Abstract：
:Proton ENDOR has been observed from frozen solutions (ca. 38K degrees) of copper meso-(4-N-tetra-methylpyridyl)porphyrin (CuTMpyP(4)) complexed with Salmon sperm DNA in water and D2O. Lines from exchangeable protons of the DNA bases have been observed in these ENDOR spectra. Analyses of these ENDOR data show that the separations of these DNA protons from the copper atom are between 3.76 and 3.84 A with angles of 19.5 to 22.5 degrees between the Cu-H vectors and the gz axis. A distant ENDOR response has also been observed from phosphorous nuclei in the DNA backbone. We estimate that the phosphorous atoms producing this ENDOR signal are 7.5-10 A from the copper center of the porphyrin. These ENDOR data combined with results from an earlier NMR investigation have been used to construct a computer simulated model of the binding site in which the porphyrin is partially intercalated and extends into the major groove of DNA. The two GC base pairs at this site are slightly inequivalent. For each, the G imino proton and one of the C amino protons are at appropriate positions to account for the ENDOR signals arising from exchangeable protons. It is unlikely that this inequivalence would persist at room temperature where dynamic processes would give an apparently symmetric interaction. Although the model accounts for all reported experimental data involving tetracationic porphyrin species which have been suggested to be intercalators, it is not a unique solution.
journal_name
J Biomol Struct Dynjournal_title
Journal of biomolecular structure & dynamicsauthors
Greiner SP,Kreilick RW,Marzilli LGdoi
10.1080/07391102.1992.10507962subject
Has Abstractpub_date
1992-04-01 00:00:00pages
837-51issue
5eissn
0739-1102issn
1538-0254journal_volume
9pub_type
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journal_title：Journal of biomolecular structure & dynamics
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journal_title：Journal of biomolecular structure & dynamics
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journal_title：Journal of biomolecular structure & dynamics
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journal_title：Journal of biomolecular structure & dynamics
pub_type： 杂志文章
doi：10.1080/07391102.2004.10506987
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journal_title：Journal of biomolecular structure & dynamics
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更新日期：2020-10-01 00:00:00
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journal_title：Journal of biomolecular structure & dynamics
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journal_title：Journal of biomolecular structure & dynamics
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journal_title：Journal of biomolecular structure & dynamics
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journal_title：Journal of biomolecular structure & dynamics
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更新日期：2020-10-01 00:00:00
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journal_title：Journal of biomolecular structure & dynamics
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doi：10.1080/07391102.2017.1418678
更新日期：2019-01-01 00:00:00
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journal_title：Journal of biomolecular structure & dynamics
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doi：10.1080/07391102.2020.1796793
更新日期：2020-07-31 00:00:00
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journal_title：Journal of biomolecular structure & dynamics
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journal_title：Journal of biomolecular structure & dynamics
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journal_title：Journal of biomolecular structure & dynamics
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doi：10.1080/07391102.2020.1865203
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journal_title：Journal of biomolecular structure & dynamics
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更新日期：1987-04-01 00:00:00
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journal_title：Journal of biomolecular structure & dynamics
pub_type： 杂志文章
doi：10.1080/07391102.2013.809317
更新日期：2014-01-01 00:00:00
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journal_title：Journal of biomolecular structure & dynamics
pub_type： 杂志文章
doi：10.1080/07391102.2020.1762743
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journal_title：Journal of biomolecular structure & dynamics
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doi：10.1080/07391102.2016.1214621
更新日期：2017-08-01 00:00:00
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journal_title：Journal of biomolecular structure & dynamics
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doi：10.1080/07391102.2005.10507056
更新日期：2005-10-01 00:00:00
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journal_title：Journal of biomolecular structure & dynamics
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更新日期：2020-03-01 00:00:00
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journal_title：Journal of biomolecular structure & dynamics
pub_type： 杂志文章
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更新日期：1985-02-01 00:00:00
abstract：:The studies on protein-dye interactions are important in biological process and it is regarded as vital step in rational drug design. The interaction of thionine (TH) with human serum albumin (HSA) was analyzed using isothermal titration calorimetry (ITC), spectroscopic, and molecular docking technique. The emission s...
journal_title：Journal of biomolecular structure & dynamics
pub_type： 杂志文章
doi：10.1080/07391102.2016.1235513
更新日期：2017-11-01 00:00:00
abstract：:Repeat regions are low-complexity regions in the human genome that largely code for intrinsic disorder in proteins. Expansions outside the normal thresholds in repeat regions are likely to be pathogenic, leading to the so-called repeat expansion diseases. There have been numerous studies on the most common group of re...
journal_title：Journal of biomolecular structure & dynamics
pub_type： 杂志文章
doi：10.1080/07391102.2021.1871957
更新日期：2021-01-18 00:00:00
