Characterization of endothelin synthetic pathways and receptor subtypes: physiological and pathophysiological implications.

Abstract:

:The endothelins are a family of three widely expressed 21 amino acid peptides. Apart from the ability to constrict vascular smooth muscle, they have numerous other potent effects, from enhancing mitogenesis to influencing nervous function. The pathway of their production involves the initial synthesis of a predominantly inactive 38 to 41 amino acid precursor, big endothelin, which is cleaved to the active form by an as yet unidentified, but widely distributed, endothelin-converting enzyme. This enzyme has been partially characterized and appears to be a metalloprotease, active at neutral pH, which is inhibited by phosphoramidon. However, other enzymes, including those contained in inflammatory cells, can also convert big endothelin to its active form. Research in the past 2 to 3 years has revealed at least two endothelin receptors. These are widely distributed throughout the body and are present, for instance, on vascular and non-vascular smooth muscle, nervous tissue, and endothelial and epithelial cells. There is also a fairly large degree of heterogeneity between species in the distribution of these endothelin receptors. The endothelins have been widely implicated in a number of disease states and the recent development of selective and non-selective antagonists of these receptors, such as BQ-123, PD 142893, and Ro 46-2005 is finally making available the tools required to elucidate their true roles.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Warner TD

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

42-7

eissn

0195-668X

issn

1522-9645

journal_volume

14 Suppl I

pub_type

杂志文章,评审
  • Effect of clopidogrel on 1-year mortality in hospital survivors of acute ST-segment elevation myocardial infarction in clinical practice.

    abstract:AIMS:We sought to assess the effect of clopidogrel on clinical events 1 year after discharge in survivors of ST-elevation myocardial infarction (STEMI) in clinical practice. METHODS AND RESULTS:We analysed data of consecutive survivors of acute STEMI and either concomitant therapy with aspirin or aspirin plus clopidog...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehl317

    authors: Zeymer U,Gitt AK,Jünger C,Heer T,Wienbergen H,Koeth O,Bauer T,Mark B,Zahn R,Gottwik M,Senges J,Acute COronary Syndromes (ACOS) registry investigators.

    更新日期:2006-11-01 00:00:00

  • The codex of science: honesty, precision, and truth--and its violations.

    abstract::Science has made enormous achievements for our understanding of the world and for everyday life: we now know that we live on a spherical planet of the solar system, we understand the origin of the species, we can take a train, survive myocardial infarction, and fly to the moon. This has been made possible thanks to a ...

    journal_title:European heart journal

    pub_type: 历史文章,杂志文章

    doi:10.1093/eurheartj/eht063

    authors: Lüscher TF

    更新日期:2013-04-01 00:00:00

  • ACE inhibitors and their influence on inflammation, bronchial reactivity and cough.

    abstract::Orally active angiotensin converting enzyme (ACE) inhibitors have been successfully used in the treatment of congestive heart failure and hypertension. However, adverse skin reactions, such as angioneurotic oedema have been reported following such medication. Furthermore, these drugs have been associated with a persis...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/15.suppl_c.52

    authors: Andersson RG,Persson K

    更新日期:1994-08-01 00:00:00

  • Diagnostic performance of body mass index to detect obesity in patients with coronary artery disease.

    abstract:BACKGROUND:Emerging evidence suggests that a mildly elevated body mass index (BMI), is related to improved survival and fewer cardiovascular events in patients with coronary artery disease (CAD). We hypothesize that these results are related to the poor diagnostic performance of BMI to detect adiposity, especially in t...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm243

    authors: Romero-Corral A,Somers VK,Sierra-Johnson J,Jensen MD,Thomas RJ,Squires RW,Allison TG,Korinek J,Lopez-Jimenez F

    更新日期:2007-09-01 00:00:00

  • Physical activity in patients with stable coronary heart disease: an international perspective.

    abstract:AIMS:Despite the known benefits of regular exercise, the reasons why many coronary heart disease (CHD) patients engage in little physical activity are not well understood. This study identifies factors associated with low activity levels in individuals with chronic CHD participating in the STABILITY study, a global cli...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht258

    authors: Stewart R,Held C,Brown R,Vedin O,Hagstrom E,Lonn E,Armstrong P,Granger CB,Hochman J,Davies R,Soffer J,Wallentin L,White H

    更新日期:2013-11-01 00:00:00

  • N-methylethanolamine attenuates cardiac fibrosis and improves diastolic function: inhibition of phospholipase D as a possible mechanism.

    abstract:AIM:Ventricular fibrosis is promoted by many effectors that chronically activate phospholipase D (PLD), and induces cardiac dysfunction and heart failure in cardiovascular diseases. Since ethanolamine is a product of PLD, we hypothesised that an administration of an analogue of ethanolamine, N-methylethanolamine (MEA),...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.05.003

    authors: Yamamoto K,Takahashi Y,Mano T,Sakata Y,Nishikawa N,Yoshida J,Oishi Y,Hori M,Miwa T,Inoue S,Masuyama T

    更新日期:2004-07-01 00:00:00

  • Calcium antagonist induced vasodilation in peripheral, coronary and cerebral vasculature as important factors in the treatment of elderly hypertensives.

    abstract::Increased arteriolar tone is the pathophysiological hallmark of essential hypertension and is determined by the intracellular free calcium concentration in the vascular smooth muscle cell. Calcium influx is an important determinant of vasoconstriction and excess calcium influx-dependent vasoconstriction has been shown...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/8.suppl_k.49

    authors: Erne P,Conen D,Kiowski W,Bolli P,Müller FB,Bühler FR

    更新日期:1987-11-01 00:00:00

  • Contractility sensor-guided optimization of cardiac resynchronization therapy: results from the RESPOND-CRT trial.

    abstract:Aims:Although cardiac resynchronization therapy (CRT) is effective in patients with systolic heart failure (HF) and a wide QRS interval, a substantial proportion of patients remain non-responsive. The SonR contractility sensor embedded in the right atrial lead enables individualized automatic optimization of the atriov...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehw526

    authors: Brugada J,Delnoy PP,Brachmann J,Reynolds D,Padeletti L,Noelker G,Kantipudi C,Rubin Lopez JM,Dichtl W,Borri-Brunetto A,Verhees L,Ritter P,Singh JP,RESPOND CRT Investigators.

    更新日期:2017-03-07 00:00:00

  • Characterization of relevant membrane antigens by two-dimensional immunoblot and n-terminal sequence analysis in patients with myocarditis.

    abstract::In myocarditis an antigen-specific immune response to cardiac epitopes has been demonstrated by several investigators. In 25 patients with histologically proven myocarditis, autoantibodies to cardiac tissue were observed in 65% by immunofluorescence assay. By immunoblot analysis 46% of sera reacted with cardiac tissue...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_o.81

    authors: Pankuweit S,Lottspeich F,Maisch B

    更新日期:1995-12-01 00:00:00

  • Failure of provision of antibiotic prophylaxis for 'at risk' cardiac patients: impetus for improvement required from cardiologists.

    abstract::We conducted a survey by questionnaire to assess whether patients 'at risk' from infective endocarditis are aware of the need for good dental hygiene and antibiotic prophylaxis, and receive appropriate advice or treatment. Of 189 patients surveyed, half had told a dentist about their heart, 8% were aware of a dental p...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.6.812

    authors: Forbat LN,Skehan JD

    更新日期:1993-06-01 00:00:00

  • Effects of multiple ischaemic events on human myocardium--an ultrastructural study.

    abstract::Chronically ischaemic myocardium from patients with coronary heart disease was investigated by light and electron microscopy using tissue biopsies taken during cardiac surgery. Light microscopy showed a significantly increased amount of fibrotic material, cell size was variable. By electron microscopy, the most obviou...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/9.suppl_a.141

    authors: Schaper J

    更新日期:1988-01-01 00:00:00

  • Drug plasma levels and coronary vasodilation after isosorbide dinitrate chewing capsules.

    abstract::Five, ten and fifteen min after sublingual administration of 10mg isosorbide dinitrate (ISDN) in chewing capsules, in 10 patients with coronary artery disease, ISDN plasma levels were correlated with the dilation of epicardial coronary arteries as well as with changes in aortic blood pressure and heart rate. Due to th...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Jost S,Rafflenbeul W,Knop I,Bossaller C,Gulba D,Hecker H,Lippolt P,Lichtlen PR

    更新日期:1989-11-01 00:00:00

  • Cardiovascular manifestations in men and women carrying a FBN1 mutation.

    abstract:AIMS:In patients with Marfan syndrome and other type-1 fibrillinopathies, genetic testing is becoming more easily available, leading to the identification of mutations early in the course of the disease. This study evaluates the cardiovascular (CV) risk associated with the discovery of a fibrillin-1 (FBN1) mutation. M...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq258

    authors: Détaint D,Faivre L,Collod-Beroud G,Child AH,Loeys BL,Binquet C,Gautier E,Arbustini E,Mayer K,Arslan-Kirchner M,Stheneur C,Halliday D,Beroud C,Bonithon-Kopp C,Claustres M,Plauchu H,Robinson PN,Kiotsekoglou A,De Backer

    更新日期:2010-09-01 00:00:00

  • Physiological parameters during the initial stages of cardiopulmonary exercise testing in patients with chronic heart failure. Their value in the assessment of clinical severity and prognosis.

    abstract:AIMS:To analyse the relationship between initial exercise parameters and peak oxygen consumption and prognosis in 96 patients with congestive heart failure. METHODS AND RESULTS:Comparison of responses during the initial 6 min of cardiopulmonary exercise testing (Naughton modified protocol) in patients stratified to th...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015201

    authors: de Vries RJ,van Veldhuisen DJ,Dunselman PH,van der Veer N,Crijns HJ

    更新日期:1997-12-01 00:00:00

  • Management of the patient with left ventricular hypertrophy.

    abstract::The management of left ventricular hypertrophy (LVH) presupposes that the patient is identified by echocardiography and is carefully evaluated for risk stratification, taking into consideration possible associated complications. The role of non-pharmacological treatment is limited, except in obese patients. Drug treat...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/14.suppl_d.22

    authors: de Divitiis O,Celentano A,De Simone G,Di Somma S,Galderisi M,Liguori V,de Divitiis M,Petitto M

    更新日期:1993-07-01 00:00:00

  • Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society.

    abstract:AIMS:Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular disease (ACVD). Given recent insights into the heterogeneity of geneti...

    journal_title:European heart journal

    pub_type: 共识发展会议,杂志文章

    doi:10.1093/eurheartj/ehu274

    authors: Cuchel M,Bruckert E,Ginsberg HN,Raal FJ,Santos RD,Hegele RA,Kuivenhoven JA,Nordestgaard BG,Descamps OS,Steinhagen-Thiessen E,Tybjærg-Hansen A,Watts GF,Averna M,Boileau C,Borén J,Catapano AL,Defesche JC,Hovingh GK,Hump

    更新日期:2014-08-21 00:00:00

  • Efficacy of N-acetylcysteine in preventing renal injury after heart surgery: a systematic review of randomized trials.

    abstract:AIMS:The aim of this study was to assess whether perioperative N-acetylcysteine (NAC), an antioxidant, prevents acute renal injury (ARI) after cardiac surgery. METHODS AND RESULTS:We performed a systematic review of randomized controlled trials (RCTs) of NAC in adult cardiac surgery patients. The RCTs were identified ...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehp053

    authors: Adabag AS,Ishani A,Bloomfield HE,Ngo AK,Wilt TJ

    更新日期:2009-08-01 00:00:00

  • Prognosis and treatment of atrial fibrillation patients by European cardiologists: one year follow-up of the EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot registry).

    abstract:BACKGROUND:The EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot) provides systematic collection of contemporary data regarding the management and treatment of 3119 subjects with AF from 9 member European Society of Cardiology (ESC) countries. In this analysis, we repor...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehu374

    authors: Lip GY,Laroche C,Ioachim PM,Rasmussen LH,Vitali-Serdoz L,Petrescu L,Darabantiu D,Crijns HJ,Kirchhof P,Vardas P,Tavazzi L,Maggioni AP,Boriani G

    更新日期:2014-12-14 00:00:00

  • Experience of percutaneous transluminal coronary angioplasty in orthotopic cardiac transplant recipients.

    abstract::We evaluated the role of percutaneous transluminal coronary angioplasty (PTCA) in a series of orthotopic cardiac transplant recipients with severe epicardial coronary occlusive disease. Ten orthotopic cardiac transplant patients treated by PTCA up to March 1990 were reviewed. All had significant epicardial coronary ar...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/12.11.1205

    authors: Mullins PA,Shapiro LM,Aravot DA,Scott JP,Large SR,Wallwork J,Schofield PM

    更新日期:1991-11-01 00:00:00

  • Simplifying cardiovascular risk estimation using resting heart rate.

    abstract:AIMS:Elevated resting heart rate (RHR) is a known, independent cardiovascular (CV) risk factor, but is not included in risk estimation systems, including Systematic COronary Risk Evaluation (SCORE). We aimed to derive risk estimation systems including RHR as an extra variable and assess the value of this addition. MET...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq164

    authors: Cooney MT,Vartiainen E,Laatikainen T,Joulevi A,Dudina A,Graham I

    更新日期:2010-09-01 00:00:00

  • Acute and long-term haemodynamic and neurohumoral response to nisoldipine vs captopril in patients with heart failure: a randomized double-blind study.

    abstract::To study the haemodynamic and neurohumoral effects of nisoldipine (2 X 10 mg) vs captopril (3 X 25 mg), 24 patients with heart failure (New York Heart Association class II and III) due to coronary artery disease were treated in a randomized double-blind trial over 3 months. Both drugs were well tolerated. Clinical sta...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a059786

    authors: Schofer J,Hobuss M,Aschenberg W,Tews A

    更新日期:1990-08-01 00:00:00

  • Assessment of multiple cardiac biomarkers in non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 trial.

    abstract:AIMS:The aim of this study is to simultaneously evaluate the incremental prognostic value of multiple cardiac biomarkers reflecting different underlying pathophysiological processes in a well-characterized population of patients with non-ST-segment acute coronary syndrome (NSTE-ACS). METHODS AND RESULTS:We measured ca...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehq468

    authors: Scirica BM,Sabatine MS,Jarolim P,Murphy SA,de Lemos JL,Braunwald E,Morrow DA

    更新日期:2011-03-01 00:00:00

  • Intravenous streptokinase in acute myocardial infarction (I.S.A.M.): assessment of left ventricular function 1 and 7 months after infarction by radionuclide ventriculography.

    abstract::I.S.A.M. was a prospective, placebo-controlled, double-blind multicentre trial of high-dose short-term intravenous streptokinase in acute myocardial infarction (AMI) within 6 h of the onset of symptoms. Determination of left ventricular ejection fraction (LVEF) by radionuclide ventriculography was performed 1 and 7 mo...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/oxfordjournals.eurheartj.a059610

    authors: Voth E,Tebbe U,Schicha H,Neumann P,Schröder R,Neuhaus KL,Emrich D

    更新日期:1990-10-01 00:00:00

  • Cardiovascular critical event pathways for the progression of heart failure; a report from the ATLAS study.

    abstract:AIMS:To determine the sequence of critical cardiovascular events in the progression of heart failure, and whether aetiology or high-dose vs low-dose lisinopril affected these pathways. METHODS AND RESULTS:This was a post-hoc investigation of the ATLAS database, which comprised 3164 patients with chronic heart failure,...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2570

    authors: Cleland JG,Thygesen K,Uretsky BF,Armstrong P,Horowitz JD,Massie B,Packer M,Poole-Wilson PA,Rydén L,ATLAS investigators.

    更新日期:2001-09-01 00:00:00

  • Intravenous acebutolol raises serum potassium in acute myocardial infarction.

    abstract::Hypokalaemia commonly occurs in acute myocardial infarction (AMI) and may be caused by elevated serum levels of adrenaline, allegedly by beta 2-adrenergic mediated influx of potassium (K) into cells. We investigated the effect on serum K of intravenous acebutolol (a relatively beta 1-selective agent) in 50 patients wi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062036

    authors: Jardine RM,Obel IW,Smith AM

    更新日期:1986-02-01 00:00:00

  • New-onset atrial fibrillation as first clinical manifestation of latent Brugada syndrome: prevalence and clinical significance.

    abstract:AIMS:To evaluate the prevalence, clinical significance, and prognosis of latent Brugada syndrome (BrS) in patients with new-onset atrial fibrillation (AF) unmasked by class 1C antiarrhythmic drugs. METHODS AND RESULTS:Between January 2000 and June 2008, all consecutive patients with new-onset AF, who after flecainide ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp326

    authors: Pappone C,Radinovic A,Manguso F,Vicedomini G,Sala S,Sacco FM,Ciconte G,Saviano M,Ferrari M,Sommariva E,Sacchi S,Ciaccio C,Kallergis EM,Santinelli V

    更新日期:2009-12-01 00:00:00

  • Myocardial map derived from two-dimensional echocardiography: reproducible and standardized description of infarction topographies.

    abstract::The aim of this study was to improve the reproducibility and the standardization of the topographical assessment of myocardial infarctions in routine two-dimensional echocardiography. A myocardial map of the left ventricle was derived from a necropsy study of normal human hearts; interventricular grooves and papillary...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061399

    authors: Touche T,Vervin P,Prasquier R,Diebold B,Curien N,Gourgon R

    更新日期:1983-11-01 00:00:00

  • Anti-ischaemic intervention with verapamil in patients recovering from acute myocardial infarction.

    abstract::The present review discusses the prognostic significance of post-infarction angina pectoris, and the significance of post-infarction intervention with verapamil on the prevalence of post-infarction ischaemia and prognosis. Angina pectoris during the first month after acute myocardial infarction (AMI) was found to be a...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/16.suppl_h.13

    authors: Jespersen CM

    更新日期:1995-08-01 00:00:00

  • Recurrent angina after coronary revascularization: a clinical challenge.

    abstract::Coronary revascularization procedures by means of percutaneous coronary interventions or coronary artery bypass graft surgeries are performed worldwide daily for the symptomatic treatment of patients with myocardial ischaemia. Nevertheless, angina remains a significant clinical problem. Management of angina recurring ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehl562

    authors: Abbate A,Biondi-Zoccai GG,Agostoni P,Lipinski MJ,Vetrovec GW

    更新日期:2007-05-01 00:00:00

  • Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population.

    abstract:AIMS:The brachial-ankle pulse wave velocity (baPWV) has been recognized as a marker that reflects arterial stiffness. We conducted an investigation to evaluate whether baPWV is independently associated with early mild diastolic heart failure (DHF) in a general middle and aged population. METHODS AND RESULTS:From 1 Jul...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq296

    authors: Kang S,Fan HM,Li J,Fan LY,Miao AY,Bao Y,Wu LZ,Zhu Y,Zhang DF,Liu ZM

    更新日期:2010-11-01 00:00:00