The diagnosis of recent herpes simplex virus type 2 genital infections by the simplex-2 test.

Abstract:

:The prevalence of complement-fixing (CF) antibody against the AG-4 early antigen of herpes simplex virus (HSV) type 2 (HSV-2) was determined in patients with culture confirmed HSV-2 genital herpes and control groups using a commercial HSV-2 early antigen (Simplex-2; Gene Link Australia Ltd). Eighty seven per cent of 39 sera collected between 14 and 28 days after confirmed primary and recurrent HSV-2 infection were positive. In acute sera collected between 2-10 days after onset the Simplex-2 test was negative in all 90 patients with presumed primary infection but positive in 53% of 230 sera from recurrent infection. A specificity of 90-94.5% was obtained by testing 36 patients with recent proven HSV-1 infection and 331 control group patients. The Simplex-2 test may be useful in some cases of culture-negative, clinically suspected genital HSV-2 lesions only when sera are collected between 14-28 days after primary and recurrent infection. Its lack of specificity makes it unsuitable for the routine diagnosis of recent HSV-2 infection in the general population.

journal_name

Pathology

journal_title

Pathology

authors

Field PR,Ho DW,Cunningham AL

doi

10.3109/00313029209068885

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

302-6

issue

4

eissn

0031-3025

issn

1465-3931

journal_volume

24

pub_type

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