Involvement of the extracellular signal regulated kinase pathway in hydrocarbon-induced reactive oxygen species formation in human neutrophil granulocytes.

abstract：:Inhalation of asbestos may activate the pulmonary endothelium to promote an inflammatory cell phenotype that participates in the development of pulmonary fibrosis. However, little is known about the effects of asbestos on endothelial cell function. Therefore, endothelial cells were exposed to chrysotile and crocidolit...

journal_title：Toxicology and applied pharmacology

authors： Treadwell MD,Mossman BT,Barchowsky A

更新日期：1996-07-01 00:00:00

abstract：:Previous research has shown that intraperitoneal injection of the solvent pyridine results in a dose- and time-dependent induction of hepatic P450IIE1 in rats, with a twofold increase observed at 6 hr post-treatment. However, inhalation is the primary route of exposure expected for humans exposed to pyridine in labora...

journal_title：Toxicology and applied pharmacology

authors： Hotchkiss JA,Kim SG,Novak RF,Dahl AR

更新日期：1993-01-01 00:00:00

abstract：:Early-life exposure to arsenic increases risk of developing a variety of non-malignant and malignant diseases. Arsenic-induced carcinogenesis may be mediated through epigenetic mechanisms and pathways leading to inflammation. Our previous study reported that prenatal arsenic exposure leads to increased mRNA expression...

journal_title：Toxicology and applied pharmacology

authors： Phookphan P,Navasumrit P,Waraprasit S,Promvijit J,Chaisatra K,Ngaotepprutaram T,Ruchirawat M

更新日期：2017-02-01 00:00:00

abstract：:Treatment with 3-aminobenzamide, known as an inhibitor of poly(ADP-ribose)polymerease, decreased the toxicity and covalent binding of the herbicide dichlobenil (2,6-dichlorobenzonitrile; 12 mg/kg; i.p.) in the mouse olfactory mucosa. In vitro studies showed that 3-aminobenzamide markedly reduced the NADPH-dependent co...

journal_title：Toxicology and applied pharmacology

authors： Eriksson C,Busk L,Brittebo EB

更新日期：1996-02-01 00:00:00

abstract：:The iron chelate, ferric nitrilotriacetate (FeNTA), induces acute proximal tubular necrosis as a consequence of lipid peroxidation and oxidative tissue damage. Chronic exposure of FeNTA leads to a high incidence of renal adenocarcinomas in rodents. NF-E2-related factor 2 (Nrf2) is a transcription factor that is activa...

journal_title：Toxicology and applied pharmacology

authors： Tanaka Y,Aleksunes LM,Goedken MJ,Chen C,Reisman SA,Manautou JE,Klaassen CD

更新日期：2008-09-15 00:00:00

abstract：:A comparative study was undertaken in order to assess the hematotoxic effects of hydroquinone (HQ), 1,4-benzoquinone (BQ), and doxorubicin (DX) on mouse and human bone marrow (BM) cells. Initial experiments indicated that the inhibitory effects of near-ambient pO2 and HQ on granulocyte/macrophage colony-stimulating fa...

journal_title：Toxicology and applied pharmacology

authors： Colinas RJ,Burkart PT,Lawrence DA

更新日期：1994-11-01 00:00:00

abstract：:Organophosphorus (OP) compounds inhibit mitochondrial enzymes, respiration, and ATP generation, in addition to inducing structural changes such as matrix swelling. This implicates mitochondria as primary subcellular targets for these compounds. In this study, the health and function of cellular mitochondria following ...

journal_title：Toxicology and applied pharmacology

authors： Carlson K,Ehrich M

更新日期：1999-10-01 00:00:00

abstract：:Methyl chloride (MeCl) metabolism and pharmacokinetics were studied in male Fischer 344 rats and male beagle dogs. Apparent steady-state blood MeCl concentrations were proportionate to exposure concentration in rats and dogs exposed to 50 and 1000 ppm. Furthermore, blood MeCl concentrations were similar in both specie...

journal_title：Toxicology and applied pharmacology

authors： Landry TD,Gushow TS,Langvardt PW,Wall JM,McKenna MJ

更新日期：1983-05-01 00:00:00

abstract：:The effect of HgCl2 on kainate (KA)-induced depression of voltage-gated potassium (K+) current in chick embryo telencephalic cells was studied using conventional and nystatin-perforated whole-cell patch-clamp recordings, fluorescence imaging, and flow cytometry techniques. Hg2+ (1 microM) alone did not effect the 4-am...

journal_title：Toxicology and applied pharmacology

authors： Dyatlov VA,Platoshin AV,Lawrence DA,Carpenter DO

更新日期：1996-06-01 00:00:00

abstract：:Poly(amidoamine) (PAMAM) dendrimer nanoparticles have been demonstrated to elicit a well defined cytotoxicological response from mammalian cell lines, the response increasing systematically with dendrimer generation and number of surface amino groups. In this work, using generation G4, G5, and G6 dendrimers, this syst...

journal_title：Toxicology and applied pharmacology

authors： Mukherjee SP,Lyng FM,Garcia A,Davoren M,Byrne HJ

更新日期：2010-11-01 00:00:00

abstract：:Previous studies in this laboratory have shown that polycyclic aromatic hydrocarbons (PAHs) alter Ca2+ homeostasis and inhibit activation of both B and T lymphocytes obtained from rodents and humans. In the present studies, we demonstrate that alpha-naphthoflavone (ANF), an inhibitor of cytochrome P4501A activity, red...

journal_title：Toxicology and applied pharmacology

authors： Romero DL,Mounho BJ,Lauer FT,Born JL,Burchiel SW

更新日期：1997-05-01 00:00:00

abstract：:Polycyclic Aromatic Hydrocarbons (PAHs) constitute a family of over one hundred compounds and can generally be found in complex mixtures. PAHs metabolites cause DNA damage which can lead to the development of carcinogenesis. Toxicity assessment of PAH complex mixtures is currently expressed in terms of toxic equivalen...

journal_title：Toxicology and applied pharmacology

authors： Audebert M,Zeman F,Beaudoin R,Péry A,Cravedi JP

更新日期：2012-04-01 00:00:00

abstract：:Many studies of nanomaterials make non-systematic alterations of nanoparticle physicochemical properties. Given the immense size of the property space for nanomaterials, such approaches are not very useful in elucidating fundamental relationships between inherent physicochemical properties of these materials and their...

journal_title：Toxicology and applied pharmacology

authors： Bai X,Liu F,Liu Y,Li C,Wang S,Zhou H,Wang W,Zhu H,Winkler DA,Yan B

更新日期：2017-05-15 00:00:00

abstract：:Chronic arsenic exposure through contaminated drinking water is a major environmental health issue. Chronic arsenic exposure is known to exert its toxic effects by a variety of mechanisms, of which generation of reactive oxygen species (ROS) is one of the most important. A high level of ROS, in turn, leads to DNA dama...

journal_title：Toxicology and applied pharmacology

authors： Banerjee M,Banerjee N,Ghosh P,Das JK,Basu S,Sarkar AK,States JC,Giri AK

更新日期：2010-11-15 00:00:00

abstract：:The purpose of this study was to characterize the induction of metallothionein (MT) by steroids in rat primary hepatocyte cultures. Comparison of the characteristics of MT induction by a steroid (dexamethasone) to that by metals (Zn and Cd), examination of the involvement of the glucocorticoid receptor in the steroid ...

journal_title：Toxicology and applied pharmacology

authors： Bracken WM,Klaassen CD

更新日期：1987-03-15 00:00:00

abstract：:Chronic exposure to high concentrations of arsenic in drinking water is associated with an increased risk for developing type 2 diabetes. The present revision focuses on the effect of arsenic on tissues that participate directly in glucose homeostasis, integrating the most important published information about the imp...

journal_title：Toxicology and applied pharmacology

authors： Díaz-Villaseñor A,Burns AL,Hiriart M,Cebrián ME,Ostrosky-Wegman P

更新日期：2007-12-01 00:00:00

abstract：:The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented. Fibroblast growth factor (Fgf) 21 plays critical roles in metabolic adaptation to fasting by increasing lipid oxidation and ketogenesis in the liver. T...

journal_title：Toxicology and applied pharmacology

authors： Cheng X,Vispute SG,Liu J,Cheng C,Kharitonenkov A,Klaassen CD

更新日期：2014-07-01 00:00:00

abstract：:Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. New BPD is characterized as having alveolar simplification. We reported previously that aryl hydrocarbon receptor (AhR) deficiency increased susceptibility to hyperoxic lung injury in adult mice, and this was associated ...

journal_title：Toxicology and applied pharmacology

authors： Shivanna B,Zhang W,Jiang W,Welty SE,Couroucli XI,Wang L,Moorthy B

更新日期：2013-03-15 00:00:00

abstract：:Cholestatic liver injury is caused by hepatocellular apoptosis induced by toxic bile salts. We have studied the effects of a traditional Chinese herbal medicine, Salvia miltiorrhiza, on apoptotic cell death in bile duct-ligated (BDL) rats. We also attempted to clarify the molecular mechanisms of the hepatoprotective e...

journal_title：Toxicology and applied pharmacology

authors： Oh SH,Nan JX,Sohn D-,Kim YC,Lee BH

更新日期：2002-07-01 00:00:00

abstract：:Decreased daily sperm production (DSP) and cauda epididymal sperm number (CESN) are some of the most sensitive effects of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. The reduction in CESN cannot be fully accounted for by decreased spermatogenesis. To explain the decrease in CESN it wa...

journal_title：Toxicology and applied pharmacology

authors： Sommer RJ,Ippolito DL,Peterson RE

更新日期：1996-09-01 00:00:00

abstract：:Melatonin is a neuroendocrine hormone which is currently receiving considerable attention as a treatment for jet lag, a treatment for insomnia and, by some, a possible "magic bullet" for delaying the effects of aging and preventing cancer. Production of melatonin is focused primarily in the pineal gland with very wide...

journal_title：Toxicology and applied pharmacology

authors： Blumenthal GM,Kohn MC,Portier CJ

更新日期：1997-11-01 00:00:00

abstract：:The ability of brain tissue preparation to generate superoxide from xenobiotic interactions has been investigated. We showed that a significant superoxide production occurred with different molecules known to undergo a single electron reductive pathway of metabolism, both in a homogenate derived from neuronal and glia...

journal_title：Toxicology and applied pharmacology

authors： Ghersi-Egea JF,Livertoux MH,Minn A,Perrin R,Siest G

更新日期：1991-08-01 00:00:00

abstract：:Four chemicals that are known to induce in rats thyroid follicular-cell adenomas and carcinomas were assayed for their ability to induce DNA damage and DNA repair synthesis in primary cultures of human thyroid cells. Significant dose-dependent increases in the frequency of DNA single-strand breaks and alkali-labile si...

journal_title：Toxicology and applied pharmacology

authors： Mattioli F,Martelli A,Garbero C,Gosmar M,Manfredi V,Mattioli FP,Torre G,Brambilla G

更新日期：2005-03-01 00:00:00

abstract：:Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects on QT interval. However, there is no report showing that this techni...

journal_title：Toxicology and applied pharmacology

authors： Nozaki Y,Honda Y,Tsujimoto S,Watanabe H,Kunimatsu T,Funabashi H

更新日期：2014-07-01 00:00:00

abstract：:The Fhit tumor suppressor protein possesses Ap(3)A (diadenosine triphosphate - ApppA) hydrolytic activity in vitro and its gene is found inactive in many pre-malignant states due to gene inactivation. For several years Fhit has been a widely investigated protein as its cellular function still remains largely unsolved....

journal_title：Toxicology and applied pharmacology

authors： Zawacka-Pankau J,Ferens B

更新日期：2009-12-01 00:00:00

abstract：:Acetaminophen (APAP) administration (600 mg/kg, ip) to 18-hr fasted, 3-month-old male CD-1 mice results in necrosis of the convoluted renal proximal tubules with a corresponding elevation of plasma urea nitrogen (BUN). Administration of the gamma-glutamyl transpeptidase inhibitor, L-(alpha S,5S)-alpha-amino-3-chloro-4...

journal_title：Toxicology and applied pharmacology

authors： Emeigh Hart SG,Wyand DS,Khairallah EA,Cohen SD

更新日期：1996-01-01 00:00:00

abstract：:Metallothionein (MT), a high-affinity metal-binding protein, is known to detoxicate cadmium and may play an important role in cadmium carcinogenesis. In the rat, the ventral lobe of the prostate is sensitive to cadmium carcinogenesis, while the dorsolateral lobe is refractory. The possibility exists that the basis of ...

journal_title：Toxicology and applied pharmacology

authors： Coogan TP,Shiraishi N,Waalkes MP

更新日期：1995-05-01 00:00:00

abstract：:The concept of toxicovigilance encompasses the active detection, validation and follow-up of clinical adverse events related to toxic exposures in human beings. Poison centers are key players in this function as poisoning statistics are essential to define the cause, incidence and severity of poisonings occurring in t...

journal_title：Toxicology and applied pharmacology

authors： Descotes J,Testud F

更新日期：2005-09-01 00:00:00

abstract：:Cyclosporin (Cs), a cyclic nonpolar undecapeptide of fungal origin, has potent immunosuppressive and antiparasitic activities, and renal and hepatic toxicities, the mechanisms of which are not worked out. Many nephrotoxins and hepatotoxins are predictably more or less harmful, depending upon the circadian stage at whi...

journal_title：Toxicology and applied pharmacology

authors： Magnus G,Cavallini M,Halberg F,Cornelissen G,Sutherland DE,Najarian JA,Hrushesky WJ

更新日期：1985-01-01 00:00:00

abstract：:Organic cations (OCs) constitute a diverse array of compounds of physiological, pharmacological, and toxicological importance. Renal secretion of these compounds, which occurs principally along the proximal portion of the nephron, plays a critical role in regulating the concentration of OCs in the plasma and in cleari...

journal_title：Toxicology and applied pharmacology

authors： Wright SH

更新日期：2005-05-01 00:00:00