Abstract:
BACKGROUND:A randomized trial of a primary care-based intervention to prevent depression relapse resulted in improved adherence to long-term antidepressant medication and depression outcomes. We evaluated the effects of this intervention on behavioural processes and identified process predictors of improved depressive symptoms. METHOD:Patients at high risk for depression recurrence or relapse following successful acute phase treatment (N=386) were randomly assigned to receive a low intensity 12-month intervention or continued usual care. The intervention combined education about depression, shared decision-making regarding use of maintenance pharmacotherapy and cognitive-behavioural strategies to promote self-management. Baseline, 3, 6, 9 and 12-month interviews assessed patients' self-care practices, self-efficacy for managing depression and depressive symptoms. RESULTS:Intervention patients had significantly greater self-efficacy for managing depression (P<0.01) and were more likely to keep track of depressive symptoms (P<0.0001), monitor early warning signs (P<0.0001), and plan for coping with high risk situations (P<0.0001) at all time points compared to usual care control patients. Self-efficacy for managing depression (P<0.0001), keeping track of depressive symptoms (P=0.05), monitoring for early warning signs (P=0.01), engaging in pleasant activities (P<0.0001) and engaging in social activities (P<0.0001) positively predicted improvements in depression symptom scores. CONCLUSIONS:A brief intervention designed to target cognitive-behavioural factors and promote adherence to pharmacotherapy in order to prevent depression relapse was highly successful in changing several behaviours related to controlling depression. Improvements in self-efficacy and several self-management behaviours that were targets of the intervention were significantly related to improvements in depression outcome.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Ludman E,Katon W,Bush T,Rutter C,Lin E,Simon G,Von Korff M,Walker Edoi
10.1017/s003329170300816xsubject
Has Abstractpub_date
2003-08-01 00:00:00pages
1061-70issue
6eissn
0033-2917issn
1469-8978journal_volume
33pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Previous research has established the relationship between cannabis use and psychotic disorders. Whether cannabis use is related to transition to psychosis in patients at ultra-high risk (UHR) for psychosis remains unclear. The present study aimed to review the existing evidence on the association between ca...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S0033291715002329
更新日期:2016-03-01 00:00:00
abstract::Increases in plasma noradrenaline were found in a group of 12 subjects smoking cigarettes. The associated rises in pulse rate, blood pressure and plasma free fatty acids could be prevented by beta-blockade with oxprenolol. This inhibition of the peripheral effects of catecholamines did not affect subjective satisfacti...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291700013799
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that purging disorder (PD) may be a common eating disorder that is associated with clinically significant levels of distress and high levels of psychiatric co-morbidity. However, no study has established evidence of disorder-related impairment or whether distress is specifically relate...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707001390
更新日期:2008-10-01 00:00:00
abstract::Comparison between general practice attenders and community subjects with emotional distress (as measured by GHQ-12) showed that women from a general practice sample reported more social problems than those from the community. In both men and women, problems with their spouse or partner were far more likely among gene...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700028063
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Public figures are at increased risk of attracting unwanted attention in the form of intrusions, stalking and, occasionally, attack. Whereas the potential threat to the British Royal Family from terrorists and organized groups is clearly defined, there is a dearth of knowledge about that from individual hara...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709005443
更新日期:2009-09-01 00:00:00
abstract::Cholecystokinin (CCK) is a peptide originally isolated from the gut. It has been investigated as a candidate treatment for schizophrenia on the assumption that the illness is associated with an imbalance between CCK and dopamine in the mesolimbic dopamine system. Many of the studies to assess the efficacy of CCK used ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,评审
doi:10.1017/s0033291700008278
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Meta-analyses link childhood trauma to depression, mania, anxiety disorders, and psychosis. It is unclear, however, whether these outcomes truly represent distinct disorders following childhood trauma, or that childhood trauma is associated with admixtures of affective, psychotic, anxiety and manic psychopat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714002372
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Subthreshold depression (SUBD) in later life is common and important as prodromal state and prominent risk factor in the development of major depressive disorder (MDD). Indicated prevention can reduce the incidence of MDD among people with SUBD substantially, but needs to be targeted to those that are truly ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001549
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Restrictive food intake in anorexia nervosa (AN) has been related to an overactive cognitive control network inhibiting intuitive motivational responses to food stimuli. However, the influence of short-term homeostatic signaling on the neural regulation of cue-induced food craving in AN is still unclear. ME...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719003970
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:Aberrant emotional biases have been reported in bipolar disorder (BD), but results are inconsistent. Despite the clinical relevance of chronic mood variability in BD, there is no previous research investigating how the extent of symptom fluctuations in bipolar disorder might relate to emotional biases. This ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171600180X
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The Met allele of the catechol-O-methyltransferase (COMT) valine-to-methionine (Val158Met) polymorphism is known to affect dopamine-dependent affective regulation within amygdala-prefrontal cortical (PFC) networks. It is also thought to increase the risk of a number of disorders characterized by affective mo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710001431
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Depressive symptoms above screening thresholds have been shown to predict functional decline in older adults. Less is known about the impact of subthreshold depression, and whether more symptoms confer significantly greater risk compared to fewer symptoms. METHOD:Using data from the Duke Established Populat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709005650
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Dissociative reactions in post-traumatic stress disorder (PTSD) have been regarded as strategic responses that limit arousal. Neuroimaging studies suggest distinct prefrontal responses in individuals displaying dissociative and hyperarousal responses to threat in PTSD. Increased prefrontal activity may refle...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708002742
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Three cognitive constructs are risk factors for eating disorders: undue influence of weight and shape, concern about weight and shape, and body dissatisfaction (BD). Undue influence, a diagnostic criterion for eating disorders, is postulated to be closely associated with self-esteem whereas BD is postulated ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710001066
更新日期:2011-04-01 00:00:00
abstract::In a prospective cohort study of consecutive primary care attenders in south London, the estimated prevalence of non-psychotic psychiatric disorder was 45.6%, using the Revised Clinical Interview Schedule (CIS-R). The estimated 12-month incidence rate was 15.7%. Extremely high stability was found in CIS-R scores over ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291796004023
更新日期:1997-01-01 00:00:00
abstract::Preliminary data from the National Institute of Mental Health-Clinical Research Branch Collaborative Program on the Psychobiology of Depression dealing with the human growth hormone (hGH) response to the Insulin Tolerance Test (ITT) during the pre-treatment (drug-free) period of the study are presented in this paper. ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700043270
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND:Empirical data on the impact of personality pathology on acute treatment outcome for depression are mixed, in part because of challenges posed by assessing trait-like personality patterns while patients are in an active mood episode. To our knowledge, no previous study has examined the effect of personality ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291703001661
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:In people with bulimic eating disorders, exposure to high-calorie foods can result in increases in food craving, raised subjective stress and salivary cortisol concentrations. This cue-induced food craving can be reduced by repetitive transcranial magnetic stimulation (rTMS). We investigated whether rTMS has...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291710001881
更新日期:2011-06-01 00:00:00
abstract::One hundred and twenty women recruited from attenders at the antenatal clinic of the Obstetrics Department of a general hospital were asked to complete ad hoc questionnaires during pregnancy; they were then interviewed by psychiatrists using a structured diagnostic interview, the Schedule for Affective Disorders and S...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170002643x
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:The salience of a visual stimulus is often reduced by nearby stimuli, an effect known as surround suppression of perceived contrast, which may help in locating the borders of an object. Weaker surround suppression has been observed in schizophrenia but it is unclear whether this abnormality is present in oth...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001439
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The World Mental Health Survey Initiative (WMHSI) has advanced our understanding of mental disorders by providing data suitable for analysis across many countries. However, these data have not yet been fully explored from a cross-national lifespan perspective. In particular, there is a shortage of research o...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001116
更新日期:2014-03-01 00:00:00
abstract::A number of computerized tests were used to study visual attention, memory and learning in elderly depressed patients. Impairment was found in approximately 70% of depressed patients and was seen particularly in memory and in measures of latency. Depressed patients showed equivalent impairment in short-term memory but...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700017025
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Delusion is the most characteristic symptom of psychosis. While researchers suggested an association between changes of the cortical salience network (CSN) and delusion, whether these CSN findings are a cause or a consequence of delusion remains unknown. METHOD:To assess the effect of CSN functioning to for...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001057
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Although cannabis is the most widely used illicit drug in the United States, few recent American studies have examined the attributes of long-term heavy cannabis users. METHOD:Using a case-control design, we obtained psychological and demographic measures on 108 individuals, age 30-55, who had smoked cannab...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008560
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:We report on the epidemiology of post-traumatic stress disorder (PTSD) in the Australian community, including information on lifetime exposure to trauma, 12-month prevalence of PTSD, sociodemographic correlates and co-morbidity. METHODS:Data were obtained from a stratified sample of 10,641 participants as p...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701004287
更新日期:2001-10-01 00:00:00
abstract::National statistics for railway fatalities in England and Wales show a reduction of train crashes and a fluctuating level of deaths, of which an increasing proportion is from suicide. A closer examination of a two-year sample from the South of England revealed a large proportion of probable suicides and a small propor...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700031469
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:Based on the developing clinical and legal literature, and using the framework adopted in draft legislation, capacity to make a valid decision about a clinically required blood test was investigated in three groups of people with a 'mental disability' (i.e. mental illness (chronic schizophrenia), 'learning d...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700001768
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Early Intervention in Psychosis Services (EIS) for young people in England experiencing first-episode psychosis (FEP) were commissioned in 2002, based on an expected incidence of 15 cases per 100 000 person-years, as reported by schizophrenia epidemiology in highly urban settings. Unconfirmed reports from EI...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002461
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Few epidemiological studies have examined the temporal relationship between chronic pain and depression using longitudinal data. In the present study, we examined major depression as both an antecedent risk factor and consequence of chronic back pain (CBP) in the general population. METHOD:Data on 9909 pain...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291705004952
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been strongly questioned or prematurely dismissed. METHODS:selective review of the recent literature on molecular genetic and genomic approaches to the ps...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291709991139
更新日期:2010-04-01 00:00:00