Renal tubule sodium transporter abundance profiling in rat kidney: response to aldosterone and variations in NaCl intake.

Abstract:

:Based on extensive physiological study of sodium transport mechanisms along the renal tubule, complementary DNAs for all of the major transporters and channels responsible for renal tubular sodium reabsorption have been cloned over the past decade. There is now a comprehensive set of cDNA and antibody probes that can be used to investigate physiological mechanisms on a molecular level. Using rabbit polyclonal antibodies to all of the major renal Na transport proteins, we have developed profiling methods allowing comprehensive, integrated analysis of sodium transporter protein abundance changes along the renal tubule in response to physiological and pathophysiological perturbations. Here, we review some of our recent findings with this approach, focusing on renal responses to aldosterone and to variations in NaCl intake.

journal_name

Ann N Y Acad Sci

authors

Knepper MA,Kim GH,Masilamani S

doi

10.1111/j.1749-6632.2003.tb07254.x

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

562-9

eissn

0077-8923

issn

1749-6632

journal_volume

986

pub_type

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