antibody directed against the alpha subunit of Na(+)/K(+)-ATPase, and indirect immunofluor...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1054/tice.1999.0063

    authors: Barradas C,Wilson JM,Dunel-Erb S

    更新日期:1999-10-01 00:00:00

  • Observations of the cellular changes in cultured mouse metrial gland explants and of the maintenance of granulated metrial gland cells in vitro.

    abstract::Mouse metrial gland explants were cultured for periods of up to 7 days. Granulated metrial gland cells migrated from the explants onto the culture dish substratum with a peak in numbers of emigrant cells usually found after 1-3 days of culture. Histological examination of the cultured explants showed that the central ...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(93)90034-i

    authors: Mukhtar DD,Stewart IJ

    更新日期:1993-12-01 00:00:00

  • Morphology of connective tissue in skeletal muscle.

    abstract::The arrangement and distribution of connective tissue in six different skeletal muscles and smooth muscle was examined by scanning electron microscopy. The endomysial arrangement of collagen was similar in all types of muscle and consisted of three components: (1) myocyte-myocyte connectives; (2) myocyte-capillary con...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(80)90061-0

    authors: Borg TK,Caulfield JB

    更新日期:1980-01-01 00:00:00

  • Effect of epidermal growth factor on cultured adult rat hepatocytes.

    abstract::When adult rat hepatocytes were cultured in plastic Petri dishes in a medium containing insulin and glucagon, supplementation with epidermal growth factor (EGF) had a pronounced effect on their viability, morphology, and biochemical integrity. Transmission and scanning electron microscopic studies showed that after 1 ...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(84)90040-5

    authors: Jansing R,Samsonoff WA

    更新日期:1984-01-01 00:00:00

  • Cytological steps during spermiogenesis in the house sparrow (Passer domesticus, Linnaeus).

    abstract::Spermiogenesis of the domestic sparrow was investigated with the light and electron microscopes and a step by step classification is proposed. Three cell populations corresponding to early, mid and late spermatids were easily divided according to their positions in the seminiferous epithelium. In addition to this init...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/s0040-8166(02)00017-4

    authors: Góes RM,Dolder H

    更新日期:2002-08-01 00:00:00

  • An in vitro system for the study of tracheal epithelial cells.

    abstract::Enzymatically dissociated hamster tracheal epithelial (HTE) cells were cultured on collagen coated Millicell filters. Within 3-5 days after being placed in culture large numbers of ciliated and mucus cells began to appear. By 1 week the HTE cells closely resembled those seen in vivo, i.e. columnar morphology and organ...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(87)90019-x

    authors: Moller PC,Partridge LR,Cox R,Pellegrini V,Ritchie DG

    更新日期:1987-01-01 00:00:00

  • Effects of androgen deprivation on the histology of adult chimpanzee testis.

    abstract::Until primate sperm are exposed to the unique microenvironment of the epididymis, they are not capable of fertilization or vigorous motility. Many of the proteins that contribute to the unique microenvironment of the primate epididymis, and thus to sperm maturation, are dependent on androgens to induce their synthesis...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1054/tice.2000.0164

    authors: Smithwick EB,Young LG

    更新日期:2001-06-01 00:00:00

  • The effect of 1,25 dihydroxyvitamin D3 on HCl/Ethanol-induced gastric injury in rats.

    abstract::This study evaluated ulceroprotective and antioxidant effect of 1,25 dihydroxyvitamin D3 against gastric damage in rats. Rats were treated intraperitoneally with either 1,25 dihydroxyvitamin D3 (0.25 μg/kg) or saline for 14 days. On day-15, the non-selective cyclooxygenase inhibitor indomethacin (10 mg/kg; subcutaneou...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/j.tice.2018.03.003

    authors: Sahin HH,Cumbul A,Uslu U,Yilmaz Z,Ercan F,Alican I

    更新日期:2018-04-01 00:00:00

  • Structure of the subgenual organ in the green lacewing, Chrysoperla carnea.

    abstract::REM and TEM studies of the subgenual organ in Chrysoperla carnea (Neuroptera: Chrysopidae) show that it is composed of three scolopidia, each with one sensory, one scolopale and one cap cell. The distal part of the dendrite shows a cilium with a '9 + 0' structure. The cross-handing pattern of the ciliary root has a pe...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(94)90100-7

    authors: Devetak D,Pabst MA

    更新日期:1994-04-01 00:00:00

  • Microtubules and the development of the corkscrew region of a mealybug sperm bundle.

    abstract::Two systems of microtubules appear to be functionally significant in the transformation of a small cell into an elongated, acellular 'corkscrew', which represents the anterior region of a sperm bundle of Pseudococcus obscurus. One system of microtubules lies within the cell; it is oriented parallel to the long axis of...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/s0040-8166(71)80029-0

    authors: Ross J

    更新日期:1971-01-01 00:00:00

  • The polycystic ovarian (PCO) condition: apoptosis and epithelialization of the ovarian antral follicles are aspects of cystogenesis in the dehydroepiandrosterone (DHEA)-treated rat model.

    abstract::This investigation was designed to study apoptosis and epithelialization during cystogenesis of the dehydroepiandrosterone rat model. Using in situ DNA 3'- end-labeling with non-radioactive digoxigenindidesoxy-UTP (dig-ddUTP), apoptosis is initially seen in cumulus granulosa cells and other granulosa cells facing the ...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/s0040-8166(97)80017-1

    authors: Anderson E,Lee GY

    更新日期:1997-04-01 00:00:00

  • Immunohistochemical localization of alpha(1a)-adrenoreceptors in muscle spindles of rabbit masseter muscle.

    abstract::The expression of alpha(1a)-adrenoreceptors (alpha(1a)-ARs) within the muscle spindles of rabbit masseter muscle was investigated. The alpha(1a)-ARs were detected by immunohistochemical fluorescent method and examined along the entire length of 109 cross serially sectioned spindles. The sympathetic fibers were visuali...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/j.tice.2005.12.003

    authors: Bombardi C,Grandis A,Chiocchetti R,Bortolami R,Johansson H,Lucchi ML

    更新日期:2006-04-01 00:00:00

  • Peroxisomes and sterol carrier protein-2 in luteal cell steroidogenesis: a possible role in cholesterol transport from lipid droplets to mitochondria.

    abstract::In the present investigation, we have studied peroxisomes and sterol carrier protein-2 (SCP2) in control and luteinizing hormone stimulated rat luteal cells. Superovulated immature rats in mid-luteal phase (8 days after ovulation) were divided into two groups (n = 4/group) and treated with vehicle (0.2 ml saline), or ...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/s0040-8166(05)80056-4

    authors: Mendis-Handagama SM,Aten RF,Watkins PA,Scallen TJ,Berhman HR

    更新日期:1995-10-01 00:00:00

  • Effects of anticancer drug docetaxel on the structure and function of the rabbit olfactory mucosa.

    abstract::Docetaxel (DCT) is an anticancer drug which acts by disrupting microtubule dynamics in the highly mitotic cancer cells. Thus, this drug has a potential to affect function and organization of tissues exhibiting high cellular turnover. We investigated, in the rabbit, the effects of a single human equivalent dose (6.26 m...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/j.tice.2014.04.005

    authors: Kavoi BM,Plendl J,Makanya AN,Ochieng' S,Kiama SG

    更新日期:2014-06-01 00:00:00

  • Structural and mechanical aspects of the skin of Bufo marinus (Anura, Amphibia).

    abstract::Specific biomechanical characters and some structures possibly related to them were investigated in the skin of the toad Bufo marinus using tensile testing techniques (at constant strain till rupture) as well as morphological methods (histological, immunohistochemical and electronmicroscopical). Mechanical parameters ...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1054/tice.2001.0208

    authors: Schwinger G,Zanger K,Greven H

    更新日期:2001-10-01 00:00:00

  • The effect of fibrin on cultured vascular endothelial cells.

    abstract::The normal cobblestone monolayer architecture of cultured vascular endothelium becomes rapidly disorganized after contact of the cell layer with a fibrin clot. The cells of a confluent endothelial monolayer separate into individual migratory cells in 4--6 hr after contact with fibrin. The effect is reversible in that ...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(79)90010-7

    authors: Kadish JL,Butterfield CE,Folkman J

    更新日期:1979-01-01 00:00:00

  • The development of branched silk gland nuclei.

    abstract::Nuclei in the giant polyploid silk gland cells of Calpodes ethlius grow by endomitosis and can develop hundreds of branches during larval life. The shape of the these nuclei is characteristic for each region of the gland. We have found shape to be correlated with arrangement of the nuclear matrix. Scanning electron mi...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(91)90036-s

    authors: Henderson SC,Locke M

    更新日期:1991-01-01 00:00:00

  • Bilateral eyestalk ablation of the blue swimmer crab, Portunus pelagicus, produces hypertrophy of the androgenic gland and an increase of cells producing insulin-like androgenic gland hormone.

    abstract::The androgenic glands (AG) of male decapod crustaceans produce insulin-like androgenic gland (IAG) hormone that controls male sex differentiation, growth and behavior. Functions of the AG are inhibited by gonad-inhibiting hormone originating from X-organ-sinus gland complex in the eyestalk. The AG, and its interaction...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/j.tice.2010.07.003

    authors: Sroyraya M,Chotwiwatthanakun C,Stewart MJ,Soonklang N,Kornthong N,Phoungpetchara I,Hanna PJ,Sobhon P

    更新日期:2010-10-01 00:00:00

  • Is the Golgi apparatus the obligatory final step for lipoprotein secretion by intestinal cells?

    abstract::It is currently admitted that the synthesis and excretion of triglyceride-rich lipoproteins (chylomicrons and 'small chylomicrons') by intestinal epithelial cells involves the Golgi apparatus as an obligatory final step before exocytosis. The cells of the proximal intestine of the trout are an excellent model for inve...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(86)90064-9

    authors: Vernier JM,Sire MF

    更新日期:1986-01-01 00:00:00

  • Intercalated discs of mammalian heart: a review of structure and function.

    abstract::Intercalated discs are exceptionally complex entities, and possess considerable functional significance in terms of the workings of the myocardium. Examination of different species and heart regions indicates that the original histological term has become out-moded; it is likely, however, that all such complexes will ...

    journal_title:Tissue & cell

    pub_type: 杂志文章,评审

    doi:10.1016/0040-8166(85)90001-1

    authors: Forbes MS,Sperelakis N

    更新日期:1985-01-01 00:00:00

  • Differential distribution of glutamylated tubulin in the flagellum of mouse spermatozoa.

    abstract::Using a monoclonal antibody (GT 335) we previously demonstrated that glutamylation is a predominant posttranslational modification of alpha and beta tubulin isoforms in the axoneme of mouse spermatozoa (Fouquet et al., Cell Motil. Cytoskel. 27, 49, 1994). However, we noted that the staining intensity and/or distributi...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/s0040-8166(95)80053-0

    authors: Kann ML,Prigent Y,Fouquet JP

    更新日期:1995-06-01 00:00:00

  • The role of the rat submandibular gland in the excretion of bis (tributyltin) oxide: electron microscopy, X-ray microanalysis and atomic absorption analysis.

    abstract::The role of the submandibular glands in the excretion of parenterally administered bis (tributyltin) oxide (TBTO) was studied. Fine structural alterations of the submandibular glands were observed with an electron microscope. Accumulation sites of TBTO were determined with an X-ray microanalyzer and tin concentrations...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(92)90044-8

    authors: Yoshizuka M,Hara K,Nagata N,Doi Y,Yokoyama M,Sagara T,Fujimoto S

    更新日期:1992-01-01 00:00:00

  • Morphological behavior of cultured bovine adrenal medulla capillary endothelial cells.

    abstract::Bovine adrenal medulla capillary endothelial cells were isolated and cloned, and their morphological behaviors in vitro were examined. In the culture of primary or early passage, one type of colony formed intracellular lumina both on the dish and in the three dimensional collagen gel. Another type proliferated well an...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(90)90059-i

    authors: Furuya S,Edwards C,Ornberg R

    更新日期:1990-01-01 00:00:00

  • Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J).

    abstract::Morphological and functional changes caused by diabetes in the accessory sex organs and especially the prostate have been reported by several investigators. The aim of the present study was to examine the possible deleterious effects of experimentally induced diabetes on the secretory epithelium of the ventral prostat...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1054/tice.2000.0123

    authors: Cagnon VH,Camargo AM,Rosa RM,Fabiani R,Padovani CR,Martinez FE

    更新日期:2000-08-01 00:00:00

  • Biological ultrastructure research; the first 50 years.

    abstract::The second half of the 20th century has witnessed the birth and growth of biological ultrastructure research--a branch of cell biology in which electron microscopy plays an important role. After a humble start in around 1950, when only a limited arsenal of instrumentation was available, a wealth of auxiliary methodolo...

    journal_title:Tissue & cell

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.tice.2003.11.001

    authors: Afzelius BA,Maunsbach AB

    更新日期:2004-04-01 00:00:00

  • Ultrastructure of the epidermal eyespots of an acoel platyhelminth.

    abstract::The epidermal eyespots of the acoel Otocelis rubropunctata would appear to consist of a single cell type provided with pigment granules and cilia. Very numerous dictyosomes characterize the cytoplasm of the cells. The cilia possess the 9X2 + 2 pattern of microtubules and the typical rootlets of acoels. Microvilli are ...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/0040-8166(90)90082-k

    authors: Lanfranchi A

    更新日期:1990-01-01 00:00:00

  • Effects of Toll-like receptor ligands on RAW 264.7 macrophage morphology and zymosan phagocytosis.

    abstract::In this study we compared the effects of the Toll-like receptor (TLR) ligands lipopolysaccharide (LPS), flagellin, the synthetic bacterial triacylated lipopeptide Pam3-Cys-Ser-Lys4 (Pam3CSK4), Polyinosinic:polycytidylic acid (Poly I:C), and macrophage-activating lipopeptide (MALP-2), which are TLR4, TLR5, TLR1/2, TLR3...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/j.tice.2016.04.002

    authors: Sigola LB,Fuentes AL,Millis LM,Vapenik J,Murira A

    更新日期:2016-08-01 00:00:00

  • Protein profiling and angiogenic effect of hypoxia-cultured human umbilical cord blood-derived mesenchymal stem cells in hindlimb ischemia.

    abstract::The aim of the present study was to investigate protein profiles of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) cultured in normoxic (21% O2) and hypoxic (1% O2) conditions, and evaluate oxygenation effects on angiogenesis in an ischemic hindlimb mouse model using a modified ischemic scoring ...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/j.tice.2017.09.006

    authors: Han KH,Kim AK,Kim MH,Kim DH,Go HN,Kang D,Chang JW,Choi SW,Kang KS,Kim DI

    更新日期:2017-12-01 00:00:00

  • Structure and development of the telotrophic ovariole in ensign scale insects (Hemiptera, Coccomorpha: Ortheziidae).

    abstract::The paired ovaries of young larva of the 3rd instar of Orthezia urticae are filled with numerous germ cell clusters that can be regarded as ovariole anlagen. Germ cells (cystocytes) belonging to one cluster form a rosette, in the centre of which a polyfusome occurs. Staining with rhodamine-phalloidin has revealed that...

    journal_title:Tissue & cell

    pub_type: 杂志文章

    doi:10.1016/s0040-8166(97)80069-9

    authors: Szklarzewicz T

    更新日期:1997-02-01 00:00:00