Survival signals in leukemic large granular lymphocytes.

Abstract:

:The central hypothesis of our laboratory research program in large granular lymphocyte (LGL) leukemia is that leukemic LGL represent antigen-driven cytotoxic T lymphocytes (CTL) with characteristics of dysregulated apoptosis. The clinical features of LGL leukemia highlight the association of autoimmune diseases such as rheumatoid arthritis with the T-cell form of LGL leukemia. We therefore used LGL leukemia as a model disease of dysregulated apoptosis leading to both malignant and autoimmune diseases. Here, we review our understanding of survival signals activated in leukemic LGL in the context of knowledge concerning apoptotic pathways in activated normal lymphocytes.

journal_name

Semin Hematol

journal_title

Seminars in hematology

authors

Epling-Burnette PK,Loughran TP Jr

doi

10.1016/s0037-1963(03)00135-5

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

213-20

issue

3

eissn

0037-1963

issn

1532-8686

pii

S0037196303001355

journal_volume

40

pub_type

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