Effects of the peroxisome proliferator mono(2-ethylhexyl)phthalate in primary hepatocyte cultures derived from rat, guinea pig, rabbit and monkey. Relationship between interspecies differences in biotransformation and peroxisome proliferating potencies.

abstract：:The interrelated signaling via TGF-beta1 and reactive oxygen species has a profound impact on fibrogenesis and is therefore selected as target for antifibrotic therapies. This prompted us to investigate the influence of the antioxidant N-acetyl-L-cysteine on TGF-beta signaling in culture-activated hepatic stellate cel...

journal_title：Biochemical pharmacology

authors： Meurer SK,Lahme B,Tihaa L,Weiskirchen R,Gressner AM

更新日期：2005-10-01 00:00:00

abstract：:AM404 is a synthetic TRPV1/CB(1) hybrid ligand with inhibitory activity on the anandamide transporter and is used for the pharmacological manipulation of the endocannabinoid system. It has been recently described that acetaminophen is metabolised in the brain to form the bioactive N-acylphenolamine AM404 and therefore...

journal_title：Biochemical pharmacology

authors： Caballero FJ,Navarrete CM,Hess S,Fiebich BL,Appendino G,Macho A,Muñoz E,Sancho R

更新日期：2007-04-01 00:00:00

abstract：:Enhanced DNA repair activity is important for the development of cellular resistance to alkylating agents. Here, we quantitated the kinetics of DNA excision repairs initiated by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in human leukemia CCRF-CEM cells. CEM cells that had been established resistant to BCNU (CEM-R) w...

journal_title：Biochemical pharmacology

authors： Yamauchi T,Kawai Y,Ueda T

更新日期：2003-09-15 00:00:00

abstract：:In the present work we set out to apply pharmacodynamic concepts derived from dose-response curves (Potency and Efficacy) to characterize the gene transfer efficiency of a vector:DNA complex. We employed two widely used vectors, the cationic lipid DOTAP (N,N, N-trimethyl 1-2-3-bis (1-oxo-9-octa-decenyl)oxy-(Z, Z)-1-pr...

journal_title：Biochemical pharmacology

authors： Aliño SF,Escrig E,Revert F,Guillem VM,Crespo A

更新日期：2000-12-15 00:00:00

abstract：:The effects of estradiol on the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and the 12-lipoxygenase activity in rat platelets in vivo were studied. Estradiol had no significant effect on the endogenous fatty acid composition of cellular phospholipid fractions. ...

journal_title：Biochemical pharmacology

authors： Chang WC,Nakao J,Orimo H,Tai HH,Murota SI

更新日期：1982-08-15 00:00:00

abstract：:Cisplatin is a potent chemotherapeutic drug widely used for the treatment of human cancer. However, its efficacy against hepatocellular carcinoma (HCC) is poor for reasons that remain unclear. We show here that prothymosin-alpha (PTMA) is overexpressed in HCC cell lines. Silencing PTMA using short-hairpin RNA sensitiz...

journal_title：Biochemical pharmacology

authors： Lin YT,Liu YC,Chao CC

更新日期：2016-12-15 00:00:00

abstract：:Phomopsins comprise a family of peptide mycotoxins containing a 13-membered ring formed by an ether bridge, produced by the fungus Phomopsis leptostromiformis, the causal agent in lupin poisoning (lupinosis). The biochemical actions of two naturally occurring phomopsins, phomopsin A and B, and the chemical derivatives...

journal_title：Biochemical pharmacology

authors： Lacey E,Edgar JA,Culvenor CC

更新日期：1987-07-01 00:00:00

abstract：:One feature that contraindicates the wide therapeutic use of retinoids is their teratogenicity. Synthetic retinoids are distinguishable from each other on the basis of their partial or exclusive preference in binding and activation of all-trans retinoic acid receptors (RARs) or retinoid X receptors (RXRs). Using mouse...

journal_title：Biochemical pharmacology

authors： Jiang H,Penner JD,Beard RL,Chandraratna RA,Kochhar DM

更新日期：1995-08-25 00:00:00

abstract：:3-alpha-Methyl substituted digitoxigenin-3-beta-glucoside (methyl-dtg-gluc) displays unusual features, e.g. a high dissociation rate constant from its binding site leading to rapid reversibility of the inotropic and toxic effects, and a flat dose-response curve attaining higher inotropic maxima thus indicating an incr...

journal_title：Biochemical pharmacology

authors： Lüllmann H,Mohr K

更新日期：1982-08-01 00:00:00

abstract：:The cytotoxicity anti-tumour intercalating agents such as the anthraquinone mitoxantrone is thought to relate to DNA binding and the trapping of DNA topoisomerase II complexes on cellular DNA. We have studied the uptake, nuclear location, DNA binding mode and DNA damaging capacity of mitoxantrone in a small cell lung ...

journal_title：Biochemical pharmacology

authors： Smith PJ,Morgan SA,Fox ME,Watson JV

更新日期：1990-11-01 00:00:00

abstract：:Lipids play a complex role in prostate cancer (PCa). Increased de novo synthesis of fatty acids and/or cholesterol is associated with the development of prostate tumors. Liver X Receptors (LXRs) are members of the nuclear receptor family that regulates intracellular lipid homeostasis. Targeting the transcriptional act...

journal_title：Biochemical pharmacology

authors： Hoang JJ,Baron S,Volle DH,Lobaccaro JM,Trousson A

更新日期：2013-07-01 00:00:00

abstract：:The aim of the present study was to estimate the relative contribution of rat P450 isoforms to the metabolism of caffeine and to assess the usefulness of caffeine as a marker substance for estimating the activity of P450 in rat liver and its potential for pharmacokinetic interactions in pharmacological experiments. Th...

journal_title：Biochemical pharmacology

authors： Kot M,Daniel WA

更新日期：2008-04-01 00:00:00

abstract：:This article has been retracted consistent with Elsevier Policy on Article Withdrawal. Please see . The Publisher apologises for any inconvenience this may cause. ...

journal_title：Biochemical pharmacology

authors： Cristofanon S,Dicato M,Ghibelli L,Diederich M

更新日期：2006-04-18 00:00:00

abstract：:The tissue distribution of captopril, an antihypertensive drug possessing a free sulfhydryl group, and its sulfur-conjugated metabolites was studied in rats by gas chromatography-mass spectrometry at 15, 30 and 60 min following a single 10 mg/kg oral dose of captopril. It was found that tissue accumulation of captopri...

journal_title：Biochemical pharmacology

authors： Drummer OH,Worland PJ,Jarrott B

更新日期：1983-05-15 00:00:00

abstract：:The aim of this review is to summarize current available information about the role of PI3K/AKT/mTOR signaling in head and neck cancer as a potential target for new therapy options. 90% of all head and neck cancers are squamous cell carcinomas (HNSCC). The most common genetic alteration is inactivation of p16 gene whi...

journal_title：Biochemical pharmacology

authors： Marquard FE,Jücker M

更新日期：2020-02-01 00:00:00

abstract：:The antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has been shown previously to be enhanced markedly by the co-administration of pyrimidine deoxyribonucleosides (Lin and Prusoff, Cancer Res 47: 394-397, 1987). In the present study, we examined the cellular mechanisms underlying the augmentation effe...

journal_title：Biochemical pharmacology

authors： Poo WJ,Guo X,Haslund B,Mozdziesz DE

更新日期：1997-03-07 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) family of regulatory growth factors can reversibly arrest cell division in the G1 phase of the cell cycle. Previously, TGF-beta3 was shown to protect epithelial cells and hematopoietic cells from cytotoxic damage in vitro and in vivo, and to reduce the severity and durati...

journal_title：Biochemical pharmacology

authors： McCormack ES,Borzillo GV,Ambrosino C,Mak G,Hamablet L,Qu GY,Haley JD

更新日期：1997-04-25 00:00:00

abstract：:Despite the substantial progress made in understanding initiation expression of the MOR gene in lymphocytes, the signal pathway associated with MOR gene transcription remains to be better defined. As the phosphatidylinositol 3-kinase (PI3K)/AKT pathway can mediate diverse biological responses and is crucial for optima...

journal_title：Biochemical pharmacology

authors： Liu H,Li H,Guo L,Li M,Li C,Wang S,Jiang W,Liu X,McNutt MA,Li G

更新日期：2010-02-01 00:00:00

abstract：:The growth inhibitory effects of 5-fluorouracil (FUra) or 5-fluoro-2'-deoxyuridine (FdUrd) combined with 5-methyltetrahydrofolate (5-CH3-H4PteGlu) were determined, as a function of time, dose, and sequence of exposure, on human T-lymphoblast leukemia cells, CCRF-CEM. Synergistic inhibitory effects on cell growth were ...

journal_title：Biochemical pharmacology

authors： Mini E,Mazzei T,Coronnello M,Criscuoli L,Gualtieri M,Periti P,Bertino JR

更新日期：1987-09-15 00:00:00

abstract：:The p53 tumor suppressor protein provides a major anti-cancer defense mechanism, as underscored by the fact that the p53 gene is the most frequent target for genetic alterations in human cancer. Recent work has led to the realization that p53 lies at the hub of a very complex network of signaling pathways, which integ...

journal_title：Biochemical pharmacology

authors： Oren M,Damalas A,Gottlieb T,Michael D,Taplick J,Leal JF,Maya R,Moas M,Seger R,Taya Y,Ben-Ze'ev A

更新日期：2002-09-01 00:00:00

abstract：:With the aid of a chiral derivatizing reagent and a sensitive and specific nitrogen-phosphorus gas chromatographic assay, metabolism of para-chloroamphetamine (PCA) enantiomers has been studied following incubation of racemic (RS)-, R(-)- and S(+)-PCA with rabbit liver microsomal preparations. Significant metabolism o...

journal_title：Biochemical pharmacology

authors： Ames MM,Frank SK

更新日期：1982-01-01 00:00:00

abstract：:The binding of 1,1-dichloroethane (1,1-DCE) to the substrate binding site of hepatic microsomal cytochrome P-450, and the stimulation of hepatic microsomal CO-inhibitable NADPH oxidation by 1,1-DCE and 1,2-dichloroethane (1,2-DCE) were enhanced by induction with phenobarbital but not with beta-naphthoflavone. Incubati...

journal_title：Biochemical pharmacology

authors： McCall SN,Jurgens P,Ivanetich KM

更新日期：1983-01-15 00:00:00

abstract：:The seminal vesicle protein No. 4 (SV-IV) secreted from the rat seminal vesicle epithelium, possesses immunosuppressive and anti-inflammatory properties and it is a potent inhibitor of platelet aggregation both in vivo and in vitro. This research aimed to investigate the possible effect of SV-IV on the process of huma...

journal_title：Biochemical pharmacology

authors： Di Micco B,Colonna G,Porta R,Metafora S

更新日期：1994-07-19 00:00:00

abstract：:Chronic treatment with a low dose of reserpine (0.1 mg/kg) caused rats to become hyperactive in the "open field" apparatus. When mianserin (5 mg/kg) or the selective serotonin uptake inhibitor ORG. 6582 (5 mg/kg) was chronically administered in combination with reserpine, the hyperactivity was attenuated. Both antidep...

journal_title：Biochemical pharmacology

authors： Jancsár SM,Leonard BE

更新日期：1983-05-15 00:00:00

abstract：:Telbivudine (LdT), a widely prescribed anti-hepatitis B virus (HBV) drug for the treatment of chronic Hepatitis B (CHB), causes adverse reactions ranging from creatine kinase (CK) elevation to myopathy. The purpose of this study was to explore the mechanism(s) of LdT induced CK elevation. The effects of LdT on mitocho...

journal_title：Biochemical pharmacology

authors： Jianfei L,Min W,Chunlai M,Bicui C,Jiming Z,Bin W

更新日期：2017-12-15 00:00:00

abstract：:We have investigated the ability of certain dietary flavonoids, known to exert beneficial effects on the central nervous system, to affect neuronal apoptosis. We used cerebellar granule cells undergoing apoptosis due to potassium deprivation in a serum-free medium in either the absence or presence of the flavonoids ge...

journal_title：Biochemical pharmacology

authors： Atlante A,Bobba A,Paventi G,Pizzuto R,Passarella S

更新日期：2010-03-01 00:00:00

abstract：:Phospho-tyrosol-indomethacin (PTI; MPI 621), a novel anti-cancer agent, is more potent and safer than conventional indomethacin. Here, we show that PTI was extensively metabolized in vitro and in vivo. PTI was rapidly hydrolyzed by carboxylesterases to generate indomethacin as its major metabolite in the liver microso...

journal_title：Biochemical pharmacology

authors： Xie G,Zhou D,Cheng KW,Wong CC,Rigas B

更新日期：2013-04-15 00:00:00

abstract：:Cardioprotective effect of a free radical-scavenging compound (HO-3073) was examined during ischaemia-reperfusion (IR) in isolated heart perfusion system and its influence on the pro-survival Akt signalling pathway was addressed. Rat hearts were perfused according to the Langendorff method and subjected to a global 25...

journal_title：Biochemical pharmacology

authors： Toth A,Kovacs K,Deres P,Halmosi R,Czopf L,Hanto K,Kalai T,Hideg K,Sumegi B,Toth K

更新日期：2003-12-01 00:00:00

abstract：:Mechanical stress is known to activate signaling cascades, including mitogen-activated protein kinase (MAPK) pathways. Although mechanical stress has been implicated in hepatic cirrhosis and liver regeneration following hepatectomy, the signaling pathway(s) that may be activated in hepatocytes in response to mechanica...

journal_title：Biochemical pharmacology

authors： Kim SK,Woodcroft KJ,Oh SJ,Abdelmegeed MA,Novak RF

更新日期：2005-12-05 00:00:00

abstract：:Four pseudo-symmetrical tamoxifen derivatives, RID-B (13), RID-C (14), RID-D (15), and bis(dimethylaminophenetole) (16), were synthesized via the novel three-component coupling reaction, and the structure-activity relationships of these pseudo-symmetrical tamoxifen derivatives were examined. It was discovered that 13 ...

journal_title：Biochemical pharmacology

authors： Shiina I,Sano Y,Nakata K,Kikuchi T,Sasaki A,Ikekita M,Nagahara Y,Hasome Y,Yamori T,Yamazaki K

更新日期：2008-03-01 00:00:00